Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRα3-RET receptor complex

Neuron

Volumn 21, Issue 6, 1998, Pages 1291-1302

  Baloh, Robert H ^a   Tansey, Malú G ^a   Lampe, Patricia A ^a   Fahrner, Timothy J ^a   Enomoto, Hideki ^a   Simburger, Kelli S ^a   Leitner, Melanie L ^a   Araki, Toshiyuki ^a   Johnson Jr , Eugene M ^a   Milbrandt, Jeffrey ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR;

ARTICLE; BINDING AFFINITY; EMBRYO; HUMAN; HUMAN TISSUE; LIGAND BINDING; NERVOUS SYSTEM DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

EID: 0032408664     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80649-2     Document Type: Article

References (54)

1. Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D.J. (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402.
2. Araki, T., and Milbrandt, J. (1996). Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth. Neuron 17, 353-361.
3. Baloh, R.H., Tansey, M.G., Golden, J.P., Creedon, D.J., Heuckeroth, R.O., Keck, C.L., Zimonjic, D.B., Popescu, N.C., Johnson, E.M.J., and Milbrandt, J. (1997). TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron 18, 793-802.
4. Baloh, R.H., Gorodinsky, A., Golden, J.P., Tansey, M.G., Keck, C.L., Popescu, N.C., Johnson, E.M., Jr., and Milbrandt, J. (1998). GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. USA 95, 5801-5806.
5. Bennett, D.L., Michael, G.J., Ramachandran, N., Munson, J.B., Averill, S., Yan, Q., McMahon, S.B., and Priestley, J.V. (1998). A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury. J. Neurosci. 18, 3059-3072.
6. Brewer, C.B. (1994). Cytomegalovirus plasmid vectors for permanent lines of polarized epithelial cells. Meth. Cell Biol. 43, 233-245.
7. Brockes, J.P., Fields, K.L., and Raff, M.C. (1979). Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerves. Brain Res. 165, 105-118.
8. Buj-Bello, A., Buchman, V.L., Norton, A., Rosenthal, A., and Davies, A.M. (1995). GDNF is an age-specific survival factor for sensory and autonomic neurons. Neuron 15, 821-828.
9. Buj-Bello, A., Adu, J., Pinon, L.G., Horton, A., Thompson, J., Rosenthal, A., Chinchetru, M., Buchman, V.L., and Davies, A.M. (1997). Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature 387, 721-724.
10. Cacalano, G., Farinas, I., Wang, L.-C., Hagler, K., Forgie, A., Moore, M., Armanini, M., Phillips, H., Ryan, A.M., Reichardt, L.F., et al. (1998). GFRα1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron 21, 53-62.
11. Creedon, D.J., Tansey, M.G., Baloh, R.H., Osborne, P.A., Lampe, P.A., Fahrner, T.J., Heuckeroth, R.O., Milbrandt, J., and Johnson, E.M.J. (1997). Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Proc. Natl. Acad. Sci. USA 94, 7018-7023.
12. Durbec, P., Marcos-Gutierrez, C.V., Kilkenny, C., Grigoriou, M., Wartiowaara, K., Suvanto, P., Smith, D., Ponder, B., Costantini, F., Saarma, M., et al. (1996). GDNF signaling through the Ret receptor tyrosine kinase. Nature 381, 789-793.
13. Ebendal, T., Tomac, A., Hoffer, B.J., and Olson, L. (1995). Glial cell line-derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia. J. Neurosci. Res. 40, 276-284.
14. Enokido, Y., de Sauvage, F., Hongo, J.-A., Ninkina, N., Rosenthal, A., Buchman, V.L., and Davies, A.M. (1998). GFRα4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Curr. Biol. 8, 1019-1022.
15. Enomoto, H., Araki, T., Jackman, A., Heuckeroth, R.O., Snider, W.D., Johnson, E.M., Jr., and Milbrandt, J. (1998). GFRα1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron 21, 317-324.
16. Farinas, I, Wilkinson, G.A., Backus, C., Reichardt, L.F., and Patapoutian, A. (1998). Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron 21, 325-334.
17. Golden, J.P., Baloh, R.H., Kotzbauer, P.T., Lampe, P.A., Osborne, P.A., Milbrandt, J., and Johnson, E.M., Jr. (1998). Expression of neurturin, GDNF, and their receptors in the adult mouse CNS. J. Comp. Neurol. 398, 139-150.
18. Grondin, R., and Gash, D.M. (1998). Glial cell line-derived neurotrophic factor (GDNF): a drug candidate for the treatment of Parkinson's disease. J. Neurol. 245 (suppl.), 35-42.
19. Henderson, C.E., Phillips, H.S., Pollock, R.A., Davies, A.M., Lemeulle, C., Armanini, M., Simpson, L.C., Moffet, B., Vandlen, R.A., Koliatsos, V.E., and Rosenthal, A. (1994). GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266, 1062-1064.
20. Heuckeroth, R.O., Lampe, P.A., Johnson, E.M., and Milbrandt, J. (1998). Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Dev. Biol. 200, 116-129.
21. Hishiki, T., Nimura, Y., Isogal, E., Kondo, K., Ichimiya, S., Nakamura, Y., Ozaki, T., Sakiyama, S., Hirose, M., Seki, N., et al. (1998). Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFRα-1, and GFRα-2 Cancer Res. 58, 2158-2165.
22. Horger, B.A., Nishimura, M.C., Armanini, M.P., Wang, L.C., Poulsen, K.T., Rosenblad, C., Kirik, D., Moffat, B., Simmons, L., Johnson, E., Jr., et al. (1998). Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons. J. Neurosci. 18, 4929-4937.
23. Ip, N.Y., Stitt, T.N., Tapley, P., Klein, R., Glass, D.J., Fandl, J., Greene, L.A., Barbacid, G.D., and Yancopoulos, G.D. (1993). Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron 10, 137-149.
24. Jing, S., Wen, D., Yu, Y., Holst, P.L., Luo, Y., Fang, M., Tamir, R., Antonio, L., Hu, Z., Cupples, R., et al. (1996). GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF. Cell 85, 1113-1124.
25. Jing, S., Yu, Y., Fang, M., Hu, Z., Holst, P.L., Boone, T., Delaney, J., Schultz, H., Zhou, R., and Fox, G.M. (1997). GFRα-2 and GFRα-3 are two new receptors for ligands of the GDNF family. J. Biol. Chem. 272, 33111-33117.
26. Klein, R.D., Sherman, D., Ho, W.H., Stone, D., Bennett, G.I., Moffat, B., Vandlen, R., Simmons, L., Gu, Q., Hongo, J.A., et al. (1997). A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature 387, 717-721.
27. Kotzbauer, P.T., Lampe, P.A., Estus, S., Milbrandt, J., and Johnson, E.M.J. (1994). Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor. Neuron 12, 763-773.
28. Kotzbauer, P.T., Lampe, P.A., Heuckeroth, R.O., Golden, J.P., Creedon, D.J., Johnson, E.M., and Milbrandt, J.D. (1996). Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384, 467-470.
29. Lewin, G.R., and Barde, Y.A. (1996). Physiology of the neurotrophins. Annu. Rev. Neurosci. 19, 289-317.
30. Lin, L.-F.H., Doherty, D.H., Lile, J.D., Bektesh, S., and Collins, F. (1993). GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260, 1130-1132.
31. Lindsay, R.M., Thoenen, H., and Barde, Y.-A. (1985). Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor. Dev. Biol. 112, 319-328.
32. Milbrandt, J., de Sauvage, F.J., Fahrner, T.J., Baloh, R.H., Leitner, M.L., Tansey, M.G., Lampe, P.A., Heuckeroth, R.O., Kotzbauer, P.T., Simburger, K.S., et al. (1998). Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron 20, 245-253.
33. Molliver, D.C., Wright, D.E., Leitner, M.L., Parsadanian, A.S., Doster. K., Wen, D., Van, Q., and Snider, W.D. (1997). IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron 19, 849-861.
34. Moore, M.W., Klein, R.D., Farinas, I., Sauer, H., Armanini, M., Phillips, H., Reichart, L.F., Ryan, A.M., Carver-Moore, K., and Rosenthal, A. (1996). Renal and neuronal abnormalities in mice lacking GDNF. Nature 382, 76-79.
35. Naveilhan, P., Baudet, C., Mikaels, A., Shen, L., Westphal, H., and Ernfors, P. (1998). Expression and regulation of GFRα3, a glial cell line-derived neurotrophic factor family receptor. Proc. Natl. Acad. Sci. USA 95, 1295-1300.
36. Oppenheim, R.W., Houenou, L.J., Johnson, J.E., Lin, L.-F.H., Li, L., Lo, A.C., Newsome, A.L., Prevette, D.M., and Wang, S. (1995). Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature 373, 344-346.
37. Pichel, J.G., Shen, L., Hui, S.Z., Granholm, A.-C., Drago, J., Grinberg, A., Lee, E.J., Huang, S.P., Saarma, M., Hoffer, B.J., et al. (1996). Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382, 73-76.
38. Sanchez, M.P., Silos-Santiago, I., Frisen, J., He, B., Lira, S.A., and Barbacid, M. (1996). Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382, 70-73.
39. Sanicola, M., Hession, C., Worley, D., Carmillo, P., Ehrenfels, C., Walus, L., Robinson, S., Jaworski, G., Wei, H., Tizard, R., et al. (1997). Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc. Natl. Acad. Sci., USA 94, 6238-6243.
40. Scherer, S.S. (1997). The biology and pathobiology of Schwann cells. Curr. Opin. Neurol. 10, 386-397.
41. Snider, W.D., and Wright, D.E. (1996). Neurotrophins cause a new sensation. Neuron 16, 229-232.
42. Suvanto, P., Wartiovaara, K., Lindahl, M., Arumae, U., Moshnyakov, M., Horelli-Kuitunen, N., Airaksinen, M.S., Palotie, A., Sariola, H., and Saarma, M. (1997). Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor β, a homologue to GDNFR-α. Hum. Mol. Genet. 6, 1267-1273.
43. Svaren, J., Sevetson, B.R., Golda, T., Stanton, J.J., Swirnoff, A.H., and Milbrandt, J. (1998). Novel mutants of NAB compressors enhance activation by Egr transactivators. EMBO J. 17, 6010-6019.
44. Treanor, J.J.S., Goodman, L., Sauvage, F., Stone, D.M., Poulsen, K.T., Beck, C.D., Gray, C., Armanini, M.P., Pollock, R.A., Hefti, F., et al. (1996). Characterization of a multicomponent receptor for GDNF. Nature 382, 80-83.
45. Trupp, M., Ryden, M., Jornvall, H., Funakoshi, H., Timmusk, T., Arenas, E., and Ibanez, C.F. (1995). Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell Biol. 130, 137-148.
46. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.-S., Sieber, B.-A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumae, U., Sariola, H., Saarma, M., and Ibanez, C.F. (1996). Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature 381, 785-789.
47. Trupp, M., Belluardo, N., Funakoshi, H., and Ibanez, C. (1997). Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-α indicates multiple mechanisms of trophic actions in the adult rat CNS. J. Neurosci. 17, 3554-3567.
48. Trupp, M., Raynoschek, C., Belluardo, N., and Ibanez, C.F. (1998). Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Mol. Cell. Neurosci. 11, 47-63.
49. Vossler, M.R., Yao, H., York, R.D., Pan, M.G., Rim, C.S., and Stork, P.J. (1997). cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89, 73-82.
50. Widenfalk, J., Tomac, A., Lindqvist, E., Hoffer, B., and Olson, L. (1998). GFRα3, a protein related to GFRα1, is expressed in developing peripheral neurons and ensheathing cells. Eur. J. Neurosci. 10, 1508-1517.
51. Worby, C.A., Vega, Q.C., Zhao, Y., Chao, H.H.-J., Seasholtz, A.F., and Dixon, J.E. (1996). Glial cell line-derived neurotrophic factor signals through the RET receptor and activates the mitogen-activated protein kinase. J. Biol. Chem. 271, 23619-23622.
52. Worby, C.A., Vega, Q.C., Chao, H.H., Seasholtz, A.F., Thompson, R.C, and Dixon, J.E. (1998). Identification and characterization of GFRα-3, a novel co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J. Biol. Chem. 273, 3502-3508.
53. York, R.D., Yao, H., Dillon, T., Ellig, C.L., Eckert, S.P., McCleskey, E.W., and Stork, P.J. (1998). Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392, 622-626.
54. Yu, T., Scully, S., Yu, Y., Fox, G.M., Jing, S., and Zhou, R. (1998). Expression of GDNF family receptor components during development: implications in the mechanisms of interaction. J. Neurosci. 18, 4684-4696.