RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons

Development

Volumn 128, Issue 20, 2001, Pages 3963-3974

  Enomoto, H ^a   Crawford, P A ^a   Gorodinsky, A ^a   Heuckeroth, R O ^a   Johnson E M , Jr ^a   Milbrandt, J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axon growth; Axon guidance; Knockout mouse; Migration; Ret; Sympathetic neuron

Indexed keywords

ARTEMIN; PROTEIN RET; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CELL DEATH; CELL DIFFERENTIATION; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; IN VITRO STUDY; MOUSE; NERVE CELL GROWTH; NERVE FIBER GROWTH; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STEM CELL; SYMPATHETIC NERVE CELL;

ANIMALS; AXONS; CELL MOVEMENT; DROSOPHILA PROTEINS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SYMPATHETIC NERVOUS SYSTEM;

ANIMALIA;

EID: 0034764503     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. GDNF family neurotrophic factor signaling: Four masters, one servant?
2. Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervation
3. Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system
4. The GDNF family ligands and receptors - Implications for neural development
5. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret
6. Artemin, a novel member of the GDNF ligand family supports peripheral and central neurons and signals through the GFRα3-RET receptor complex
7. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system
8. p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation
9. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase
10. GFRα1 is an essential receptor component for GDNF in the developing nervous system and kidney
11. Conservation and divergence of axon guidance mechanisms
12. Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts
13. c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway
14. GFR α1-deficient mice have deficits in the enteric nervous system and kidneys
15. Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin
16. The expression of dopamine beta-hydroxylase, tyrosine hydroxylase, and Phox2 transcription factors in sympathetic neurons: Evidence for common regulation during noradrenergic induction and diverging regulation later in development
17. TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo
18. NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors
19. Expression of Neurturin, GDNF, and GDNF Family-Receptor mRNA in the Developing and Mature Mouse
20. Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons
21. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
22. Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells
23. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons
24. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF
25. GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family
26. A GPI-linkied protein that interacts with Ret to form a candidate neurturin receptor
27. Neurturin, a relative of glial-cell-line-derived neurotrophic factor
28. Neurturin is a neurotrophic factor for penile parasympathetic neurons in adult rat
29. The migration of neural crest cells to the wall of the digestive tract in avian embryo
30. Cell line segregation during peripheral nervous system ontogeny
31. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
32. c-src gene product in developing rat brain is enriched in nerve growth cone membranes
33. The effect of the ret- mutation on the normal development of the central and parasympathetic nervous systems
34. Sympathetic nerve fibers ingrowth in the central nervous system of neonatal rodent upon intracerebral NGF injections
35. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
36. Persephin, a novel neurotrophic factor related to GDNF and neurturin
37. Renal and neuronal abnormalities in mice lacking GDNF
38. p59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway
39. GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion
40. Development of sensory neurons in the absence of NGF/TrkA signaling in vivo
41. Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
42. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
43. Defects in enteric innervation and kidney development in mice lacking GDNF
44. Functional regeneration of sensory axons into the adult spinal cord
45. The GDNF protein family: Gene ablation studies reveal what they really do and how
46. Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor
47. Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo
48. Development of the rat superior cervical ganglion: Ganglion cell maturation
49. Renal agenesis and the absence of enteric neurons in mice lacking GDNF
50. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins
51. Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons
52. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
53. Double immunofluorescent staining using two unconjugated primary antisera raised in the same species
54. Neurotrophins cause a new sensation
55. The cellular function of MASH1 in autonomic neurogenesis
56. The cell biology of neuronal navigation
57. Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor-β, a homologue to GDNFR-α
58. The RET-glial cell-derived neurotrophic factor (GDNF) pathway stimulates migration and chemoattraction of epithelial cells
59. GFRa-mediated localization of RET to lipid raft is required for effective downstream signaling, differentiation, and neuronal survival
60. The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system
61. Characterization of a multicomponent receptor for GDNF
62. Neurotrophins are required for nerve growth during development
63. Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation
64. Sympathetic neuron survival and TrkA expression in NT3-deficient mouse embryos
65. A new logic for DNA engineering using recombination in Escherichia coli