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Volumn 8, Issue 3, 1998, Pages 425-430

Huntingtin: A single bait hooks many species

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN;

EID: 0032103078     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80071-8     Document Type: Article
Times cited : (63)

References (56)
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    • of outstanding interest. This paper and the one by Li et al. 1998 [25] show that huntingtin-associated protein HAP1 binds to an accessory protein for cytoplasmic dynein, a microtubule motor protein, thereby implicating huntingtin in intracellular transport.
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    • of outstanding interest. The enzyme cystathionine beta-synthase binds to huntingtin, raising the possibility that a component of HD pathogenesis may be CBS deficiency, which is also associated with homocystinuria and leads to accumulation of homocysteine, a substrate metabolized to powerful excitotoxic amino acids.
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