-
1
-
-
0022876328
-
Huntington's disease. Pathogenesis and management
-
Martin JB, Gusella JF. Huntington's disease. Pathogenesis and management. N Engl J Med. 315:1986;1267-1276.
-
(1986)
N Engl J Med
, vol.315
, pp. 1267-1276
-
-
Martin, J.B.1
Gusella, J.F.2
-
2
-
-
0022395922
-
Neuropathological classification of Huntington's disease
-
Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP Jr. Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol. 44:1985;559-577.
-
(1985)
J Neuropathol Exp Neurol
, vol.44
, pp. 559-577
-
-
Vonsattel, J.P.1
Myers, R.H.2
Stevens, T.J.3
Ferrante, R.J.4
Bird, E.D.5
Richardson E.P., Jr.6
-
3
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell. 72:1993;971-983.
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
4
-
-
0029991245
-
Neurobiology of Huntington's disease
-
Sharp AH, Ross CA. Neurobiology of Huntington's disease. Neurobiol Dis. 3:1996;3-15.
-
(1996)
Neurobiol Dis
, vol.3
, pp. 3-15
-
-
Sharp, A.H.1
Ross, C.A.2
-
5
-
-
0028260436
-
Structure and expression of the Huntington's disease gene: Evidence against simple inactivation due to an expanded CAG repeat
-
Ambrose CM, Duyao MP, Barnes G, Bates GP, Lin CS, Srinidhi J, Baxendale S, Hummerich H, Lehrach H, Altherr M, et al. Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat. Somat Cell Mol Genet. 20:1994;27-38.
-
(1994)
Somat Cell Mol Genet
, vol.20
, pp. 27-38
-
-
Ambrose, C.M.1
Duyao, M.P.2
Barnes, G.3
Bates, G.P.4
Lin, C.S.5
Srinidhi, J.6
Baxendale, S.7
Hummerich, H.8
Lehrach, H.9
Altherr, M.10
-
6
-
-
0029018046
-
Comparative sequence analysis of the human and pufferfish Huntington's disease genes
-
Baxendale S, Abdulla S, Elgar G, Buck D, Berks M, Micklem G, Durbin R, Bates G, Brenner S, Beck S. Comparative sequence analysis of the human and pufferfish Huntington's disease genes. Nat Genet. 10:1995;67-76.
-
(1995)
Nat Genet
, vol.10
, pp. 67-76
-
-
Baxendale, S.1
Abdulla, S.2
Elgar, G.3
Buck, D.4
Berks, M.5
Micklem, G.6
Durbin, R.7
Bates, G.8
Brenner, S.9
Beck, S.10
-
7
-
-
0029392854
-
HEAT repeats in the Huntington's disease protein
-
Andrade MA, Bork P. HEAT repeats in the Huntington's disease protein. Nat Genet. 11:1995;115-116.
-
(1995)
Nat Genet
, vol.11
, pp. 115-116
-
-
Andrade, M.A.1
Bork, P.2
-
8
-
-
0029816724
-
Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation
-
De Rooij KE, Dorsman JC, Smoor MA, Den Dunnen JT, Van Ommen GJ. Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation. Hum Mol Genet. 5:1996;1093-1099.
-
(1996)
Hum Mol Genet
, vol.5
, pp. 1093-1099
-
-
De Rooij, K.E.1
Dorsman, J.C.2
Smoor, M.A.3
Den Dunnen, J.T.4
Van Ommen, G.J.5
-
9
-
-
0028989602
-
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
-
DiFiglia M, Sapp E, Chase K, Schwarz C, Meloni A, Young C, Martin E, Vonsattel JP, Carraway R, Reeves SA, et al. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron. 14:1995;1075-1081.
-
(1995)
Neuron
, vol.14
, pp. 1075-1081
-
-
Difiglia, M.1
Sapp, E.2
Chase, K.3
Schwarz, C.4
Meloni, A.5
Young, C.6
Martin, E.7
Vonsattel, J.P.8
Carraway, R.9
Reeves, S.A.10
-
10
-
-
0030950980
-
Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum
-
Ferrante RJ, Gutekunst CA, Persichetti F, McNeil SM, Kowall NW, Gusella JF, MacDonald ME, Beal MF, Hersch SM. Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum. J Neurosci. 17:1997;3052-3063.
-
(1997)
J Neurosci
, vol.17
, pp. 3052-3063
-
-
Ferrante, R.J.1
Gutekunst, C.A.2
Persichetti, F.3
McNeil, S.M.4
Kowall, N.W.5
Gusella, J.F.6
MacDonald, M.E.7
Beal, M.F.8
Hersch, S.M.9
-
11
-
-
0029152808
-
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
-
Gutekunst CA, Levey AI, Heilman CJ, Whaley WL, Yi H, Nash NR, Rees HD, Madden JJ, Hersch SM. Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc Natl Acad Sci USA. 92:1995;8710-8714.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8710-8714
-
-
Gutekunst, C.A.1
Levey, A.I.2
Heilman, C.J.3
Whaley, W.L.4
Yi, H.5
Nash, N.R.6
Rees, H.D.7
Madden, J.J.8
Hersch, S.M.9
-
12
-
-
0027759564
-
Characterization and localization of the Huntington disease gene product
-
Hoogeveen AT, Willemsen R, Meyer N, De Rooij KE, Roos RA, Van Ommen GJ, Galjaard H. Characterization and localization of the Huntington disease gene product. Hum Mol Genet. 2:1993;2069-2073.
-
(1993)
Hum Mol Genet
, vol.2
, pp. 2069-2073
-
-
Hoogeveen, A.T.1
Willemsen, R.2
Meyer, N.3
De Rooij, K.E.4
Roos, R.A.5
Van Ommen, G.J.6
Galjaard, H.7
-
13
-
-
0029295607
-
Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat
-
Persichetti F, Ambrose CM, Ge P, McNeil SM, Srinidhi J, Anderson MA, Jenkins B, Barnes GT, Duyao MP, Kanaley L, et al. Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat. Mol Med. 1:1995;374-383.
-
(1995)
Mol Med
, vol.1
, pp. 374-383
-
-
Persichetti, F.1
Ambrose, C.M.2
Ge, P.3
McNeil, S.M.4
Srinidhi, J.5
Anderson, M.A.6
Jenkins, B.7
Barnes, G.T.8
Duyao, M.P.9
Kanaley, L.10
-
14
-
-
0029034511
-
Widespread expression of Huntington's disease gene (IT15) protein product
-
Sharp AH, Loev SJ, Schilling G, Li SH, Li XJ, Bao J, Wagster MV, Kotzuk JA, Steiner JP, Lo A, et al. Widespread expression of Huntington's disease gene (IT15) protein product. Neuron. 14:1995;1065-1074.
-
(1995)
Neuron
, vol.14
, pp. 1065-1074
-
-
Sharp, A.H.1
Loev, S.J.2
Schilling, G.3
Li, S.H.4
Li, X.J.5
Bao, J.6
Wagster, M.V.7
Kotzuk, J.A.8
Steiner, J.P.9
Lo, A.10
-
15
-
-
0030771894
-
Huntingtin localization in brains of normal and Huntington's disease patients
-
Sapp E, Schwarz C, Chase K, Bhide PG, Young AB, Penney J, Vonsattel JP, Aronin N, DiFiglia M. Huntingtin localization in brains of normal and Huntington's disease patients. Ann Neurol. 42:1997;604-612.
-
(1997)
Ann Neurol
, vol.42
, pp. 604-612
-
-
Sapp, E.1
Schwarz, C.2
Chase, K.3
Bhide, P.G.4
Young, A.B.5
Penney, J.6
Vonsattel, J.P.7
Aronin, N.8
Difiglia, M.9
-
16
-
-
0029055601
-
Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form
-
Trottier Y, Devys D, Imbert G, Saudou F, An I, Lutz Y, Weber C, Agid Y, Hirsch EC, Mandel JL. Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form. Nat Genet. 10:1995;104-110.
-
(1995)
Nat Genet
, vol.10
, pp. 104-110
-
-
Trottier, Y.1
Devys, D.2
Imbert, G.3
Saudou, F.4
An, I.5
Lutz, Y.6
Weber, C.7
Agid, Y.8
Hirsch, E.C.9
Mandel, J.L.10
-
17
-
-
0030001072
-
Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin
-
Bao J, Sharp AH, Wagster MV, Becher M, Schilling G, Ross CA, Dawson VL, Dawson TM. Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin. Proc Natl Acad Sci USA. 93:1996;5037-5042.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5037-5042
-
-
Bao, J.1
Sharp, A.H.2
Wagster, M.V.3
Becher, M.4
Schilling, G.5
Ross, C.A.6
Dawson, V.L.7
Dawson, T.M.8
-
18
-
-
0030819255
-
Huntington's disease gene product, huntingtin, associates with microtubules in vitro
-
Tukamoto T, Nukina N, Ide K, Kanazawa I. Huntington's disease gene product, huntingtin, associates with microtubules in vitro. Brain Res Mol Brain Res. 51:1997;8-14.
-
(1997)
Brain Res Mol Brain Res
, vol.51
, pp. 8-14
-
-
Tukamoto, T.1
Nukina, N.2
Ide, K.3
Kanazawa, I.4
-
19
-
-
0029082383
-
Inactivation of the mouse Huntington's disease gene homolog Hdh
-
Duyao MP, Auerbach AB, Ryan A, Persichetti F, Barnes GT, McNeil SM, Ge P, Vonsattel JP, Gusella JF, Joyner AL, et al. Inactivation of the mouse Huntington's disease gene homolog Hdh. Science. 269:1995;407-410.
-
(1995)
Science
, vol.269
, pp. 407-410
-
-
Duyao, M.P.1
Auerbach, A.B.2
Ryan, A.3
Persichetti, F.4
Barnes, G.T.5
McNeil, S.M.6
Ge, P.7
Vonsattel, J.P.8
Gusella, J.F.9
Joyner, A.L.10
-
20
-
-
0029055717
-
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
-
Nasir J, Floresco SB, O'Kusky JR, Diewert VM, Richman JM, Ziesler J, Borowski A, Marth JD, Phillips AG, Hayden MR. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell. 81:1995;811-823.
-
(1995)
Cell
, vol.81
, pp. 811-823
-
-
Nasir, J.1
Floresco, S.B.2
O'Kusky, J.R.3
Diewert, V.M.4
Richman, J.M.5
Ziesler, J.6
Borowski, A.7
Marth, J.D.8
Phillips, A.G.9
Hayden, M.R.10
-
21
-
-
84993912315
-
Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue
-
Zeitlin S, Liu JP, Chapman DL, Papaioannou VE, Efstratiadis A. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat Genet. 11:1995;155-163.
-
(1995)
Nat Genet
, vol.11
, pp. 155-163
-
-
Zeitlin, S.1
Liu, J.P.2
Chapman, D.L.3
Papaioannou, V.E.4
Efstratiadis, A.5
-
22
-
-
0030613177
-
Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion
-
of outstanding interest. The expanded CAG repeat of a human HD gene was 'knocked into' the endogenous mouse Hdh gene to create a mutant gene capable of producing mouse huntingtin with a longer polyglutamine segment. Two alleles were produced, one showing reduced expression and one showing wild-type expression levels of the mutant protein. The latter was not associated with any phenotype in hemizygotes, heterozygotes or homozygotes, indicating that the HD mutation does not abrogate huntingtin's normal developmental function. Severely reduced expression caused abnormal neurogenesis indicating a role for huntingtin in brain development.
-
White JK, Auerbach W, Duyao MP, Vonsattel JP, Gusella JF, Joyner AL, MacDonald ME. Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. of outstanding interest Nat Genet. 17:1997;404-410 The expanded CAG repeat of a human HD gene was 'knocked into' the endogenous mouse Hdh gene to create a mutant gene capable of producing mouse huntingtin with a longer polyglutamine segment. Two alleles were produced, one showing reduced expression and one showing wild-type expression levels of the mutant protein. The latter was not associated with any phenotype in hemizygotes, heterozygotes or homozygotes, indicating that the HD mutation does not abrogate huntingtin's normal developmental function. Severely reduced expression caused abnormal neurogenesis indicating a role for huntingtin in brain development.
-
(1997)
Nat Genet
, vol.17
, pp. 404-410
-
-
White, J.K.1
Auerbach, W.2
Duyao, M.P.3
Vonsattel, J.P.4
Gusella, J.F.5
Joyner, A.L.6
MacDonald, M.E.7
-
23
-
-
0028803757
-
A huntingtin-associated protein enriched in brain with implications for pathology
-
Li XJ, Li SH, Sharp AH, Nucifora FC Jr, Schilling G, Lanahan A, Worley P, Snyder SH, Ross CA. A huntingtin-associated protein enriched in brain with implications for pathology. Nature. 378:1995;398-402.
-
(1995)
Nature
, vol.378
, pp. 398-402
-
-
Li, X.J.1
Li, S.H.2
Sharp, A.H.3
Nucifora F.C., Jr.4
Schilling, G.5
Lanahan, A.6
Worley, P.7
Snyder, S.H.8
Ross, C.A.9
-
24
-
-
0029899868
-
Huntingtin-associated protein (HAP1): Discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase
-
Li XJ, Sharp AH, Li SH, Dawson TM, Snyder SH, Ross CA. Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase. Proc Natl Acad Sci USA. 93:1996;4839-4844.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 4839-4844
-
-
Li, X.J.1
Sharp, A.H.2
Li, S.H.3
Dawson, T.M.4
Snyder, S.H.5
Ross, C.A.6
-
25
-
-
0032519646
-
Interaction of huntingtin-associated protein with dynactin P150
-
of outstanding interest. See annotation [26].
-
Li SH, Gutekunst CA, Hersch SM, Li XJ. Interaction of huntingtin-associated protein with dynactin P150. of outstanding interest J Neurosci. 18:1998;1261-1269 See annotation [26].
-
(1998)
J Neurosci
, vol.18
, pp. 1261-1269
-
-
Li, S.H.1
Gutekunst, C.A.2
Hersch, S.M.3
Li, X.J.4
-
26
-
-
0030726894
-
Glued subunit of dynactin
-
of outstanding interest. This paper and the one by Li et al. 1998 [25] show that huntingtin-associated protein HAP1 binds to an accessory protein for cytoplasmic dynein, a microtubule motor protein, thereby implicating huntingtin in intracellular transport.
-
Glued subunit of dynactin. of outstanding interest Hum Mol Genet. 6:1997;2205-2212 This paper and the one by Li et al. 1998 [25] show that huntingtin-associated protein HAP1 binds to an accessory protein for cytoplasmic dynein, a microtubule motor protein, thereby implicating huntingtin in intracellular transport.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 2205-2212
-
-
Engelender, S.1
Sharp, A.H.2
Colomer, V.3
Tokito, M.K.4
Lanahan, A.5
Worley, P.6
Holzbaur, E.L.F.7
Ross, C.A.8
-
27
-
-
0028806377
-
Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex
-
Karki S, Holzbaur EL. Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex. J Biol Chem. 270:1995;28806-28811.
-
(1995)
J Biol Chem
, vol.270
, pp. 28806-28811
-
-
Karki, S.1
Holzbaur, E.L.2
-
29
-
-
0030767266
-
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain
-
of outstanding interest. Huntingtin-associated protein HAP1 is shown to bind to Duo, a Trio-like protein with a likely rac1-specific guanine nucleotide exchange factor (GEF) domain, a pleckstrin homology (PH) domain and spectrin-like repeat units, implicating huntingtin in vesicle trafficking and cytoskeletal functions, and possibly ras-related signaling.
-
Colomer V, Engelender S, Sharp AH, Duan K, Cooper JK, Lanahan A, Lyford G, Worley P, Ross CA. Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. of outstanding interest Hum Mol Genet. 6:1997;1519-1525 Huntingtin-associated protein HAP1 is shown to bind to Duo, a Trio-like protein with a likely rac1-specific guanine nucleotide exchange factor (GEF) domain, a pleckstrin homology (PH) domain and spectrin-like repeat units, implicating huntingtin in vesicle trafficking and cytoskeletal functions, and possibly ras-related signaling.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 1519-1525
-
-
Colomer, V.1
Engelender, S.2
Sharp, A.H.3
Duan, K.4
Cooper, J.K.5
Lanahan, A.6
Lyford, G.7
Worley, P.8
Ross, C.A.9
-
30
-
-
0030986659
-
HIP1, a human homologue of S. cerevisiae SIa2p, interacts with membrane-associated huntingtin in the brain
-
of outstanding interest. Huntingtin's amino terminus interacts with HIP1, a human homologue of the yeast SIa2 gene product, which is involved in endocytosis and cytoskeletal assembly and function.
-
Kalchman MA, Koide HB, McCutcheon K, Graham PK, Nichol K, Nishiyama K, Kazemi-Esfarjani P, Lynn FC, Wellington C, Metzler M, et al. HIP1, a human homologue of S. cerevisiae SIa2p, interacts with membrane-associated huntingtin in the brain. of outstanding interest Nat Genet. 16:1997;44-53 Huntingtin's amino terminus interacts with HIP1, a human homologue of the yeast SIa2 gene product, which is involved in endocytosis and cytoskeletal assembly and function.
-
(1997)
Nat Genet
, vol.16
, pp. 44-53
-
-
Kalchman, M.A.1
Koide, H.B.2
McCutcheon, K.3
Graham, P.K.4
Nichol, K.5
Nishiyama, K.6
Kazemi-Esfarjani, P.7
Lynn, F.C.8
Wellington, C.9
Metzler, M.10
-
31
-
-
0031056478
-
HIP-I: A huntingtin interacting protein isolated by the yeast two-hybrid system
-
of outstanding interest. Huntingtin's amino terminus interacts with HIP1, a human homologue of the yeast SIa2 gene product, which is involved in endocytosis and cytoskeletal assembly and function.
-
Wanker EE, Rovira C, Scherzinger E, Hasenbank R, Walter S, Tait D, Colicelli J, Lehrach H. HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system. of outstanding interest Hum Mol Genet. 6:1997;487-495 Huntingtin's amino terminus interacts with HIP1, a human homologue of the yeast SIa2 gene product, which is involved in endocytosis and cytoskeletal assembly and function.
-
(1997)
Hum Mol Genet
, vol.6
, pp. 487-495
-
-
Wanker, E.E.1
Rovira, C.2
Scherzinger, E.3
Hasenbank, R.4
Walter, S.5
Tait, D.6
Colicelli, J.7
Lehrach, H.8
-
32
-
-
0027244817
-
Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae
-
Holtzman DA, Yang S, Drubin DG. Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae. J Cell Biol. 122:1993;635-644.
-
(1993)
J Cell Biol
, vol.122
, pp. 635-644
-
-
Holtzman, D.A.1
Yang, S.2
Drubin, D.G.3
-
33
-
-
0028871169
-
Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast
-
Li R, Zheng Y, Drubin DG. Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast. J Cell Biol. 128:1995;599-615.
-
(1995)
J Cell Biol
, vol.128
, pp. 599-615
-
-
Li, R.1
Zheng, Y.2
Drubin, D.G.3
-
34
-
-
0028934931
-
MOP2 (SLA2) affects the abundance of the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae
-
Na S, Hincapie M, McCusker JH, Haber JE. MOP2 (SLA2) affects the abundance of the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae. J Biol Chem. 270:1995;6815-6823.
-
(1995)
J Biol Chem
, vol.270
, pp. 6815-6823
-
-
Na, S.1
Hincapie, M.2
McCusker, J.H.3
Haber, J.E.4
-
35
-
-
0030785341
-
End4p/SIa2p interacts with actin-associated proteins for endocytosis in Saccharomyces cerevisiae
-
Wesp A, Hicke L, Palecek J, Lombardi R, Aust T, Munn AL, Riezman H. End4p/SIa2p interacts with actin-associated proteins for endocytosis in Saccharomyces cerevisiae. Mol Biol Cell. 8:1997;2291-2306.
-
(1997)
Mol Biol Cell
, vol.8
, pp. 2291-2306
-
-
Wesp, A.1
Hicke, L.2
Palecek, J.3
Lombardi, R.4
Aust, T.5
Munn, A.L.6
Riezman, H.7
-
36
-
-
9444239187
-
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme
-
Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR. Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. J Biol Chem. 271:1996;19385-19394.
-
(1996)
J Biol Chem
, vol.271
, pp. 19385-19394
-
-
Kalchman, M.A.1
Graham, R.K.2
Xia, G.3
Koide, H.B.4
Hodgson, J.G.5
Graham, K.C.6
Goldberg, Y.P.7
Gietz, R.D.8
Pickart, C.M.9
Hayden, M.R.10
-
37
-
-
0024321969
-
Murine erythroleukemia cells possess an active ubiquitin- and ATP- dependent proteolytic pathway
-
Pickart CM, Graziani LA, Dosch SF. Murine erythroleukemia cells possess an active ubiquitin- and ATP- dependent proteolytic pathway. Arch Biochem Biophys. 272:1989;114-121.
-
(1989)
Arch Biochem Biophys
, vol.272
, pp. 114-121
-
-
Pickart, C.M.1
Graziani, L.A.2
Dosch, S.F.3
-
38
-
-
0030910308
-
FBP WW domains and the AbI SH3 domain bind to a specific class of proline-rich ligands
-
Bedford MT, Chan DC, Leder P. FBP WW domains and the AbI SH3 domain bind to a specific class of proline-rich ligands. EMBO J. 16:1997;2376-2383.
-
(1997)
EMBO J
, vol.16
, pp. 2376-2383
-
-
Bedford, M.T.1
Chan, D.C.2
Leder, P.3
-
39
-
-
0029981652
-
Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains
-
Chan DC, Bedford MT, Leder P. Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 15:1996;1045-1054.
-
(1996)
EMBO J
, vol.15
, pp. 1045-1054
-
-
Chan, D.C.1
Bedford, M.T.2
Leder, P.3
-
40
-
-
0029991867
-
The WW module competes with the SH3 domain?
-
Sudol M. The WW module competes with the SH3 domain? Trends Biochem Sci. 21:1996;161-163.
-
(1996)
Trends Biochem Sci
, vol.21
, pp. 161-163
-
-
Sudol, M.1
-
41
-
-
0029146950
-
Characterization of a novel protein-binding module - The WW domain
-
Sudol M, Chen HI, Bougeret C, Einbond A, Bork P. Characterization of a novel protein-binding module - the WW domain. FEBS Lett. 369:1995;67-71.
-
(1995)
FEBS Lett
, vol.369
, pp. 67-71
-
-
Sudol, M.1
Chen, H.I.2
Bougeret, C.3
Einbond, A.4
Bork, P.5
-
42
-
-
0030424581
-
Structural and function of the WW domain
-
Sudol M. Structural and function of the WW domain. Prog Biophys Mol Biol. 65:1996;113-132.
-
(1996)
Prog Biophys Mol Biol
, vol.65
, pp. 113-132
-
-
Sudol, M.1
-
43
-
-
0030778411
-
The dodo gene family encodes a novel protein involved in signal transduction and protein folding
-
Maleszka R, Lupas A, Hanes SD, Miklos GL. The dodo gene family encodes a novel protein involved in signal transduction and protein folding. Gene. 203:1997;89-93.
-
(1997)
Gene
, vol.203
, pp. 89-93
-
-
Maleszka, R.1
Lupas, A.2
Hanes, S.D.3
Miklos, G.L.4
-
44
-
-
0000790724
-
SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes
-
Liu YF, Deth RC, Devys D. SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes. J Biol Chem. 272:1997;8121-8124.
-
(1997)
J Biol Chem
, vol.272
, pp. 8121-8124
-
-
Liu, Y.F.1
Deth, R.C.2
Devys, D.3
-
45
-
-
0024523484
-
Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)
-
Robinson MS. Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 108:1989;833-842.
-
(1989)
J Cell Biol
, vol.108
, pp. 833-842
-
-
Robinson, M.S.1
-
46
-
-
0028984226
-
Expression and localization of alpha-adaptin isoforms
-
Ball CL, Hunt SP, Robinson MS. Expression and localization of alpha-adaptin isoforms. J Cell Sci. 108:1995;2865-2875.
-
(1995)
J Cell Sci
, vol.108
, pp. 2865-2875
-
-
Ball, C.L.1
Hunt, S.P.2
Robinson, M.S.3
-
47
-
-
1842329783
-
Alpha-adaptin, a marker for endocytosis, is expressed in complex patterns during Drosophila development
-
Dornan S, Jackson AP, Gay NJ. Alpha-adaptin, a marker for endocytosis, is expressed in complex patterns during Drosophila development. Mol Biol Cell. 8:1997;1391-1403.
-
(1997)
Mol Biol Cell
, vol.8
, pp. 1391-1403
-
-
Dornan, S.1
Jackson, A.P.2
Gay, N.J.3
-
48
-
-
0029840160
-
Symplekin, a novel type of tight junction plaque protein
-
Keon BH, Schafer S, Kuhn C, Grund C, Franke WW. Symplekin, a novel type of tight junction plaque protein. J Cell Biol. 134:1996;1003-1018.
-
(1996)
J Cell Biol
, vol.134
, pp. 1003-1018
-
-
Keon, B.H.1
Schafer, S.2
Kuhn, C.3
Grund, C.4
Franke, W.W.5
-
49
-
-
0029024819
-
Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae
-
Kominami K, DeMartino GN, Moomaw CR, Slaughter CA, Shimbara N, Fujimuro M, Yokosawa H, Hisamatsu H, Tanahashi N, Shimizu Y, et al. Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. EMBO J. 14:1995;3105-3115.
-
(1995)
EMBO J
, vol.14
, pp. 3105-3115
-
-
Kominami, K.1
Demartino, G.N.2
Moomaw, C.R.3
Slaughter, C.A.4
Shimbara, N.5
Fujimuro, M.6
Yokosawa, H.7
Hisamatsu, H.8
Tanahashi, N.9
Shimizu, Y.10
-
50
-
-
0031909798
-
Huntingtin interacts with cystathionine beta-synthase
-
of outstanding interest. The enzyme cystathionine beta-synthase binds to huntingtin, raising the possibility that a component of HD pathogenesis may be CBS deficiency, which is also associated with homocystinuria and leads to accumulation of homocysteine, a substrate metabolized to powerful excitotoxic amino acids.
-
Boutell JM, Wood JD, Harper PS, Jones AL. Huntingtin interacts with cystathionine beta-synthase. of outstanding interest Hum Mol Genet. 7:1998;371-378 The enzyme cystathionine beta-synthase binds to huntingtin, raising the possibility that a component of HD pathogenesis may be CBS deficiency, which is also associated with homocystinuria and leads to accumulation of homocysteine, a substrate metabolized to powerful excitotoxic amino acids.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 371-378
-
-
Boutell, J.M.1
Wood, J.D.2
Harper, P.S.3
Jones, A.L.4
-
51
-
-
0344624842
-
Identification and tissue distribution of human cystathionine beta-synthase mRNA isoforms
-
Bao L, Vlcek C, Paces V, Kraus JP. Identification and tissue distribution of human cystathionine beta-synthase mRNA isoforms. Arch Biochem Biophys. 350:1998;95-103.
-
(1998)
Arch Biochem Biophys
, vol.350
, pp. 95-103
-
-
Bao, L.1
Vlcek, C.2
Paces, V.3
Kraus, J.P.4
-
52
-
-
0029664992
-
Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH
-
Burke JR, Enghild JJ, Martin ME, Jou YS, Myers RM, Roses AD, Vance JM, Strittmatter WJ. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nat Med. 2:1996;347-350.
-
(1996)
Nat Med
, vol.2
, pp. 347-350
-
-
Burke, J.R.1
Enghild, J.J.2
Martin, M.E.3
Jou, Y.S.4
Myers, R.M.5
Roses, A.D.6
Vance, J.M.7
Strittmatter, W.J.8
-
53
-
-
0028972448
-
Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias
-
Trottier Y, Lutz Y, Stevanin G, Imbert G, Devys D, Cancel G, Saudou F, Weber C, David G, Tora L, et al. Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias. Nature. 378:1995;403-406.
-
(1995)
Nature
, vol.378
, pp. 403-406
-
-
Trottier, Y.1
Lutz, Y.2
Stevanin, G.3
Imbert, G.4
Devys, D.5
Cancel, G.6
Saudou, F.7
Weber, C.8
David, G.9
Tora, L.10
-
54
-
-
18544400323
-
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
-
Scherzinger E, Lurz R, Turmaine M, Mangiarini L, Hollenbach B, Hasenbank R, Bates GP, Davies SW, Lehrach H, Wanker EE. Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell. 90:1997;549-558.
-
(1997)
Cell
, vol.90
, pp. 549-558
-
-
Scherzinger, E.1
Lurz, R.2
Turmaine, M.3
Mangiarini, L.4
Hollenbach, B.5
Hasenbank, R.6
Bates, G.P.7
Davies, S.W.8
Lehrach, H.9
Wanker, E.E.10
-
55
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
of outstanding interest. Neuroanatomical studies provide evidence for abnormal deposits of aggregated protein containing huntingtin and ubiquitin. This paper provides an in vivo correlate for the in vitro demonstration of physical differences between normal and mutant huntingtin.
-
DiFiglia M, Sapp E, Chase KO, Davies SW, Bates GP, Vonsattel JP, Aronin N. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. of outstanding interest Science. 277:1997;1990-1993 Neuroanatomical studies provide evidence for abnormal deposits of aggregated protein containing huntingtin and ubiquitin. This paper provides an in vivo correlate for the in vitro demonstration of physical differences between normal and mutant huntingtin.
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
Difiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
Aronin, N.7
-
56
-
-
0030948716
-
The genetic defect causing Huntington's disease: Repeated in other contexts?
-
Gusella JF, Persichetti F, MacDonald ME. The genetic defect causing Huntington's disease: repeated in other contexts? Mol Med. 3:1997;238-246.
-
(1997)
Mol Med
, vol.3
, pp. 238-246
-
-
Gusella, J.F.1
Persichetti, F.2
MacDonald, M.E.3
|