Molecular cloning, expression and tissue distribution of glial-cell- line-derived neurotrophic factor family receptor α-3 (GFRα-3)

European Journal of Biochemistry

Volumn 251, Issue 3, 1998, Pages 622-630

  Masure, Stefan ^a   Cik, Miroslav ^a   Pangalos, Menelas N ^a   Bonaventure, Pascal ^a,b   Verhasselt, Peter ^a   Lesage, Anne S J ^a   Leysen, Josee E ^a,b   Gordon, Robert D ^a  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Glial cell line derived neurotrophic factor; Growth factor; Neurturin; Receptor; Transforming growth factor

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR RECEPTOR;

ARTICLE; CEREBELLUM; CHROMOSOME 5; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; KIDNEY CELL; MOLECULAR WEIGHT; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD;

EID: 0032006819     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2510622.x     Document Type: Article

References (31)

1. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. (1990) Basic local alignment search tool, J. Mol. Biol. 215, 403-410.
2. Angrist, M., Bolk, S., Halushka, M., Lapehak, P. A. & Chakravarti, A. (1996) Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient, Nat. Genet. 14, 341-344.
3. Baloh, R. H., Tansey, M. G., Golden, J. P., Creedon, D. J., Heuckeroth, R. O., Keck, C. L., Zimonjic, D. B., Popescu, N. C., Johnson, E. M. & Milbrandt, J. (1997) TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret, Neuron 18, 793-802.
4. 1D, receptor messenger RNA and ligand binding sites in guinea pig brain and trigeminal ganglion: clues for function, Neuroscience 82, 469-484.
5. Buj-Bello, A., Adu, J., Piñón, L. G. P., Horton, A., Thompson, J., Rosenthal, A., Chinchetru, M., Buchman, V. L. & Davies, A. M. (1997) Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase, Nature 387, 721-724.
6. Cullen, B. R. (1987) Use of eukaryotic expression technology in the functional analysis of cloned genes, Methods Enzymol. 152, 684-704.
7. Durbec, P., Marcos-Gutierrez, C. V., Kilkenny, C., Grigoriou, M., Wartiowaara, K., Suvanto, P., Smith, D., Ponder, B., Costantini, F., Saarma, M., Sariola, H. & Pachnis, V. (1996) GDNF signalling through the RET receptor tyrosine kinase, Nature 381, 789-793.
8. Gerber, L. D., Kodukula, K. & Udenfriend, S. (1992) Phosphalidylinositol glycan (PI-G) anchored membrane proteins, J. Biol. Chem. 267, 12168-12173.
9. GFRα Nomenclature Committee (1997) Nomenclature of GPI-linked receptors for the GDNF ligand family, Neuron 19, 485.
10. Heng, H. H. Q., Squire, J. & Tsui, L.-C. (1992) High resolution mapping of mammalian genes by in situ hybridization to free chromatin, Proc. Natl Acad. Sci. USA 89, 9509-9513.
11. Heng, H. H. Q. & Tsui, L.-C. (1993) Modes of DAPI banding and simultaneous in situ hybridization, Chromosoma 102, 325-332.
12. Jing, S., Wen, D., Yu, Y., Holst, P. L., Luo, Y., Fang, M., Tamir, R., Antonio, L., Hu, Z., Cupples, R., Louis, J.-C., Hu, S., Altrock, B. W. & Fox, G. M. (1996) GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF, Cell 85, 1113-1124.
13. Klein, R. D., Sherman, D., Ho, W.-H., Stone, D., Bennett, G. L., Moffat, B., Vandlen, R., Simmons, L., Gu, Q., Hongo, J.-A., Devaux, B., Poulsen, K., Armanini, M., Nozaki, C., Asai, N., Goddard, A., Phillips, H., Henderson, C. E., Takahashi, M. & Rosenthal, A. (1997) A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor, Nature 387, 717-721.
14. Knappik, A. & Pluckthun, A. (1994) An improved affinity tag based on the FLAG peptide for the detection and purification of recombinant antibody fragments, Biotechniques 17, 754-761.
15. Kotzbauer, P. T., Lampe, P. A., Heuckeroth, R. O., Golden, J. P., Creedon, D. J., Johnson, E. M. & Milbrandt, J. (1996) Neurturin, a relative of glial-cell-line-derived neurotrophic factor, Nature 384, 467-470.
16. Kozak, M. (1989) The scanning model for translation: an update, J. Cell Biol. 108, 229-241.
17. Lennon, G., Auffray, C., Polymeropoulos, M. & Soares, M. B. (1996) The I.M.A.G.E. consortium: an integrated molecular analysis of genomes and their expression, Gonomics 33, 151-152.
18. Li, X., Wise, C. A., Le Paslier, D., Hawkins, A. L., Griffin, C. A., Pittler, S. J., Lovett, M. & Jabs, E. W. (1994) A YAC contig of approximately 3 Mb from human chromosome 5q31→q33, Genomics 19, 470-477.
19. Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S. & Collins, F. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons, Science 260, 1130-1132.
20. Moore, M. W., Klein, R. D., Farinas, I., Sauer, H., Armanini, M., Phillips, H., Reichardt, L. F., Ryan, A. M., Carver-Moore, K. & Rosenthal, A. (1996) Renal and neuronal abnormalities in mice lacking GDNF, Nature 382, 76-79.
21. Pichel, J. G., Shen, L., Sheng, H. Z., Granholm, A. C., Drago, J., Grinberg, A., Lee, E. J., Huang, S. P., Saarma, M., Hoffer, B. J., Sariola, H. & Westphal, H. (1996) Defects in enteric innervation and kidney development in mice lacking GDNF, Nature 382, 73-76.
22. Saltman, D. L., Dolganov, G. M., Warrington, J. A., Wasmuth, J. J. & Lovett, M. (1993) A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization, Genomics 16, 726-732.
23. Sanchez, M. P., Silos-Santiago, I., Frisen, J., He, B., Lira, S. A. & Barbacid, M. (1996) Renal agenesis and the absence of enteric neurons in mice lacking GDNF, Nature 382, 70-73.
24. Sanicola, M., Hession, C., Worley, D., Carmillo, P., Ehrenfels, C., Walus, L., Robinson, S., Jaworski, G., Wei, H., Tizard, R., Whitty, A., Pepinsky, R. B. & Cate, R. L. (1997) Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins, Proc. Natl Acad. Sci. USA 94, 6238-6243.
25. Suvanto, P., Wartiovaara, K., Lindahl, M., Arumäe, U., Moshnyakov, M., Horelli-Kuitunen, N., Airaksinen, M. S., Palotie, A., Sariola, H. & Saarma, M. (1997) Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor β, a homologue to GDNFR-α, Human Mol. Genet. 6, 1267-1273.
26. Treanor, J. J. S., Goodman, L., de Sauvage, F., Stone, D. M., Poulsen, K. T., Beck, C. D., Gray, C., Armanini, M. P., Pollock, R. A., Hefti, F., Phillips, H. S., Goddard, A., Moore, M. W., Buj-Bello, A., Davies, A. M., Asai, N., Takahashi, M., Vandlen, R., Henderson, C. E. & Rosenthal, A. (1996) Characterization of a multicomponent receptor for GDNF, Nature 382, 80-83.
27. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A. S., Sieber, B. A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumäe, U., Sariola, H., Saarma, M. & Ibanez, C. F. (1996) Functional receptor for GDNF encoded by the c-ret proto-oncogene, Nature 381, 785-788.
28. Trupp, M., Belluardo, N., Funakoshi, H. & Ibañez, C. F. (1997) Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-α indicates multiple mechanisms of trophic actions in the adult rat CNS, J. Neurosci. 17, 3554-3567.
29. Von Heijne, G. (1986) A new method for predicting signal sequences cleavage sites, Nucleic Acid Res. 14, 4683-4690.
30. Widenfalk, J., Nosrat, C., Tomac, A., Westphal, H., Hoffer, B. & Olson, L. (1997) Neurturin and glial cell line-derived neurotrophic factor receptor-β (GDNFR-β), novel proteins related to GDNF and GDNFR-α with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs, J. Neurosci. 17, 8506-8519.
31. Worby, C. A., Vega, Q. C., Zhao, Y., Chao, H. H.-J., Seasholtz, A. F. & Dixon, J. E. (1996) Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase, J. Biol. Chem. 271, 23619-23622.