GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF

Cell

Volumn 85, Issue 7, 1996, Pages 1113-1124

  Jing, Shuqian ^a   Wen, Duanzhi ^a   Yu, Yanbin ^a   Holst, Paige L ^a   Luo, Yi ^a   Fang, Mei ^a   Tamir, Rami ^a   Antonio, Laarni ^a   Hu, Zheng ^a   Cupples, Rod ^a   Louis, Jean Claude ^a   Hu, Sylvia ^a   Altrock, Bruce W ^a   Fox, Gary M ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; DNA; GLYCOSYLPHOSPHATIDYLINOSITOL; HYBRID PROTEIN; NEUROTROPHIC FACTOR; PROTEIN TYROSINE KINASE; RNA;

ANIMAL CELL; ANIMAL TISSUE; AUTOPHOSPHORYLATION; CLONING; EMBRYO; ENZYME ACTIVATION; IMMUNOPRECIPITATION; MOTONEURON; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 15844365303     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81311-2     Document Type: Article

References (40)

1. Angrist, M., Bolk, S., Thiel, B., Puffenberger, E.G., Hofstra, R.M., Buys, C.H., Cass, D.T., and Chakravarti, A. (1995). Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease. Hum. Mol. Genet. 4, 821-830.
2. Aruffo, A., and Seed, B. (1987). Molecular cloning of a CD28 cDNA by a high efficiency COS cell expression system. Proc. Natl. Acad. Sci. USA 84, 8573-8577.
3. Bartley, T.D., Hunt, R.W., Welcher, A.A., Boyle, W.J., Parker, V.P., Lindberg, R.A., Lu, H.S., Colombero, A.M., Elliott, R.L., Guthrie, B.A., Holst, P.L., Skrine, J.D., Toso, R.J., Zhang, M., Fernandez, E., Trail, G., Varnum, B., Yarden, Y., Hunter, T., and Fox, G.M. (1994). B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature 368, 558-560.
4. Buj-Bello, A., Buchman, V.L., Horton, A., Rosenthal, A., and Davies, A.M. (1995). GDNF is an age-specific survival factor for sensory and autonomic neurons. Neuron 15, 821-828.
5. Camu, W., and Henderson, C. (1992). Purification of embryonic rat motoneurons by panning on a monoclonal antibody to the low affinity nerve growth factor receptor. J. Neurosc. 44, 59-70.
6. Choi-Lundberg, D.L., and Bohn, M.C. (1995). Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. Brain Res. Dev. Brain Res. 85, 80-88.
7. Culouscou, J.-M., Carlton, G.W., and Aruffo, A. (1995). HER4 receptor activation and phosphorylation of Shc proteins by recombinant heregulin-Fc fusion proteins. J. Biol. Chem. 270, 12857-12863.
8. Davis, S., Aldrich, T.H., Valenzuela, D.M., Wong, V.V., Furth, M.E., Squinto.S.P., and Yancopoulos, G.D. (1991). The receptor for ciliary neurotrophic factor. Science 253, 59-63.
9. Davis, S., Aldrich, T.H., Ip, N.Y., Stahl, N., Scherer, S., Farruggella, T., DeStefano, P.S., Curtis, R., Panayotatos, N., Gascan, H., Chevalier, S., and Yancopoulos, G.D. (1993). Released form of CNTF receptor component as a soluble mediator of CNTF responses. Science 259, 1736-1739.
10. Donis-Keller, H., Dou, S., Chi, D., Carlson, K., Toshima, K., Lairmore, T., Howe, J., Moley, J., Goodfellow, P., and Wells, S. (1993). Mutations in the ret proto-oncogene are associated with MEN2A and familial medullary thyroid carcinoma. Hum. Mol. Genet. 2, 851-856.
11. Edery, P., Lyonnet, S., Mulligan, L., Pelet, A., Dow, E., Abel, L., Holder, S., Nihoul-Fekete, C., Ponder, B., and Munnich, A. (1994). Mutations of the ret proto-oncogene in Hirschsprung's disease. Nature 367, 378-380.
12. Gearing, D.P., King, J.A., Gough, N.M., and Nicola, N.A. (1989). Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J. 8, 3667-3676.
13. Harlow, E., and Lane, D. (1988). Antibodies: A Laboratory Manual. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.)
14. Henderson, C.E., Phillips, H.S., Pollock, R.A., Davies, A.M., Lemeulle, C., Armanini, M., Simpson, L.C., Moffet, B., Vandlen, R.A., Koliatsos, V.E., and Rosenthal, A. (1994). GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266, 1062-1064.
15. Hofstra, R., Landsvater, R., Ceccherini, I., Stulp, R., Stelwagen, T., Luo, Y., Pasini, B., Hoppener, J., van Amstel, H., Romeo, G., Lips, C.,and Buys, C. (1994). A mutation in the ret proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature 367, 375-376.
16. Ikeda, I., Ishizaka, Y., Tahira, T., Suzuki, T., Onda, M., Sugimura, T., and Nagao, M. (1990). Specific expression of the ret proto-oncogene in human neuroblastoma cell lines. Oncogene 5, 1291-1296.
17. Iwamoto, T., Taniguchi, M., Asia, N., Ohkusu, K., Nakashima, I., and Takahashi, M. (1993). cDNA cloning of mouse ret proto-oncongene and its sequence similarity to the cadherin superfamily. Oncogene 8, 1087-1091.
18. Jing, S.Q., Spencer, T., Miller, K., Hopkins, C., and Trowbridge, I.S. (1990). Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequencef or internalization. J. Cell Biol. 110, 283-294.
19. Kozak, M. (1987). An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucl. Acids Res. 15, 8125-8148.
20. Li, L., Wu, W., Lin, L.F., Lei, M., Oppenheim, R.W., and Houenou, L.J. (1995). Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor. Proc. Natl. Acad. Sci. USA 92, 9771-9775.
21. Lin, L.-F.H., Doherty, D.H., Lile, J.D., Bektesh, S., and Collins, F. (1993). GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260,1130-1132.
22. Louis, J.C., Magal, E., and Varon, S. (1992). Receptor-mediated toxicity of norepinephrine on cultured catecholaminergic neurons of the rat brain stem. J. Pharmacol. Exp. Ther. 262, 1274-1283.
23. Mulligan, L., Kwok, J., Healey, C., Elsdon, M., Eng, C., Gardner, E., Love, D., Mole, S., Moore, J., Papi, L., Ponder, M., Telenius, H., Tunnacliffe, A., and Ponder, A. (1993). Germ-line mutations of the ret proto-oncongene in mutiple endocrine neoplasia type 2A. Nature 363, 458-460.
24. Nagao, M., Ishizaka, Y., Nakagawara, A., Kohno, K., Kuwano, M., Tahira, T., Itoh, F., Ikeda, I., and Sugimura, T. (1990) Expression of ret proto-oncogene in human neuroblastomas. Jpn. J. Cancer Res. 81, 309-312.
25. Oppenheim, R.W., Houenou, L.J., Johnson, J.E., Lin, L.F., Li, L., Lo, A.C., Newsome, A.L., Prevette, D.M., and Wang, S. (1995). Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature 373, 344-346.
26. Pearson, W.R., and Lipman, D.J. (1988). Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA 85, 2444-2448.
27. Poulsen, K.T., Armanini, M.P., Klein, R.D., Hynes, M.A., Phillips, H.S., and Rosenthal, A. (1994). TGF β 2 and TGF β 3 are potent survival factors for midbrain dopaminergic neurons. Neuron 13, 1245-1252.
28. Romeo, G., Patrizia, R., Luo, Y., Barone, V., Seri, M., Ceccherini, I., Pasini, B., Bocciardi, R., Lerone, M., Kaariainen, H., and Maartucciello, G. (1994). Point mutations affecting the tyrosine kinase domain of the ret proto-oncogene in Hirschsprung's disease. Nature 367, 377-378.
29. Sanchez, M., Silos-Santiago, I., Frisen, J., He, B., Lira, S., and Barbacid, M. (1996). Newborn mice lacking GDNF display renal agenesis and absence of enteric neurons, but no deficits in midbrain dopaminergic neurons. Nature, in press.
30. Santoro, M., Carlomagno, F., Romeo, A., Bottaro, D., Dathan, N., Grieco, M., Fusco, A., Vecchio, G., Matoskova, B., Kraus, M., and Di Fiore, P. (1995). Activation of ret as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science 267, 381-383.
31. Saxen, L. (1987). Organogenesis of the kidney. In Development and Cell Biology Series. (Cambridge: Cambridge University Press.)
32. Schuchardt, A., D'Agati, V., Larsson-Blomberg, L., Costantini, F., and Pachnis, V. (1994). Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor ret. Nature 367, 380-383.
33. Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., and Kishimoto, T. (1989). Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58, 573-581.
34. Takahashi, M., and Cooper, G. (1987). Ret transforming gene encodes a fusion protein homologous to tyrosine kinases. Mol. Cell. Biol. 7, 1378-1385.
35. Takebe, Y., Seiki, M., Fujisawa, J., Hoy, P., Yokota, K., Arai, K., Yoshida, M., and Arai, N. (1988). SRa promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8, 466-472.
36. Trupp, M., Ryden, M., Joernvall, H., Funakoshi, H., Timmusk, T., Arenas, E., and Ibanez, C.F. (1995). Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell Biol. 130, 137-148.
37. Tsuzuki, T., Takahashi, M., Asai, N., Iwashita, T., Matsuyama, M., and Asai, J. (1995). Spatial and temporal expression of the ret protooncongene product in embryonic, infant, and adult rat tissues. Oncogene 10, 191-198.
38. Ullrich, A., and Schlessinger, J. (1990). Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203-211.
39. von Heijne, G. (1986). A new method for predicting signal sequence cleavage sites. Nucl. Acids Res. 14, 4683-4690.
40. Wen, D., Suggs, S., Devarajan, K., Liu, N., Cupples, R., Luo, Y., Janssen, A., Ben-Barruch, N., Trollinger, D., Jacobsen, V., Meng, T., Lu, H., Hu, S., Chang, D., Yanigahara, D., Koski, R., and Yarden, Y. (1994). Structural and functional aspects of the multiplicity of Neu differentiation factors. Mol. Cell Biol. 14, 1909-1919.