The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans

Current Drug Metabolism

Volumn 3, Issue 6, 2002, Pages 561-597

  Danielson, P B ^a  

^a UNIVERSITY OF DENVER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGRICULTURAL CHEMICAL; AMFEBUTAMONE; AMITRIPTYLINE; CARBON MONOXIDE; CITALOPRAM; CLOMIPRAMINE; CYCLOPHOSPHAMIDE; CYTOCHROME P450; DIAZEPAM; DRUG METABOLIZING ENZYME; FATTY ACID; FLUVOXAMINE; GENE PRODUCT; HALOPERIDOL; HEME; HEXOBARBITAL; IFOSFAMIDE; IMIPRAMINE; INDOMETACIN; LANSOPRAZOLE; MEXILETINE; MOCLOBEMIDE; NAPROXEN; NELFINAVIR; ONDANSETRON; PROSTAGLANDIN; STEROID; THIOL DERIVATIVE; UNINDEXED DRUG; XENOBIOTIC AGENT;

AB INITIO CALCULATION; AEROBIC METABOLISM; AMINO ACID SEQUENCE; ARCHAEBACTERIUM; CHEMICAL ANALYSIS; CHEMICAL REACTION KINETICS; CLINICAL PHARMACOLOGY; CONTROLLED STUDY; DATA BASE; DRUG METABOLISM; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENE DUPLICATION; GENETIC ANALYSIS; HUMAN; MEDICAL RESEARCH; MOLECULAR EVOLUTION; MULTIGENE FAMILY; PEROXIDATION; PLANT PRODUCT; POLLUTANT; PROTEIN FUNCTION; PROTEOMICS; REDUCTION; REVIEW;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; EVOLUTION, MOLECULAR; HUMANS; PHARMACEUTICAL PREPARATIONS;

EID: 0036890399     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200023337054     Document Type: Review

References (349)

1. Ohta, T. (1991) J. Mol. Evol., 33, 34-41.
2. Haldane, J.B.S. (1932) The Causes of Evolution., Longman and Green, London.
3. Muller, H.J. (1935) Genetics, 17, 237-252.
4. Ohno, S. (1970) Evolution of Gene Duplication., Springer-Verlag, New York
5. Gherardi, E.; Gonzalez Manzano, R.; Cottage, A.; Hawker, K. and Aparicio, S. (1997) Ciba Found. Symp., 212, 24-45.
6. Hunter, T. (1987) Cell, 50, 823-829.
7. Kruse, M.; Muller, I.M. and Muller, W.E. (1997) Mol. Biol. Evol., 14, 1326-1334.
8. Nelson, D.R.; Kamataki, T.; Waxman, D.J.; Guengerich, F.P.; Estabrook, R.W.; Feyereisen, R.; Gonzalez, F.J.; Coon, M.J.; Gunsalus, I.C.; Gotoh, O.; Okuda, K. and Nebert, D.W. (1993) DNA Cell Biol., 12, 1-51.
9. Garfinkle, D. (1958) Arch. Biochem. Biophys., 77, 493-509.
10. Klingenberfg, M. (1958) Arch. Biochem. Biophys., 75, 376-386.
11. Omura, T. and Sato, R. (1961) J. Biol. Chem., 237, 1375-1376.
12. Omura, T. and Sato, R. (1964) J. Bio. Chem., 239, 2370-2378.
13. Dawson, J. H. and Sono, M. (1987) Chem. Rev., 87,1255-1276.
14. Stuehr, D. J. and Saito, M. I. (1992) J. Biol. Chem., 267, 20547-20550.
15. Griffin, B. W. (1991) In Peroxidases in Chemistry and Biology, Vol. II, (Everse, J.; Everse, K. E. and Grisham, M. B. Eds.), CRC Press, Boca Raton, Florida, pp. 85-137.
16. Kim, I. C and Deal, W. C. (1976) Biochemistry, 15, 4925-4930.
17. Loomis, W. F. (1988) Four Billion Years, An Essay on the EVolution of Genes and Organisms., Sinauer Associates, Inc., Sunderland, Massachusetts, pp. 286.
18. Tijet, N.; Helvig, C. and Feyereisen, R. (2001) Gene, 262, 189-198.
19. Nebert, D.W. and Nelson, D.R. (1991) In Methods in Enzymology. Cytochrome P450, Vol. 206, (Waterman, M.R. and Johnson, E. F. Eds.), Academic Press, New York, pp. 3-11.
20. Nelson, D.R. (1998) Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol., 121, 15-22.
21. Doolittle, R.F. (1985) Trends Biochem. Sci., 10, 233-237.
22. Patthy, L. (1985) Cell, 41, 657-663.
23. Barrell, B.G.; Air, G.M. and Hutchison III, C.A. (1976) Nature, 264, 34-41.
24. Anderson, S.; Bankier, A.T.; Barrell, B.G.; de Bruijn, M.H.L.; Coulson, A.R.; Drouin, J.; Eperon, I.C.; Nierlich, D.P.; Roe, B.A.; Sanger, F.; Schreier, P.H.; Smith, A.J.H.; Staden, R. and Young I.G. (1981) Nature, 290, 457-464.
25. Atkins, J.F.; Weiss, R.B. and Gesteland, R.F. (1990) Cell, 62, 413-423.
26. Blinkowa, A.L. and Walker, J.R. (1990) Nucleic Acids Res., 18, 1725-1729.
27. Andreadis, A.; Gallego, M.E. and Nadal-Ginard, B. (1987) Annu. Rev. Cell Biol., 3, 207-242.
28. Leff, S.; Rosenfeld, M. and Evans, R. (1986) Annu. Rev. Biochem., 55, 1091-1117.
29. Hajduk, S.L.; Harris, M.E. and Pollard, V.W. (1993) FASEB J., 7, 54-63.
30. Piatigorsky, J.; O'Brien, W.E.; Norman, B.L.; Kalumuck, K.; Wistow, G.J.; Borrass, T.; Nickerson, J.M. and Wawrousek, E.F. (1988) Proc. Natl. Acad. Sci. USA, 85, 3479-3483.
31. Chothia, C. (1994) Dev. Suppl., 27-33.
32. Nebert, D.W. and Feyereisen, R. (1994) In Cytochrome P450, Biochemistry, Biophysics and Molecular Biology, (Lechner M.C. Ed.), Libbey Eurotext, London, pp. 3-13.
33. Schlezinger, J.J.; White, R.D. and Stegeman, J.J. (1999) Mol. Pharmacol., 56, 588-597.
34. Ullrich, V. and Diehl, H. (1971) Eur. J. Biochem., 20, 509-512.
35. Nebert, D.W. and Gonzalez, F.J. (1985) Trends in Pharmacol. Sci., 6, 160-164.
36. Nelson, D.R. and Strobel, H.W. (1987) Mol. Biol. Evol., 4, 572-593.
37. Gonzalez, F.J. and Nebert D.W. (1990) Trends Genet., 6, 182-186.
38. Dover, G.A. and Tautz, D. (1986) Phil. Trans. R. Soc. Lond. B, 312, 275-289.
39. Dover, G.A. (1987) J. Mol. Evol., 26, 47-58.
40. Nelson, D.R.; Kamataki, T.; Waxman, D.J.; Guengerich, F.P.; Estabrook, R.W.; Feyereisen, R.; Gonzalez, F.J.; Coon, M.J.; Gunsalus, I.C.; Gotoh, O.; Okuda, K. and Nebert, D.W. (1993), DNA Cell Biol., 12, 1-51.
41. Miller, W.L. (1987) J. Steroid Biochem., 27, 759-766.
42. Nebert, D.W. and Gonzalez, F.J. (1987) Annu. Rev. Biochem., 5, 945-993.
43. Dey, A. and Nebert, D.W. (1998) Biochem. Biophys. Res. Comm., 251, 657-661.
44. Nebert, D.W. and McKinnon, R.A. (1994) Progr. Liver Dis., 12, 63-97.
45. Ryner, L.C. and Swain, A. (1995) Cell, 81, 483-493.
46. Goldstein, J.A. and de Morais, S.M. (1994) Pharmacogenetics, 4, 285-299.
47. Fisslthaler, B.; Popp, R.; Kiss, L.; Potente, M.; Harder, D.R.; Fleming, I. and Busse, R. (1999) Nature, 401, 493-497.
48. Zhou, L.X.; Pihlstrom, B.; Hardwick, J.P.; Park, S.S.; Wrighton, S.A. and Holtzman, J.L. (1996) Clin. Pharmacol. Ther., 60, 191-198.
49. Niznik, H.B.; Tyndale, R.F.; Sallee, F.R.; Gonzalez, F.J.; Hardwick, J.P.; Inaba, T. and Kalow, W. (1990) Arch. Biochem. Biophys., 276, 424-432.
50. Llerena, A.L.; Herraiz, A.G.; Cobaleda, J.; Johansson, I. and Dahl, M.L. (1998) Clin. Pharmacol. Ther., 54, 606-611.
51. Brattsten, L.B. (1988) J. Chem. Ecol., 14, 1919-1939.
52. Scott, J.G.; Liu, N. and Wen, Z. (1998) Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol., 121(1-3), 147-155.
53. Krieger, R.I.; Feeny, P.P. and Wilkinson, C.F. (1971) Science, 172, 579-581.
54. Ahmad, S. (1983) Ecology, 64, 235-243.
55. Fogleman, J.C. and Abril, J.R. (1990) In Ecological and Evolutionary Genetics of Drosophila, (Barker, J.S.F.; MacIntyre, R.J. and Starmer, W.T. Eds.) Plenum Press, New York, pp. 121-143.
56. Danielson, P.B.; MacIntyre, R.J. and Fogleman, J.C. (1997) Proc. Natl. Acad. Sci. USA, 94, 10797-10802.
57. Danielson, P.B.; Foster, J.L.M.; McMahill, M.M.; Smith, M.K. and Fogleman, J.C. (1998) Mol. Gen. Genet., 259, 54-59.
58. Danielson, P.B.; Frank, M.R.; and Fogleman, J.C. (1994) J. Chem. Ecol., 20, 1893-1906.
59. Fogleman, J.C.; Danielson, P.B. and MacIntyre, R.J. (1997) Evol. Biol., 30, 15-77.
60. Frank, M.R. and Fogleman, J.C. (1992) Proc. Natl. Acad. Sci. USA, 89, 11998-12002.
61. Prapaipong, H.; Berenbaum, M.R. and Schuler, M.A. (1994) Nucleic Acids Res., 22, 3210-3217.
62. Hung, C-F.; Prapaipong, H.; Bernbaum, M.R. and Schuler, M.A. (1995) Insect Biochem. Mol. Biol., 25, 89-99.
63. Li, W.; Berenbaum, M.R. and Schuler, M.A. (2001) Insect Biochem. Mol. Biol., 31(10), 999-1011.
64. Petersen, R.A.; Zangerl, A.R.; Berenbaum, M.R.; Schuler, M.A. (2001) Insect Biochem. Mol. Biol., 31(6-7), 679-90.
65. Nelson, D.R.; Koymans, L.; Kamataki, T.; Stegeman, J.J.; Feyereisen, R.; Waxman, D.J.; Waterman, M.R.; Gotoh, O.; Coon M.J.; Estabrook, R.W.; Gunsalus, I.C. and Nebert, D.W. (1996) Pharmacogenetics, 6, 1-42.
66. Kusano, K.; Kagawa, N.; Sakaguchi, M.; Omura, T. and Waterman, M.R. (2001) J. Biochem., 42, 128-136.
67. Kusano, K.; Sakaguchi, M.; Kagawa, N.; Waterman, M.R. and Omura, T. (2001) J. Biochem., 129, 259-269.
68. Gotoh, O.; Tagashira, Y.; Iizuka, T. and Fujii-Kuriyama, Y. (1983) J. Biochem., 93, 807-817.
69. Haniu, M.; Armes, L.G., Tanaka, M.; Yasunobu, K.T.; Shastry, B.S.; Wagner, G.C. and Gunsalus, I.C. (1982) Biochem. Biophys. Res. Comm., 105, 889-894.
70. Graham-Lorence, S.E. and Peterson, J.A. (1995) In Advances in Molecular and Cell Biology, (Jefcoate, C. Ed.), JAI Press, Greenwich, C.T.
71. Hasemann, C.A.; Ravichandran, K.G.; Boddupalli, S.S.; Peterson, J.A. and Deisenhofer, J. (1995) Structure, 3, 41-62.
72. Podust, L.M.; Poulos, T.L. and Waterman, M.R. (2001) Proc. Natl. Acad. Sci. USA., 98(6), 3068-3073.
73. Williams, P.A.; Cosme, J.; Sridhar, V.; Johnson, E.F. and McRee, D.E. (2000) Arch. Biochem. Biophys., 1, 24-29.
74. Poulos, T.L.; Finzel, B.C. and Howard, A.J. (1987) J. Mol. Biol., 195, 687-700.
75. Nebert, D.W.; Jones, J.E.; Owens, J. and Puga, A. (1988) In Oxidases and Related Redox Systems, (King Mason, T. H. and Morrison, M. Eds.), Liss, New York, pp.557-578,
76. Lindberg, R.L.P. and Negishi, M. (1989) Nature, 339, 632-634.
77. Lindberg, R.L.P. and Negishi, M. (1991) Methods Enzymol., 202, 741-752.
78. Hanioka, N.; Gonzalez, F.J.; Lindberg, N.A.; Liu, G.; Gelboin, H.V.; Korzekwa, K.R. (1992) Biochemistry, 31(13), 3364-3370.
79. Gillam, E.M.; Guo, Z.; Ueng, Y.F.; Yamazaki, H.; Cock, I.; Reilly, P.E.; Hooper, W.D. and Guengerich, F.P. (1995) Arch. Biochem. Biophys., 317, 374-384.
80. Wang, H.; Dick, R.; Yin, H.; Licad-Coles, E.; Kroetz, D.L.; Szklarz, G.; Harlow, G.; Halpert, J.R.; Correia, M.A. (1998) Biochemistry, 37(36), 12536-12545.
81. Gotoh, O. (1992) J. Biol. Chem., 267, 83-90.
82. Sligar, S.G.; Murray, R.I. (1986) In Cytochrome P-450 (Ortiz de Montellano, P.R., Ed), Plenum Press, New York, pp. 429-503.
83. Stryer, L. (1995) Biochemistry 4th Edition., Freeman, W.H. New York, Fig. 21-27.
84. Goeptar, A.R.; Scheerens, H. and Vermculen, N.P.E. (1995) Crit. Rev. Toxicol., 25, 25-65.
85. Frommer, U.; Ullrich, V. and Staudinger, H. (1970) Hoppe-Seyler's Z. Physiol. Chem., 351, 903-912.
86. White, R.E.; McCarthy, M.B.; Egeberg, K.D. and Sligar, S.G. (1984) Arch. Biochem. Biophys., 228, 493-502.
87. CaJacob, C.A.; Chan, W.; Shephard, E. and Ortiz de Montellano, P.R. (1988) J. Biol. Chem., 263, 18640-18649.
88. Raucy, J.L.; Kraner, J.C. and Lasker, J.M. (1993) Crit. Rev. Toxicol., 23, 1-20.
89. Mehendale, H.M.; Roth, R.A.; Gandolfi, A.J.; Klaunig, J.E.; Lemasters, J.J. and Curtis, L.R. (1994) FASEB J., 8, 1285-1295.
90. Ortiz de Montellano, P.R. and Reich, N.O. (1995) In Cytochrome P450, Structure, Mechanism, and Biochemistry. (Ortiz de Montellano, P.R. Ed.) Plenum Press, New York, pp. 273-214.
91. Brodie, B.B.; Axelrod, J.; Cooper, J.R.; Gaudette, L.; La Du, B.N.; Mitoma, C. and Udenfriend, S. (1955) Science, 121, 603-604.
92. Seto, Y. and Guengerich F.P. (1993) J. Biol. Chem., 268(14), 9986-9997.
93. Dong, H.; Haining, R.L.; Thummel, K.E.; Rettie, A.E. and Nelson, S.D. (2000) Drug Metab. Disp., 28(12), 1397-400.
94. Conney, A. H. (1967) Pharmcol. Rev., 19, 317-366.
95. Okey, A.B. (1990) Pharmacol. Ther., 45, 241-298.
96. Giachelli, C.M. and Omiecinski, C.J. (1987) Mol. Pharmacol., 31, 477-484.
97. Rodgers, R. J.; Waterman, M. R.; Simpson, E.R. (1987) Mol. Endocrinol., 1, 274-279.
98. Whitlock, J.P. Jr. (1986) Annu. Rev. Pharmacol. Toxicol., 26, 333-369.
99. Simmons, D.L.; McQuiddy, P. and Kasper, C.B. (1987) J. Biol. Chem., 262, 325-332.
100. Silver, G. and Krauter, K.S. (1988) J. Biol. Chem., 263, 11802-11807.
101. Pan, J., Hong, J.Y. and Yang, C.S. (1992) Arch. Biochem. Biophys., 299, 110-115.
102. Gelboin, H.V. (1980) Physiol. Rev., 60, 1107-1166.
103. Conney, A.H. (1982) Cancer Res., 42, 4875-4917.
104. Gelboin, H.V. and Blackburn, N. (1963) Biochim. Biophys. Acta, 72, 657-660.
105. Nebert, D.W. and Gelboin, H.V. (1970) J. Biol. Chem., 245, 160-168.
106. Poland, A.; Glover, E.; Ebetino, F.H. and Kende, A.S. (1986) J. Biol. Chem., 261, 6352-6365.
107. Burbach, K.M.; Poland, A. and Bradfield, C.A. (1992) Proc. Natl. Acad. Sci. USA, 89(17), 8185-8189.
108. Ema, M.; Sugawa, K.; Wanatabe, N.; Chujoh, Y.; Matsushita, N.; Gotoh, O.; Funae, Y. and Fuji-Kuriyama, Y. (1992) Biochem. Biophys. Res. Comm., 184, 246-253.
109. Swanson, H.I.; Tulis, K. and Denison, M.S. (1993) Biochemistry, 32, 12841-12849.
110. Elferink, C.J. and Whitlock, J.P. Jr. (1990) J. Biol. Chem., 265, 5718-5721.
111. Waxman, D.J. and Azaroff, L. (1992) J. Biol. Chem., 261, 577-592.
112. Gonzalez, F.J. (1989) Pharmacol. Rev., 40, 243-288.
113. Tieney, B. and Bresnick, E. (1981) Arch. Biochem. Biophys., 210, 729-739.
114. Fulco, A.J. (1991) Annu. Rev. Pharmacol. Toxicol., 31, 177-203.
115. Shaw, G. and Fulco, A.J. (1993) J. Biol. Chem., 267, 5515-5526.
116. He, J. and Fulco, A.J. (1991) J. Biol. Chem., 266, 7864-7869.
117. Hahn, C.N.; Hansen, A.J. and May, B.K. (1991) J. Biol. Chem., 266, 17031-17039.
118. Lock, E.A.; Mitchell, A.M. and Elcombe, C.R. (1989) Annu. Rev. Pharmacol. Toxicol., 29, 145-163.
119. Issemann, I. and Green, S. (1990) Nature, 347, 645-650.
120. Selye, H. (1971) J. Pharmacol. Sci., 60, 1-28.
121. Elshourbagy, N.A. and Guzelian, P.S. (1980) J. Biol. Chem., 255(4), 1279-1285.
122. Schuetz, E.G. and Guzelian, P.S. (1984) J. Biol. Chem., 259, 2007-2012.
123. Waxman, D.J. (1992) J. Steroid Biochem. Mol. Biol., 43, 1055-1072.
124. Zimniak, P. and Waxman, D.J. (1993) In Handbook of Experimental Pharmacology, Cytochrome P450, (Schenkman, J. B. and Greim, H. Eds.), Springer-Verlag, Berlin, pp. 123-144.
125. Kato, R.; Yamazoe, Y.; Shimada, M.; Murayama, N. and Kamataki, T. (1986) J. Biochem., 100, 895-902.
126. Waxman, D.J.; Morrissey, J.J. and LeBlanc, G.A. (1989) Mol. Pharmacol., 35, 519-525.
127. Ram, P.A. and Waxman, D.J. (1990) J. Biol. Chem., 265, 19223-19229.
128. Waxman, D.J.; Lapenson, D.P.; Aoyama, T.; Gelboin, H.V.; Gonzalez, F.J. and Korzekwa, K. (1991) Arch. Biochem. Biophys., 290, 160-166.
129. Mode, A. and Norstedt, G. (1982) J. Endocrinol., 95, 181-187.
130. Lund, J.; Faucher, D.J.; Ford, S.P.; Porter, J.C.; Waterman, M.R. and Mason, J.I. (1988) J. Biol. Chem., 263, 16195-16201.
131. Lund, J.; Ahlgren, R.; Wu, D.; Kagimoto, M.; Simpson, E.R. and Waterman, M.R. (1990) J. Biol. Chem., 265, 3304-3312.
132. Honda, S.; Morohashi, K.; Nomura, M.; Takeya, M.; Kitajimi, M. and Omura, T. (1993) J. Biol. Chem., 268, 7479-7502.
133. Ikeda, Y.; Shen, W.H.; Ingraham, H.A. and Parker, K.L. (1994) Mol. Endocrinol., 8, 654-662.
134. Khani, S.C.; Zaphiropoulos, P.G.; Fujita, V.S.; Porter, T.D.; Koop, D.R. and Coon, M.J. (1987) Proc. Natl. Acad. Sci. USA., 84(3), 638-42.
135. Song, B.J.; Veech, R.L.; Park, S.S.; Gelboin, H.V. and Gonzalez, F.J. (1989) J. Biol. Chem., 264(6), 3568-3572.
136. Eliasson, E.; Johansson, I. and Ingelman-Sundberg, M. (1988) Biochem. Biophys. Res. Comm., 150(1), 436-443.
137. Schweikl, H.; Taylor, J.A.; Kitareewan, S.; Linko, P.; Nagorney, D. and Goldstein, J.A. (1993) Pharmacogenetics, 3(5), 239-249.
138. Shimada, T.; Yun, C.H.; Yamazaki, H.; Gautier, J.C.; Beaune, P.H. and Guengerich, F.P. (1992) Mol. Pharmacol., 41(5), 856-864.
139. Shimada, T.; Martin, M.V.; Pruess-Schwartz, D.; Marnett, L.J. and Guengerich, F.P. (1989) Cancer Res., 49(22), 6304-6312.
140. Sutter, T.R.; Tang, Y.M.; Hayes, C.L.; Wo, Y.Y.; Jabs, E.W.; Li, X.; Yin, H.; Cody, C.W. and Greenlee, W.F. (1994) J. Biol. Chem., 269(18), 13092-13099.
141. MacLeod, S.; Sinha, R.; Kadlubar, F.F. and Lang, N.P. (1997) Mutat. Res. 376(1-2), 135-142.
142. Kawajiri, K. (1999) IARC Sci. Publ., 148, 159-172.
143. Williams, P.A.; Cosme, J.; Sridhar, V.; Johnson, E.F. and McRee, D.E. (2000) J. Inorg. Biochem., 81(3), 183-190.
144. Whitlock, J.P. Jr. (1999) Annu. Rev. Pharmacol. Toxicol., 39, 103-125.
145. Piechocki, M.P. and Hines, R.N. (1998) Carcinogenesis, 19(5), 771-780.
146. Lekas, P.; Tin, K.L.; Lee, C. and Prokipcak, R.D. (2000) Arch. Biochem. Biophys., 384(2), 311-318.
147. Marques, M.P.; Takayanagui, O.M. and Lanchote, V.L. (2002) Braz. J. Med. Biol. Res., 35(2), 261-269.
148. Nakajima, M.; Kobayashi, K.; Shimada, N.; Tokudome, S.; Yamamoto, T. and Kuroiwa, Y. (1998) Br. J. Clin. Pharmacol., 46(1), 55-62.
149. Corrigan, B.W.; Nicholls, B.; Thakrar, B.; Lam, R.; Grosse, C.; Alianti, J. and Palmer, J.L. (1999) Drug Metab. Disp., 27(1), 110-112.
150. Härtter, S.; Ursing, C.; Morita, S.; Tybring, G.; von Bahr, C.; Christensen, M.; Röjdmark, S. and Bertilsson, L. (2001) Clin. Pharmacol. Ther., 70(1), 10-16.
151. Peters, J.M.; Morishima, H.; Ward, J.M.; Coakley, C.J.; Kimura, S. and Gonzalez, F.J. (1999) Toxicol. Sci., 50(1), 82-89.
152. Gu, L.; Gonzalez, F.J.; Kalow, W. and Tang, B.K. (1992) Pharmacogenetics, 2(2), 73-77.
153. Lehmann, D.E. (2000) Pharmacotherapy, 20(12), 1464-1468.
154. Stresser, D.M. and Kupfer, D. (1998) Drug. Metab. Disp., 26(9), 868-874.
155. Aklillu, E.; Oscarson, M.; Hidestrand, M.; Leidvik, B.; Otter, C. and Ingelman-Sundberg, M. (2002) Mol. Pharmacol., 61(3), 586-594.
156. Hatanaka, N.; Yamazaki, H.; Kizu, R.; Hayakawa, K.; Aoki, Y.; Iwanari, M.; Nakajima, M. and Yokoi, T. (2001) Carcinogenesis, 22(12), 2033-2038.
157. Stoilov, I.; Akarsu, A.N. and Sarfarazi, M. (1997) Hum. Mol. Genet., 6(4), 641-647.
158. Stoilov, I.; Akarsu, A.N.; Alozie, I.; Child, A.; Barsoum-Homsy, M.; Turacli, M.E.; Or, M.; Lewis, R.A.; Ozdemir, N.; Brice, G.; Aktan, S.G.; Chevrette, L.; Coca-Prados, M. and Sarfarazi, M. (1998) Am. J. Hum. Genet., 62(3), 573-584.
159. Gu, J.; Su, T.; Chen, Y.; Zhang, Q.Y. and Ding, X. (2000) Toxicol. Appl. Pharmacol., 165(2), 158-162.
160. Koskela, S.; Hakkola, J.; Hukkanen, J.; Pelkonen, O.; Sorri, M.; Saranen, A.; Anttila, S.; Fernandez-Salguero, P.; Gonzalez, F. and Raunio, H. (1999) Biochem. Pharmacol., 57(12), 1407-1413.
161. Paschke, T.; Riefler, M.; Schuler-Metz, A.; Wolz, L.; Scherer, G.; McBride, C.M. and Bepler, G. (2001) Toxicology, 168(3), 259-68.
162. Raunio, H.; Rautio, A. and Pelkonen, O. (1999) IARC Sci. Publ. 148, 197-207.
163. Yamano, S.; Tatsuno, J. and Gonzalez, F.J. (1990) Biochemistry, 29(5), 1322-1329.
164. Ding, S.; Lake, B.G.; Friedberg, T. and Wolf, C.R. (1995) Biochem J., 306 (Pt 1), 161-166.
165. Su, T.; Bao, Z.; Zhang, Q.Y.; Smith, T.J.; Hong, J.Y. and Ding, X. (2000) Cancer Res., 60(18), 5074-5079.
166. Goodwin, B.; Moore, L.B.; Stoltz, C.M.; McKee, D.D. and Kliewer, S.A. (2001) Mol. Pharmacol., 60(3), 427-431.
167. Lang, T.; Klein, K.; Fischer, J.; Nüssler, A.K.; Neuhaus, P.; Hofmann, U.; Eichelbaum, M.; Schwab, M. and Zanger, U.M. (2001) Pharmacogenetics, 11(5), 399-415.
168. Wang, Q. and Halpert, J.R. (2002) Drug Metab. Disp., 30(1), 86-95.
169. Hidestrand, M.; Oscarson, M.; Salonen, J.S.; Nyman, L.; Pelkonen, O.; Turpeinen, M. and Ingelman-Sundberg, M. (2001) Drug Metab. Disp., 29(11), 1480-1484.
170. Finta, C. and Zaphiropoulos, P.G. (2000) Genomics, 63(3), 433-438.
171. Imaoka, S.; Yamada, T.; Hiroi, T.; Hayashi, K.; Sakaki, T.; Yabusaki, Y. and Funae, Y. (1996) Biochem. Pharmacol., 51, 1041-1050.
172. Edwards, R.J.; Adams, D.A.; Watts, P.S.; Davies, D.S. and Boobis, A.R. (1998) Biochem. Pharmacol., 56, 377-387.
173. Richardson, T.H.; Griffin, K.J.; Jung, F.; Raucy, J.L. and Johnson, E.F. (1997) Arch. Biochem. Biophys., 338, 157-164.
174. Perrot, N.; Nalpas, B.; Yang, C.S. and Beaune, P.H. (1989) Eur. J. Clin. Invest., 19, 549-555.
175. Treluyer, J.M.; Gueret, G.; Cheron, G.; Sonnier, M. and Cresteil, T. (1997) Pharmacogenetics, 7, 441-452.
176. Pascussi, J.M.; Gerbal-Chaloin, S.; Pichard-Garcia, L.; Daujat, M.; Fabre, J.M.; Maurel, P. and Vilarem M.J. (2000) Biochem. Biophys. Res. Comm., 274, 707-713.
177. Gerbal-Chaloin, S.; Daujat, M.; Pascussi, J.M.; Pichard-Garcia, L.; Vilarem, M.J. and Maurel, P. (2002) J. Biol. Chem., 277(1), 209-217.
178. Harris, J.W.; Rahman, A.; Kim, B.R.; Guengerich, F.P. and Collins, J.M. (1994) Cancer Res., 54(15), 4026-4035.
179. Leo, M.A.; Lasker, J.M.; Raucy, J.L.; Kim, C.I.; Black, M. and Lieber, C.S. (1989) Arch Biochem. Biophys., 269(1), 305-312.
180. Cosme, J.; Maurel, P.; Soucek, P.; Guengerich, F.P. and Collins, J.M. (1994) Abstracts, 14th European Drug Metabolism Workshop (July 3-8, Paris).
181. Brian, W.R.; Srivastava, P.K.; Umbenhauer, D.R.; Lloyd, R.S. and Guengerich, F.P. (1989) Biochemistry, 28(12), 4993-4999.
182. Zilly, W.; Breimer, D.D. and Richter, E. (1977) Eur. J. Clin. Pharmacol., 11(4), 287-293.
183. Leemann, T.; Transon, C. and Dayer, P. (1993) Life Sci., 52(1), 29-34.
184. Leemann, T.D.; Transon, C.; Bonnabry, P. and Dayer, P. (1993) Drugs Exp. Clin. Res., 19(5), 189-195.
185. Veronese, M.E.; Mackenzie, P.I.; Doecke, C.J.; McManus, M.E.; Miners, J.O. and Birkett, D.J. (1991) Biochem. Biophys. Res. Comm., 175(3), 1112-1118.
186. Relling, M.V.; Aoyama, T.; Gonzalez, F.J. and Meyer, U.A. (1990) J. Pharmacol. Exp. Ther., 252(1), 442-447.
187. Nakamura, M.; Tanaka, E.; Misawa, S.; Shimada, T.; Imaoka, S. and Funae, Y. (1994) Biochem. Pharmacol., 47(2), 247-251.
188. Dai, D.; Zeldin, D.C.; Blaisdell, J.A.; Chanas, B.; Coulter, S.J.; Ghanayem, B.I. and Goldstein, J.A. (2001) Pharmacogenetics, 11(7), 597-607.
189. Wilkinson, G.R.; Guengerich, F.P. and Branch, R.A. (1989) Pharmacol. Ther., 43, 53-76.
190. Nelson, D.R.; Koymans, L.; Kamataki, T.; Stegeman, J.J.; Feyereisen, R.; Waxman, D.J.; Waterman, M.R.; Gotoh, O.; Coon, M.J.; Estabrook, R.W.; Gunsalus, I.C. and Nebert, D.W. (1996) Pharmacogenetics, 6, 1-42.
191. Shimada, T.; Yamazaki, H.; Mimura, M.; Inui, Y. and Guengerich, F.P. (1994) J. Pharmacol. Exp. Ther., 270, 414-423.
192. Pelkonen, O. and Raunio, H. (1997) Environ. Health Perspect., 105, 767-774.
193. Eichelbaum, M.; Spannbrucker, N.; Steincke, B. and Dengler, H.J. (1979) Eur. J. Clin. Pharmacol., 16, 183-187.
194. Gonzalez, F.J.; Skoda, R.C.; Kimura, S.; Umeno, M.; Zanger, U.M.; Nebert, D.W.; Gelboin, H.V.; Hardwick, J.P. and Meyer, U.A. (1988) Nature, 331, 442-446.
195. Ingelman-Sundberg, M. (1999) Biochem. Biophys. Res. Comm., 259, 201-205.
196. Pelkonen, O.; Mäenpää, J.; Taavitsainen, P.; Rautio, A. and Raunio, H. (1998) Xenobiotica, 28, 1203-1253.
197. Sallustio, B.C. and Morris, R.G. (1999) Ther. Drug. Monit., 21, 389-394.
198. Larrey, D.; Pageaux, G.P. (1997) J. Hepatol., 26, 12-21.
199. McLellan, R.A.; Oscarson, M.; Seidegard, J.; Evans, D.A.P. and Ingelman-Sudberg, M. (1997) Pharmacogenetics, 7, 181-191.
200. Daly, A.K.; Brockmoller, J.; Broly, F.; Eichelbaum, M.; Evans, W.E.; Gonzalez, F.J.; Huang, J.D.; Idle, J.R.; Ingelman-Sundberg, M.; Ishizaki, T.; Jacqz-Aigrain, E.; Meyer, U.A.; Nebert, D.W.; Steen, V.M.; Wolf, C.R. and Zanger, U.M. (1996) Pharmacogenetics, 6, 193-201.
201. Johansson, I.; Lundqvist, E.; Bertilsson, L.; Dahl, M.L.; Sjöqvist, F. and Ingelman-Sundberg, M. (1993) Proc. Natl. Acad. Sci. USA, 90, 11825-11829.
202. Dalen, P.; Dahl, M.L.; Ruiz, M.L.; Nordin, J. and Bertilsson, L. (1998) Clin. Pharmacol. Ther., 63, 444-452.
203. Rostami-Hodjegan, A.; Lennard, M.S.;, Woods, H.F. and Tucker, G.T. (1998) Pharmacogenetics, 8, 227-238.
204. Saarikoski, S.T.; Sata, F.; Husgafvel-Pursiainen, K.; Rautalahti, M.; Haukka, J.; Impivaara, O.; Järvisalo, J.; Vainio, H. and Hirvonen, A. (2000) Pharmacogenetics, 10, 5-10.
205. Crespi, C.L.; Penman, B.W.; Gelboin, H.V. and Gonzalez, F.J. (1991) Carcinogenesis, 12, 1197-1201.
206. Hecht, S.S. (1998) Chem. Res. Toxicol., 11, 559-603.
207. Shimada, T.; Yamazaki, H.; Mimura, M.; Inui, Y. and Guengerich, F.P. (1994) J. Pharmacol. Exp. Ther., 270, 414-423.
208. Peter, R.; Bocker, R.; Beaune, P.H.; Iwasaki, M.; Guengerich, F.P. and Yang, C.S. (1990) Chem. Res. Toxicol., 3(6), 566-573.
209. Guengerich, F.P. and Turvy, C.G. (1991) J. Pharmacol. Exp. Ther., 256(3), 1189-1194.
210. Raunio, H.; Pasanen, M.; Mäenpää, J.; Hakkola, J. and Pelkonen, O. (1995) In Advances in Drug Metabolism in Man, (Pacifici, G.M. and Fracchia, G.N. Eds.), European Commission, Office for Official Publications of the European Communities, Luxembourg, pp. 234-287.
211. Song, B.J.; Veech, R.L. and Saenger, P. (1990) J. Clin. Endocrinol. Metab., 71(4), 1036-1040.
212. Ronis, M.J.; Badger, T.M.; Shema, S.J.; Roberson, P.K. and Shaikh, F. (1996) Toxicol. Appl. Pharmacol., 136(2), 361-371.
213. Lieber, C.S. (1997) Physiol. Rev., 77, 517-544.
214. Yamazaki, H.; Inui, Y.; Yun, C.H.; Guengerich, F.P. and Shimada, T. (1992) Carcinogenesis, 13(10), 1789-1794.
215. Kushida, H.; Fujita, K.; Suzuki, A.; Yamada, M.; Endo, T.; Nohmi, T. and Kamataki, T. (2000) Carcinogenesis. 21(6), 1227-1232.
216. Hecht, S.S. (1999) Mutat. Res., 424(1-2), 127-142.
217. Guengerich, F.P. (1995) In Advances in Drug Metabolism in Man, (Pacifici, G.M. and Fracchia, G.N. Eds.), Office for the Official Publications of the European Communities, Luxenbourg, pp. 179-231.
218. Spracklin, D.K.; Hankins, D.C.; Fisher, J.M.; Thummel, K.E. and Kharasch, E.D. (1997) J. Pharmacol. Exp. Ther., 281(1), 400-411.
219. Song, B-J. (1995) In Drug and Alcohol Abuse Reviews, Vol. 6, Alcohol and Hormones, (Watson, R.R. Ed.), Humana Press, Totowa, pp. 177-192.
220. Ronis, M.J.J.; Lindros, K.O. and Ingelman-Sundberg, M. (1996) In Cytochromes P450, Metabolic and Toxicological Aspects, (Ioannides, C. and Parke, D.V. Eds), CRC Press, Boca Raton, pp. 211-239.
221. Abdel-Razzak, Z.; Loyer, P.; Fautrel, A.; Gautier, J-C.; Corcos, L.; Turlin, B.; Beaune, P. and Guillouzo, A. (1993) Mol. Pharmacol., 44, 707-715.
222. Daly, A.K. (1995) J. Mol. Med., 73(11), 539-553.
223. Stephens, E.A.; Taylor, J.A.; Kaplan, N.; Yang, C.H.; Hsieh, L.L.; Lucier, G.W. and Bell, D.A. (1994) Pharmacogenetics, 4(4), 185-192.
224. Grove, J.; Brown, A.S.; Daly, A.K.; Bassendine, M.F.; James, O.F. and Day, C.P. (1998) Pharmacogenetics, 8(4), 335-342.
225. Hu, Y.; Oscarson, M.; Johansson, I.; Yue, Q-Y.; Dahl, M-L.; Tabone, M.; Arinco, S.; Albano, E. and Ingelman-Sundberg, M. (1997) Mol. Pharmacol., 51, 370-376.
226. Fairbrother, K.S.; Grove, J.; de Waziers, I.; Steimel, D.T.; Day, C.P.; Crespi, C. and Daly, A.K. (1998) Pharmacogenetics, 8, 543-552.
227. Tsutsumi, M.; Takada, A. and Wang, J.S. (1994) Gastroenterology, 107(5), 1430-1435.
228. Ingelman-Sundberg, M.; Johansson, I.; Persson, I.; Yue, Q.Y.; Dahl, M.L.; Bertilsson, L. and Sjoqvist, F. (1992) Pharmacogenetics, 2(6), 264-271.
229. Lanza, D.L.; Code, E.; Crespi, C.L.; Gonzalez, F.J. and Yost, G.S (1999). Drug Metab. Disp., 27, 798-803.
230. Nhamburo, P.T.; Kimura, S.; McBride, O.W.; Kozak, C.A.; Gelboin, H.V. and Gonzalez, F.J. (1990) Biochemistry, 29, 5491-5499.
231. Hakkola, J.; Pasanen, M.; Hukkanen, J.; Pelkonen, O.; Mäenpää, J.; Edwards, R.J.; Boobis, A.R. and Raunio, H. (1996) Biochem. Pharmacol., 51, 403-411.
232. Hakkola, J.; Pasanen, M.; Purkunen, R.; Saarikoski, S.; Pelkonen, O.; Mäenpää J.; Rane, A. and Raunio, H. (1994) Biochem. Pharmacol., 48, 59-64.
233. Sheng, J.; Guo, J.; Hua, Z.; Caggana, M. and Ding, X. (2000) Pharmacogenetics, 10(8), 667-678.
234. Zeldin, D.C.; Foley, J.; Goldsworthy, S.M.; Cook, M.E.; Boyle, J.E.; Ma, J.; Moomaw, C.R.; Tomer, K.B.; Steenbergen, C. and Wu, S. (1997) Mol. Pharmacol., 51, 931-943.
235. Wu, S.; Moomaw, C.R.; Tomer, K.B.; Falck, J.R. and Zeldin, D.C. (1996) J. Biol. Chem., 271, 3460-3468.
236. Zeldin, D.C.; Foley, J.; Ma, J.; Boyle, J.E.; Pascual, J.M.; Moomaw, C.R.; Tomer, K.B.; Steenbergen, C. and Wu, S. (1996) Mol. Pharmacol., 50, 1111-1117.
237. Zeldin, D.C.; Foley, J.; Boyle, J.E.; Moomaw, C.R.; Tomer, K.B.; Parker, C.; Steenbergen, C. and Wu, S. (1997) Endocrinology, 138, 1338-1346.
238. Capdevila, J.H.; Falck, J.R. and Harris, R.C. (2000) J. Lipid Res., 41, 163-181.
239. Hashizume, T.; Imaoka, S.; Mise, M.; Terauchi, Y.; Fujii, T.; Miyazaki, H.; Kamataki, T.; and Funae, Y. (2002) J. Pharmacol. Exp. Ther., 300(1), 298-304.
240. Wrighton, S.A.; Ring, B.J.; Watkins, P.B. and VandenBranden, M. (1989) Mol. Pharmacol., 86, 97-105.
241. Kivistö, K.T.; Griese, E-U.; Fritz, P.; Linder, A.; Hakkola, J.; Raunio, H.; Beaune, P. and Kroemer, H.K. (1996) Naunyn-Schmiedeberg Arch. Pharmacol., 353, 207-212.
242. Gervot, L.; Carriere, V.; Costet, P.; Cugnenc, P.H.; Berger, A.; Beaune, P. and de Waziers, I. (1996) Environ. Tox. Pharm., 2, 381-388.
243. Schuetz, E.G.; Schuetz, J.D.; Grogan, W.M.; Naray-Fejes-Toth, A.; Fejes-Toth, G.; Raucy, J.; Guzelian, P.; Gionela, K. and Watlington, C.O. (1992) Arch. Biochem. Biophys., 294, 206-214.
244. Haehner, B.D.; Gorski, J.C.; VandenBranden, M.; Wrighton, S.A.; Janardan, S.K.; Watkins, P.B. and Hall, S.D. (1996) Mol. Pharmacol., 50, 52-59.
245. Lechevrel, M.; Casson, A.G.; Wolf, C.R.; Hardie, L.J.; Flinterman, M.B.; Montesano, R. and Wild, C.P. (1999) Carcinogenesis, 20, 243-248.
246. Murray, G.I.; Pritchard, S.; Melvin, W.T. and Burke, M.D. (1995) FEBS Lett., 364, 79-82.
247. Wrighton, S.A.; Brian, W.R.; Sari, M.A.; Iwasaki, M.; Guengerich, F.P.; Raucy, J.L.; Molowa, D.T. and VandenBranden, M. (1990) Mol. Pharmacol., 38, 207-213.
248. Yamazaki, H.; Inui, Y.; Wrighton, S.A.; Guengerich, F.P. and Shimada, T. (1995) Carcinogenesis, 16, 2167-2170.
249. Schuetz, E.G.; Schuetz, J.D.; Strom, S.C.; Thompson, M.T.; Fisher, R.A.; Molowa, D.T.; Li, D. and Guzelian, P.S. (1993) Hepatology, 18, 1254-1262.
250. Chang, T.K.H.; Yu, L.; Maurel, P. and Waxman, D.J. (1997) Cancer Res., 57, 1946-1954.
251. Rodríguez-Antona, C.; Jover, R.; Gómez-Lechón, M.J. and Castell, J.V. (2000) Arch. Biochem. Biophys., 376, 109-116.
252. Schuetz, E.G.; Beck, W.T. and Schuetz, J.D. (1996) Mol. Pharmacol., 49, 311-318.
253. Thummel, K.E. and Wilkinson, G.R. (1998) Annu. Rev. Pharmacol. Toxicol., 38, 389-430.
254. Schuetz, J.D.; Beach, D.L. and Guzelian, P.S. (1994) Pharmacogenetics, 4, 11-20.
255. Kitada, M.; Taneda, M.; Itahashi, K. and Kamataki, T. (1991) Jpn. J. Cancer. Res., 82, 426-432.
256. Greuet, J.; Pichard, L.; Bonfils, C.; Domergue, J. and Maurel, P. (1996) Biochem. Biophys. Res. Comm., 225, 689-694.
257. Pascussi, J.M.; Jounaidi, Y.; Drocourt, L.; Domergue, J.; Balabaud, C.; Maurel, P. amd Vilarem, M-J. (1999) Biochem. Biophys. Res. Comm., 260, 377-381.
258. Gellner, K.; Eiselt, R.; Hustert, E.; Arnold, H.; Koch, I.; Haberl, M.; Deglmann, C.J.; Burk, O.; Buntefuss, D.; Escher, S.; Bishop, C.; Koebe, H.G.; Brinkmann, U.; Klenk, H.P.; Kleine, K.; Meyer, U.A. and Wojnowski, L. (2001) Pharmacogenetics, 11(2), 111-121.
259. Westlind, A.; Malmebo, S.; Johansson, I.; Otter, C.; Andersson, T.B.; Ingelman-Sundberg, M. and Oscarson, M. (2001) Biochem. Biophys. Res. Comm., 281(5), 1349-55.
260. Waxman, D.J. (1999) Arch. Biochem. Biophys., 369, 11-23.
261. McKinnon, R.A.; Burgess, W.M.; Hall, P.M.; Roberts-Thomson, S.J.; Gonzalez, F.J. and McManus, M.E. (1995) Gut, 36(2), 259-267.
262. Aoyama, T.; Yamano, S.; Guzelian, P.S.; Gelboin, H.V. and Gonzalez, F.J. (1990) Proc. Natl. Acad. Sci. USA, 87, 4790-4793.
263. Guengerich, F.P. (1999) Annu. Rev. Pharmacol. Toxicol., 39, 1-17.
264. Ged, C.; Rouillon, J.M.; Pichard, L.; Combalbert, J.; Bressot, N.; Bories, P.; Michel, H.; Beaune, P. and Maurel, P. (1989) Br. J. Clin. Pharmacol., 28, 373-387.
265. Kolars, J.C.; Schmiedlin-Ren, P.; Schuetz, J.D.; Fang, C. and Watkins, P.B. (1992) J. Clin. Invest., 90, 1871-1878.
266. Lehmann, J.M.; McKee, D.D.; Watson, M.A.; Willson, T.M.; Moore, J.T. and Kliewer, S.A. (1998) J. Clin. Invest., 102, 1016-1023.
267. Moore, L.B.; Parks, D.J.; Jones, S.A.; Bledsoe, R.K.; Consler, T.G.; Stimmel, J.B.; Goodwin, B.; Liddle, C.; Blanchard, S.G.; Willson, T.M.; Collins, J.L. and Kliewer, S.A. (2000) J. Biol. Chem., 275, 15122-15127.
268. Sueyoshi, T.; Kawamoto, T.; Zelko, I.; Honkakoski, P. and Negishi, M. (1999) J. Biol. Chem., 274, 6043-6046.
269. Sata, F.; Sapone, A.; Elizondo, G.; Stocker, P.; Miller, V.P.; Zheng, W.; Raunio, H.; Crespi, C.L. and Gonzalez, F.J. (2000) Clin. Pharmacol. Ther., 67, 48-56.
270. Rebbeck, T.R.; Jaffe, J.M.; Walker, A.H.; Wein, A.J. and Malkowicz, S.B. (1998) J. Natl. Cancer Inst., 90, 1225-1229.
271. Felix, C.A.; Walker, A.H.; Lange, B.J.; Williams, T.M.; Winick, N.J.; Cheung, N.V.; Lovett, B.D.; Nowell, P.C.; Blair, I.A. and Rebbeck, T.R. (1998) Proc. Natl. Acad. Sci. USA, 95, 13176-13181.
272. Westlind, A.; Löfberg, L.; Tindberg, N.; Andersson, T.B. and Ingelman-Sundberg, M. (1999) Biochem. Biophys. Res. Comm., 259, 201-205.
273. Venkatesan, K.(1992) Clin. Pharmacokinet., 22(1), 47-65.
274. Wilkinson, G.R. (1996) J. Pharmacokinet. Biopharm., 24(5), 475-90.
275. Ameer, B. and Weintraub, R.A. (1997) Clin. Pharmacokinet., 33(2), 103-121.
276. Bertz, R.J. and Granneman, G.R. (1997) Clin. Pharmacokinet., 32, 210-258.
277. Lin, J.H. and Lu, A.Y.H. (1997) Annu. Rev. Med. Chem., 32, 295-304.
278. Lin, J.H. and Lu, A.Y.H. (1997) Pharmacol. Rev., 49, 403-449.
279. Korzekwa, K.R.; Krishnamachary, N.; Shou, M.; Ogai, A.; Parise, R.A.; Rettie, A.E.; Gonzalez, F.J. and Tracy, T.S. (1998) Biochemistry, 37, 4137-4147.
280. Wang, R.W.; Newton, D.J.; Scheri, T.D. and Lu, A.Y.H. (1997) Drug Metab. Disp., 25, 502-507.
281. Henne, K.R.; Kunze, K.L.; Zheng, Y.M.; Christmas, P.; Soberman, R.J. and Rettie, A.E. (2001) Biochemistry, 40(43), 12925-12931.
282. Powell, P.K.; Wolf, I.; Jin, R. and Lasker, J.M. (1998) J. Pharmacol. Exp. Ther., 285(3), 1327-1336.
283. McKinnon, R.A.; Burgess, W.M.; Gonzalez, F.J.; Gasser, R. and McManus, M.E. (1994) Pharmacogenetics, 4, 260-270.
284. Nhamburo, P.T.; Gonzalez, F.J.; McBride, O.W.; Gelboin, H.V. and Kimura, S. (1989) Biochemistry, 28, 8060-8066.
285. Yokotani, N.; Sogawa, K.; Matsubara, S.; Gotoh, O.; Kusunose, E.; Kusunose, M. and Fujii-Kuriyama, Y. (1990) Eur. J. Biochem., 187, 23-29.
286. Asghar, A.; Gorski, J.C.; Haehner-Daniels, B. and Hall, S.D. (2002) Drug Metab. Disp., 30(1), 20-26.
287. Imaoka, S.; Yoneda, Y.; Sugimoto, T.; Hiroi, T.; Yamamoto, K.; Nakatani, T. and Funae, Y. (2000) Biochem. Biophys. Res. Comm., 277, 776-780.
288. Czerwinski, M.; McLemore, T.L.; Philpot, R.N.; Nhamburo, P.T; Korzekwa, K.; Gelboin, H.V. and Gonzalez, F.J. (1991) Cancer Res., 51, 4636-4638.
289. Christmas, P.; Jones, J.P.; Patten, C.J.; Rock, D.A.; Zheng, Y.; Cheng, S.M.; Weber, B.M.; Carlesso, N.; Scadden, D.T.; Rettie, A.E. and Soberman, R.J. (2001) J. Biol. Chem., 276(41), 38166-38172.
290. Bylund, J.; Hidestrand, M.; Ingelman-Sundberg, M. and Oliw, E.H. (2000) J. Biol. Chem., 275(29), 21844-21849.
291. Cui, X.; Nelson, D.R. and Strobel, H.W. (2000) Genomics, 68(2), 161-166.
292. Bylund, J.; Bylund, M. and Oliw, E.H. (2001) Biochem. Biophys. Res. Comm., 280(3), 892-897.
293. Hashizume, T.; Imaoka, S.; Hiroi, T.; Terauchi, Y.; Fujii, T.; Miyazaki, H.; Kamataki, T. and Funae, Y. (2001) Biochem. Biophys. Res. Comm., 280(4), 1135-1141.
294. Haurand, M. and Ullrich, V. (1985) J. Biol. Chem., 260(28), 15059-15067.
295. Nusing, R.; Schneider-Voss, S. and Ullrich, V. (1990) Arch. Biochem. Biophys., 280(2), 325-330.
296. Hecker, M. and Ullrich, V. (1989) J. Biol. Chem., 264(1), 141-150.
297. Pandak, W.M.; Schwarz, C.; Hylemon, P.B.; Mallonee, D.; Valerie, K.; Heuman, D.M.; Fisher, R.A.; Redford, K. and Vlahcevic, Z.R. (2001) Am. J. Physiol. Gastrointest. Liver Physiol., 281(4), G878-G889.
298. Rose, K.A.; Stapleton, G.; Dott, K.; Kieny, M.P.; Best, R.; Schwarz, M.; Russell, D.W.; Bjorkhem, I.; Seckl, J. and Lathe, R. (1997) Proc. Natl. Acad. Sci. USA., 94(10), 4925-4930.
299. Setchell, K.D.; Schwarz, M.; O'Connell, N.C.; Lund, E.G.; Davis, D.L.; Lathe, R.; Thompson, H.R.; Weslie Tyson, R.; Sokol, R.J. and Russell, D.W. (1998) J. Clin. Invest., 102(9), 1690-1703.
300. Wu, Z. and Chiang, J.Y. (2001) Gene, 272(1-2), 191-197.
301. Ishida, H.; Kuruta, Y.; Gotoh, O.; Yamashita, C.; Yoshida, Y. and Noshiro, M. (1999) J. Biochem., 126(1), 19-25.
302. Gafvels, M.; Olin, M.; Chowdhary, B.P.; Raudsepp, T.; Andersson, U.; Persson, B.; Jansson, M.; Bjorkhem, I. and, Eggertsen, G. (1999) Genomics, 56(2), 184-196.
303. Watzka, M.; Bidlingmaier, F.; Schramm, J.; Klingmuller, D. and Stoffel-Wagner, B. (1999) J. Neuroendocrinol., 11(12), 901-905.
304. Rainey, W.E. (1999) Mol. Cell. Endocrinol., 151(1-2), 151-160.
305. Hampf, M.; Dao, N.T.; Hoan, N.T. and Bernhardt, R. (2001) J. Clin. Endocrinol. Metab., 86(9), 4445-4452.
306. Kayes-Wandover, K.M. and White, P.C. (2000) J. Clin. Endocrinol. Metab., 85(7), 2519-2525.
307. Satoh, M.; Nakamura, M.; Saitoh, H.; Satoh, H.; Akatsu, T.; Iwasaka, J.; Masuda, T. and Hiramori, K. (2002) Clin. Sci. (Lond), 102(4), 381-386.
308. Geller, D.H.; Auchus, R.J.; Mendonça, B.B. and Miller, W.L. (1997) Nat. Genet., 17(2), 201-205
309. Gupta, M.K.; Geller, D.H. and Auchus, R.J. (2001) J. Clin. Endocrinol. Metab., 86(9), 4416-4423.
310. Stanford, J.L.; Noonan, E.A.; Iwasaki, L.; Kolb, S.; Chadwick, R.B.;
311. Puche, C.; Jose, M.; Cabero, A. and Meseguer, A. (2002) Eur. J. Endocrinol., 146(2), 223-229.
312. Kamat, A.; Hinshelwood, M.M.; Murry, B.A. and Mendelson, C.R. (2002) Trends Endocrinol. Metab., 13(3), 122-128.
313. Brueggemeier, R.W.; Richards, J.A.; Joomprabutra, S.; Bhat, A.S. and Whetstone, J.L. (2001) J. Steroid Biochem. Mol. Biol., 79(1-5), 75-84
314. Nativelle-Serpentini, C.; Lambard, S.; Seralini, G.E. and Sourdaine, P. (2002) Eur. J. Endocrinol., 146(4), 583-589.
315. Lajic, S.; Robins, T.; Krone, N.; Schwarz, H.P. and Wedell, A. (2001) J. Mol. Med, 79(10), 581-586.
316. White, P.C. and Speiser, P.W. (2000) Endocr. Rev., 21(3), 245-291.
317. Sakaki, T.; Sawada, N.; Komai, K.; Shiozawa, S.; Yamada, S.; Yamamoto, K.; Ohyama, Y. and Inouye, K. (2000) Eur. J. Biochem., 267(20), 6158-6165.
318. Nelson, D.R. (1999) Arch. Biochem. Biophys., 371, 345-347.
319. Trofimova-Griffin, M.E.; Brzezinski, M.R. and Juchau, M.R. (2000) Brain Res. Dev. Brain. Res., 120(1), 7-16.
320. Trofimova-Griffin, M.E. and Juchau, M.R. (1998) Biochem. Biophys. Res. Comm., 252(2), 487-491.
321. Ray, W.J.; Bain, G.; Yao, M. and Gottlieb, D.I. (1997) J. Biol. Chem., 272(30), 18702-18708.
322. Wikvall, K. (2001) Int. J. Mol. Med., 7(2), 201-209.
323. Gascon-Barre, M.; Demers, C.; Ghrab, O.; Theodoropoulos, C.; Lapointe, R.; Jones, G.; Valiquette, L. and Menard, D. (2001) Clin. Endocrinol., 54(1), 107-115.
324. Sawada, N.; Sakaki, T.; Ohta, M. and Inouye, K. (2000) Biochem. Biophys. Res. Comm., 273(3), 977-984.
325. Segev, H.; Honigman, A.; Rosen, H. and Leitersdorf, E. (2001) Atherosclerosis, 156(2), 339-347.
326. Babiker, A.; Andersson, O.; Lindblom, D.; van der Linden, J.; Wiklund, B.; Lutjohann, D.; Diczfalusy, U. and Bjorkhem, I. (1999) J. Lipid Res., 40(8), 1417-1425.
327. Inouye, K. and Sakaki, T. (2001) Biotechnol. Annu. Rev., 7, 179-194.
328. Zehnder, D.; Bland, R.; Williams, M.C.; McNinch, R.W.; Howie, A.J.; Stewart, P.M. and Hewison, M. (2001) J. Clin. Endocrinol. Metab., 86(2), 888-894.
329. Shinki, T.; Ueno, Y.; DeLuca, H.F. and Suda, T. (1999) Proc. Natl. Acad. Sci. USA, 96(14), 8253-8258.
330. Takeyama, K.; Kitanaka, S.; Sato, T.; Kobori, M.; Yanagisawa, J. and Kato, S. (1997) Science, 277(5333), 1827-1830.
331. Yoshida, T.; Yoshida, N.; Nakamura, A.; Monkawa, T.; Hayashi, M.; and Saruta, T. (1999) J. Am. Soc. Nephrol., 10(5), 963-990.
332. Bareis, P.; Bises, G.; Bischof, M.G.; Cross, H.S. and Peterlik, M. (2001) Biochem. Biophys. Res. Comm., 285(4), 1012-1017.
333. Hsu, J.Y.; Feldman, D.; McNeal, J.E. and Peehl, D.M. (2001) Cancer Res., 61(7), 2852-2856.
334. Sawada, N.; Sakaki, T.; Kitanaka, S.; Kato, S. and Inouye, K. (2001) Eur. J. Biochem., 268(24), 6607-6615.
335. Kitanaka, S.; Takeyama, K.; Murayama, A.; Sato, T.; Okumura, K.; Nogami, M.; Hasegawa, Y.; Niimi, H.; Yanagisawa, J.; Tanaka, T. and Kato, S. (1998) New England J. Med., 338, 653-661.
336. Kitanaka, S.; Murayama, A.; Sakaki, T.; Inouye, K.; Seino, Y.; Fukumoto, S.; Shima, M.; Yukizane, S.; Takayanagi, M.; Niimi, H.; Takeyama, K. and Kato, S. (1999) J. Clin. Endocrinol. Metab., 84, 4111-4117.
337. Li-Hawkins, J.; Lund, E.G.; Bronson, A.D. and Russell, D.W. (2000) J. Biol. Chem., 275(22), 16543-16549.
338. Lund, E.G.; Guileyardo, J.M. and Russell, D.W. (1999) Proc. Natl. Acad. Sci. USA, 96(13), 7238-7243.
339. Bogdanovic, N.; Bretillon, L.; Lund, E.G.; Diczfalusy, U.; Lannfelt, L.; Winblad, B.; Russell, D.W. and Bjorkhem, I. (2001) Neurosci. Lett., 314(1-2), 45-48.
340. Papassotiropoulos, A.; Lutjohann, D.; Bagli, M.; Locatelli, S.; Jessen, F.; Buschfort, R.; Ptok, U.; Bjorkhem, I.; von Bergmann, K. and Heun R. (2002) J. Psychiatr. Res., 36(1), 27-32.
341. Debeljak, N.; Horvat, S.; Vouk, K.; Lee, M. and Rozman, D. (2000) Arch. Biochem. Biophys., 379(1), 37-45.
342. Tacer, K.F.; Haugen, T.B.; Baltsen, M.; Debeljak, N. and Rozman, D. (2002) J. Lipid Res., 43(1), 82-89.
343. Stromstedt, M.; Rozman, D.; Waterman, M.R. (1996) Arch. Biochem. Biophys., 329(1), 73-81.
344. Rozman, D. (2000) Pflugers Arch., 439(3 Suppl), R56-R57.
345. De Groot, M.J.; Havenith, R.W.; Vinkers, H.M.; Zwaans, R.; Vermeulen, N.P. and van Lenthe, J.H. (1998) J. Comput. Aided Mol. Des., 12(2), 183-193.
346. Harris, D.L. and Loew, G.H. (1998) J. Am. Chem. Soc., 120(35), 8941-8948.
347. Segall, M.D.; Payne, M.C.; Ellis, S.W.; Tucker, G.T. and Eddershaw, P.J. (1999) Xenobiotica, 29(6), 561-571.
348. Bowler, D.R.; Bush, I.J. and Gillan, M.J. (2000) J. Quantum Chem., 77, 831-842.
349. Isaacs, E.D.; Shukla, A.; Platzman, P.M.; Hamann, D.R.; Barbiellini, B. and Tulk, C. (1999) Phys. Rev. Lett., 82(3), 600-603.