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Volumn 46, Issue 1, 1998, Pages 55-62

Involvement of CYP1A2 in mexiletine metabolism

Author keywords

Bufuralol; cDNA expressed microsomes; CYP2D6; Cytochrome P450; Ethoxyresorufin; Furafylline; Relative activity factor

Indexed keywords

DEBRISOQUINE 4 HYDROXYLASE; ETHOXYRESORUFIN; FURAFYLLINE; MEXILETINE; PHENACETIN O DEETHYLASE; QUINIDINE;

EID: 0031803092     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1998.00048.x     Document Type: Article
Times cited : (69)

References (35)
  • 1
    • 0021209490 scopus 로고
    • Clinical pharmacokinetics of the newer antiarrhythmic agents
    • Gillis AM, Kates RE. Clinical pharmacokinetics of the newer antiarrhythmic agents. Clin Pharmacokinet 1984; 9: 375-403.
    • (1984) Clin Pharmacokinet , vol.9 , pp. 375-403
    • Gillis, A.M.1    Kates, R.E.2
  • 3
    • 0017441704 scopus 로고
    • The distribution, metabolism and excretion of mexiletine in man
    • Beckett AH, Chidomere EC. The distribution, metabolism and excretion of mexiletine in man. Postgrad Med J 1977; 53 (Suppl 1): 60-66.
    • (1977) Postgrad Med J , vol.53 , Issue.1 SUPPL. , pp. 60-66
    • Beckett, A.H.1    Chidomere, E.C.2
  • 4
    • 17644446267 scopus 로고
    • Absorption, distribution and elimination of mexiletine
    • Prescott LF, Pottage A, Clements JA. Absorption, distribution and elimination of mexiletine. Postgrad Med J 1977; 53 (Suppl 1): 50-55.
    • (1977) Postgrad Med J , vol.53 , Issue.1 SUPPL. , pp. 50-55
    • Prescott, L.F.1    Pottage, A.2    Clements, J.A.3
  • 5
    • 0021349128 scopus 로고
    • Pharmacology, electrophysiology and pharmacokinetics of mexiletine
    • Woosley RL, Wang T, Stone W. Pharmacology, electrophysiology and pharmacokinetics of mexiletine. Am Heart J 1984; 107: 1058-1065.
    • (1984) Am Heart J , vol.107 , pp. 1058-1065
    • Woosley, R.L.1    Wang, T.2    Stone, W.3
  • 6
    • 0025283998 scopus 로고
    • Mexiletine metabolism in vitro by human liver
    • Broly F, Libersa C, Lhermitte M. Mexiletine metabolism in vitro by human liver. Drug Metab Dispos 1990; 18: 362-368.
    • (1990) Drug Metab Dispos , vol.18 , pp. 362-368
    • Broly, F.1    Libersa, C.2    Lhermitte, M.3
  • 7
    • 0026051838 scopus 로고
    • The metabolism of mexiletine in relation to the debrisoquine/ sparteine-type polymorphism of drug oxidation
    • Broly F, Vandamme N, Libersa C, Lhermitte M. The metabolism of mexiletine in relation to the debrisoquine/ sparteine-type polymorphism of drug oxidation. Br J Clin Pharmacol 1991; 32: 459-466.
    • (1991) Br J Clin Pharmacol , vol.32 , pp. 459-466
    • Broly, F.1    Vandamme, N.2    Libersa, C.3    Lhermitte, M.4
  • 8
    • 0026342550 scopus 로고
    • Influence of debrisoquine phenotype and of quinidine on mexiletine disposition in man
    • Turgeon J, Fiset C, Giguère R, et al. Influence of debrisoquine phenotype and of quinidine on mexiletine disposition in man. J Pharmacol Exp Ther 1991; 259: 789-798.
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 789-798
    • Turgeon, J.1    Fiset, C.2    Giguère, R.3
  • 9
    • 0027392759 scopus 로고
    • Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine
    • Lledó P, Abrams SML, Johnston A, et al. Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine. Eur J Clin Pharmacol 1993; 44: 63-67.
    • (1993) Eur J Clin Pharmacol , vol.44 , pp. 63-67
    • Lledó, P.1    Abrams, S.M.L.2    Johnston, A.3
  • 11
    • 0026675188 scopus 로고
    • Theophylline-mexiletine interaction: A case report
    • Kendall JD, Chrymko MM, Cooper BE. Theophylline-mexiletine interaction: a case report. Pharmacotherapy 1992; 12: 416-418.
    • (1992) Pharmacotherapy , vol.12 , pp. 416-418
    • Kendall, J.D.1    Chrymko, M.M.2    Cooper, B.E.3
  • 12
    • 0023918857 scopus 로고
    • Characterization of theophylline metabolism by human liver microsomes
    • Robson RA, Miners JO, Matthews AP, et al. Characterization of theophylline metabolism by human liver microsomes. Biochem Pharmacol 1988; 37: 1651-1659.
    • (1988) Biochem Pharmacol , vol.37 , pp. 1651-1659
    • Robson, R.A.1    Miners, J.O.2    Matthews, A.P.3
  • 13
    • 0026508999 scopus 로고
    • Characterization of human liver cytochromes P-450 involved in theophylline metabolism
    • Sarkar MA, Hunt C, Guzelian PS, Kanies HT. Characterization of human liver cytochromes P-450 involved in theophylline metabolism. Drug Metab Dispos 1992; 20: 31-37.
    • (1992) Drug Metab Dispos , vol.20 , pp. 31-37
    • Sarkar, M.A.1    Hunt, C.2    Guzelian, P.S.3    Kanies, H.T.4
  • 15
    • 0016260282 scopus 로고
    • Effects of lyophilization and storage of rat liver microsomes on activity of aniline hydroxylase, contents of cytochrome B5 and cytochrome P-450 and aniline-induced P-450 difference spectrum
    • Kamataki T, Kitagawa H. Effects of lyophilization and storage of rat liver microsomes on activity of aniline hydroxylase, contents of cytochrome B5 and cytochrome P-450 and aniline-induced P-450 difference spectrum. Jpn J Pharmacol 1974; 24: 195-203.
    • (1974) Jpn J Pharmacol , vol.24 , pp. 195-203
    • Kamataki, T.1    Kitagawa, H.2
  • 17
    • 0018081845 scopus 로고
    • Measurement of cytochrome P-450 in the presence of large amounts of contaminating hemoglobin and methemoglobin
    • Johannesen KAM, Depierre JW. Measurement of cytochrome P-450 in the presence of large amounts of contaminating hemoglobin and methemoglobin. Anal Biochem 1978; 86: 725-732.
    • (1978) Anal Biochem , vol.86 , pp. 725-732
    • Johannesen, K.A.M.1    Depierre, J.W.2
  • 18
    • 0028362263 scopus 로고
    • Characterization of the inhibition of P4501A2 by furafylline
    • Clarke SE, Ayrton AD, Chenery RJ. Characterization of the inhibition of P4501A2 by furafylline. Xenobiotica 1994; 24: 517-526.
    • (1994) Xenobiotica , vol.24 , pp. 517-526
    • Clarke, S.E.1    Ayrton, A.D.2    Chenery, R.J.3
  • 20
    • 0024359553 scopus 로고
    • Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver
    • Broly F, Libersa C, Lhermitte M, Bechtel P, Dupuis B. Effect of quinidine on the dextromethorphan O-demethylase activity of microsomal fractions from human liver. Br J Clin Pharmacol 1989; 28: 29-36.
    • (1989) Br J Clin Pharmacol , vol.28 , pp. 29-36
    • Broly, F.1    Libersa, C.2    Lhermitte, M.3    Bechtel, P.4    Dupuis, B.5
  • 21
    • 0023258883 scopus 로고
    • High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver
    • Kronbach T, Mathys D, Gut J, Catin T, Meyer UA. High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver. Anal Biochem 1987; 162: 24-32.
    • (1987) Anal Biochem , vol.162 , pp. 24-32
    • Kronbach, T.1    Mathys, D.2    Gut, J.3    Catin, T.4    Meyer, U.A.5
  • 22
    • 0027399312 scopus 로고
    • Induction of 7-ethoxyresorufin-O-deethylase (EROD) activity in mice foetuses by the PCB-congener 3,3′-4,4′-tetrachlorobiphenyl
    • Sinjari T, Törnwall U, Darnerud PO. Induction of 7-ethoxyresorufin-O-deethylase (EROD) activity in mice foetuses by the PCB-congener 3,3′-4,4′-tetrachlorobiphenyl. Xenobiotica 1993; 23: 107-114.
    • (1993) Xenobiotica , vol.23 , pp. 107-114
    • Sinjari, T.1    Törnwall, U.2    Darnerud, P.O.3
  • 23
    • 14444282584 scopus 로고    scopus 로고
    • Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes
    • Kobayashi K, Chiba K, Yagi T, et al. Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes. J Pharmacol Exp Ther 1997; 280: 927-933.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 927-933
    • Kobayashi, K.1    Chiba, K.2    Yagi, T.3
  • 24
    • 0028674392 scopus 로고
    • Xenobiotic-metabolizing human cells as tools for pharmacological and toxicological research
    • Crespi CL. Xenobiotic-metabolizing human cells as tools for pharmacological and toxicological research. Adv Drug Res 1995; 26: 179-235.
    • (1995) Adv Drug Res , vol.26 , pp. 179-235
    • Crespi, C.L.1
  • 25
    • 0027990736 scopus 로고
    • Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes
    • Yamazaki H, Guo Z, Persmark M, et al. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Mol Pharmacol 1994; 46: 568-577.
    • (1994) Mol Pharmacol , vol.46 , pp. 568-577
    • Yamazaki, H.1    Guo, Z.2    Persmark, M.3
  • 27
    • 0023687412 scopus 로고
    • A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking
    • Sesardic D, Boobis AR, Edwards RJ, Davis DS. A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking. Br J Clin Pharmacol 1988; 26: 363-372.
    • (1988) Br J Clin Pharmacol , vol.26 , pp. 363-372
    • Sesardic, D.1    Boobis, A.R.2    Edwards, R.J.3    Davis, D.S.4
  • 28
    • 0031596547 scopus 로고    scopus 로고
    • Inhibitory effects of antiarrhythmic drugs on phenacetin O-deethylation catalysed by human CYP1A2
    • Kobayashi K, Nakajima M, Chiba K, et al. Inhibitory effects of antiarrhythmic drugs on phenacetin O-deethylation catalysed by human CYP1A2. Br J Clin Pharmacol 1998; 45: 361-368.
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 361-368
    • Kobayashi, K.1    Nakajima, M.2    Chiba, K.3
  • 29
    • 0028064672 scopus 로고
    • Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: Substrate specificity with model substrates and promutagens
    • Penman BW, Chen L, Gelboin HV, Gonzalez FJ, Crespi CL. Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: substrate specificity with model substrates and promutagens. Carcinogenesis 1994; 15: 1931-1937.
    • (1994) Carcinogenesis , vol.15 , pp. 1931-1937
    • Penman, B.W.1    Chen, L.2    Gelboin, H.V.3    Gonzalez, F.J.4    Crespi, C.L.5
  • 30
    • 0027419948 scopus 로고
    • Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae
    • Eugster H-P, Probst M, Würgler FE, Sengstag C. Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae. Drug Metab Dispos 1993; 21: 43-49.
    • (1993) Drug Metab Dispos , vol.21 , pp. 43-49
    • Eugster, H.-P.1    Probst, M.2    Würgler, F.E.3    Sengstag, C.4
  • 31
    • 0025296345 scopus 로고
    • Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450
    • McManus ME, Burgess WM, Veronese ME, et al. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res 1990; 50: 3367-3376.
    • (1990) Cancer Res , vol.50 , pp. 3367-3376
    • McManus, M.E.1    Burgess, W.M.2    Veronese, M.E.3
  • 32
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994; 270: 414-423.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 34
    • 0023217640 scopus 로고
    • Characterization of theophylline metabolism in human liver microsomes
    • Robson RA, Matthew AP, Miners JO, et al. Characterization of theophylline metabolism in human liver microsomes. Br J Clin Pharmacol 1987; 24: 293-300.
    • (1987) Br J Clin Pharmacol , vol.24 , pp. 293-300
    • Robson, R.A.1    Matthew, A.P.2    Miners, J.O.3
  • 35
    • 0028929645 scopus 로고
    • Metabolism of theophylline by cDNA-expressed human cytochrome P-450
    • Ha HR, Chen J, Freiburghaus U, Follath F. Metabolism of theophylline by cDNA-expressed human cytochrome P-450. Br J Clin Pharmacol 1995; 39: 321-326.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 321-326
    • Ha, H.R.1    Chen, J.2    Freiburghaus, U.3    Follath, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.