Polymorphisms of CYP1A1 and GSTM1 influence the in vivo function of CYP1A2

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 376, Issue 1-2, 1997, Pages 135-142

  MacLeod, Stewart ^a   Sinha, Rashmi ^b   Kadlubar, Fred F ^c   Lang, Nicholas P ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Cytochrome P4501A1; Cytochrsme P4501A2; Glutathione S transferase M1; Polymorphism

Indexed keywords

CAFFEINE; CIGARETTE SMOKE; CYTOCHROME P450 ISOENZYME; GLUTATHIONE TRANSFERASE;

ARTICLE; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MEAT; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ARYLAMINE N-ACETYLTRANSFERASE; BIOTRANSFORMATION; COOKERY; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; GENE EXPRESSION; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; MEAT; POLYMORPHISM, GENETIC; SMOKE;

EID: 0030976824     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00036-5     Document Type: Article

References (27)

1. Alvarez, A.P., A. Kappas, J.L. Eisenman, K.E. Anderson, C.B. Pantuck, E.J. Pantuck, K.C. Hsiao, W.A. Garland and A.H. Conney (1979) Interindividual variation in drug metabolism, Clin. Pharmacol. Ther., 26, 407-419.
2. Bartsch, H., M. Rojas, K. Alexander, A.-M. Camus, M. Castegnaro, C. Malaveille, S. Antilla, A. Hirvonen, K. Husgafvel-Pursiainen, E. Hietanen and H. Vainio (1995) Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans, Pharmacogenetics, 5, S84-S90.
3. Bell, D.A., J.A. Taylor, D.F. Paulson, C.N. Robertson, J.L. Mohler and G.W. Lucier (1993) Genetic risk and carcinogen exposure: a common inherited defect, of the carcinogen-metabolism gene glutathione S-transferase M1 (GST M1) that increases susceptibility to bladder cancer, J. Natl. Cancer Inst., 85, 1159-1164.
4. Bell, D.A., A.F. Badawi, N.P. Lang, K.F. Ilett, F.F. Kadlubar and A. Hirvonen (1995) Polymorphism in the NAT1 polyadenylation signal: association of NAT1* 10 allele with higher N-acetylation activity in bladder and colon tissue samples, Cancer Res., 55, 5226-5229.
5. Blin, N. and D.W. Stafford (1976) Isolation of high-molecular weight DNA, Nucleic Acids Res., 3, 2303.
6. Blum, M., D.M. Grant, A. Demierre and U.A. Meyer (1989) N-Acetylation pharmacogenetics: a gene deletion causes absence of arylamine N-acetyltransferase in liver of slow acetylator rabbits, Proc. Natl. Acad. Sci., USA, 86, 9554-9557.
7. PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines, Proc. Natl. Acad. Sci., USA, 86, 7696-7700.
8. Butler, M., N. Lang, J. Young, N. Caporaso, P. Vineis, R. Hayes, C. Teitel, J. Massengill, M. Lawsen and F. Kadlubar (1992) Determination of CYP1A2 and acetylator phenotypes in several human populations by analysis of caffeine urinary metabolites, Pharmacogenetics, 2, 116-127.
9. Cosma, G., F. Crofts, E. Taioli, P. Toniolo and S. Garte (1993) Relationship between genotype and function of the human CYP1A1 gene, J. Toxicol. Environ. Health, 40, 309-319.
10. Crofts, F., E. Taioli, J. Trachman, G.N. Cosma, D. Currie, P. Toniolo and S.J. Garte (1994) Functional significance of different human CYP1A1 genotypes, Carcinogenesis, 15, 2961-2963.
11. Devonshire, H.W., I. Kong, M. Cooper, T.P. Sloan, J.R. Idle and R.L. Smith (1983) The contribution of genetically determined oxidation status to interindividual variation in phenacetin disposition, Br. J. Clin. Pharmacol., 16, 157-166.
12. Flammang, T.J., Y. Yamazoe, F.P. Guengerich and F.F. Kadlubar (1987) The S-acetyl coenzyme A-dependent metabolic activation of the carcinogen N-hydroxy-2-aminofluorene by human liver cytosol and its relationship to the aromatic amine N-acetyltransferase phenotype, Carcinogenesis, 8, 1967-1970.
13. Gonzalez, F.J. (1989) The molecular biology of cytochrome P450's, Pharmacol. Rev., 40, 244-288.
14. Gonzalez, F.J. and H.V. Gelboin (1993) Role of human cytochrome P-450s in risk assessment and susceptibility to environmentally based disease, J. Toxicol. Environ. Health, 40, 289-308.
15. Grant, D.M., B.K. Tang and W. Kalow (1984) A simple test for acetylator phenotype using caffeine, Br. J. Clin. Pharmacol., 17, 459-64.
16. Hayashi, S.-I., J. Watanabe, K. Nakachi and K. Kawajiri (1991a) Genetic linkage of lung cancer-associated Msp I polymorphism with amino acid replacement in the heme binding region of the human cytochrome P4501A1 gene, J. Biochem., 110, 407-411.
17. Hayashi, S.-I., J. Watanabe, K. Nakachi and K. Kawajiri (1991b) PCR detection of an A/G polymorphism within exon 7 of the CYP1A1 gene, Nucleic Acids Res., 18, 7194.
18. Kadlubar, F.F. (1994) Biochemical individuality and its implications for drug and carcinogen metabolism: recent insights from acetyltransferase and cytochrome P4501A2 phenotyping and genotyping in humans, Drug Metab. Rev., 26, 37-46.
19. Lang, N.P., M.A. Butler, J. Massengill, M. Lawson, R.C. Stotts, M. Hauer-Jensen and F.F. Kadlubar (1994) Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps, Cancer Epidemiol., Biomarkers Prev., 3, 675-682.
20. Nakachi, K., K. Imai, S. Hayashi, J. Watanabe and K. Kawajiri (1991) Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose, Cancer Res., 51, 5177-5180.
21. Nakajima, M., T. Yokoi, M. Mizutani, S. Shin, F.F. Kadlubar and T. Kamataki (1994) Phenotyping of CYP1A2 in Japanese populations by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene, Cancer Epidemiol., Biomarkers Prev., 3, 413-421.
22. Seidegard, J., W.R. Vosachek, R.W. Pero and W.R. Pearson (1988) Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion, Proc. Natl. Acad., Sci. USA, 85, 7293-7297.
23. Shahidi, N.T. (1968) Acetophenetidin-induced methemoglobinemia, Ann. N.Y. Acad. Sci., 151, 822-832.
24. Sinha, R., N. Rothman, E.D. Brown, S.D. Mark, R.N. Hoover, N.B. Caporaso, O.A. Lavender, M.G. Knize, N.P. Lang and F.F. Kadlubar (1994) Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P450IA2 activity in humans, Cancer Res., 54, 6154-6159.
25. Turesky, R.J., N.P. Lang, M.A. Butler, C.H. Teitel and F.F. Kadlubar (1991) Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon, Carcinogenesis, 12, 1839-1845.
26. Vaury, C., R. Laine', P. Noguiez, P. De Coppet, C. Jaulin, F. Praz, D. Pompon and M. Amor-Guéret (1995) Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription, Cancer Res., 55, 5520-5523.
27. Yu, M.C., R.K. Ross, K.K. Chan, B.E. Henderson, P.L. Skippper, S.R. Tannenbaum and G.A. Coetzee (1995) Glutathione S-transferase M1 genotype affects aminobiphenyl-hemoglobin adduct levels in White, Black, and Asian smokers and non-smokers, Cancer Epidemiol., Biomarkers Prev., 4, 861-864.