메뉴 건너뛰기




Volumn 56, Issue 3, 1998, Pages 377-387

Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans

Author keywords

Anti peptide antibodies; Cytochrome P450; Human; Liver

Indexed keywords

ANTIBODY; CYTOCHROME P450; OXYGENASE; PHENACETIN O DEETHYLASE;

EID: 0031661240     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00033-1     Document Type: Article
Times cited : (133)

References (70)
  • 2
    • 0030098181 scopus 로고    scopus 로고
    • Cytochrome P450 2: Peroxidative reactions of diversozymes
    • Coon MJ, Vaz AD, Bestervelt LL. Cytochrome P450 2 peroxidative reactions of diversozymes . FASEB J. 10:1996;428-434.
    • (1996) FASEB J , vol.10 , pp. 428-434
    • Coon, M.J.1    Vaz, A.D.2    Bestervelt, L.L.3
  • 3
    • 0029820670 scopus 로고    scopus 로고
    • Constitutive expression of hepatic cytochrome P450 genes
    • Gonzalez FJ, Lee YH. Constitutive expression of hepatic cytochrome P450 genes. FASEB J. 10:1996;1112-1117.
    • (1996) FASEB J , vol.10 , pp. 1112-1117
    • Gonzalez, F.J.1    Lee, Y.H.2
  • 4
    • 0029963622 scopus 로고    scopus 로고
    • Human drug-metabolizing enzyme polymorphisms: Effects on risk of toxicity and cancer
    • Nebert DW, McKinnon RA, Puga A. Human drug-metabolizing enzyme polymorphisms effects on risk of toxicity and cancer . DNA Cell Biol. 15:1996;273-280.
    • (1996) DNA Cell Biol , vol.15 , pp. 273-280
    • Nebert, D.W.1    McKinnon, R.A.2    Puga, A.3
  • 6
    • 0026334526 scopus 로고
    • Production and purification of antibodies against rat liver P450 enzymes
    • Parkinson A, Gemzik B. Production and purification of antibodies against rat liver P450 enzymes. Methods Enzymol. 206:1991;233-245.
    • (1991) Methods Enzymol , vol.206 , pp. 233-245
    • Parkinson, A.1    Gemzik, B.2
  • 8
    • 0021742125 scopus 로고
    • Use of monoclonal antibody probes against rat hepatic cytochromes P-450c and P-450d to detect immunochemically related isozymes in liver microsomes from different species
    • Thomas PE, Reidy J, Reik LM, Ryan DE, Koop DR, Levin W. Use of monoclonal antibody probes against rat hepatic cytochromes P-450c and P-450d to detect immunochemically related isozymes in liver microsomes from different species. Arch Biochem Biophys. 235:1984;239-253.
    • (1984) Arch Biochem Biophys , vol.235 , pp. 239-253
    • Thomas, P.E.1    Reidy, J.2    Reik, L.M.3    Ryan, D.E.4    Koop, D.R.5    Levin, W.6
  • 10
    • 0027219850 scopus 로고
    • Cross-reactivity of thirteen monoclonal antibodies with ten vaccinia cDNA expressed rat, mouse and human cytochrome P450s
    • Goldfarb I, Korzekwa K, Krausz KW, Gonzalez F, Gelboin HV. Cross-reactivity of thirteen monoclonal antibodies with ten vaccinia cDNA expressed rat, mouse and human cytochrome P450s. Biochem Pharmacol. 46:1993;787-790.
    • (1993) Biochem Pharmacol , vol.46 , pp. 787-790
    • Goldfarb, I.1    Korzekwa, K.2    Krausz, K.W.3    Gonzalez, F.4    Gelboin, H.V.5
  • 11
    • 0026575415 scopus 로고
    • Two monoclonal antibodies recognizing different epitopes on rat cytochrome IIB1 react with human IIE1
    • Wrighton SA, VandenBranden M, Becker GW, Black SD, Thomas PE. Two monoclonal antibodies recognizing different epitopes on rat cytochrome IIB1 react with human IIE1. Mol Pharmacol. 41:1992;76-82.
    • (1992) Mol Pharmacol , vol.41 , pp. 76-82
    • Wrighton, S.A.1    Vandenbranden, M.2    Becker, G.W.3    Black, S.D.4    Thomas, P.E.5
  • 14
    • 0026336155 scopus 로고
    • Antipeptide antibodies in studies of cytochromes P450IA
    • Edwards RJ, Murray BP, Boobis AR. Antipeptide antibodies in studies of cytochromes P450IA. Methods Enzymol. 206:1991;220-233.
    • (1991) Methods Enzymol , vol.206 , pp. 220-233
    • Edwards, R.J.1    Murray, B.P.2    Boobis, A.R.3
  • 17
    • 0023765220 scopus 로고
    • Antibodies to a synthetic peptide that react specifically with a common surface region on two hydrocarbon-inducible isoenzymes of cytochrome P-450 in the rat
    • Edwards RJ, Singleton AM, Sesardic D, Boobis AR, Davies DS. Antibodies to a synthetic peptide that react specifically with a common surface region on two hydrocarbon-inducible isoenzymes of cytochrome P-450 in the rat. Biochem Pharmacol. 37:1988;3735-3741.
    • (1988) Biochem Pharmacol , vol.37 , pp. 3735-3741
    • Edwards, R.J.1    Singleton, A.M.2    Sesardic, D.3    Boobis, A.R.4    Davies, D.S.5
  • 18
    • 0025265062 scopus 로고
    • Solid-phase synthesis of peptides with C terminal asparagine or glutamine. An effective, mild procedure based on N-alpha-fluorenylmethyloxycarbonyl (Fmoc) protection and side-chain anchoring to a tris(alkoxy)benzylamide (PAL) handle
    • Albericio F, van Abel R, Barany G. Solid-phase synthesis of peptides with C terminal asparagine or glutamine. An effective, mild procedure based on N-alpha-fluorenylmethyloxycarbonyl (Fmoc) protection and side-chain anchoring to a tris(alkoxy)benzylamide (PAL) handle. Int J Pept Protein Res. 35:1990;284-286.
    • (1990) Int J Pept Protein Res , vol.35 , pp. 284-286
    • Albericio, F.1    Van Abel, R.2    Barany, G.3
  • 19
    • 0025217832 scopus 로고
    • Facile SPS of peptides having C-terminal Asn and Gln
    • Breipohl G, Knolle J, Stuber W. Facile SPS of peptides having C-terminal Asn and Gln. Int J Pept Protein Res. 35:1990;281-283.
    • (1990) Int J Pept Protein Res , vol.35 , pp. 281-283
    • Breipohl, G.1    Knolle, J.2    Stuber, W.3
  • 22
    • 0022607657 scopus 로고
    • An assay for paracetamol, produced by the O-deethylation of phenacetin in vitro, using gas chromatography/electron capture negative ion chemical ionization mass spectrometry
    • Murray S, Boobis AR. An assay for paracetamol, produced by the O-deethylation of phenacetin in vitro, using gas chromatography/electron capture negative ion chemical ionization mass spectrometry. Biomed Environ Mass Spectrom. 13:1986;91-93.
    • (1986) Biomed Environ Mass Spectrom , vol.13 , pp. 91-93
    • Murray, S.1    Boobis, A.R.2
  • 23
    • 0018170362 scopus 로고
    • A simple and sensitive assay of 7-ethoxycoumarin deethylation
    • Aitio A. A simple and sensitive assay of 7-ethoxycoumarin deethylation. Anal Biochem. 85:1978;488-491.
    • (1978) Anal Biochem , vol.85 , pp. 488-491
    • Aitio, A.1
  • 24
    • 0023873591 scopus 로고
    • Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations
    • Miners JO, Smith KJ, Robson RA, McManus ME, Veronese ME, Birkett DJ. Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations. Biochem Pharmacol. 37:1988;1137-1144.
    • (1988) Biochem Pharmacol , vol.37 , pp. 1137-1144
    • Miners, J.O.1    Smith, K.J.2    Robson, R.A.3    McManus, M.E.4    Veronese, M.E.5    Birkett, D.J.6
  • 25
    • 0025014594 scopus 로고
    • Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily
    • Relling MV, Aoyama T, Gonzalez FJ, Meyer UA. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J Pharmacol Exp Ther. 252:1990;442-447.
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 442-447
    • Relling, M.V.1    Aoyama, T.2    Gonzalez, F.J.3    Meyer, U.A.4
  • 26
    • 0022330348 scopus 로고
    • Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography
    • Meier UT, Kronbach T, Meyer UA. Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography. Anal Biochem. 151:1985;286-291.
    • (1985) Anal Biochem , vol.151 , pp. 286-291
    • Meier, U.T.1    Kronbach, T.2    Meyer, U.A.3
  • 27
    • 0020464151 scopus 로고
    • Assay and characterisation of debrisoquine 4-hydroxylase activity of microsomal fractions of human liver
    • Kahn GC, Boobis AR, Murray S, Brodie MJ, Davies DS. Assay and characterisation of debrisoquine 4-hydroxylase activity of microsomal fractions of human liver. Br J Clin Pharmacol. 13:1982;637-645.
    • (1982) Br J Clin Pharmacol , vol.13 , pp. 637-645
    • Kahn, G.C.1    Boobis, A.R.2    Murray, S.3    Brodie, M.J.4    Davies, D.S.5
  • 29
    • 0026000430 scopus 로고
    • Solid-phase extraction of midazolam and two of its metabolites from plasma for high-performance liquid chromatographic analysis
    • Sautou V, Chopineau J, Terrisse MP, Bastide P. Solid-phase extraction of midazolam and two of its metabolites from plasma for high-performance liquid chromatographic analysis. J Chromatogr. 571:1991;298-304.
    • (1991) J Chromatogr , vol.571 , pp. 298-304
    • Sautou, V.1    Chopineau, J.2    Terrisse, M.P.3    Bastide, P.4
  • 30
    • 0019949059 scopus 로고
    • Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- And 11-hydroxylation of dodecanoic acid (lauric acid)
    • Gibson GG, Orton TC, Tamburini PP. Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid). Biochem J. 203:1982;161-168.
    • (1982) Biochem J , vol.203 , pp. 161-168
    • Gibson, G.G.1    Orton, T.C.2    Tamburini, P.P.3
  • 31
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes I. Evidence for its hemoprotein nature
    • Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes I. Evidence for its hemoprotein nature. J Biol Chem. 239:1964;2370-2378.
    • (1964) J Biol Chem , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 32
    • 0028798307 scopus 로고
    • Short synthetic peptides exploited for reliable and specific targeting of antibodies to the C termini of cytochrome P450 enzymes
    • Edwards RJ, Singleton AM, Murray BP, Davies DS, Boobis AR. Short synthetic peptides exploited for reliable and specific targeting of antibodies to the C termini of cytochrome P450 enzymes. Biochem Pharmacol. 49:1995;39-47.
    • (1995) Biochem Pharmacol , vol.49 , pp. 39-47
    • Edwards, R.J.1    Singleton, A.M.2    Murray, B.P.3    Davies, D.S.4    Boobis, A.R.5
  • 33
    • 0029552401 scopus 로고
    • Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues
    • Debri K, Boobis AR, Davies DS, Edwards RJ. Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues. Biochem Pharmacol. 50:1995;2047-2056.
    • (1995) Biochem Pharmacol , vol.50 , pp. 2047-2056
    • Debri, K.1    Boobis, A.R.2    Davies, D.S.3    Edwards, R.J.4
  • 36
    • 0028590127 scopus 로고
    • Biochemistry and molecular biology of the human CYP2C subfamily
    • Goldstein JA, de Morais SM. Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics. 4:1994;285-299.
    • (1994) Pharmacogenetics , vol.4 , pp. 285-299
    • Goldstein, J.A.1    De Morais, S.M.2
  • 37
    • 0031568856 scopus 로고    scopus 로고
    • Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51
    • Richardson TH, Griffin KJ, Jung F, Raucy JL, Johnson EF. Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51. Arch Biochem Biophys. 338:1997;157-164.
    • (1997) Arch Biochem Biophys , vol.338 , pp. 157-164
    • Richardson, T.H.1    Griffin, K.J.2    Jung, F.3    Raucy, J.L.4    Johnson, E.F.5
  • 38
    • 0027207764 scopus 로고
    • Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP
    • Murray BP, Edwards RJ, Murray S, Singleton AM, Davies DS, Boobis AR. Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP. Carcinogenesis. 14:1993;585-592.
    • (1993) Carcinogenesis , vol.14 , pp. 585-592
    • Murray, B.P.1    Edwards, R.J.2    Murray, S.3    Singleton, A.M.4    Davies, D.S.5    Boobis, A.R.6
  • 39
    • 0024498616 scopus 로고
    • Identification and location of alpha-helices in mammalian cytochromes P450
    • Edwards RJ, Murray BP, Boobis AR, Davies DS. Identification and location of alpha-helices in mammalian cytochromes P450. Biochemistry. 28:1989;3762-3770.
    • (1989) Biochemistry , vol.28 , pp. 3762-3770
    • Edwards, R.J.1    Murray, B.P.2    Boobis, A.R.3    Davies, D.S.4
  • 40
    • 0023687412 scopus 로고
    • A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking
    • Sesardic D, Boobis AR, Edwards RJ, Davies DS. A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking. Br J Clin Pharmacol. 26:1988;363-372.
    • (1988) Br J Clin Pharmacol , vol.26 , pp. 363-372
    • Sesardic, D.1    Boobis, A.R.2    Edwards, R.J.3    Davies, D.S.4
  • 41
    • 0025214234 scopus 로고
    • Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity
    • Miles JS, McLaren AW, Forrester LM, Glancey MJ, Lang MA, Wolf CR. Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity. Biochem J. 267:1990;365-371.
    • (1990) Biochem J , vol.267 , pp. 365-371
    • Miles, J.S.1    McLaren, A.W.2    Forrester, L.M.3    Glancey, M.J.4    Lang, M.A.5    Wolf, C.R.6
  • 42
    • 0024354143 scopus 로고
    • Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae
    • Brian WR, Srivastava PK, Umbenhauer DR, Lloyd RS, Guengerich FP. Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae. Biochemistry. 28:1989;4993-4999.
    • (1989) Biochemistry , vol.28 , pp. 4993-4999
    • Brian, W.R.1    Srivastava, P.K.2    Umbenhauer, D.R.3    Lloyd, R.S.4    Guengerich, F.P.5
  • 44
    • 0027445449 scopus 로고
    • Isolation and characterization of human liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4′-hydroxylation
    • Wrighton SA, Stevens JC, Becker GW, VandenBranden M. Isolation and characterization of human liver cytochrome P450 2C19 correlation between 2C19 and S-mephenytoin 4′-hydroxylation . Arch Biochem Biophys. 306:1993;240-245.
    • (1993) Arch Biochem Biophys , vol.306 , pp. 240-245
    • Wrighton, S.A.1    Stevens, J.C.2    Becker, G.W.3    Vandenbranden, M.4
  • 46
    • 0022263133 scopus 로고
    • Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism
    • Distlerath LM, Reilly PE, Martin MV, Davis GG, Wilkinson GR, Guengerich FP. Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism. J Biol Chem. 260:1985;9057-9067.
    • (1985) J Biol Chem , vol.260 , pp. 9057-9067
    • Distlerath, L.M.1    Reilly, P.E.2    Martin, M.V.3    Davis, G.G.4    Wilkinson, G.R.5    Guengerich, F.P.6
  • 48
    • 0030297422 scopus 로고    scopus 로고
    • Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes
    • Powell PK, Wolf I, Lasker JM. Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. Arch Biochem Biophys. 335:1996;219-226.
    • (1996) Arch Biochem Biophys , vol.335 , pp. 219-226
    • Powell, P.K.1    Wolf, I.2    Lasker, J.M.3
  • 50
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals studies with liver microsomes of 30 Japanese and 30 Caucasians . J Pharmacol Exp Ther. 270:1994;414-423.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 51
    • 0029971798 scopus 로고    scopus 로고
    • Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat
    • Imaoka S, Yamada T, Hiroi T, Hayashi K, Sakaki T, Yabusaki Y, Funae Y. Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat. Biochem Pharmacol. 51:1996;1041-1050.
    • (1996) Biochem Pharmacol , vol.51 , pp. 1041-1050
    • Imaoka, S.1    Yamada, T.2    Hiroi, T.3    Hayashi, K.4    Sakaki, T.5    Yabusaki, Y.6    Funae, Y.7
  • 53
    • 0030895593 scopus 로고    scopus 로고
    • Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone
    • Gorski JC, Jones DR, Wrighton SA, Hall SD. Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone. Xenobiotica. 27:1997;243-256.
    • (1997) Xenobiotica , vol.27 , pp. 243-256
    • Gorski, J.C.1    Jones, D.R.2    Wrighton, S.A.3    Hall, S.D.4
  • 60
    • 0342468270 scopus 로고    scopus 로고
    • Detection of CYP3A5 allelic variant: A candidate for the polymorphic expression of the protein?
    • Jounaidi Y, Hyrailles V, Gervot L, Maurel P. Detection of CYP3A5 allelic variant a candidate for the polymorphic expression of the protein? Biochem Biophys Res Commun. 221:1996;466-470.
    • (1996) Biochem Biophys Res Commun , vol.221 , pp. 466-470
    • Jounaidi, Y.1    Hyrailles, V.2    Gervot, L.3    Maurel, P.4
  • 62
    • 0028820801 scopus 로고
    • Role of cytochrome P4501A2 in chemical carcinogenesis: Implications for human variability in expression and enzyme activity
    • Eaton DL, Gallagher EP, Bammler TK, Kunze KL. Role of cytochrome P4501A2 in chemical carcinogenesis implications for human variability in expression and enzyme activity . Pharmacogenetics. 5:1995;259-274.
    • (1995) Pharmacogenetics , vol.5 , pp. 259-274
    • Eaton, D.L.1    Gallagher, E.P.2    Bammler, T.K.3    Kunze, K.L.4
  • 63
    • 0029974530 scopus 로고    scopus 로고
    • Caffeine urinary metabolite ratios as markers of enzyme activity: A theoretical assessment
    • Rostami-Hodjegan A, Nurminen S, Jackson PR, Tucker GT. Caffeine urinary metabolite ratios as markers of enzyme activity a theoretical assessment . Pharmacogenetics. 6:1996;121-149.
    • (1996) Pharmacogenetics , vol.6 , pp. 121-149
    • Rostami-Hodjegan, A.1    Nurminen, S.2    Jackson, P.R.3    Tucker, G.T.4
  • 64
    • 0026062622 scopus 로고
    • Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene
    • Hayashi S, Watanabe J, Kawajiri K. Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J Biochem Tokyo. 110:1991;559-565.
    • (1991) J Biochem Tokyo , vol.110 , pp. 559-565
    • Hayashi, S.1    Watanabe, J.2    Kawajiri, K.3
  • 66
    • 0025296345 scopus 로고
    • Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450
    • McManus ME, Burgess WM, Veronese ME, Huggett A, Quattrochi LC, Tukey RH. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res. 50:1990;3367-3376.
    • (1990) Cancer Res , vol.50 , pp. 3367-3376
    • McManus, M.E.1    Burgess, W.M.2    Veronese, M.E.3    Huggett, A.4    Quattrochi, L.C.5    Tukey, R.H.6
  • 70
    • 0025790577 scopus 로고
    • Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization
    • McKinnon RA, Hall PD, Quattrochi LC, Tukey RH, McManus ME. Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization. Hepatology. 14:1991;848-856.
    • (1991) Hepatology , vol.14 , pp. 848-856
    • McKinnon, R.A.1    Hall, P.D.2    Quattrochi, L.C.3    Tukey, R.H.4    McManus, M.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.