Microsomal cytochrome P450 2C5: Comparison to microbial P450s and unique features

Journal of Inorganic Biochemistry

Volumn 81, Issue 3, 2000, Pages 183-190

  Williams, P A ^a   Cosme, J ^a   Sridhar, V ^a   Johnson, E F ^a   McRee, D E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Crystal structure; Cytochrome P450; Microsomal P450

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2C5; CYTOCHROME P450 REDUCTASE; MICROBIAL ENZYME; MICROSOME ENZYME; MUTANT PROTEIN; OXYGENASE; PROGESTERONE HYDROXYLASE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME STRUCTURE; ENZYME SUBSTRATE; MEMBRANE BINDING; MODEL; NONHUMAN; RABBIT;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; MICROSOMES; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MUTATION; NADPH-FERRIHEMOPROTEIN REDUCTASE; PROGESTERONE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RABBITS; STEROID 21-HYDROXYLASE; SUBSTRATE SPECIFICITY;

EID: 0034738973     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-0134(00)00102-1     Document Type: Article

References (20)

1. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., Nebert D.W. Pharmacogenetics. 6:1996;1.
2. Guengerich F.P. Ortiz de Montellano P.R. Cytochrome P450: Structure, Mechanism, and Biochemistry. 1995;473-535 Plenum Press, New York.
3. Geungerich F.P. J. Biol. Chem. 266:1991;10019.
4. Poulos T.L., Finzel B.C., Gunsalus I.C., Wagner G.C., Kraut J. J. Biol. Chem. 260:1985;16122.
5. Poulos T.L., Finzel B.C., Howard A.J. J. Mol. Biol. 195:1987;687.
6. Cupp-Vickery J.R., Han O., Hutchinson C.R., Poulos T.L. Nat. Struct. Biol. 3:1996;632.
7. Ravichandran K.G., Boddupalli S.S., Hasemann C.A., Peterson J.A., Deisenhofer J. Science. 261:1993;731.
8. Hasemann C.A., Ravichandran K.G., Peterson J.A., Deisenhofer J. J. Mol. Biol. 236:1994;1169.
9. Williams P.A., Cosme J., Sridhar V., Johnson E.F., McRee D.E. Mol. Cell. 5:2000;121.
10. Peterson J.A., Graham S.E. Structure. 6:1998;1079.
11. Cosme J., Johnson E.F. J. Biol. Chem. 275:2000;2545-2553.
12. Gotoh O. J. Biol. Chem. 267:1992;83.
13. Morris G.M., Goodsell D.S., Halliday R.S., Huey R., Hart W.E., Belew R.K., Olson A.J. J. Comput. Chem. 19:1998;1639.
14. von Wachenfeldt C., Johnson E.F. Ortiz de Montellano P.R. Cytochrome P450: Structure, Mechanism, and Biochemistry. 1995;183-244 Plenum Press, New York.
15. Kronbach T., Larabee T.M., Johnson E.F. Proc. Natl. Acad. Sci. USA. 86:1989;8262.
16. Richardson T.H., Johnson E.F. Ionnides C. Cytochromes P450: Metabolic and Toxicological Aspects. 1996;161-181 CRC Press, Boca Raton, FL.
17. Wang M., Roberts D.L., Paschke R., Shea T.M., Masters B.S.S., Kim J.J.P. Proc. Natl. Acad. Sci. USA. 94:1997;8411.
18. Bridges A., Gruenke L., Chang Y.T., Vakser I.A., Loew G., Waskell L. J. Biol. Chem. 273:1998;17036.
19. Sevrioukova I.F., Li H.Y., Zhang H., Peterson J.A., Poulos T.L. Proc. Natl. Acad. Sci. USA. 96:1999;1863.
20. Li H., Poulos T.L. Nat. Struct. Biol. 4:1997;140.