Human cytochrome P450 3A4-catalyzed testosterone 6β-hydroxylation and erythromycln N-demethylation: Competition during catalysis

Drug Metabolism and Disposition

Volumn 25, Issue 4, 1997, Pages 502-507

  Wang, Regina W ^a   Newton, Deborah J ^b   Scheri, Tad D ^b   Lu, Anthony Y H ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; ERYTHROMYCIN; RECOMBINANT ENZYME; TESTOSTERONE;

ADULT; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEMETHYLATION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; MALE; METABOLIC INHIBITION; MICHAELIS CONSTANT; PRIORITY JOURNAL; STEROID HYDROXYLATION;

ARYL HYDROCARBON HYDROXYLASES; BINDING, COMPETITIVE; CATALYSIS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROXYLATION; KINETICS; METHYLATION; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES, N-DEMETHYLATING; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY;

EID: 0031005752     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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