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Volumn 277, Issue 5333, 1997, Pages 1827-1830

25-Hydroxyvitamin D3 1α-hydroxylase and vitamin D synthesis

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CALCIDIOL 1 MONOOXYGENASE; CALCIFEDIOL; CALCITRIOL; CALCITRIOL RECEPTOR; LIGAND; MESSENGER RNA;

EID: 0030612651     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.277.5333.1827     Document Type: Article
Times cited : (487)

References (60)
  • 1
    • 0020185344 scopus 로고
    • A. W. Norman, J. Roth, L. Orchi, Endocr. Rev. 3, 331 (1982); H. F. DeLuca, Adv. Exp. Med. Biol. 196, 361 (1986); M. R. Walters, Endocr. Rev. 13, 719 (1992).
    • (1982) Endocr. Rev. , vol.3 , pp. 331
    • Norman, A.W.1    Roth, J.2    Orchi, L.3
  • 2
    • 0022507477 scopus 로고
    • A. W. Norman, J. Roth, L. Orchi, Endocr. Rev. 3, 331 (1982); H. F. DeLuca, Adv. Exp. Med. Biol. 196, 361 (1986); M. R. Walters, Endocr. Rev. 13, 719 (1992).
    • (1986) Adv. Exp. Med. Biol. , vol.196 , pp. 361
    • DeLuca, H.F.1
  • 3
    • 0027050850 scopus 로고
    • A. W. Norman, J. Roth, L. Orchi, Endocr. Rev. 3, 331 (1982); H. F. DeLuca, Adv. Exp. Med. Biol. 196, 361 (1986); M. R. Walters, Endocr. Rev. 13, 719 (1992).
    • (1992) Endocr. Rev. , vol.13 , pp. 719
    • Walters, M.R.1
  • 4
    • 0026554293 scopus 로고
    • H. L. Henry et al., J. Cell Biochem. 49, 4 (1992); H. Kawashima, S. Torikai, K. Kurokawa, Proc. Natl. Acad. Sci. U.S.A. 78, 1199 (1981).
    • (1992) J. Cell Biochem. , vol.49 , pp. 4
    • Henry, H.L.1
  • 6
    • 0029618368 scopus 로고
    • M. Beato, P. Herrlich, G. Schuts, Cell 83, 851 (1995); H. Darwish and H. F. DeLuca, Eukaryotic Gene Exp. 3, 89 (1993); B. D. Lemon, J. D. Fondell, L. P. Freedman, Mol. Cell. Biol. 17, 1923 (1997).
    • (1995) Cell , vol.83 , pp. 851
    • Beato, M.1    Herrlich, P.2    Schuts, G.3
  • 7
    • 0027153183 scopus 로고
    • M. Beato, P. Herrlich, G. Schuts, Cell 83, 851 (1995); H. Darwish and H. F. DeLuca, Eukaryotic Gene Exp. 3, 89 (1993); B. D. Lemon, J. D. Fondell, L. P. Freedman, Mol. Cell. Biol. 17, 1923 (1997).
    • (1993) Eukaryotic Gene Exp. , vol.3 , pp. 89
    • Darwish, H.1    DeLuca, H.F.2
  • 8
    • 0030984225 scopus 로고    scopus 로고
    • M. Beato, P. Herrlich, G. Schuts, Cell 83, 851 (1995); H. Darwish and H. F. DeLuca, Eukaryotic Gene Exp. 3, 89 (1993); B. D. Lemon, J. D. Fondell, L. P. Freedman, Mol. Cell. Biol. 17, 1923 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1923
    • Lemon, B.D.1    Fondell, J.D.2    Freedman, L.P.3
  • 9
    • 0027404624 scopus 로고
    • D. D. Bikle and S. Pillai, Endocr. Rev. 14, 3 (1993); R. Bouillon, W. H. Okamura, A. W. Norman, ibid. 16, 200 (1995); M. R. Haussler et al., Recent Prog. Horm. Res. 44, 263 (1988); P. J. Malloy et al., J. Clin. Invest. 86, 2071 (1990).
    • (1993) Endocr. Rev. , vol.14 , pp. 3
    • Bikle, D.D.1    Pillai, S.2
  • 10
    • 0028988403 scopus 로고
    • D. D. Bikle and S. Pillai, Endocr. Rev. 14, 3 (1993); R. Bouillon, W. H. Okamura, A. W. Norman, ibid. 16, 200 (1995); M. R. Haussler et al., Recent Prog. Horm. Res. 44, 263 (1988); P. J. Malloy et al., J. Clin. Invest. 86, 2071 (1990).
    • (1995) Endocr. Rev. , vol.16 , pp. 200
    • Bouillon, R.1    Okamura, W.H.2    Norman, A.W.3
  • 11
    • 0024228102 scopus 로고
    • D. D. Bikle and S. Pillai, Endocr. Rev. 14, 3 (1993); R. Bouillon, W. H. Okamura, A. W. Norman, ibid. 16, 200 (1995); M. R. Haussler et al., Recent Prog. Horm. Res. 44, 263 (1988); P. J. Malloy et al., J. Clin. Invest. 86, 2071 (1990).
    • (1988) Recent Prog. Horm. Res. , vol.44 , pp. 263
    • Haussler, M.R.1
  • 12
    • 0025607934 scopus 로고
    • D. D. Bikle and S. Pillai, Endocr. Rev. 14, 3 (1993); R. Bouillon, W. H. Okamura, A. W. Norman, ibid. 16, 200 (1995); M. R. Haussler et al., Recent Prog. Horm. Res. 44, 263 (1988); P. J. Malloy et al., J. Clin. Invest. 86, 2071 (1990).
    • (1990) J. Clin. Invest. , vol.86 , pp. 2071
    • Malloy, P.J.1
  • 13
    • 0015984535 scopus 로고
    • Y. Tanaka and H. F. DeLuca, Science 183, 1198 (1974); K. Ikeda et al., Proc. Natl. Acad. Sci. U.S.A. 92, 6112 (1995); H. L. Henry, R. J. Midgett, A. W. Norman, J. Biol. Chem. 249, 7584 (1974).
    • (1974) Science , vol.183 , pp. 1198
    • Tanaka, Y.1    DeLuca, H.F.2
  • 14
    • 0015984535 scopus 로고
    • Y. Tanaka and H. F. DeLuca, Science 183, 1198 (1974); K. Ikeda et al., Proc. Natl. Acad. Sci. U.S.A. 92, 6112 (1995); H. L. Henry, R. J. Midgett, A. W. Norman, J. Biol. Chem. 249, 7584 (1974).
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 6112
    • Ikeda, K.1
  • 15
    • 0016333323 scopus 로고
    • Y. Tanaka and H. F. DeLuca, Science 183, 1198 (1974); K. Ikeda et al., Proc. Natl. Acad. Sci. U.S.A. 92, 6112 (1995); H. L. Henry, R. J. Midgett, A. W. Norman, J. Biol. Chem. 249, 7584 (1974).
    • (1974) J. Biol. Chem. , vol.249 , pp. 7584
    • Henry, H.L.1    Midgett, R.J.2    Norman, A.W.3
  • 16
    • 0019795626 scopus 로고
    • H. Kawashima, S. Torikai, K. Kurokawa, Nature 291, 327 (1981); K. W. Colston, I. M. Evans, L. Galauto, I. MacIntyre, D. W. Moss, Biochem. J. 134, 817 (1973).
    • (1981) Nature , vol.291 , pp. 327
    • Kawashima, H.1    Torikai, S.2    Kurokawa, K.3
  • 18
    • 0346184677 scopus 로고
    • D. R. Fraser and E. Kodicek, Nature New Biol. 241, 163 (1973); M. J. Beckman et al., Arch. Biochem. Biophys. 319, 535 (1995).
    • (1973) Nature New Biol. , vol.241 , pp. 163
    • Fraser, D.R.1    Kodicek, E.2
  • 19
    • 0029061051 scopus 로고
    • D. R. Fraser and E. Kodicek, Nature New Biol. 241, 163 (1973); M. J. Beckman et al., Arch. Biochem. Biophys. 319, 535 (1995).
    • (1995) Arch. Biochem. Biophys. , vol.319 , pp. 535
    • Beckman, M.J.1
  • 20
    • 0015929252 scopus 로고
    • D. Fraser et al., N. Engl. J. Med. 289, 817 (1973); S. Balsan, in Rickets, F. H. Glorieux, Ed. (Raven, New York, 1991), pp. 155-165.
    • (1973) N. Engl. J. Med. , vol.289 , pp. 817
    • Fraser, D.1
  • 21
    • 0001868060 scopus 로고
    • F. H. Glorieux, Ed. Raven, New York
    • D. Fraser et al., N. Engl. J. Med. 289, 817 (1973); S. Balsan, in Rickets, F. H. Glorieux, Ed. (Raven, New York, 1991), pp. 155-165.
    • (1991) Rickets , pp. 155-165
    • Balsan, S.1
  • 22
    • 0029974612 scopus 로고    scopus 로고
    • S. Wakino et al., Gerontology 42, 67 (1996); E. Axen, FEBS Left. 375, 277 (1995); M. Burgos-Trinidad, R. Ismail, R. A. Ettinger, J. M. Prahl, H. F. DeLuca, J. Biol. Chem. 267, 3498 (1992); M. Warner et al., ibid. 257, 12995 (1982); H. L. Henry and A. W. Norman, ibid. 249, 7529 (1974).
    • (1996) Gerontology , vol.42 , pp. 67
    • Wakino, S.1
  • 23
    • 0028791854 scopus 로고
    • S. Wakino et al., Gerontology 42, 67 (1996); E. Axen, FEBS Left. 375, 277 (1995); M. Burgos-Trinidad, R. Ismail, R. A. Ettinger, J. M. Prahl, H. F. DeLuca, J. Biol. Chem. 267, 3498 (1992); M. Warner et al., ibid. 257, 12995 (1982); H. L. Henry and A. W. Norman, ibid. 249, 7529 (1974).
    • (1995) FEBS Left. , vol.375 , pp. 277
    • Axen, E.1
  • 24
    • 0026723045 scopus 로고
    • S. Wakino et al., Gerontology 42, 67 (1996); E. Axen, FEBS Left. 375, 277 (1995); M. Burgos-Trinidad, R. Ismail, R. A. Ettinger, J. M. Prahl, H. F. DeLuca, J. Biol. Chem. 267, 3498 (1992); M. Warner et al., ibid. 257, 12995 (1982); H. L. Henry and A. W. Norman, ibid. 249, 7529 (1974).
    • (1992) J. Biol. Chem. , vol.267 , pp. 3498
    • Burgos-Trinidad, M.1    Ismail, R.2    Ettinger, R.A.3    Prahl, J.M.4    DeLuca, H.F.5
  • 25
    • 0020364627 scopus 로고
    • S. Wakino et al., Gerontology 42, 67 (1996); E. Axen, FEBS Left. 375, 277 (1995); M. Burgos-Trinidad, R. Ismail, R. A. Ettinger, J. M. Prahl, H. F. DeLuca, J. Biol. Chem. 267, 3498 (1992); M. Warner et al., ibid. 257, 12995 (1982); H. L. Henry and A. W. Norman, ibid. 249, 7529 (1974).
    • (1982) J. Biol. Chem. , vol.257 , pp. 12995
    • Warner, M.1
  • 26
    • 0016246288 scopus 로고
    • S. Wakino et al., Gerontology 42, 67 (1996); E. Axen, FEBS Left. 375, 277 (1995); M. Burgos-Trinidad, R. Ismail, R. A. Ettinger, J. M. Prahl, H. F. DeLuca, J. Biol. Chem. 267, 3498 (1992); M. Warner et al., ibid. 257, 12995 (1982); H. L. Henry and A. W. Norman, ibid. 249, 7529 (1974).
    • (1974) J. Biol. Chem. , vol.249 , pp. 7529
    • Henry, H.L.1    Norman, A.W.2
  • 28
    • 15844386531 scopus 로고    scopus 로고
    • K. Ebihara et al., Mol. Cell. Biol. 16, 3393 (1996); T. Imai et al., Biochem. Biophys. Res. Commun. 233, 765 (1997).
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3393
    • Ebihara, K.1
  • 29
  • 31
    • 0029025357 scopus 로고
    • T. Sakaki, S. Kominami, K. Hayashi, M. Akiyoshi-Shibata, Y. Yabusaki, J. Biol. Chem. 271, 26209 (1996); F. J. Dilworth et al., ibid. 270, 16766 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 16766
    • Dilworth, F.J.1
  • 34
    • 0025149281 scopus 로고
    • P. Su et al., ibid. 9, 657 (1990); E. Usui, M. Noshiro, Y. Ohyama, K. Okuda, FEBS Lett. 262, 367 (1990).
    • (1990) DNA Cell Biol. , vol.9 , pp. 657
    • Su, P.1
  • 39
    • 0028886694 scopus 로고
    • S. Kato et al., Science 270, 1491 (1995).
    • (1995) Science , vol.270 , pp. 1491
    • Kato, S.1
  • 41
    • 0030872361 scopus 로고    scopus 로고
    • E. B. Mawer et al., J. Clin. Endocrinol. Metab. 79, 554 (1994); H. Fujii et al., EMBO J. 16, 4163 (1997).
    • (1997) EMBO J. , vol.16 , pp. 4163
    • Fujii, H.1
  • 42
    • 9844234492 scopus 로고    scopus 로고
    • data not shown
    • K. Takeyama et al., data not shown.
    • Takeyama, K.1
  • 43
    • 0019193314 scopus 로고
    • R. T. Turner et al., Proc. Natl. Acad. Sci. U.S.A. 77, 5720 (1980); J. S. Adams et al., J. Clin. Endocrinol. Metab. 60, 960 (1985).
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , pp. 5720
    • Turner, R.T.1
  • 44
    • 0021881989 scopus 로고
    • R. T. Turner et al., Proc. Natl. Acad. Sci. U.S.A. 77, 5720 (1980); J. S. Adams et al., J. Clin. Endocrinol. Metab. 60, 960 (1985).
    • (1985) J. Clin. Endocrinol. Metab. , vol.60 , pp. 960
    • Adams, J.S.1
  • 46
    • 0018746180 scopus 로고
    • G. A. Howard, R. T. Turner, D. J. Sherrard, D. J. Baylink, J. Biol. Chem. 256, 7738 (1981); T. K. Gray, G. E. Lester, R. S. Lorenc, Science 204, 1311 (1979).
    • (1979) Science , vol.204 , pp. 1311
    • Gray, T.K.1    Lester, G.E.2    Lorenc, R.S.3
  • 49
    • 0028292148 scopus 로고
    • C. Zierold, H. M. Darwisn, H. F. DeLuca, J. Biol. Chem. 270, 1675 (1995); Y. Ohyama et al., ibid. 269, 10545 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 10545
    • Ohyama, Y.1
  • 51
    • 0028055147 scopus 로고
    • K. Takeyama et al., Biochem. Biophys. Res. Commun. 222, 395 (1996); H. Mano et al., J. Biol. Chem. 269, 1591 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 1591
    • Mano, H.1
  • 52
    • 0021016329 scopus 로고
    • U. Gubler and B. J. Hoffmann, Gene 25, 263 (1983); M. Kobori and H. Nojima, Nucleic Acids Res. 21, 2782 (1993).
    • (1983) Gene , vol.25 , pp. 263
    • Gubler, U.1    Hoffmann, B.J.2
  • 54
    • 9844245549 scopus 로고    scopus 로고
    • note
    • + RNA (27). The cDNA fragments were subsequently inserted into the Hind III site of the mammalian expression vector pcDNA3 (Invitrogen). The reporter plasmid 17M2-G-lacZ was constructed by inserting yeast GAL4 upstream activating sequence x2 and β-globin promoter into a multicloning site of the Basic expression vector (Clontech). The ligand-binding domain of VDR [VDR(DEF)] fused to the GAL4 DNA-binding domain [GAL4-VDR(DEF)] (11) was used to detect ligand-induced AF-2 function. COS-1 cells cultured with Dulbecco's modified Eagle's medium containing 10% fetal bovine serum were transiently transfected with 0.5 μg of GAL4-VDR(DEF) expression vector, 1 μg of 17M2-G-lacZ, 0.2 μg each of the ADX and ADR expression vectors (12), and 0.1 μg of expression cDNA library in OPTI-MEM using lipofection agent (GIBCO BRL).
  • 56
    • 9844266465 scopus 로고    scopus 로고
    • note
    • Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
  • 58
    • 9844261390 scopus 로고    scopus 로고
    • note
    • 3 (21).
  • 60
    • 9844268182 scopus 로고    scopus 로고
    • note
    • We thank P. Chambon for critical reading of the manuscript; T. Yoshizawa, Y. Masuhiro, S. Takeda, K. Suzuki, F. Ichikawa, N. Kubota, N. Ohishi, K. Kumaki, and A. Murayama for technical assistance; Y. Nogi, T. Sakaki, and T. Matsumoto for helpful discussion and suggestions; Y. Yabusaki for the ADX and ADR cDNA plasmids; and Chugai Pharmaceuticals for vitamin D-related compounds.


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