Reproductive toxicity and growth effects in rats exposed to lead at different periods during development

Toxicology and Applied Pharmacology

Volumn 136, Issue 2, 1996, Pages 361-371

  Ronis, Martin J J ^a,b,c   Badger, Thomas M ^a,b   Shema, Sarah J ^a,b   Roberson, Paula K ^a,b   Shaikh, Fatima ^a,b,d  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b ARKANSAS CHILDREN S HOSPITAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 ISOENZYME; ESTRADIOL; LEAD; LEAD ACETATE; LUTEINIZING HORMONE; OXYGENASE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GROWTH RATE; HYDROXYLATION; MALE; NONHUMAN; ORGAN WEIGHT; PRENATAL EXPOSURE; RAT; REPRODUCTIVE TOXICITY; TESTOSTERONE BLOOD LEVEL;

EID: 0030025829     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0044     Document Type: Article

References (47)

1. Angle, C. R., and Kunzelman, D. R. (1989). Increased erythrocyte protoporphyrins and blood lead - a pilot study of childhood growth patterns. J. Toxicol. Environ. Health 26, 149-156.
2. Badger, T. M., Loughlin, J. S., and Naddaff, P. G. (1983). The luteinizing hormone-releasing hormone (LHRH)-desensitized rat pituitary: Luteinizing hormone responsiveness to LHRH in vitro. Endocrinology 112, 793-799.
3. Badger, T. M., Ronis, M. J. J., Lumpkin, C. K., Valentine, C. R., Shahare, M., Irby, D., Huang, J., Mercado, C., Thomas, P. E., Ingelman-Sundberg, M., and Crouch, J. (1993a). Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat. J. Pharmacol. Exp. Ther. 264, 438-447.
4. Badger, T. M., Ronis, M. J. J., and Lumpkin, C. K. (1993b). The effects of alcohol on growth hormone and growth hormone-regulated systems. In Alcohol and the Endocrine System (Zakhari, S., Ed.)., Vol. 23, pp. 339-363. NIAAA Research Monograph, Bethesda, MA.
5. Bell, J. U., and Thomas, J. A. (1980). Effects of lead on mammalian reproduction. In Lead Toxicity (R. L. Singhal and J. A. Thomas, Eds.), pp. 167-187. Urban & Schwartzberg, Baltimore/Zurich.
6. Bennett, W. M. (1985). Lead nephropathy. Kidney Int. 28, 212-218.
7. Bornschein, R. L., Succop, P. A., Dietrich, K. N., Kraft, K. M., Schula, R., and Hammond, P. B. (1987). Prenatal lead exposure and pregnancy outcomes in the Cincinnati lead study. In Proc. 6th International Conference on Heavy Metals in the Environment (S. E. Lindberg and T. Hutchinson, Eds.), New Orleans.
8. Chipman, J. K., Kuruckgy, M., and Walker, C. H. (1979). Comparative metabolism of a dieldrin analogue: Hepatic microsomal systems as models for metabolism in the whole animal. Biochem. Pharmacol. 28, 69-75.
9. Comoratto, A. M., White, L. M., Lau, Y-S., Ware, G. O., Berry, W. D., and Moriarty, C. M. (1993). Effect of exposure to low level lead on growth and growth hormone release in rats. Toxicology 83, 101-114.
10. Del Rosario, A. R., Guirguis, G. N., Perez, G. P., Martias, V. C., and Flessel, C. P. (1982). A rapid and precise system for lead determination in whole blood. Int. J. Environ. Anal. Chem. 12, 223-231.
11. Eyden, B. P., Maison, J. R., and Mattelin, G. (1978). Long term effects of dietary lead acetate on survival, body weight and seminal cytology in mice. Bull. Environ. Contam. Toxicol. 19, 266-272.
12. Forbes, G. J., and Reina, J. C. (1972). Effect of age on gastrointestinal absorption (Fe, Sn, Pb) in the rat. J. Nutr. 102, 647-652.
13. Foster, W. G., McMahon, A., YoungLai, E. V., Hughes, E. G., and Rice, D. C. (1993). Reproductive endocrine effects of chronic lead exposure in the male cynomologous monkey. Reprod. Toxicol. 7, 203-209.
14. Gay, V. L., and Bogdavone, E. M. (1969). Plasma and pituitary LH and FSH in castrated rats following short term steroid treatment. Endocrinology 84, 1132-1135.
15. Grant, L. D., Kimmel, C. A., Martinez-Vargas, C. M., and West, G. L. (1976). Assessment of developmental toxicity associated with chronic lead exposure. Environ. Health Perspect. 17, 290-295.
16. Grant, L. D., Kimmel, C. A., West, G. L., Martinez-Vargas, C. M., and Howard, J. L. (1980). Chronic low-level lead toxicity in the rat. II. Effects on postnatal physical and behavioral development. Toxicol. Appl. Pharmacol. 56, 42-58.
17. Hammond, P. B., Chernausek, S. D., Succop, P. A., Shukla, R., and Bornschein, R. L. (1989). Mechanisms by which lead depresses linear and ponderal growth in weanling rats. Toxicol. Appl. Pharmacol. 99, 474-486.
18. Hammond, P. B., Minnema, D. J., and Shukla, R. (1990). Lead lowers the set point for food consumption and growth in weanling rats. Toxicol. Appl. Pharmacol. 106, 80-87.
19. Hammond, P. B., Minnema, D. J., and Succop, P. A. (1993). Reversibility of lead-induced depression of growth. Toxicol. Appl. Pharmacol. 123, 9-15.
20. Hollander, M., and Wolfe, D. A. (1987). Nonparametric Statistical Methods. pp. 115-120, Wiley, New York.
21. Huseman, C. A., Moriarty, C. M., and Angle, C. R. (1987). Childhood lead toxicity and impaired release of thyroid stimulating hormone. Environ. Res. 42, 524-533.
22. Huseman, C. A., Varma, M. M., and Angle, C. R. (1992). Neuroendocrine effects of toxic and low blood lead levels in children. Pediatrics 90, 186-189.
23. Keller, C. A., and Doherty, R. A. (1980). Bone lead mobilization in lactating mice and lead transfer to suckling offspring. Toxicol. Appl. Pharmacol. 55, 220-226.
24. Kempinas, W. G., Farvaretto, A. L. V., Melo, V. R., Lamano Carvalho, T. L., Petenusci, S. O., and Oliveira-Filho, R. M. (1994). Time-dependent effects of lead on rat reproductive functions. J. Appl. Toxicol. 14, 427-433.
25. Kimmel, C. A., Grant, L. D., Sloan, C. S., and Sladen, B. C. (1980). Chronic low-level lead toxicity and perinatal effects. Toxicol. Appl. Pharmacol. 56, 28-41.
26. Klein, D., Wan, Y-J., Kamyab, S., Okuda, H., and Sokol, R. Z. (1994). Effects of toxic levels of lead on gene regulation in the male axis: Increase in messenger ribonucleic acids and intracellular stores of gonadotrophs within the central nervous system. Biol. Reprod. 50, 802-811.
27. Kobliakov, V., Popova, N., and Rossi, L. (1991). Regulation of the expression of sex-specific isoforms of cytochrome P450 in rat liver. Eur. J. Biochem. 195, 588-591.
28. Kostial, K., and Momcilovic, B. (1974). Transport of lead 203 and calcium 47 from mother to offspring. Arch. Environ. Health 29, 28-32.
29. Lau, Y-S., Camoratto, A. M., White, L. M., and Moriarty, C. M. (1991). Effects of lead on TRH and GRF binding in rat anterior pituitary membranes. Toxicology 68, 169-179.
30. Lin-Fu, J. S. (1992). Modern history of lead poisoning: A century of discovery and rediscovery. In Human Lead Exposure (H. L. Needleman, Ed.), pp. 233-242, CRC Press, Boca Raton, FL.
31. Markowitz, M. E., Saenger, P., Bijur, P. E. (1990). (EDTA)-Chelatable lead: Inverse correlation with growth velocity in lead toxic children. Pediatr. Res. 27, 62-67A.
32. McGivern, R. F., Sokol, R. Z., and Berman, N. C. (1991). Prenatal lead exposure in the rat during the third week of gestation: Long-term behavioral, physiological and anatomical effects associated with reproduction. Toxicol. Appl. Pharmacol. 110, 206-215.
33. McMichael, A. J., Vimpani, G. V., Robertson, E. F., Baghurst, P. A., and Clark, P. D. (1986). The Port Pirie cohort study: Maternal blood lead and pregnancy outcome. J. Epidemiol. Commun. Health 40, 18-25.
34. Minnema, D. J., and Hammond, P. B. (1994). Effect of lead exposure on patterns of food intake in weanling rats. Neurotoxicol. Teratol. 16, 623-629.
35. Needleman, H. L. (1992). Human Lead Exposure. CRC Press, Boca Raton, FL.
36. Rom, W. N. (1976). Effects of lead on the female and reproduction. Mt. Sinai J. Med. 43, 542-546.
37. Ronis, M. J. J., Lumpkin, C. K., Ingelman-Sundberg, M., and Badger, T. M. (1991). Effects of short-term ethanol and nutrition on the hepatic microsomal monooxygenase system in a model utilizing total enteral nutrition. Alc. Clin. Exp. Res. 15, 693-699.
38. Schwartz, J. (1992). Low level health effects of lead: Growth, developmental and neurological disturbances. In Human Lead Exposure (H. L. Needleman, Ed.), pp. 233-242. CRC Press, Boca Raton, FL.
39. Schwartz, J., Angle, C., and Pitcher, H. (1986). Relationship between childhood blood lead levels and stature. Pediatrics 77, 281-288.
40. Shukla, R., Dietrich, K. N., Bornschein, R. L., Berger, O., and Hammond, P. B. (1991). Lead exposure and growth in the early preschool child: A follow-up report from the Cincinnati lead study. Pediatrics 88, 886-892.
41. Sokol, R. Z. (1987). Hormonal effects of lead acetate in the male rat: Mechanism of action. Biol. Reprod. 37, 1135-1138.
42. Sokol, R. Z. (1990). The effect of duration of exposure on the expression of lead toxicity on the male reproductive axis. J. Androl. 11, 521-526.
43. Sokol, R. Z., and Berman, N. (1991). The effect of age of exposure on lead induced testicular toxicity. Toxicology 69, 269-278.
44. Sokol, R. Z., Madding, C. E., and Swerdloff, R. S. (1985). Lead toxicity and the hypothalamic-pituitary-testicular axis. Biol. Reprod. 33, 722-728.
45. Wiebe, J. P., Barr, K. J., and Buckingham, K. D. (1982). Lead administration during pregnancy and lactation affects steroidogenesis and hormone receptors in the testis of offspring. J. Toxicol. Environ. Health 10, 653-660.
46. Wierman, M. E., Gharib, S. D., LaRovere, J. M., Badger, T. M., and Chin, W. W. (1988). Selective failure of androgens to regulate follicle stimulating hormone β messenger ribonucleic acid levels in the male rat. Mol. Endocrinol. 2, 492-498.
47. Winder, C. (1989). Reproductive and chromosomal effects of occupational exposure to lead. Reprod. Toxicol. 3, 221-226.