Human cytochrome P450 CYP2A13: Predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Cancer Research

Volumn 60, Issue 18, 2000, Pages 5074-5079

  Su, T ^a   Bao, Z ^a   Zhang, Q Y ^a   Smith, T J ^a   Hong, J Y ^a   Ding, X ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; CARCINOGEN; COUMARIN 7 HYDROXYLASE; CYTOCHROME P450 2A13; CYTOCHROME P450 2A6; CYTOCHROME P450 2A7; CYTOCHROME P450 ISOENZYME; HEMPA; N,N DIMETHYLANILINE; NICOTINE; TOBACCO; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CARCINOGENESIS; CATALYSIS; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LUNG; METABOLIC ACTIVATION; NOSE MUCOSA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRACHEA; VIRUS EXPRESSION; XENOBIOTIC METABOLISM;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; BIOTRANSFORMATION; CARCINOGENS; COMPARATIVE STUDY; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; HUMAN; LIVER; LUNG; MIDDLE AGE; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; NASAL MUCOSA; NITROSAMINES; ORGAN SPECIFICITY; PLANTS, TOXIC; POLYMERASE CHAIN REACTION; RESPIRATORY SYSTEM; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, U.S. GOV'T, P.H.S.; TOBACCO;

EID: 0034665139     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. A genetic polymorphism in coumarin 7-hydroxylation: Sequence of the human CYP2A genes and identification of variant CYP2A6 alleles
2. Purification and characterization of human liver microsomal cytochrome P-450 2A6
3. Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes
4. Immunohistochemical localization of a cytochrome P-450 isozyme in human nasal mucosa: Age-related trends
5. Expression of CYP2A genes in rodent and human nasal mucosa
6. Nasal cytochrome P450 2A: Identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen
7. Expression of CYP2A genes in human liver and extrahepatic tissues
8. Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs
9. Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells
10. Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues
11. The CYP2A gene subfamily: Species differences, regulation, catalytic activities and role in chemical carcinogenesis
12. A major rule for CYP2A6 in nicotine C-oxidation by human liver microsomes
13. Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes
14. Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2A6: Role in metabolic activation of nasal toxicants
15. Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonor-nicotine α-hydroxylation by human liver microsomes
16. CYP2A6 gene deletion reduces susceptibility to lung cancer. Biochem
17. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
18. Expression and alternative splicing of the cytochrome P-450 CYP2A7
19. Tobacco smoke carcinogenslung cancer
20. Biochemistry, biology and carcinogenicity of tobacco-specific N-nitrosamines
21. Metabolism of 4-(methylnitrosamino)-1-(3-pyddyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells
22. Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides
23. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate
24. Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6
25. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes
26. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction
27. An improved assay of 7-ethoxycoumarin O-deethylase activity: Induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin
28. Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes P450
29. Metabolism of N-nitrosodialkylamines by human liver microsomes
30. Rat olfactory mucosa displays a high activity in metabolizing methyl ten-butyl ether and other gasoline ethers
31. Role of cytochromes P450 in the metabolism of methyl ten-butyl ether in human livers
32. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates
33. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by inducible and constitutive cytochrome P450 enzymes in rats
34. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from ceil and tissue samples
35. The carbon monoxide-binding protein of liver microsomes. I. Evidence for its hemoprotein nature
36. Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1 - Role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal micrusomes
37. A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans
38. Quantitation of microsomal α-hydroxylation of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
39. Metabolism of methyl tert-butyl ether and other gasoline ethers by human liver microsomes and heterologously expressed human cytochromes P450: Identification of CYP2A6 as a major catalyst
40. Immunochemical characterization of multiple forms of cytochrome P-450 in rabbit nasal microsomes and evidence for tissue-specific expression of P-450s NMa and NMb
41. Tobacco-specific N-nitrosamines, and Areca-derived N-nitrosamines: Chemistry, biochemistry, carcinogenicity, and relevance to humans
42. The molecular epidemiology of lung cancer
43. Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonomicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
44. Approaches to cancer prevention based on an understanding of N-nitrosamine carcinogenesis
45. The epidemiology of malignant neoplasms of the nasal cavities, the paranasal sinuses and the middle ear in Canada
46. Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes
47. Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): Mutational specificity in the gpt gene of AS52 cells