메뉴 건너뛰기




Volumn 165, Issue 2, 2000, Pages 158-162

Expression of biotransformation enzymes in human fetal olfactory mucosa: Potential roles in developmental toxicity

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; EPOXIDE HYDROLASE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

EID: 0034212519     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2000.8923     Document Type: Article
Times cited : (68)

References (31)
  • 1
    • 0023543709 scopus 로고
    • Molecular dosimetry of DNA adduct formation and cell toxicity in rat nasal mucosa following exposure to tobacco-specific nitrosamine 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and their relationship to induction of neoplasia
    • Belinsky S. A., Walker V. E., Maronpot R. R., Swenberg J. A., Anderson M. W. Molecular dosimetry of DNA adduct formation and cell toxicity in rat nasal mucosa following exposure to tobacco-specific nitrosamine 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and their relationship to induction of neoplasia. Cancer Res. 47:1987;6058-6065.
    • (1987) Cancer Res. , vol.47 , pp. 6058-6065
    • Belinsky, S.A.1    Walker, V.E.2    Maronpot, R.R.3    Swenberg, J.A.4    Anderson, M.W.5
  • 2
    • 0025860746 scopus 로고
    • Toxic and neoplastic responses in the nasal passages: Future research needs
    • Bonnefoi M., Monticello T. M., Morgan K. T. Toxic and neoplastic responses in the nasal passages: future research needs. Exp. Lung Res. 17:1991;853-868.
    • (1991) Exp. Lung Res. , vol.17 , pp. 853-868
    • Bonnefoi, M.1    Monticello, T.M.2    Morgan, K.T.3
  • 3
    • 0027170148 scopus 로고
    • Metabolism of xenobiotics in the nasal olfactory mucosa: Implications for local toxicity
    • Brittebo E. B. Metabolism of xenobiotics in the nasal olfactory mucosa: Implications for local toxicity. Pharmacol. Toxicol. 72:1993;50-52.
    • (1993) Pharmacol. Toxicol. , vol.72 , pp. 50-52
    • Brittebo, E.B.1
  • 4
    • 0025838093 scopus 로고
    • Nasal cavity enzymes involved in xenobiotic metabolism: Effects on the toxicity of inhalants
    • Dahl A. R., Hadley W. M. Nasal cavity enzymes involved in xenobiotic metabolism: Effects on the toxicity of inhalants. CRC Crit. Rev. Toxicol. 21:1991;345-372.
    • (1991) CRC Crit. Rev. Toxicol. , vol.21 , pp. 345-372
    • Dahl, A.R.1    Hadley, W.M.2
  • 5
    • 0027967098 scopus 로고
    • Olfactory toxicity resulting from dermal application of 2,6-dichlorobenzonitrile (dichlobenil) in the C57Bl mouse
    • Deamer N. J., O'Callaghan J. P., Genter M. B. Olfactory toxicity resulting from dermal application of 2,6-dichlorobenzonitrile (dichlobenil) in the C57Bl mouse. Neurotoxicol. 15:1994;287-294.
    • (1994) Neurotoxicol. , vol.15 , pp. 287-294
    • Deamer, N.J.1    O'Callaghan, J.P.2    Genter, M.B.3
  • 6
    • 0025278261 scopus 로고
    • Immunochemical characterization of multiple forms of cytochrome P-450 in rabbit nasal microsomes and evidence for tissue-specific expression of P450s NMa and NMb
    • Ding X., Coon M. J. Immunochemical characterization of multiple forms of cytochrome P-450 in rabbit nasal microsomes and evidence for tissue-specific expression of P450s NMa and NMb. Mol. Pharmacol. 37:1990;489-496.
    • (1990) Mol. Pharmacol. , vol.37 , pp. 489-496
    • Ding, X.1    Coon, M.J.2
  • 8
    • 0027053618 scopus 로고
    • Cytochromes P450 NMa, NMb (2G1), and LM4 (1A2) are differentially expressed during development in rabbit olfactory mucosa and liver
    • Ding X., Peng H.-M., Coon M. J. Cytochromes P450 NMa, NMb (2G1), and LM4 (1A2) are differentially expressed during development in rabbit olfactory mucosa and liver. Mol. Pharmacol. 42:1992;1027-1032.
    • (1992) Mol. Pharmacol. , vol.42 , pp. 1027-1032
    • Ding, X.1    Peng, H.-M.2    Coon, M.J.3
  • 9
    • 0029048772 scopus 로고
    • The CYP2A gene subfamily: Species differences, regulation, catalytic activities and role in chemical carcinogenesis
    • Fernandez-Salguero P., Gonzalez F. J. The CYP2A gene subfamily: Species differences, regulation, catalytic activities and role in chemical carcinogenesis. Pharmacogenetics. 5:1995;S123-S128.
    • (1995) Pharmacogenetics , vol.5
    • Fernandez-Salguero, P.1    Gonzalez, F.J.2
  • 12
    • 0027178395 scopus 로고
    • Immunohistochemical localization of a cytochrome P450 isozyme in human nasal mucosa: Age-related trends
    • Getchell M. L., Chen Y., Ding X., Sparks D. L., Getchell T. V. Immunohistochemical localization of a cytochrome P450 isozyme in human nasal mucosa: age-related trends. Otol. Rhinol. Laryngol. 102:1993;368-374.
    • (1993) Otol. Rhinol. Laryngol. , vol.102 , pp. 368-374
    • Getchell, M.L.1    Chen, Y.2    Ding, X.3    Sparks, D.L.4    Getchell, T.V.5
  • 13
    • 0030883797 scopus 로고    scopus 로고
    • Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 And cytotoxicity in the olfactory mucosa
    • Gu J., Walker V. E., Lipinskas T. W., Walker D. M., Ding X. Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 And cytotoxicity in the olfactory mucosa. Toxicol. Appl. Pharmacol. 146:1997;134-143.
    • (1997) Toxicol. Appl. Pharmacol. , vol.146 , pp. 134-143
    • Gu, J.1    Walker, V.E.2    Lipinskas, T.W.3    Walker, D.M.4    Ding, X.5
  • 14
    • 0031862390 scopus 로고    scopus 로고
    • Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1 - role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes
    • Gu J., Zhang Q. Y., Genter M. B., Lipinskas T. W., Negishi M., Nebert D. W., Ding X. Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1 - role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes. J. Pharmacol. Exp. Ther. 285:1998;1287-1295.
    • (1998) J. Pharmacol. Exp. Ther. , vol.285 , pp. 1287-1295
    • Gu, J.1    Zhang, Q.Y.2    Genter, M.B.3    Lipinskas, T.W.4    Negishi, M.5    Nebert, D.W.6    Ding, X.7
  • 15
    • 0031909983 scopus 로고    scopus 로고
    • Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit - role in intrauterine toxicity
    • Hakkola J., Pelkonen O., Pasanen M., Raunio H. Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit - role in intrauterine toxicity. CRC Crit. Rev. Toxicol. 28:1998;35-72.
    • (1998) CRC Crit. Rev. Toxicol. , vol.28 , pp. 35-72
    • Hakkola, J.1    Pelkonen, O.2    Pasanen, M.3    Raunio, H.4
  • 18
    • 0029862553 scopus 로고    scopus 로고
    • Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2A6: Role in metabolic activation of nasal toxicants
    • Liu C., Zhuo X., Gonzalez F. J., Ding X. Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2A6: Role in metabolic activation of nasal toxicants. Mol. Pharmacol. 50:1996;781-788.
    • (1996) Mol. Pharmacol. , vol.50 , pp. 781-788
    • Liu, C.1    Zhuo, X.2    Gonzalez, F.J.3    Ding, X.4
  • 19
    • 0024320060 scopus 로고
    • Metabolism of diethylnitrosamine by microsomes of human respiratory nasal mucosa and liver
    • Longo V., Pacifici G. M., Panattoni G., Ursino F., Gervasi P. G. Metabolism of diethylnitrosamine by microsomes of human respiratory nasal mucosa and liver. Biochem. Pharmacol. 38:1989;1867-1869.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1867-1869
    • Longo, V.1    Pacifici, G.M.2    Panattoni, G.3    Ursino, F.4    Gervasi, P.G.5
  • 20
    • 0027460173 scopus 로고
    • Cytochrome P450 isoforms in human fetal tissues related to phenobarbital-inducible forms in the mouse
    • Maenpaa J., Rane A., Raunio H., Honkakoski P., Pelkonen O. Cytochrome P450 isoforms in human fetal tissues related to phenobarbital-inducible forms in the mouse. Biochem. Pharmacol. 45:1993;899-907.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 899-907
    • Maenpaa, J.1    Rane, A.2    Raunio, H.3    Honkakoski, P.4    Pelkonen, O.5
  • 21
    • 0027262474 scopus 로고
    • Expression of olfactory receptor and transduction genes during rat development
    • Margalit T., Lancet D. Expression of olfactory receptor and transduction genes during rat development. Dev. Brain Res. 73:1993;7-16.
    • (1993) Dev. Brain Res. , vol.73 , pp. 7-16
    • Margalit, T.1    Lancet, D.2
  • 23
    • 0032422311 scopus 로고    scopus 로고
    • Olfactory function in the human fetus: Evidence from selective neonatal responsiveness to the odor of amniotic fluid
    • Schaal B., Marlier L., Soussignan R. Olfactory function in the human fetus: Evidence from selective neonatal responsiveness to the odor of amniotic fluid. Behav. Neurosci. 112:1998;1438-1449.
    • (1998) Behav. Neurosci. , vol.112 , pp. 1438-1449
    • Schaal, B.1    Marlier, L.2    Soussignan, R.3
  • 25
    • 0029789370 scopus 로고    scopus 로고
    • Expression of CYP2A genes in rodent and human nasal mucosa
    • Su T., Sheng J. J., Thomas L. W., Ding X. Expression of CYP2A genes in rodent and human nasal mucosa. Drug Metab. Dispos. 24:1996;884-890.
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 884-890
    • Su, T.1    Sheng, J.J.2    Thomas, L.W.3    Ding, X.4
  • 26
    • 0031018163 scopus 로고    scopus 로고
    • Nasal cytochrome P450 2A: Identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen
    • Thornton-Manning J. R., Nikula K. J., Hotchkiss J. A., Avila K. J., Rohrbacher K. D., Ding X., Dahl A. R. Nasal cytochrome P450 2A: Identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen. Toxicol. Appl. Pharmacol. 142:1997;22-30.
    • (1997) Toxicol. Appl. Pharmacol. , vol.142 , pp. 22-30
    • Thornton-Manning, J.R.1    Nikula, K.J.2    Hotchkiss, J.A.3    Avila, K.J.4    Rohrbacher, K.D.5    Ding, X.6    Dahl, A.R.7
  • 27
    • 0030063499 scopus 로고    scopus 로고
    • Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
    • Wu S., Moomaw C. R., Tomer K. B., Falck J. R., Zeldin D. C. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J. Biol. Chem. 271:1996;3460-3468.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3460-3468
    • Wu, S.1    Moomaw, C.R.2    Tomer, K.B.3    Falck, J.R.4    Zeldin, D.C.5
  • 28
    • 0024464027 scopus 로고
    • CDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: Identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver
    • Yamano S., Nhamburo P. T., Aoyama T., Meyer U. A., Inaba T., Kalow W., Gelboin H. V., McBride O. W., Gonzalez F. J. cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: Identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. Biochemistry. 28:1989;7340-7348.
    • (1989) Biochemistry , vol.28 , pp. 7340-7348
    • Yamano, S.1    Nhamburo, P.T.2    Aoyama, T.3    Meyer, U.A.4    Inaba, T.5    Kalow, W.6    Gelboin, H.V.7    McBride, O.W.8    Gonzalez, F.J.9
  • 29
    • 0025022689 scopus 로고
    • The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
    • Yamano S., Tatsuno J., Gonzalez F. J. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry. 29:1990;1322-1329.
    • (1990) Biochemistry , vol.29 , pp. 1322-1329
    • Yamano, S.1    Tatsuno, J.2    Gonzalez, F.J.3
  • 30
    • 0032524371 scopus 로고    scopus 로고
    • Characterization of the cytochrome P450 CYP2J4-expression in rat small intestine and role in retinoic acid biotransformation from retinal
    • Zhang Q. Y., Raner G., Ding X., Dunbar D., Coon M. J., Kaminsky L. S. Characterization of the cytochrome P450 CYP2J4-expression in rat small intestine and role in retinoic acid biotransformation from retinal. Arch. Biochem. Biophys. 353:1998;257-264.
    • (1998) Arch. Biochem. Biophys. , vol.353 , pp. 257-264
    • Zhang, Q.Y.1    Raner, G.2    Ding, X.3    Dunbar, D.4    Coon, M.J.5    Kaminsky, L.S.6
  • 31
    • 0033058630 scopus 로고    scopus 로고
    • Biotransformation of coumarin by rodent and human cytochromes P-450: Metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice
    • Zhuo X. L., Gu J., Zhang Q. Y., Spink D. C., Kaminsky L. S., Ding X. Biotransformation of coumarin by rodent and human cytochromes P-450: Metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice. J. Pharmacol. Exp. Ther. 288:1999;463-471.
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 463-471
    • Zhuo, X.L.1    Gu, J.2    Zhang, Q.Y.3    Spink, D.C.4    Kaminsky, L.S.5    Ding, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.