Structure-function relationships of human liver cytochromes P450 3A: Aflatoxin B1 metabolism as a probe

Biochemistry

Volumn 37, Issue 36, 1998, Pages 12536-12545

  Wang, Huifen ^a   Dick, Ryan ^a   Yin, Hequn ^a,d   Licad Coles, Estefania ^a   Kroetz, Deanna L ^b   Szklarz, Grazyna ^c   Harlow, Greg ^c   Halpert, James R ^c   Correia, Maria Almira ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN B1; TOXIN;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL METABOLISM; DETOXIFICATION; ENZYME INDUCTION; ENZYME METABOLISM; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MEMBRANE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; VIRUS EXPRESSION;

AFLATOXIN B1; AMINO ACID SEQUENCE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; COMPUTER SIMULATION; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES B5; HUMANS; MALE; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RECOMBINANT PROTEINS; STEREOISOMERISM; STEROID HYDROXYLASES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS PHAGE 3A;

EID: 0032497361     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980895g     Document Type: Article

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