Predominant expression of an arachidonate epoxygenase in islets of langerhans cells in human and rat pancreas

Endocrinology

Volumn 138, Issue 3, 1997, Pages 1338-1346

  Zeldin, Darryl C ^a   Foley, Julie ^a   Boyle, James E ^a,b   Moomaw, Cindy R ^a   Tomer, Kenneth B ^a   Parker, Carol ^a   Steenbergen, Charles ^c   Wu, Shu ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CYTOCHROME P450; GLUCAGON; INSULIN;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME LOCALIZATION; GLUCAGON RELEASE; HORMONAL REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

EID: 0031057495     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.3.4970     Document Type: Article

References (49)

1. Capdevila JH, Zeldin DC, Makita K, Karara A, Falck JR 1995 Cytochrome P450 and the metabolism of arachidonic acid and oxygenated eicosanoids. In: Ortiz de Montellano PR (ed) Cytochrome P450: Structure, Mechanism, and Biochemistry. Plenum Press, New York, pp 443-471 (and references therein)
2. Oliw EH 1994 Oxygenation of polyunsaturated fatty acids by Cytochrome P450 monooxygenases. Prog Lipid Res 33:329-354 (and references therein)
3. Pilote S, Villerand P, Borgeat P 1982 Transformation of arachidonic acid in the rat anterior pituitary. Biochem Biophys Res Commun 104:867-873
4. Snyder GD, Capdevila J, Chacos N, Manna S, Falck JR 1983 Action of luteinizing hormone-releasing hormone: involvement of novel arachidonic acid metabolites. Proc Natl Acad Sci USA 80:3504-3507
5. Judd AM, Koike K, MacLeod RM 1986 A possible role of arachidonate metabolism in the mechanism of prolactin release. Am J Physiol 250:E288-E295
6. Ojeda SR, Naor Z, Negro-Vilar A 1979 The role of prostaglandins in the control of gonadotropin and prolactin secretion. Prostaglandins Med 5:249-275
7. Cashman JR, Hanks D, Weiner RI 1987 Epoxy derivatives of arachidonic acid are potent stimulators of prolactin secretion. Neuroendocrinology 46:246-251
8. Snyder GD, Yadagiri P, Falck JR 1989 Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs. Am J Physiol 256:E221-E226
9. ++ in anterior pituitary cells. Biochem Biophys Res Commun 139:1188-1194
10. Negro-Vilar A, Snyder GD, Falck JR, Manna S, Chacos N, Capdevila J 1985 Involvement of eicosanoids in release of oxytocin and vasopressin from the neural lobe of the rat pituitary. Endocrinology 116:2663-2668
11. Ojeda SR, Urbanski HF, Junier MP, Capdevila J 1989 The role of arachidonic acid and its metabolites in the release of neuropeptides. Ann NY Acad Sci 559:192-207
12. Capdevila J, Chacos N, Falck JR, Manna S, Negro-Villar A, Ojeda SR 1983 Novel hypothalamic arachidonate products stimulate somatostatin release from the median eminence. Endocrinology 113:421-423
13. Nadler JL, Natarajan R, Stern N 1987 Specific action of the lipoxygenase pathway in mediating angiotensin II-induced aldosterone synthesis in isolated adrenal glomerulosa cells. J Clin Invest 80:1763-1769
14. Walsh MF, Pek SB 1984 Possible role of endogenous arachidonic acid metabolites in stimulated release of insulin and glucagon from the isolated, perfused rat pancreas. Diabetes 33:929-936
15. Kelly KL, Laychock SG 1981 Prostaglandin synthesis and metabolism in isolated pancreatic islets of the rat. Prostaglandins 21:759-769
16. Turk J, Colca JR, Kotagal N, McDaniel ML 1984 Arachidonic acid metabolism in isolated pancreatic islets: identification and quantification of lipoxygenase and cyclooxygenase products. Biochim Biophys Acta 794:110-124
17. Yamamoto S, Ishii M, Nakadate T, Nakaki T, Kato R 1983 Modulation of insulin secretion by lipoxygenase products of arachidonic acid. J Biol Chem 258:12149-12152
18. Turk J, Colca JR, Kotagal N, McDaniel ML 1984 Arachidonic acid metabolism in isolated pancreatic islets: the effects of glucose and of inhibitors of arachidonate metabolism on insulin secretion and metabolite synthesis. Biochim Biophys Acta 794:125-136
19. Falck JR, Manna S, Moltz J, Chacos N, Capdevila J 1983 Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. Biochem Biophys Res Commun 114:743-749
20. Turk J, Wolf BA, Comens PG, Colca J, Jakschik B, McDaniel ML 1985 Arachidonic acid metabolism in isolated pancreatic islets: negative ion-mass spectrometric quantitation of monooxygenase product synthesis by liver and islets. Biochim Biophys Acta 835:1-17
21. Wu S, Moomaw CR, Tomer KB, Falck JR, Zeldin DC 1996 Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J Biol Chem 271:3460-3468
22. Zeldin DC, Plitman JD, Kobayashi J, Miller RF, Snapper JR, Falck JR, Szarek JL, Philpot RM, Capdevila JH 1995 The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. J Clin Invest 95:2150-2160
23. Capdevila JH, Dishman E, Karara A, Falck JR 1991 Cytochrome P450 arachidonic acid epoxygenase: stereochemical characterization of epoxyeicosatrienoic acids. Methods Enzymol 206:441-453
24. Hammonds TD, Blair IA, Falck JR, Capdevila JH 1989 Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. Anal Biochem 182:300-303
25. Corey EJ, Marfat A, Falck JR, Albright JO 1980 Controlled chemical synthesis of enzymatically produced eicosanoids 11-, 12- and 15-HETE from arachidonic acid and conversion to corresponding HPETEs. J Am Chem Soc 102:1433-1435
26. Falck JR, Manna S 1982 8,9-Epoxy arachidonic acid: a cytochrome P450 metabolite. Tetrahedron Lett 23:1755-1756
27. Falck JR, Yadagiri P, Capdevila JH 1990 Synthesis of epoxyeicosatrienoic acids and heteroatom analogs. Methods Enzvmol 187:357-364
28. Bradford MM 1976 A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
29. Guengerich FP 1991 Reactions and significance of cytochrome P450 enzymes. J Biol Chem 266:10019-10022
30. Capdevila JH, Wei S, Yan J, Karara A, Jacobson HR, Falck JR, Guengerich FP, Dubois RN 1992 Cytochrome P450 arachidonic acid epoxygenase: regulatory control of the renal epoxygenase by dietary salt loading. J Biol Chem 267:21720-21726
31. Kawabata TT, Wick DG, Guengerich FP, Baron J 1984 Immunohistochemical localization of carcinogen-metabolizing enzymes within the rat and hamster exocrine pancreas. Cancer Res 44:215-223
32. Murray GI, Barnes TS, Sewell HF, Ewen SWB, Melvin WT, Burke MD 1988 The immunocytochemical localization and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P450. Br J Clin Pharmacol 25:465-475
33. Hall PM, Stupans I, Burgess W, Birkett DJ, McManus ME 1989 Immunohistochemical localization of NADPH-cytochrome P450 reductase in human tissues. Carcinogenesis 10:521-530
34. Capdevila J, Gil L, Orellana M, Marnett LJ, Mason JI, Yadagiri P, Falck JR 1988 Inhibitors of cytochrome P450-dependent arachidonic acid metabolism. Arch Biochem Biophys 261:257-263
35. 2+ homeostasis by islet endoplasmic reticulum and its role in insulin secretion. Am J Physiol 254:E121-E136
36. 2+ mobilization by arachidonic acid: comparison with myo-inositol 1,4,5-triphosphate in isolated pancreatic islets. J Biol Chem 261:3501-3511
37. Misler S, Barnett DW, Gillis KD, Pressel DM 1992 Electrophysiology of stimulus-secretion coupling in human β-cells. Diabetes 41:1221-1228
38. Rorsman P, Bokvist K, Ammala C, Eliasson L, Renstrom E, Gabel J 1994 Ion channels, electrical activity, and insulin secretion. Diabetes Metab 20:138-145
39. ++ binding, uptake, and release. Prostaglandins 26:13-21
40. Moffat MP, Ward CA, Bend JR, Mock T, Farhangkhoee P, Karmazyn M 1993 Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. Am J Physiol 264:H1154-H1160
41. Scarpelli DG, Kokkinakis KM, Rao MS, Subbarao V, Luetteke N, Hollenberg PF 1982 Metabolism of the pancreatic carcinogen N-nitroso-2,6-dimethylorpholine by hamster liver and component cells of pancreas. Cancer Res 42:5089-5095
42. Iqbal ZM, Varnes ME, Yoshida A, Epstein SS 1977 Metabolism of benzo-(a)pyrene by guinea pig pancreatic microsomes. Cancer Res 37:1011-1015
43. Karara A, Dishman E, Blair I, Falck JR, Capdevila JH 1989 Endogenous epoxyeicosatrienoic acids: cytochrome P450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase. J Biol Chem 264:19822-19827
44. Katoh T, Takahashi K, Capdevila J, Karara A, Falck JR, Jacobson HR, Badr KF 1991 Clomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. Am J Physiol 261:F578-F586
45. Zeldin DC, Moomaw CR, Jesse N, Tomer KB, Beetham J, Hammock BD, Wu S 1996 Biochemical characterization of the human liver cytochrome P450 arachidonic acid epoxygenase pathway. Arch Biochem Biophys 330:87-96
46. Karara A, Dishman E, Falck JR, Capdevila JH 1990 Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex. FEBS Lett 268:227-230
47. Turk J, Colca JR, McDaniel ML 1985 Arachidonic acid metabolism in isolated pancreatic islets: effects of exogenous lipoxygenase products and inhibitors on insulin secretion. Biochim Biophys Acta 834:23-36
48. Zeldin DC, Kobayashi J, Falck JR, Winder BS, Hammock BD, Snapper JR, Capdevila JH 1993 Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase. J Biol Chem 268:6402-6407
49. Karara A, Dishman E, Falck JR, Capdevila JH 1991 Endogenous epoxyeicosatrienoyl-phospholipids: a novel class of cellular glycerolipids containing epoxidized arachidonate moieties. J Biol Chem 266:7561-7569