Polarity determination in the Drosophila eye: A novel role for unpaired and JAK/STAT signaling

Genes and Development

Volumn 13, Issue 10, 1999, Pages 1342-1353

  Zeidler, Martin P ^a   Perrimon, Norbert ^a   Strutt, David I ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Equator; Hopscotch; Ommatidia; Rotation; Stat92E; Unpaired

Indexed keywords

CYTOKINE; PROTEIN KINASE;

ANIMAL EXPERIMENT; ARTICLE; DROSOPHILA; EMBRYO POLARITY; EMBRYO SEGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EYE DEVELOPMENT; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; HEMATOPOIESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0033563103     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.10.1342     Document Type: Article

References (47)

1. Baker, N.E. and G.M. Rubin. 1992. Ellipse mutations in the Drosophila homologue of the EGF receptor affect pattern formation, cell division, and cell death in eye imaginal discs. Dev. Biol 150: 381-396.
2. Binari, R. and N. Perrimon. 1994. Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes & Dev. 8: 300-312.
3. Bonni, A., Y. Sun, V.M. Nadal, A. Bhatt, D.A. Frank, I. Rozovsky, N. Stahl, G.D. Yancopoulos and M.E. Greenberg. 1997. Regulation of gliagenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278: 477-483.
4. Brand, A.H. and N. Perrimon. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
5. Brodsky, M.H. and H. Steller. 1996. Positional information along the dorsal-ventral axis of the Drosophila eye: Graded expression of the four-jointed gene. Dev. Biol. 173: 428-446.
6. Chanut, F. and U. Heberlein. 1995. Role of the morphogenetic furrow in establishing polarity in the Drosophila eye. Development 121: 4085-4094.
7. Cho, K.-O. and K.-W. Choi. 1998. Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye. Nature 396: 272-276.
8. Choi, K.W., B. Mozer, and S. Benzer. 1996. Independent determination of symmetry and polarity in the Drosophila eye. Proc. Natl. Acad. Sci. 93: 5737-5741.
9. Cooper, M.T.D. and S.J. Bray. 1999. Frizzled regulation of Notch signaling polarizes cell fate in the Drosophila eye. Nature 397: 526-530.
10. Darnell, J.J. 1997. STATs and gene regulation. Science 277: 1630-1635.
11. Davis, I., C.H. Girdham, and P.H. O'Farrell. 1995. A nuclear GFP that marks nuclei in living Drosophila embryos: Maternal supply overcomes a delay in the appearance of zygotic fluorescence. Dev. Biol. 170: 726-729.
12. Domínguez, M. and J.F. de Celis. 1998. A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature 396: 276-278.
13. Durbin, J.E., R. Hackenmiller, M.C. Simon, and D.E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84: 443-450.
14. Fanto, M. and M. Mlodzik. 1999. Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye. Nature 397: 523-526.
15. Golic, K.G. and S. Lindquist. 1989. The FLP recombinase of yeast catalyses site-specific recombination in the Drosophila genome. Cell 59: 499-509.
16. Hanratty, W.P. and C.R. Dearolf 1993. The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus. Mol. & Gen. Genet. 238: 33-37.
17. Harrison, D.A., R. Binari, T.S. Nahreini, M. Gilman, and N. Perrimon. 1995, Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J. 14: 2857-2865.
18. Harrison, D.A., P.E. McCoon, R. Binari, M. Gilman, and N. Perrimon. 1998. Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes & Dev. 12: 3252-3263.
19. Heberlein, U., E. Borod, and F. Chanut. 1998. Dorsoventral patterning in the Drosophila retina by wingless. Development 125: 567-577.
20. Hou, X.S., M.B. Melnick, and N. Perrimon. 1996. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell 84: 411-419.
21. Ito, K., W. Awano, K. Suzuki, Y. Hiromi, and D. Yamamoto. 1997. The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells. Development 124: 761-771.
22. Kaplan, M.H, Y.L. Sun, T. Hoey, and M.J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382: 174-177.
23. Liu, X., G.W. Robinson, K.U. Wagner, L. Garrett, B.A. Wynshaw, and L. Hennighausen. 1997. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes & Dev. 11: 179-186.
24. Luo, H., W.P. Hanratty, and C.R. Dearolf. 1995. An ammo acid substitution in the Drosophila hopTum-1 Jak kinase causes leukemia-like hematopoietic defects. EMBO J. 14: 1412-1420.
25. Ma, C. and K. Moses. 1995. Wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye. Development 121: 2279-2289.
26. Macchi, P., A. Villa, S. Gillani, M.G. Sacco, A. Frattini, F. Porta, A.G. Ugazio, J.A. Johnston, F. Candotti, J.J. O'Shea, P. Vezzoni, and L.D. Notarangelo. 1995. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 377: 65-68.
27. McNeill, H., C.H. Yang, M. Brodsky, J. Ungos, and M.A. Simon. 1997. mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. Genes & Dev. 11: 1073-1082.
28. O'Shea, J.J. 1997. Jaks, STATs, cytokine signal transduction, and immunoregulation: Are we there yet? Immunity 7; 1-11.
29. Papayannopoulos, V., A. Tomlinson, V.M. Panin, C. Rauskolb, and K.D. Irvine. 1998. Dorsal-ventral signaling in the Drosophila eye. Science 281: 2031-2034.
30. Perrimon, N. and A.P. Mahowald. 1986. I(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila. Dev. Biol. 118: 28-41.
31. Reifegerste, R., C. Ma, and K. Moses. 1997. A polarity field is established early in the development of the Drosophila compound eye. Mech. Dev. 68: 69-79.
32. Robinow, S. and K. White. 1991. Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J. Neurobiol. 22: 443-461.
33. Schindler, C., K. Shuai, V.R. Prezioso, and J.E. Darnell. 1992. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257: 809-813.
34. Shimoda, K., J. van Dearsen, M.Y. Sangster, S.R. Sarawar, R.T. Carson, R.A. Tripp, C. Chu, F.W. Quelle, T. Nosaka, D.A. Vignali, P.C. Doherty, G. Grosveld, W.E. Paul, and J.N. Ihle. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380: 630-633.
35. Spana, E.P. and C.Q. Doe. 1995. The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development 121: 3187-3195.
36. Struhl, G. and K. Basler. 1993. Organizing activity of wingless protein in Drosophila. Cell 72: 527-540.
37. Strutt, D.I. and M. Mlodzik. 1995. Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions. Development 121: 4247-4256.
38. Sweitzer, S.M., S. Calvo, M.H. Kraus, D.S. Finbloom, and A.C. Lamer 1995. Characterization of a Stat-like DNA binding activity in Drosophila melanogaster. J. Biol. Chem. 270: 16510-16513.
39. Tomlinson, A. and D.F. Ready. 1987. Neuronal differentiation in the Drosophila ommatidium. Dev. Biol. 120: 366-376.
40. Treisman, J.E. and G.M. Rubin. 1995. wingless inhibits morphogenetic furrow movement in the Drosophila eye disc. Development 121: 3519-3527.
41. Vinson, C.R., S. Conover, and P.N. Adler. 1989. A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains. Nature 338: 263-264.
42. Wehrli, M. and A. Tomlinson. 1998. Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis. Development 125: 1421-1432.
43. Wolff, T. and D.F. Ready. 1993. Pattern formation in the Drosophila retina. In The development of Drosophila melanogaster (ed. M. Bate and A. Martinez-Arias). pp. 1277-1326, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
44. Xu, T. and G.M. Rubin. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
45. Yan, R., H. Luo, J. Darnell, and C.R. Dearolf. 1996a. A JAK-STAT pathway regulates wing vein formation in Drosophila. Proc. Natl. Acad. Sci. 93: 5842-5847.
46. Yan, R., S. Small, C. Desplan, C.R. Dearolf, and J.J. Darnell. 1996b. Identification of a Stat gene that functions in Drosophila development. Cell 84: 421-430.
47. Zheng, L., J. Zhang, and R.W. Carthew. 1995. frizzled regulates mirror-symmetric pattern formation in the Drosophila eye. Development 121: 3045-3055.