Activation of the MHC class II transactivator CIITA by interferon-γ requires cooperative interaction between Stat1 and USF-1

Immunity

Volumn 8, Issue 2, 1998, Pages 157-166

  Muhlethaler Mottet, Annick ^a   Berardino, Wilma Di ^a   Otten, Luc A ^a   Mach, Bernard ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; STAT1 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UPSTREAM STIMULATORY FACTOR 1;

ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR INTERACTION; PRIORITY JOURNAL; TRANSACTIVATION;

EID: 0032006255     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80468-9     Document Type: Article

References (49)

1. Ayer, D.E., Kretzner, L., and Eisenman, R.N. (1993). Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72, 211-222.
2. Beckmann, H., Su, L., and Kadesch, T. (1990). TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer μE3. Genes Dev. 4, 167-179.
3. Blackwood, E.M., and Eisenman, R.N. (1991). Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251, 1211-1217.
4. Boehm, U., Klamp, T., Groot, M., and Howard, J.C. (1997). Cellular responses to interferon-gamma. Ann. Rev. Immunol. 15, 749-795.
5. Briken, V., Ruffner, H., Schultz, U., Schwarz, A., Reis, L.F., Strehlow, I., Decker, T., and Staeheli, P. (1995). Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon. Mol. Cell Biol. 15, 975-982.
6. Carr, C.S., and Sharp, P. (1990). A helix-loop-helix protein related to the immunoglobulin Ebox-binding proteins. Mol. Cell. Biol. 10, 4384-4388.
7. Caterina, J.J., Ciavatta, D.J., Donze, D., Behringer, R.R., and Townes, T.M. (1994). Multiple elements in human beta-globin locus control region 5′ HS 2 are involved in enhancer activity and position-independent, transgene expression. Nucleic Acids Res. 22, 1006-1011.
8. Chang, L.A., Smith, T., Pognonec, P., Roeder, R.G., and Murialdo, H. (1992). Identification of USF as the ubiquitous murine factor that binds to and stimulates transcription from the immunoglobulin lambda 2-chain promoter. Nucleic Acids Res. 20, 287-293.
9. Chang, C.H., Fontes, J.D., Peterlin, M., and Flavell, R.A. (1994). Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes. J. Exp. Med. 180, 1367-1374.
10. Choo, Y., Sanchez Garcia, I., and Klug, A. (1994). In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence. Nature 372, 642-645.
11. Darnell, J.E., Jr. (1997). STATs and gene regulation. Science 277, 1630-1635.
12. Darnell, J.E., Jr., Kerr, I.M., and Stark, G.R. (1994). Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421.
13. Decker, T., Lew, D.J., Mirkovitch, J., and Darnell, J.E. (1991). Cytoplasmic activation of GAF, an IFNγamma-regulated DNA-binding factor. EMBO J 10, 927-932.
14. Durand, B., Sperisen, P., Emery, P., Barras, E., Zufferey, M., Mach, B., and Reith, W. (1997). RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency. EMBO J. 16, 1045-1055.
15. Glimcher, L.H., and Kara, C.J. (1992). Sequences and factors: a guide to MHC class-II transcription. Annu. Rev. Immunol. 10, 13-49.
16. Greenlund, A.C., Morales, M.O., Viviano, B.L., Yan, H., Krolewski, J., and Schreiber, R.D. (1995). Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity 2, 677-687.
17. Gregor, P.D., Sawadago, M., and Roeder, R.G. (1990). The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Dev. 4, 1730-1740.
18. Griscelli, C., Lisowska-Grospierre, B., and Mach, B. (1989). Combined immunodeficiency with defective expression in MHC class II genes. Immunodefic. Rev. 1, 135-153.
19. Harroch, S., Revel, M., and Chebath, J. (1994). Induction by interleukin-6 of Interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA. EMBO J. 13, 1942-1949.
20. Hobart, M., Ramassar, V., Goes, N., Urmson, J., and Halloran, P.F. (1997). IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo. J. Immunol. 158, 4260-4269.
21. Kamijo, R., Harada, H., Matsuyama, T., Bosland, M., Gerecitano, J., Shapiro, D., Le, J., Koh, S.I., Kimura, T., Green, S.J., et al. (1994). Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263, 1612-1615.
22. Kimura, T., Nakayama, K., Penninger, J., Kitagawa, M., Harada, H., Matsuyama, T., Tanaka, N., Kamijo, R., Vilcek, J., Mak, T.W., and Taniguchi, T. (1994). Involvement of the IRF-1 transcription factor in antiviral response to interferons. Science 264, 1921-1924.
23. Kobr, M., Reith, W., Herrero Sanchez, C., and Mach, B. (1990). Two DNA-binding proteins discriminate between the promoters of different members of the major histocompatibility complex class II multigene family. Mol. Cell. Biol. 10, 965-971.
24. Lee, Y.J., and Benveniste, E.N. (1996). Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes. J. Immunol. 157, 1559-1568.
25. Littlewood, T.D., Amati, B., Land, H., and Evan, G.I. (1992). Max and c-Myc/Max DNA-binding activities in cell extracts. Oncogene 7, 1783-1792.
26. Look, D.C., Pelletier, M.R., Tidwell, R.M., Roswit, W.T., and Holtzman, M.J. (1995). Stat1 depends on transcriptional synergy with Sp1. J. Biol. Chem. 270, 30264-30267.
27. Mach, B., Steimle, V., and Reith, W. (1994). MHC class II-deficient combined immunodeficiency: a disease of gene regulation. Immunol. Rev. 138, 207-221.
28. Mach, B., Steimle, V., Martinez-Soria, E., and Reith, W. (1996). Regulation of MHC class II genes: lessons from a disease. Annu. Rev. Immunol. 14, 301-331.
29. Meraz, M.A., White, J.M., Sheehan, K.C., Bach, E.A., Rodig, S.J., Dighe, A.S., Kaplan, D.H., Riley, J.K., Greenlund, A.C., Campbell, D., R.D., et al. (1996). Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84, 431-442.
30. Muhlethaler-Mottet, A., Otten, L.A., Steimle, V., and Mach, B. (1997). Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 16, 2851-2860.
31. Ohmori, Y., Schreiber, R.D., and Hamilton, T.A. (1997). Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB. J Biol. Chem. 272, 14899-14907.
32. Otten, L.A., Steimle, V., Bontron, S., and Mach, B. (1998). Quantitative control of MHC class II expression by the transactivator CIITA. Eur. J. Immunol. 28, 473-478.
33. Peritz, L.N., Fodor, E.J., Silversides, D.W., Cattini, P.A., Baxter, J.D., and Eberhardt, N.L. (1988). The human growth hormone gene contains both positive and negative control elements. J. Biol. Chem. 263, 5005-5007.
34. Pognonec, P., and Roeder, R.G. (1991). Recombinant 43-kDa USF binds to DNA and activates transcription in a manner indistinguishable from that of natural 43/44-kDa USF. Mol. Cell Biol. 11, 5125-5136.
35. Reisman, D., and Rotter, V. (1993). The helix-loop-helix containing transcription factor USF binds to and transactivates the promoter of the p53 tumor suppressor gene. Nucleic Acids Res. 21, 345-350.
36. Reith, W., Satola, S., Herrero Sanchez, C., Amaldi, I., Lisowska-Grospierre, B., Griscelli, C., Hadam, M.R., and Mach, B. (1988). Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Cell 53, 897-906.
37. Reith, W., Kobr, M., Emery, P., Durand, B., Siegrist, C.A., and Mach, B. (1994a). Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promoters. J. Biol. Chem. 269, 20020-20025.
38. Reith, W., Siegrist, C.A., Durand, B., Barras, E., and Mach, B. (1994b). Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y. Proc. Natl. Acad. Sci. USA 91, 554-558.
39. Riccio, A., Pedone, P.V., Lund, L.R., Olesen, T., Olsen, H.S., and Andreasen, P.A. (1992). Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor 1 in the type 1 plasminogen activator inhibitor gene. Mol. Cell Biol. 12, 1846-1855.
40. Roy, A.L., Meisterernst, M., Pognonec, P., and Roeder, R.G. (1991). Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF. Nature 354, 245-248.
41. Schindler, C., and Darnell, J.E. (1995). Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64, 621-651.
42. Silacci, P., Mottet, A., Steimle, V., Reith, W., and Mach, B. (1994). Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA. J. Exp. Med. 180, 1329-1336.
43. Sirito, M., Lin, Q., Maity, T., and Sawadogo, M. (1994). Ubiquitous expression of the 43-and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res. 22, 427-433.
44. Sperisen, P., Wang, S.M., Reichenbach, P., and Nabholz, M. (1992). A PCR-based assay for reporter gene expression. PCR Meth. Appl. 1, 164-170.
45. Steimle, V., Otten, L.A., Zufferey, M., and Mach, B. (1993). Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75, 135-146.
46. Steimle, V., Siegrist, C., Mottet, A., Lisowska-Grospierre, B., and Mach, B. (1994). Regulation of MHC class II expression by Interferon-gamma mediated by the transactivator gene CIITA. Science 265, 106-109.
47. Steimle, V., Durand, B., Barras, E., Zufferey, M., Hadam, M.R., Mach, B., and Reith, W. (1995). A novel DNA binding regulatory factor is mutated in primary MHC class II deficiency (Bare Lymphocyte Syndrome). Genes and Dev. 9, 1021-1032.
48. Zhang, J.J., Vinkemeier, U., Gu, W., Chakravarti, D., Horvath, C.M., and Darnell, J.E. (1996). Two contact regions between Stat1 and CBP/p300in interferon gamma signaling. Proc. Natl. Acad. Sci. USA 93, 15092-15096.
49. Zhou, H., and Glimcher, L.H. (1995). Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency. Immunity 2, 545-553.