What does Stat3 do?

Journal of Clinical Investigation

Volumn 109, Issue 9, 2002, Pages 1143-1148

  Levy, David E ^a   Lee, Chien Kuo ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; INTERLEUKIN 6; STAT PROTEIN; STAT3 PROTEIN;

ACUTE PHASE RESPONSE; BONE MARROW CELL; BREAST DEVELOPMENT; DNA BINDING; EMBRYO DEVELOPMENT; GENE TARGETING; INFLAMMATION; KNOCKOUT MOUSE; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SKIN; T LYMPHOCYTE; THYMUS;

EID: 0036256644     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215650     Document Type: Review

References (47)

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2. Interferon-dependent transcriptional activation: Signal transduction without second messenger involvement?
3. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
4. STAT family of transcription factors in cytokine-mediated biological responses
5. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
6. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
7. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
8. Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
9. Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth facrors
10. gp130 and the interleukin-6 family of cytokines
11. Interleukin-6-type cytokine signalling through the gp 130/Jak/STAT pathway 1
12. A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6
13. Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)
14. Serine phosphorylation of STATs
15. Ser727-dependent recruitment of MCM5 by stat1alpha in IFN-gamma-induced transcriptional activation
16. Leukemia inhibitoty factor-dependent transcriptional activation in embryonic stem cells
17. Self-renewal of pluriporenr embryonic stem cells is mediated via activation of STAT3
18. Essential role of STAT3 for embryonic stem cell pluripotency
19. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
20. Essential Role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation in the liver
21. STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation
22. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
23. Interleukin-10 receptor signaling through theJAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action
24. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice
25. Stat proteins and oncogenesis
26. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
27. STAT signaling is active during early mammalian development
28. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cycokines, leads to myocardial and hematological disorders
29. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
30. Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing moroneurons
31. Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathways
32. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
33. Strain-dependent epithelial defects in mice lacking the EGF receptor
34. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
35. c-Src activates both STAT1 and STAT3 in PDGF-stimulated N1H3T3 cells
36. Targeted disruption of the c-src proro-oncogene leads to osteoperrosis in mice
37. Src family kinases are required for integrin but not PDGFR signal transduction
38. Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice
39. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice
40. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
41. Stat3 in thymic epithelial cells is essential for post-natal maintenance of thymic architecture and thymocyte survival
42. Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-defiient T lymphocytes
43. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
44. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3
45. Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons
46. Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult
47. Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock