Longer and shorter forms of Sendai virus C proteins play different roles in modulating the cellular antiviral response

Journal of Virology

Volumn 75, Issue 15, 2001, Pages 6800-6807

  Garcin, D ^a   Curran, J ^a   Itoh, M ^a   Kolakofsky, D ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GENE PRODUCT; INTERFERON; STAT1 PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL DEATH; CYTOPATHOGENIC EFFECT; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; RNA SYNTHESIS; SENDAI VIRUS; SIGNAL TRANSDUCTION; VESICULAR STOMATITIS VIRUS; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CRICETINAE; CYTOPATHOGENIC EFFECT, VIRAL; DNA-BINDING PROTEINS; GENES, VIRAL; HELA CELLS; HUMANS; INTERFERON-ALPHA; INTERFERON-STIMULATED GENE FACTOR 3; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; JANUS KINASE 1; MACACA MULATTA; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; PROTEIN-TYROSINE KINASES; RESPIROVIRUS; RNA, VIRAL; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; VIRAL PROTEINS;

EID: 0034952729     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.15.6800-6807.2001     Document Type: Article

References (44)

1. The Sendai paramyxovirus accessory C proteins inhibit viral genome amplification in a promoter-specific fashion
2. The rule of six: A basic feature for efficient replication of Sendai virus defective interfering RNA
3. How Stat1 mediates constitutive gene expression: A complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene
4. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis
5. The Sendai virus nonstructural C proteins specifically inhibit viral mRNA synthesis
6. An acidic activation-like domain of the Sendai virus P protein is required for RNA synthesis and encapsidation
7. An N-terminal domain of the Sendai virus P protein acts as a chaperone for NP protein during the nascent chain assembly step of genome replication
8. Reexamination of the Sendai virus P protein domains required for RNA synthesis: A possible supplemental role for the P protein
9. Translational gymnastics on the Sendai virus P/C mRNA
10. Normal cellular replication of Sendai without the trans-frame, nonstructural V protein
11. Site-directed mutagenic analysis of reovirus sigma 3 protein binding to dsRNA
12. The V protein of simian virus 5 inhibits interferon signaling by targeting STAT1 for proteasome-mediated degradation
13. Sendai virus and simian virus 5 block activation of interferon-responsive genes: Importance for virus pathogenesis
14. A highly recombinogenie system for the recovery of infectious Sendai paramyxovirus from cDNA: Generation of a novel copy-back nondefective interfering virus
15. A point mutation in the Sendai virus accessory C proteins attenuates virulence for mice, but not virus growth in cell culture
16. The short Sendai virus leader region controls induction of programmed cell death
17. Sendai virus C proteins counteract the interferon-mediated induction of an antiviral state
18. Sendai virus C proteins must interact directly with cellular components to interfere with interferon action
19. Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon-alpha/beta-mediated responses
20. Versatility of the accessory C proteins of Sendai virus: Contribution to virus assembly as an additional role
21. Increased induction of apoptosis by a Sendai virus mutant is associated with attenuation of mouse pathogenicity
22. Isolation of an avirulent mutant of Sendai virus with two amino acid mutations from a highly virulent field strain through adaptation to LLC-MK2 cells
23. The paramyxovirus Sendai virus V protein encodes a luxury function required for viral pathogenesis
24. The β-interferon promoter responds to priming through multiple independent regulatory elements
25. STAT1 is inactivated by a caspase
26. Sendai virus blocks alpha interferon signaling to signal transducers and activators of transcription
27. Defective TNFα-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
28. Sendai virus C proteins are categorically non-essential gene products but silencing their expression severely impairs viral replication and pathogenesis
29. The synthesis of Sendai virus polypeptides in infected cells
30. The various Sendai virus C proteins are not functionally equivalent and exert both positive and negative effects on viral RNA accumulation during the course of infection
31. Sendai virus Y proteins are initiated by a ribosomal shunt
32. The neutralization of type I IFN biologic actions by anti-IFNAR-2 monoclonal antibodies is not entirely due to inhibition of jak-stat tyrosine phosphorylation
33. The effects of monoclonal antibodies on biological activities of structural proteins of Sendai virus
34. Partial characterization of a Sendai virus replication promoter and the rule of six
35. STATs as activators of apoptosis
36. Evidence for a newly discovered cellular anti-HIV-1 phenotype
37. How cells respond to interferons
38. Inhibition of Sendai virus genome replication due to promoter-increased selectivity: A possible role for the accessory C proteins
39. Two mRNAs that differ by two nontemplated nucleotides encode the amino coterminal proteins P and V of the parmyxovirus SV5
40. When accessories turn out to be essential
41. A stuttering model for paramyxovirus P mRNA editing
42. Single amino acid changes that render human IFN-alpha 2 biologically active on mouse cells
43. Association of the Sendai virus C protein with nucleocapsids
44. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase