Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction

Journal of Virology

Volumn 76, Issue 9, 2002, Pages 4190-4198

  Parisien, Jean Patrick ^a   Lau, Joe F ^a   Rodriguez, Jason J ^a   Ulane, Christina M ^a   Horvath, Curt M ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; BETA INTERFERON; BETA INTERFERON RECEPTOR; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 9; JANUS KINASE; PROTEIN TYROSINE KINASE; STAT PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; PARAMYXOVIRUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SIMIAN VIRUS; SOMATIC CELL; TRANSCRIPTION INITIATION; VIRUS CELL INTERACTION; VIRUS PATHOGENESIS; VIRUS REPLICATION;

ANIMALS; CELL LINE; DNA-BINDING PROTEINS; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; INTERFERON-STIMULATED GENE FACTOR 3; INTERFERON-STIMULATED GENE FACTOR 3, GAMMA SUBUNIT; PARAINFLUENZA VIRUS 2, HUMAN; RUBULAVIRUS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; VIRAL PROTEINS; VIRAL STRUCTURAL PROTEINS;

EID: 0036223378     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.9.4190-4198.2002     Document Type: Article

References (57)

1. Three- dimensional structure of the Stat3β homodimer bound to DNA
2. Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain
3. Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication
4. A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation
5. Resistance to interferon of a human adenocarcinoma cell line. HEC-1, and its sensitivity to natural killer cell action
6. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
7. UV-damaged DNA binding proteins are targets of Cul4A-mediated ubiquitination and degradation
8. STATs and gene regulation
9. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
10. Sendai virus and simian virus 5 block activation of interferon-responsive genes: Importance for virus pathogenesis
11. The V protein of simian virus 5 inhibits interferon signaling by targeting STAT1 for proteasome-mediated degradation
12. Sendai virus C proteins must interact directly with cellular components to interfere with interferon action
13. Sendai virus C proteins counteract the interferon-mediated induction of an antiviral state
14. Interferons: Cell signalling, immune modulation, antiviral response and virus countermeasures
15. Immunoproteasome assembly: Cooperative incorporation of interferon gamma (IFN-γ)-inducible subunits
16. A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1
17. The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends on a protein tyrosine phosphatase
18. Recovery of infectious SV5 from cloned DNA and expression of a foreign gene
19. STAT proteins and transcriptional responses to extracellular signals
20. The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein
21. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex
22. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
23. Virus interference. I. The interferons
24. Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons
25. RNA replication from the simian virus 5 antigenomic promoter requires three sequence-dependent elements separated by sequence-independent spacer regions
26. Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase
27. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors
28. Role of STAT2 in the alpha interferon signaling pathway
29. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling
30. The paramyxovirus simian virus 5 V protein slows progression of the cell cycle
31. The V protein of the paramyxovirus SV5 interacts with damage-specific DNA binding protein
32. Nuclear export signal located within the DNA-binding domain of the STAT1 transcription factor
33. High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons
34. The genetics of proteasomes and antigen processing
35. Regulation of STAT1 nuclear export by Jak1
36. The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
37. Complementation of a mutant cell line: Central role of the 91-kDa polypeptide of ISGF3 in the interferon-α and -γ signal transduction pathway
38. The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells
39. The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2
40. Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway
41. Function of Stat2 protein in transcriptional activation by IFN-α
42. Cullin 4A associates with the UV-damaged DNA-binding protein DDB
43. 2-phosphotyrosyl peptide interactions
44. Genetic analysis of interferon and other mammalian signaling pathways
45. How cells respond to interferons
46. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein
47. Abnormal behavior of interferon-induced enzymatic activities in an interferon-resistant cell line
48. 2 terminal domains stabilizes binding of two dimers to tandem DNA sites
49. Structure of the amino-terminal protein interaction domain of STAT-4
50. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1
51. Cooperative DNA binding and sequence selective recognition conferred by the Stat amino terminal domain
52. Binding of human interferon alpha to cells of different sensitivities: Studies with internally radiolabeled interferon retaining full biological activity
53. Single amino acid substitution in the V protein of simian virus 5 differentiates its ability to block interferon signaling in human and murine cells
54. Paramyxoviridae use distinct virus-specific mechanisms to circumvent the interferon response
55. Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein
56. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation