-
2
-
-
0033520326
-
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
-
(1999)
Cell
, vol.98
, pp. 597-608
-
-
Alexander, W.S.1
Starr, R.2
Fenner, J.E.3
Scott, C.L.4
Handman, E.5
Sprigg, N.S.6
Corbin, J.E.7
Cornish, A.L.8
Darwiche, R.9
Owczarek, C.M.10
Kay, T.W.11
Nicola, N.A.12
Hertzog, P.J.13
Metcalf, D.14
Hilton, D.J.15
-
3
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
Gillette, J.4
Schubert, M.5
Orban, P.C.6
Klein, R.7
Krone, W.8
Muller-Wieland, D.9
Kahn, C.R.10
-
6
-
-
0035804251
-
The lipid phosphatase SHIP2 controls insulin sensitivity
-
(2001)
Nature
, vol.409
, pp. 92-97
-
-
Clement, S.1
Krause, U.2
Desmedt, F.3
Tanti, J.F.4
Behrends, J.5
Pesesse, X.6
Sasaki, T.7
Penninger, J.8
Doherty, M.9
Malaisse, W.10
Dumont, J.E.11
Le Marchand-Brustel, Y.12
Erneux, C.13
Hue, L.14
Schurmans, S.15
-
9
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
Payette, P.2
Michaliszyn, E.3
Cromlish, W.4
Collins, S.5
Loy, A.L.6
Normandin, D.7
Cheng, A.8
Himms-Hagen, J.9
Chan, C.C.10
Ramachandran, C.11
Gresser, M.J.12
Tremblay, M.L.13
Kennedy, B.P.14
-
12
-
-
0034513781
-
Insulin receptor substrate (IRS) transduction system: Distinct and overlapping signaling potential
-
(2000)
Diabetes Metab. Res. Rev.
, vol.16
, pp. 434-441
-
-
Giovannone, B.1
Scaldaferri, M.L.2
Federici, M.3
Porzio, O.4
Lauro, D.5
Fusco, A.6
Sbraccia, P.7
Borboni, P.8
Lauro, R.9
Sesti, G.10
-
13
-
-
0035798660
-
A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 40746-40754
-
-
Hanada, T.1
Yoshida, T.2
Kinjyo, I.3
Minoguchi, S.4
Yasukawa, H.5
Kato, S.6
Mimata, H.7
Nomura, Y.8
Seki, Y.9
Kubo, M.10
Yoshimura, A.11
-
16
-
-
0035918239
-
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 12530-12538
-
-
Kamizono, S.1
Hanada, T.2
Yasukawa, H.3
Minoguchi, S.4
Kato, R.5
Minoguchi, M.6
Hattori, K.7
Hatakeyama, S.8
Yada, M.9
Morita, S.10
Kitamura, T.11
Kato, H.12
Nakayama, K.13
Yoshimura, A.14
-
17
-
-
0035839577
-
MUF1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29748-29753
-
-
Kamura, T.1
Burian, D.2
Yan, Q.3
Schmidt, S.L.4
Lane, W.S.5
Querido, E.6
Branton, P.E.7
Shilatifard, A.8
Conaway, R.C.9
Conaway, J.W.10
-
18
-
-
0032535364
-
The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
-
(1998)
Genes Dev.
, vol.12
, pp. 3872-3881
-
-
Kamura, T.1
Sato, S.2
Haque, D.3
Liu, L.4
Kaelin W.G., Jr.5
Conaway, R.C.6
Conaway, J.W.7
-
19
-
-
0035862334
-
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation
-
(2001)
J. Exp. Med.
, vol.193
, pp. 263-269
-
-
Kawazoe, Y.1
Naka, T.2
Fujimoto, M.3
Kohzaki, H.4
Morita, Y.5
Narazaki, M.6
Okumura, K.7
Saitoh, H.8
Nakagawa, R.9
Uchiyama, Y.10
Akira, S.11
Kishimoto, T.12
-
23
-
-
0033520389
-
SOCS3 is essential in the regulation of fetal liver erythropoiesis
-
(1999)
Cell
, vol.98
, pp. 617-627
-
-
Marine, J.C.1
McKay, C.2
Wang, D.3
Topham, D.J.4
Parganas, E.5
Nakajima, H.6
Pendeville, H.7
Yasukawa, H.8
Sasaki, A.9
Yoshimura, A.10
Ihle, J.N.11
-
24
-
-
0033520467
-
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
-
(1999)
Cell
, vol.98
, pp. 609-616
-
-
Marine, J.C.1
Topham, D.J.2
McKay, C.3
Wang, D.4
Parganas, E.5
Stravopodis, D.6
Yoshimura, A.7
Ihle, J.N.8
-
25
-
-
0031581086
-
Cloning and characterization of novel CIS family genes
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.239
, pp. 439-446
-
-
Masuhara, M.1
Sakamoto, H.2
Matsumoto, A.3
Suzuki, R.4
Yasukawa, H.5
Mitsui, K.6
Wakioka, T.7
Tanimura, S.8
Sasaki, A.9
Misawa, H.10
Yokouchi, M.11
Ohtsubo, M.12
Yoshimura, A.13
-
27
-
-
0034729710
-
Gigantism in mice lacking suppressor of cytokine signalling-2
-
(2000)
Nature
, vol.405
, pp. 1069-1073
-
-
Metcalf, D.1
Greenhalgh, C.J.2
Viney, E.3
Willson, T.A.4
Starr, R.5
Nicola, N.A.6
Hilton, D.J.7
Alexander, W.S.8
-
28
-
-
0035864739
-
The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells
-
(2001)
Oncogene
, vol.20
, pp. 849-858
-
-
Monni, R.1
Santos, S.C.2
Mauchauffe, M.3
Berger, R.4
Ghysdael, J.5
Gouilleux, F.6
Gisselbrecht, S.7
Bernard, O.8
Penard-Lacronique, V.9
-
30
-
-
13044276245
-
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15577-15582
-
-
Naka, T.1
Matsumoto, T.2
Narazaki, M.3
Fujimoto, M.4
Morita, Y.5
Ohsawa, Y.6
Saito, H.7
Nagasawa, T.8
Uchiyama, Y.9
Kishimoto, T.10
-
31
-
-
0033555258
-
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
-
(1999)
EMBO J.
, vol.18
, pp. 375-385
-
-
Nicholson, S.E.1
Willson, T.A.2
Farley, A.3
Starr, R.4
Zhang, J.G.5
Baca, M.6
Alexander, W.S.7
Metcalf, D.8
Hilton, D.J.9
Nicola, N.A.10
-
33
-
-
0034671535
-
Role of the cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth hormone
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39487-39496
-
-
Ram, P.A.1
Waxman, D.J.2
-
35
-
-
0035979275
-
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9324-9329
-
-
Roberts, A.W.1
Robb, L.2
Rakar, S.3
Hartley, L.4
Cluse, L.5
Nicola, N.A.6
Metcalf, D.7
Hilton, D.J.8
Alexander, W.S.9
-
36
-
-
0032803530
-
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain
-
(1999)
Genes Cells
, vol.4
, pp. 339-351
-
-
Sasaki, A.1
Yasukawa, H.2
Suzuki, A.3
Kamizono, S.4
Syoda, T.5
Kinjyo, I.6
Sasaki, M.7
Johnston, J.A.8
Yoshimura, A.9
-
37
-
-
0032564463
-
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 14395-14399
-
-
Starr, R.1
Metcalf, D.2
Elefanty, A.G.3
Brysha, M.4
Willson, T.A.5
Nicola, N.A.6
Hilton, D.J.7
Alexander, W.S.8
-
38
-
-
0030792590
-
A family of cytokine-inducible inhibitors of signalling
-
(1997)
Nature
, vol.387
, pp. 917-921
-
-
Starr, R.1
Willson, T.A.2
Viney, E.M.3
Murray, L.J.4
Rayner, J.R.5
Jenkins, B.J.6
Gonda, T.J.7
Alexander, W.S.8
Metcalf, D.9
Nicola, N.A.10
Hilton, D.J.11
-
41
-
-
20244389693
-
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
-
(1999)
EMBO J.
, vol.18
, pp. 1309-1320
-
-
Yasukawa, H.1
Misawa, H.2
Sakamoto, H.3
Masuhara, M.4
Sasaki, A.5
Wakioka, T.6
Ohtsuka, S.7
Imaizumi, T.8
Matsuda, T.9
Ihle, J.N.10
Yoshimura, A.11
-
42
-
-
0029014206
-
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
-
(1995)
EMBO J.
, vol.14
, pp. 2816-2826
-
-
Yoshimura, A.1
Ohkubo, T.2
Kiguchi, T.3
Jenkins, N.A.4
Gilbert, D.J.5
Copeland, N.G.6
Hara, T.7
Miyajima, A.8
-
43
-
-
13044263097
-
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2071-2076
-
-
Zhang, J.G.1
Farley, A.2
Nicholson, S.E.3
Willson, T.A.4
Zugaro, L.M.5
Simpson, R.J.6
Moritz, R.L.7
Cary, D.8
Richardson, R.9
Hausmann, G.10
Kile, B.J.11
Kent, S.B.12
Alexander, W.S.13
Metcalf, D.14
Hilton, D.J.15
Nicola, N.A.16
Baca, M.17
|