STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-γ

Journal of Immunology

Volumn 164, Issue 3, 2000, Pages 1286-1292

  Lee, Chien Kuo ^a   Smith, Eric ^a   Gimeno, Ramon ^a   Gertner, Rachel ^a   Levy, David E ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; STAT PROTEIN;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; IMMUNOBLOTTING; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0034142230     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.3.1286     Document Type: Article

References (50)

1. Penninger, J. M., and G. Kroemer. 1998. Molecular and cellular mechanisms of T lymphocyte apoptosis. Adv. Immunol. 68:51.
2. Salvesen, G. S., and V. M. Dixit. 1997. Caspases: intracellular signaling by proteolysis. Cell 91:443.
3. Nagata, S. 1997. Apoptosis by death factor. Cell 88:355.
4. Li, P., H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld, et al. 1995. Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 80:401.
5. Wang, S., M. Miura, Y. Jung, H. Zhu, E. Li, and J. Yuan. 1998. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92:501.
6. Woo, M., R. Hakem, M. S. Soengas, G. S. Duncan, A. Shahinian, D. Kagi, A. Hakem, M. McCurrach, W. Khoo, S. A. Kaufman, et al. 1998. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 12:806.
7. Hakem, R., A. Hakem, G. S. Duncan, J. T. Henderson, M. Woo, M. S. Soengas, A. Elia, J. L. de la Pompa, D. Kagi, W. Khoo, et al. 1998. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94:339.
8. Kuida, K., T. F. Haydar, C.-Y. Kuan, Y. Gu, C. Taya, H. Karasuyama, M. Su, P. Rakic, and R. A. Flavell. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94:325.
9. Hu, S., S. Snipas, C. Vincenz, G. Salvesen, and V. Dixit. 1998. Caspase-14 is a novel developmentally regulated protease. J. Biol. Chem. 273:29648.
10. Chao, D. T., and S. J. Korsmeyer. 1998. Bcl-2 family: regulators of cell death. Annu. Rev. Immunol. 16:395.
11. Sato, S., M. Hanasa, S. Bodrug, S. Irie, N. Iwama, L. H. Boise, C. B. Thompson, E. Golemis, L. Fong, H. G. Wang, and J. C. Reed. 1994. Interactions among members of the BCL-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad. Sci. USA 91:7834.
12. Gratiot-Deans, J., L. Ding, L. A. Turka, and G. Nunez. 1993. Bcl-2 proto-oncogene expression during human T cell development: evidence for biphasic regulation. J. Immunol. 151:83.
13. Ma, A., J. C. Pena, B. Chang, E. Margosian, L. Davison, F. W. Alt, and C. B. Thompson. 1995. Bcl-x regulates the survival of double-positive thymocytes. Proc. Natl. Acad. Sci. USA 92:4763.
14. Merino, R., L. Ding, D. J. Veis, S. J. Korsmeyer, and G. Nunez. 1994. Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes. EMBO J. 13:683.
15. Grillot, D. A., R. Merino, J. C. Pena, W. C. Fanslow, F. D. Finkelman, C. B. Thompson, and G. Nunez. 1996. bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocytes survival in transgenic mice. J. Exp. Med. 183:381.
16. Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev. 8:9.
17. Firpo, E. J., A. Koff, M. J. Solomon, and J. M. Roberts. 1994. Inactivation of a Cdk2 inhibitor during interleukin-2-induced proliferation of human T lymphocytes. Mol. Cell. Biol. 14:4889.
18. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570.
19. Rebollo, A., J. Gomez, and A. C. Martinez. 1996. Lessons from immunological, biochemical, molecular pathway of the activation by IL-2 and IL-4. Adv. Immunol. 63:127.
20. Minami, Y., T. Kono, T. Miyozaki, and T. Taniguchi. 1993. The IL-2 receptor complex: its structure, function, and target genes. Annu. Rev. Immunol. 11:245.
21. Nakajima, H., X.-W. Liu, A. Wynshaw-Boris, L. A. Rosenthal, K. Imada, D. S. Finbloom, L. Hennighausen, and J. L. Warren. 1997. An indirect erfect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor a chain induction. Immunity 7:691.
22. Moriggl, R., D. J. Topham, S. Teglund, V. Sexl, C. McKay, D. Wang, A. Hoffmeyer, J. van Deursen, M. Y. Sangster, K. D. Bunting, G. C. Grosveld, and J. N. Ihle. 1999. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10:249.
23. Moriggl, R., V. Sexl, R. Piekorz, D. Topham, and J. N. Ihle. 1999. Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11:225.
24. Kip1 expression. Mol. Cell. Biol. 18:1996.
25. WAF1/ CIP1 mediated by STAT1. Science 272:719.
26. Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443.
27. Müller, U., U. Steinhoff, L. F. L. Reis, S. Hemmi, J. Pavlovic, R. M. Zinkernagel, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918.
28. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R. M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-γ receptor. Science 259:1742.
29. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259:1739.
30. Lee, C.-K., H. A. R. Bluyssen, and D. E. Levy. 1997. Regulation of interferon-α responsiveness by the duration of Janus kinase activity. J. Biol. Chem. 272: 21872.
31. Kowalik, T. F., J. DeGregori, J. K. Schwarz, and J. R. Nevins. 1995. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69:2491.
32. 0 cell state from a G, cell state. Mol. Cell. Biol. 16:6965.
33. Mangues, R., J. M. Kahn, I. Seidman, and A. Pellicer. 1994. An overexpressed N-ras proto-oncogene cooperates with N-methylnitrosourea in mouse mammary carcinogenesis. Cancer Res. 54:6395.
34. Thompson, C.R. 1999. Apoptosis. In Fundamental Immunology. W. E. Paul, ed. Lippincott-Raven Publishers, Philadelphia, p. 813.
35. Lee, H. H., H. Dadgostar, Q. Cheng, J. Shu, and G. Cheng. 1999. NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc. Natl. Acad. Sci. USA 96:9136.
36. Broome, H. E., C. M. Dargan, S. Krajewski, and J. C. Reed. 1995. Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J. Immunol. 155:2311.
37. Young, H. A., and P. Ghosh. 1997. Molecular regulation of cytokine gene expression: interferon-γ as a model system. Prog. Nucleic Acid Res. Mol. Biol. 56:109.
38. Belardelli, F., and I. Gresser. 1996. The neglected role of type 1 imerferon in the T-cell response: implications for its clinical use. Immunol. Today 17:369.
39. Lee, C. K., R. Gimeno, and D. E. Levy. 1999. Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes. J. Exp.Med. 190:1451.
40. Sahni, M., D. C. Ambrosetti, A. Mansukhani, R. Gertner, D. E. Levy, and C. Basilico. 1999. FGF signaling inhibits chondrocyte proliferating and regulates bone development through the Stat1 pathway. Genes Dev. 13:1361.
41. Chin, Y. E., M. Kitagawa, K. Kuida, R. A. Flavell, and X. Y. Fu. 1997. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol. Cell. Biol. 17:5328.
42. Ossina, N. K., A. Cannas, V. C. Powers, P. A. Fitzpatrick, J. D. Knight, J. R. Gilbert, E. M. Shekhtman, L. D. Tomei, S. R. Umansky, and M. C. Kiefer. 1997. Interferon-γ modulates a p53-independent apoptotic pathway and apoptosis-related gene expression. J. Biol. Chem. 272:16351.
43. Kuida, K., J. A. Lippke. M. W. Harding, D. J. Livingston, M. S. Su, and R. A. Flavell. 1995. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267:2000.
44. Deveraux, Q. L., and J. C. Reed. 1999. IAP family proteins: suppressors of apoptosis. Genes Dev. 13:239.
45. Kumar, A., M. Commane, T. W. Flickinger, C. M. Horvath, and G. R. Stark. 1997. Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science 278:1630.
46. kip1-deficient mice. Cell 85:733.
47. Pagano, M., R. Pepperkok, J. Lukas, B. Baldin, W. Ansorge, J. Bartek, and G. Draetta. 1993. Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J. Cell Biol. 121:101.
48. Erickson, S., O. Sangfelt, J. Castro, M. Heyman, S. Einhorn, and D. Grander. 1999. Interferon-α inhibits proliferation in human T lymphocytes by abrogation of interleukin-2-induced changes in cell cycle-regulatory proteins. Cell Growth Differ. 10:575.
49. Kaplan, D. H., V. Shankaran, A. S. Dighe, E. Stockert, M. Aguet, L. J. Old, and R. D. Schreiber. 1998. Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice. Proc. Natl. Acad. Sci. USA 95:7556.
50. Perou, C. M., S. S. Jeffrey, M. van de Rijn, C. A. Rees, M. B. Eisen, D. T. Ross, A. Pergamenschikov, C. F. Williams, S. X. Zhu, J. C. Lee, D. Lashkari, D. Shalon, P. O. Brown, and D. Botstein. 1999. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc. Natl. Acad. Sci. USA 96:9212.