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Volumn 16, Issue 9, 1996, Pages 4932-4941

Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MUTANT PROTEIN; PROTEIN TYROSINE PHOSPHATASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR STAT 1; TYROSINE; UNCLASSIFIED DRUG;

EID: 0029742102     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.9.4932     Document Type: Article
Times cited : (133)

References (53)
  • 1
    • 0029863169 scopus 로고    scopus 로고
    • Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) prolcins in hematopoietic cell lines transformed by Bcr/Abl
    • Carlesso, N., D. A. Frank, and J. D. Griffin. 1996. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) prolcins in hematopoietic cell lines transformed by Bcr/Abl. J. Exp. Med. 183:811-820.
    • (1996) J. Exp. Med. , vol.183 , pp. 811-820
    • Carlesso, N.1    Frank, D.A.2    Griffin, J.D.3
  • 2
    • 0027980301 scopus 로고
    • Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction
    • Cheng, G., Z. S. Ye, and D. Baltimore. 1994. Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. Proc. Natl. Acad. Sci. USA 91:8152-8155.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8152-8155
    • Cheng, G.1    Ye, Z.S.2    Baltimore, D.3
  • 3
    • 0028817880 scopus 로고
    • Jak-STAT signaling induced by the v-abl oncogene
    • Danial, N. N., S. Pernis, and P. B. Rothman. 1995. Jak-STAT signaling induced by the v-abl oncogene. Science 269:1875-1877.
    • (1995) Science , vol.269 , pp. 1875-1877
    • Danial, N.N.1    Pernis, S.2    Rothman, P.B.3
  • 4
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFN's and other extracellular signaling proteins
    • Darnell, J. E., Jr., I. M. Kerr, and G. M. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFN's and other extracellular signaling proteins. Science 264:1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.M.3
  • 5
    • 0027443228 scopus 로고
    • A nuclear tyrosine phosphatase downregulates interferon-induced gene expression
    • David, M., P. M. Grimley, D. S. Finbloom, and A. C. Larner. 1993. A nuclear tyrosine phosphatase downregulates interferon-induced gene expression. Mol. Cell. Biol. 13:7515-7521.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7515-7521
    • David, M.1    Grimley, P.M.2    Finbloom, D.S.3    Larner, A.C.4
  • 6
    • 0026019924 scopus 로고
    • Cytoplasmic activation of GAF. an IFN-gamma regulated DNA binding factor
    • Decker, T., D. J. Lew, J. Mirkovitch, and J. E. Darnell, Jr. 1991. Cytoplasmic activation of GAF. an IFN-gamma regulated DNA binding factor. EMBO J. 10:927-932.
    • (1991) EMBO J. , vol.10 , pp. 927-932
    • Decker, T.1    Lew, D.J.2    Mirkovitch, J.3    Darnell Jr., J.E.4
  • 7
    • 0028831202 scopus 로고
    • Identification of a novel serine theorine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death
    • Deiss, L. P., E. Feinstein, H. Berissi, O. Cohen, and A. Kimchi. 1995. Identification of a novel serine theorine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 9:15-30.
    • (1995) Genes Dev. , vol.9 , pp. 15-30
    • Deiss, L.P.1    Feinstein, E.2    Berissi, H.3    Cohen, O.4    Kimchi, A.5
  • 9
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443-450.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 10
    • 0026723419 scopus 로고
    • A transcriptional factor with SH2 and SH3 domains is directly activated by an Interferon α-induced cytoplasmic protein tyrosine kinase(s)
    • Fu, X.-Y. 1992. A transcriptional factor with SH2 and SH3 domains is directly activated by an Interferon α-induced cytoplasmic protein tyrosine kinase(s). Cell 70:323-335.
    • (1992) Cell , vol.70 , pp. 323-335
    • Fu, X.-Y.1
  • 11
    • 0026686488 scopus 로고
    • The proteins of ISGF-3, the Interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction
    • Fu, X.-Y., C. Schindler, T. Improta, R. Aebersold, and J. E. Darnell, Jr. 1992. The proteins of ISGF-3, the Interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl. Acad. Sci. USA 89:7840-7843.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7840-7843
    • Fu, X.-Y.1    Schindler, C.2    Improta, T.3    Aebersold, R.4    Darnell Jr., J.E.5
  • 12
    • 0028175454 scopus 로고
    • Ligand-induced IFN-gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system
    • Greenlund, A. C., M. A. Farrar, B. L. Viviano. and R. D. Schreiber. 1994. Ligand-induced IFN-gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system. EMBO J. 13:1591-1600.
    • (1994) EMBO J. , vol.13 , pp. 1591-1600
    • Greenlund, A.C.1    Farrar, M.A.2    Viviano, B.L.3    Schreiber, R.D.4
  • 13
    • 0028979707 scopus 로고
    • Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process
    • Greenlund, A. C., M. O. Morales, B. L. Viviano, H. Yan, J. Krolewski, and R.D. Schreiber. 1995. Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process. Immunity 2:677-687.
    • (1995) Immunity , vol.2 , pp. 677-687
    • Greenlund, A.C.1    Morales, M.O.2    Viviano, B.L.3    Yan, H.4    Krolewski, J.5    Schreiber, R.D.6
  • 14
    • 0026497476 scopus 로고
    • Tyrosine phosphorylation is required for activation of an alpha-interferon-stimulated transcription factor
    • Gutch, M. J., C. Daly, and N. C. Reich. 1992. Tyrosine phosphorylation is required for activation of an alpha-interferon-stimulated transcription factor. Proc. Natl. Acad. Sci. USA 89:11411-11415.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11411-11415
    • Gutch, M.J.1    Daly, C.2    Reich, N.C.3
  • 15
    • 0028791664 scopus 로고
    • Roles of protein-tyrosine phosphotases in Stat1alpha-mediated cell signaling
    • Haque, S. J., V. Flati, A. Deb, and B. R. G. Williams. 1995. Roles of protein-tyrosine phosphotases in Stat1alpha-mediated cell signaling. J. Biol. Chem. 270:25709-25714.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25709-25714
    • Haque, S.J.1    Flati, V.2    Deb, A.3    Williams, B.R.G.4
  • 16
    • 0028946158 scopus 로고
    • Contribution of STAT SH2 groups to specific Interferon signaling by the Jak-STAT pathway
    • Heim, M. H., I. M. Kerr, G. R. Stark, and J. E. Darnell, Jr. 1995. Contribution of STAT SH2 groups to specific Interferon signaling by the Jak-STAT pathway. Science 267:1347-1349.
    • (1995) Science , vol.267 , pp. 1347-1349
    • Heim, M.H.1    Kerr, I.M.2    Stark, G.R.3    Darnell Jr., J.E.4
  • 17
    • 0028913109 scopus 로고
    • A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
    • Horvath, C. M., Z. Wen, and J. E. Darnell, Jr. 1995. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9:984-994.
    • (1995) Genes Dev. , vol.9 , pp. 984-994
    • Horvath, C.M.1    Wen, Z.2    Darnell Jr., J.E.3
  • 18
    • 0028964916 scopus 로고
    • Identification and purification of human Stat proteins activated in response to inlerleukin-2
    • Hou, J., U. Schindler, W. J. Henzel, S. C. Wong, and S. L. McKnight. 1995. Identification and purification of human Stat proteins activated in response to inlerleukin-2. Immunity 2:321-329.
    • (1995) Immunity , vol.2 , pp. 321-329
    • Hou, J.1    Schindler, U.2    Henzel, W.J.3    Wong, S.C.4    McKnight, S.L.5
  • 19
    • 0028838971 scopus 로고
    • Protein kinases and phosphatases: The yin and yang of protein phosphorylation and signaling
    • Hunter, T. 1995. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80:225-236.
    • (1995) Cell , vol.80 , pp. 225-236
    • Hunter, T.1
  • 20
    • 0027511822 scopus 로고
    • In vitro activation of the transcription factor gamma interferon-activating factor by gamma interferon: Evidence for a tyrosine phosphatase/kinase signaling cascade
    • Igarashi, K., M. David, D. S. Finbloom, and A. C. Larner. 1993. In vitro activation of the transcription factor gamma interferon-activating factor by gamma interferon: evidence for a tyrosine phosphatase/kinase signaling cascade. Mol. Cell. Biol. 13:1634-1640.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1634-1640
    • Igarashi, K.1    David, M.2    Finbloom, D.S.3    Larner, A.C.4
  • 21
    • 0027232215 scopus 로고
    • In vitro activation of a transcription factor by gamma Interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate
    • Igarashi, K. I., M. David, A. C. Larner, and D. S. Finbloom. 1993. In vitro activation of a transcription factor by gamma Interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate. Mol. Cell. Biol. 13:3984-3989.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3984-3989
    • Igarashi, K.I.1    David, M.2    Larner, A.C.3    Finbloom, D.S.4
  • 22
    • 0028845212 scopus 로고
    • Cytokine receptor signaling
    • Ihle, J. N. 1995. Cytokine receptor signaling. Nature (London) 377:591-594.
    • (1995) Nature (London) , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 23
    • 0028242693 scopus 로고
    • Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Slat91 protein
    • Improta, T., C. Schindler, C. M. Horvath, I. M. Kerr, G. R. Stark, and J. E. Darnell, Jr. 1994. Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Slat91 protein. Proc. Natl. Acad. Sci. USA 91:4776-4780.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4776-4780
    • Improta, T.1    Schindler, C.2    Horvath, C.M.3    Kerr, I.M.4    Stark, G.R.5    Darnell Jr., J.E.6
  • 24
    • 0027165321 scopus 로고
    • Induction of the Ly-6A/E gene by both Interferon alpha/beta and gamma requires a DNA element to which a tyrosine phosphorylated 91 kDa protein binds
    • Kahn, K. D., K. Shuai, G. Lindwall, S. E. Maher, J. E. Darnell, Jr., and A. L. M. Bothwell. 1993. Induction of the Ly-6A/E gene by both Interferon alpha/beta and gamma requires a DNA element to which a tyrosine phosphorylated 91 kDa protein binds. Proc. Natl. Acad. Sci. USA 90:6806-6810.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6806-6810
    • Kahn, K.D.1    Shuai, K.2    Lindwall, G.3    Maher, S.E.4    Darnell Jr., J.E.5    Bothwell, A.L.M.6
  • 25
    • 0001823786 scopus 로고
    • Recombinant PCR
    • M. Innis, D. Gelfand, J. Sninsky, and T. White (ed.), Academic Press, San Diego, Calif
    • Kawasaki, E. 1990. Recombinant PCR, p. 117-183. In M. Innis, D. Gelfand, J. Sninsky, and T. White (ed.), PCR protocols: a guide to methods and applications. Academic Press, San Diego, Calif.
    • (1990) PCR Protocols: A Guide to Methods and Applications , pp. 117-183
    • Kawasaki, E.1
  • 26
    • 0026646066 scopus 로고
    • Cytokine triggered molecular pathways that control cell cycle arrest
    • Kimchi, A. 1992. Cytokine triggered molecular pathways that control cell cycle arrest. J. Cell. Biochem. 50:1-9.
    • (1992) J. Cell. Biochem. , vol.50 , pp. 1-9
    • Kimchi, A.1
  • 27
  • 28
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz, M. A., J. M. White, K. C. F. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, and J. K. Riley. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431-442.
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1    White, J.M.2    Sheehan, K.C.F.3    Bach, E.A.4    Rodig, S.J.5    Dighe, A.S.6    Kaplan, D.H.7    Riley, J.K.8
  • 31
    • 0027434082 scopus 로고
    • Complementation of a mutant cell line: Central role of the 91-kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathway
    • Muller, M., C. Laxton, J. Briscoe, C. Schindler, T. Improta, J. E. Darnell, Jr., G. R. Stark, and I. M. Kerr. 1993. Complementation of a mutant cell line: central role of the 91-kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathway. EMBO J. 12:4221-4228.
    • (1993) EMBO J. , vol.12 , pp. 4221-4228
    • Muller, M.1    Laxton, C.2    Briscoe, J.3    Schindler, C.4    Improta, T.5    Darnell Jr., J.E.6    Stark, G.R.7    Kerr, I.M.8
  • 32
    • 0027151991 scopus 로고
    • Interferon gamma-induced transcription of the high-affinity Fc receptor of IgF requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3
    • Pearse, R. N., R. Feinman, K. Shuai, J. E. Darnell, Jr., and J. V. Ravetch. 1993. Interferon gamma-induced transcription of the high-affinity Fc receptor of IgF requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. Proc. Natl. Acad. Sci. USA 90:4314-4318.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4314-4318
    • Pearse, R.N.1    Feinman, R.2    Shuai, K.3    Darnell Jr., J.E.4    Ravetch, J.V.5
  • 33
    • 0029057858 scopus 로고
    • Cloning of murine Stat6 and human Stat6, Slat proteins that are tyrosine phosphorylated in responses to interleukin-4 (1L-4) and IL-3 but arc not required for mitogenesis
    • Quelle, F. W., K. Shimoda, W. Theirfelder, C. Fishner, A. Kim, S. M. Ruben, J. L. Cleveland, J. H. Pierce, A. D. Keegan, K. Nelms, et al. 1995. Cloning of murine Stat6 and human Stat6, Slat proteins that are tyrosine phosphorylated in responses to interleukin-4 (1L-4) and IL-3 but arc not required for mitogenesis. Mol. Cell. Biol. 15:3336-3343.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3336-3343
    • Quelle, F.W.1    Shimoda, K.2    Theirfelder, W.3    Fishner, C.4    Kim, A.5    Ruben, S.M.6    Cleveland, J.L.7    Pierce, J.H.8    Keegan, A.D.9    Nelms, K.10
  • 34
    • 0026725868 scopus 로고
    • Proteins of transcription factor ISGF-3: One gene encodes the 91 and 84 kDa ISGF-3 proteins that arc activated by interferon-alpha
    • Schindler, C., X.-Y. Fu, T. Improta, R. Aebersold, and J. E. Darnell, Jr. 1992. Proteins of transcription factor ISGF-3: one gene encodes the 91 and 84 kDa ISGF-3 proteins that arc activated by interferon-alpha. Proc. Natl. Acad. Sci. USA 89:7836-7839.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7836-7839
    • Schindler, C.1    Fu, X.-Y.2    Improta, T.3    Aebersold, R.4    Darnell Jr., J.E.5
  • 35
    • 0026770248 scopus 로고
    • Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
    • Schindler, C., K. Shuai, V. R. Prezioso, and J. E. Darnell, Jr. 1992. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257:809-815.
    • (1992) Science , vol.257 , pp. 809-815
    • Schindler, C.1    Shuai, K.2    Prezioso, V.R.3    Darnell Jr., J.E.4
  • 36
    • 0028331926 scopus 로고
    • Interferon-activated signal transduction to the nucleus
    • Shuai, K. 1994. Interferon-activated signal transduction to the nucleus. Curr. Opin. Cell Biol. 6:253-259.
    • (1994) Curr. Opin. Cell Biol. , vol.6 , pp. 253-259
    • Shuai, K.1
  • 37
    • 85035181535 scopus 로고    scopus 로고
    • Constitutive activation of STATS by the BCR-ABL oncogene in chronic myelogenous leukemia
    • in press
    • Shuai, K., J. Halpern, J. ten Hoeve, X. Rao, and C. L. Sawyers. Constitutive activation of STATS by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene, in press.
    • Oncogene
    • Shuai, K.1    Halpern, J.2    Ten Hoeve, J.3    Rao, X.4    Sawyers, C.L.5
  • 38
    • 0028349904 scopus 로고
    • Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
    • Shuai, K., C. M. Horvath, L. H. Tsai-Huang, S. Qureshi, D. Cowburn, and J. E. Darnell, Jr. 1994. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76:821-828.
    • (1994) Cell , vol.76 , pp. 821-828
    • Shuai, K.1    Horvath, C.M.2    Tsai-Huang, L.H.3    Qureshi, S.4    Cowburn, D.5    Darnell Jr., J.E.6
  • 39
    • 0027090310 scopus 로고
    • Activation of transcription by IFN-γ: Tyrosine phosphorylation of a 91 kD DNA binding protein
    • Shuai, K., C. Schindler, V. R. Prezioso, and J. E. Darnell, Jr. 1992 Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91 kD DNA binding protein. Science 259:1808-1812.
    • (1992) Science , vol.259 , pp. 1808-1812
    • Shuai, K.1    Schindler, C.2    Prezioso, V.R.3    Darnell Jr., J.E.4
  • 40
    • 0027493650 scopus 로고
    • A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma
    • Shuai, K., G. R. Stark, I. M. Kerr, and J. E. Darnell, Jr. 1993. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 261:1744-1746.
    • (1993) Science , vol.261 , pp. 1744-1746
    • Shuai, K.1    Stark, G.R.2    Kerr, I.M.3    Darnell Jr., J.E.4
  • 42
    • 0027742729 scopus 로고
    • Interferon-induced nuclear signaling by Jak protein tyrosine kinases
    • Silvennoinen, O., J. N. Ihle, J. Schlessinger, and D. E. Levy. 1993. Interferon-induced nuclear signaling by Jak protein tyrosine kinases. Nature (London) 366:583-585.
    • (1993) Nature (London) , vol.366 , pp. 583-585
    • Silvennoinen, O.1    Ihle, J.N.2    Schlessinger, J.3    Levy, D.E.4
  • 43
    • 0028931604 scopus 로고
    • Choice of Stats and other substrates specified by modular tyrosine-based motifs in cytokine receptors
    • Stahl, N., T. J. Farruggella, T. G. Boulton, Z. Zhong, J. E. Darnell, Jr., and G. D. Yancopoulos. 1995. Choice of Stats and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349-1353.
    • (1995) Science , vol.267 , pp. 1349-1353
    • Stahl, N.1    Farruggella, T.J.2    Boulton, T.G.3    Zhong, Z.4    Darnell Jr., J.E.5    Yancopoulos, G.D.6
  • 44
    • 0028149381 scopus 로고
    • The coordinated action of protein tyrosine phosphatases and kinases in cell signaling
    • Sun, H., and N. K. Tonks. 1994. The coordinated action of protein tyrosine phosphatases and kinases in cell signaling. Trends Biochem. Sci. 19:480-485.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 480-485
    • Sun, H.1    Tonks, N.K.2
  • 45
    • 0028964465 scopus 로고
    • Cytokine signaling through nonreceptor protein tyrosine kinase
    • Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinase. Science 268:251-255.
    • (1995) Science , vol.268 , pp. 251-255
    • Taniguchi, T.1
  • 46
    • 0026632288 scopus 로고
    • A protein tyrosine kinase in the Interferon alpha/beta signalling pathway
    • Velazquez, L., M. Fellows, G. R. Stark, and S. Pellegrini. 1992. A protein tyrosine kinase in the Interferon alpha/beta signalling pathway. Cell 70:313-322.
    • (1992) Cell , vol.70 , pp. 313-322
    • Velazquez, L.1    Fellows, M.2    Stark, G.R.3    Pellegrini, S.4
  • 47
    • 0028217452 scopus 로고
    • Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
    • Wakao, H., F. Gouilleux, and B. Groner. 1994. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 13:2182-2191.
    • (1994) EMBO J. , vol.13 , pp. 2182-2191
    • Wakao, H.1    Gouilleux, F.2    Groner, B.3
  • 48
    • 0027914818 scopus 로고
    • Complementation of a mutant cell line defective in the interferon-gamma signal transduction pathway by the protein tyrosine kinase Jak2
    • Walling, D., D. Guschin, M. Muller, B. A. Witthuhn. O. Silvennionen, J. N. Ihle, G. R. Stark, and I. M. Kerr. 1993. Complementation of a mutant cell line defective in the interferon-gamma signal transduction pathway by the protein tyrosine kinase Jak2. Nature (London) 366:166-170.
    • (1993) Nature (London) , vol.366 , pp. 166-170
    • Walling, D.1    Guschin, D.2    Muller, M.3    Witthuhn, B.A.4    Silvennionen, O.5    Ihle, J.N.6    Stark, G.R.7    Kerr, I.M.8
  • 49
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen, Z., Z. Zhong, and J. E. Darnell, Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 51
    • 0028155865 scopus 로고
    • Protein tyrosine phosphatases: Mechanism of catalysis and substrate specificity
    • Zhang, Z. Y., and J. E. Dixon. 1994. Protein tyrosine phosphatases: mechanism of catalysis and substrate specificity. Adv. Enzymol. Relat. Areas Mol. Biol. 68:1-36.
    • (1994) Adv. Enzymol. Relat. Areas Mol. Biol. , vol.68 , pp. 1-36
    • Zhang, Z.Y.1    Dixon, J.E.2
  • 53
    • 0028284762 scopus 로고
    • Stat3 and Stat4: Members of the family of signal transducers and activators of transcription
    • Zhong, Z., Z. Wen, and J. E. Darnell, Jr. 1995. Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc. Natl. Acad. Sci. USA 91:4806-4810.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4806-4810
    • Zhong, Z.1    Wen, Z.2    Darnell Jr., J.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.