-
2
-
-
12944260632
-
Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5346-5350
-
-
Amson, R.1
Lassalle, J.M.2
Halley, H.3
Prieur, S.4
Lethrosne, F.5
Roperch, J.P.6
Israeli, D.7
Gendron, M.C.8
Duyckaerts, C.9
Checler, F.10
Dausset, J.11
Cohen, D.12
Oren, M.13
Telerman, A.14
-
3
-
-
0032575687
-
Is apoptosis key in Alzheimer's disease?
-
(1998)
Science
, vol.281
, pp. 1303-1304
-
-
Barinaga, M.1
-
4
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
5
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
-
(1997)
Neuron
, vol.19
, pp. 939-945
-
-
Borchelt, D.R.1
Ratovitski, T.2
Van Lare, J.3
Lee, M.K.4
Gonzales, V.5
Jenkins, N.A.6
Copeland, N.G.7
Price, D.L.8
Sisodia, S.S.9
-
7
-
-
0033152441
-
Presenilins, processing of beta-amyloid precursor protein, and Notch signaling
-
(1999)
Neuron
, vol.23
, pp. 201-204
-
-
Chan, Y.M.1
Jan, Y.N.2
-
9
-
-
0026659777
-
Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF
-
(1992)
Exp. Neurol.
, vol.117
, pp. 114-123
-
-
Cheng, B.1
Mattson, M.P.2
-
12
-
-
0032032019
-
An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos
-
(1998)
Neuron
, vol.20
, pp. 603-609
-
-
Davis, J.A.1
Naruse, S.2
Chen, H.3
Eckman, C.4
Younkin, S.5
Price, D.L.6
Borchelt, D.R.7
Sisodia, S.S.8
Wong, P.C.9
-
13
-
-
0034621823
-
Alzheimer's disease. Closing in on gamma-secretase
-
(2000)
Nature
, vol.405
, pp. 627-629
-
-
De Strooper, B.1
-
14
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
15
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
Goate, A.11
Kopan, R.12
-
17
-
-
0030293854
-
Protein topology of presenilin 1
-
(1996)
Neuron
, vol.17
, pp. 1023-1030
-
-
Doan, A.1
Thinakaran, G.2
Borchelt, D.R.3
Slunt, H.H.4
Ratovitsky, T.5
Podlisny, M.6
Selkoe, D.J.7
Seeger, M.8
Gandy, S.E.9
Price, D.L.10
Sisodia, S.S.11
-
18
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
19
-
-
0033373067
-
Modulation of presenilin-1 processing by nitric oxide during apoptosis induced by serum withdrawal and glucose deprivation
-
(1999)
Ann. NY Acad. Sci.
, vol.893
, pp. 294-297
-
-
Gasparini, L.1
Ghidoni, R.2
Alberici, A.C.3
Benussi, L.4
Moratto, D.5
Trabucchi, M.6
Growdon, J.H.7
Nitsch, R.M.8
Binetti, G.9
-
20
-
-
12944305721
-
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 12822-12827
-
-
Grilli, M.1
Diodato, E.2
Lozza, G.3
Brusa, R.4
Casarini, M.5
Uberti, D.6
Rozmahel, R.7
Westaway, D.8
St George-Hyslop, P.9
Memo, M.10
Ongini, E.11
-
21
-
-
0030891662
-
Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide
-
(1996)
Neuroreport
, vol.8
, pp. 379-383
-
-
Guo, Q.1
Furukawa, K.2
Sopher, B.L.3
Pham, D.G.4
Xie, J.5
Robinson, N.6
Martin, G.M.7
Mattson, M.P.8
-
23
-
-
0032524319
-
Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 12341-12351
-
-
Guo, Q.1
Robinson, N.2
Mattson, M.P.3
-
28
-
-
0031927628
-
Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease
-
(1998)
Nat. Med.
, vol.4
, pp. 957-962
-
-
Guo, Q.1
Fu, W.2
Xie, J.3
Luo, H.4
Sells, S.F.5
Geddes, J.W.6
Bondada, V.7
Rangnekar, V.M.8
Mattson, M.P.9
-
29
-
-
0034714361
-
Par-4 induces cholinergic hypoactivity by suppressing ChAT protein synthesis and inhibiting NGF-inducibility of ChAT activity
-
(2000)
Brain Res.
, vol.874
, pp. 221-232
-
-
Guo, Q.1
Xie, J.2
Du, H.3
-
30
-
-
0030922421
-
Presenilins: Genes for life and death
-
(1997)
Neuron
, vol.18
, pp. 687-690
-
-
Haass, C.1
-
34
-
-
0034440140
-
A unifying hypothesis of Alzheimer's disease. IV. Causation and sequence of events
-
(2000)
Rev. Neurosci.
, vol.11
, pp. 213-328
-
-
Heininger, K.1
-
35
-
-
0027195933
-
Seeding 'one-dimensional crystallization' of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
-
(1993)
Cell
, vol.73
, pp. 1055-1058
-
-
Jarrett, J.T.1
Lansbury, P.T.2
-
37
-
-
0026539331
-
Alzheimer's disease: A cell biological perspective
-
(1992)
Science
, vol.256
, pp. 780-783
-
-
Kosik, K.S.1
-
38
-
-
0032559189
-
Presenilin interactions and Alzheimer's disease
-
(1998)
Science
, vol.279
, pp. 463-465
-
-
Kosik, K.S.1
-
39
-
-
0034705196
-
Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5913-5918
-
-
Kulic, L.1
Walter, J.2
Multhaup, G.3
Teplow, D.B.4
Baumeister, R.5
Romig, H.6
Capell, A.7
Steiner, H.8
Haass, C.9
-
42
-
-
0034647003
-
Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model
-
(2000)
Science
, vol.288
, pp. 335-339
-
-
Li, M.1
Ona, V.O.2
Guegan, C.3
Chen, M.4
Jackson-Lewis, V.5
Andrews, L.J.6
Olszewski, A.J.7
Stieg, P.E.8
Lee, J.P.9
Przedborski, S.10
Friedlander, R.M.11
-
43
-
-
0343819757
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
Huang, Q.4
DiMuzio-Mower, J.5
Sardana, M.K.6
Shi, X.P.7
Yin, K.C.8
Shafer, J.A.9
Gardell, S.J.10
-
45
-
-
0034621824
-
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
Xu, M.2
Lai, M.T.3
Huang, Q.4
Castro, J.L.5
DiMuzio-Mower, J.6
Harrison, T.7
Lellis, C.8
Nadin, A.9
Neduvelil, J.G.10
Register, R.B.11
Sardana, M.K.12
Shearman, M.S.13
Smith, A.L.14
Shi, X.P.15
Yin, K.C.16
Shafer, J.A.17
Gardell, S.J.18
-
47
-
-
0030300114
-
Dissecting how presinilins function - And malfunction
-
(1996)
Science
, vol.274
, pp. 1838-1840
-
-
Marx, J.1
-
48
-
-
0034652369
-
Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: Involvement of perturbed calcium homeostasis
-
(2000)
J. Neurosci.
, vol.20
, pp. 1358-1364
-
-
Mattson, M.P.1
Zhu, H.2
Yu, J.3
Kindy, M.S.4
-
49
-
-
0033230623
-
Neuroplasticity failure in Alzheimer's disease: Bridging the gap between plaques and tangles
-
(1999)
Neuron
, vol.24
, pp. 521-529
-
-
Mesulam, M.M.1
-
52
-
-
0033695947
-
Presenilins, Alzheimer's disease, and capacitative calcium entry
-
(2000)
Neuron
, vol.27
, pp. 411-412
-
-
Putney, J.W.1
-
53
-
-
0032032847
-
Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression
-
(1998)
Neuron
, vol.20
, pp. 611-617
-
-
Qian, S.1
Jiang, P.2
Guan, X.M.3
Singh, G.4
Trumbauer, M.E.5
Yu, H.6
Chen, H.Y.7
Van de Ploeg, L.H.8
Zheng, H.9
-
54
-
-
0033014046
-
Evidence for a physical interaction between presenilin and Notch
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3263-3268
-
-
Ray, W.J.1
Yao, M.2
Nowotny, P.3
Mumm, J.4
Zhang, W.5
Wu, J.Y.6
Kopan, R.7
Goate, A.M.8
-
55
-
-
18744435477
-
Presenilin-1 mutations in Alzheimer's disease
-
(2000)
Nature
, vol.405
, pp. 531-532
-
-
Russo, C.1
Schettini, G.2
Saido, T.C.3
Hulette, C.4
Lippa, C.5
Lannfelt, L.6
Ghetti, B.7
Gambetti, P.8
Tabaton, M.9
Teller, J.K.10
-
57
-
-
0034618556
-
Alzheimer's disease. A partner for presenilin
-
(2000)
Nature
, vol.407
, pp. 34-35
-
-
Schenk, D.1
-
58
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
59
-
-
0024314702
-
Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease
-
(1989)
Cell
, vol.58
, pp. 611-612
-
-
Selkoe, D.J.1
-
60
-
-
0025295036
-
Deciphering Alzheimer's disease: The amyloid precursor protein yields new clues
-
(1990)
Science
, vol.248
, pp. 1058-1060
-
-
Selkoe, D.J.1
-
61
-
-
0031038918
-
Alzheimer's disease: Genotypes, phenotypes, and treatments
-
(1997)
Science
, vol.275
, pp. 630-631
-
-
Selkoe, D.J.1
-
62
-
-
0033600274
-
Translating cell biology into therapeutic advances in Alzheimer's disease
-
(1999)
Nature
, vol.399
, pp. A23-A31
-
-
Selkoe, D.J.1
-
64
-
-
0030990094
-
Expression and function of the leucine zipper protein Par-4 in apoptosis
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 3823-3832
-
-
Sells, S.F.1
Han, S.S.2
Muthukkumar, S.3
Maddiwar, N.4
Johnstone, R.5
Boghaert, E.6
Gillis, D.7
Liu, G.8
Nair, P.9
Monnig, S.10
Collini, P.11
Mattson, M.P.12
Sukhatme, V.P.13
Zimmer, S.G.14
Wood, D.P.15
McRoberts, J.W.16
Shi, Y.17
Rangnekar, V.M.18
-
66
-
-
0034730295
-
Neuroscience. An accomplice for gamma-secretase brought into focus
-
(2000)
Science
, vol.289
, pp. 2296-2297
-
-
Sisodia, S.S.1
-
69
-
-
13144265717
-
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9637-9641
-
-
Takashima, A.1
Murayama, M.2
Murayama, O.3
Kohno, T.4
Honda, T.5
Yasutake, K.6
Nihonmatsu, N.7
Mercken, M.8
Yamaguchi, H.9
Sugihara, S.10
Wolozin, B.11
-
70
-
-
0032756806
-
Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis
-
(2000)
Neuroscience
, vol.95
, pp. 593-601
-
-
Tanii, H.1
Ankarcrona, M.2
Flood, F.3
Nilsberth, C.4
Mehta, N.D.5
Perez-Tur, J.6
Winblad, B.7
Benedikz, E.8
Cowburn, R.F.9
-
71
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
Kim, G.6
Ratovitsky, T.7
Davenport, F.8
Nordstedt, C.9
Seeger, M.10
Hardy, J.11
Levey, A.I.12
Gandy, S.E.13
Jenkins, N.A.14
Copeland, N.G.15
Price, D.L.16
Sisodia, S.S.17
-
72
-
-
12644258498
-
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2025-2030
-
-
Tomita, T.1
Maruyama, K.2
Saido, T.C.3
Kume, H.4
Shinozaki, K.5
Tokuhiro, S.6
Capell, A.7
Walter, J.8
Grunberg, J.9
Haass, C.10
Iwatsubo, T.11
Obata, K.12
-
73
-
-
0033623415
-
Abeta-generating enzymes: Recent advances in beta- and gamma-secretase research
-
(2000)
Neuron
, vol.27
, pp. 419-422
-
-
Vassar, R.1
Citron, M.2
-
74
-
-
12644264304
-
Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 5349-5354
-
-
Walter, J.1
Grunberg, J.2
Capell, A.3
Pesold, B.4
Schindzielorz, A.5
Citron, M.6
Mendla, K.7
George-Hyslop, P.S.8
Multhaup, G.9
Selkoe, D.J.10
Haass, C.11
-
78
-
-
10544224542
-
Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
-
(1996)
Science
, vol.274
, pp. 1710-1713
-
-
Wolozin, B.1
Iwasaki, K.2
Vito, P.3
Ganjei, J.K.4
Lacana, E.5
Sunderland, T.6
Zhao, B.7
Kusiak, J.W.8
Wasco, W.9
D'Adamio, L.10
-
79
-
-
17744401440
-
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm
-
(1997)
Nature
, vol.387
, pp. 288-292
-
-
Wong, P.C.1
Zheng, H.2
Chen, H.3
Becher, M.W.4
Sirinathsinghji, D.J.5
Trumbauer, M.E.6
Chen, H.Y.7
Price, D.L.8
Van der Ploeg, L.H.9
Sisodia, S.S.10
-
81
-
-
0034255029
-
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9299-9304
-
-
Xia, W.1
Ray, W.J.2
Ostaszewski, B.L.3
Rahmati, T.4
Kimberly, W.T.5
Wolfe, M.S.6
Zhang, J.7
Goate, A.M.8
Selkoe, D.J.9
-
82
-
-
0029896354
-
Mechanisms of neuronal degeneration in Alzheimer's disease
-
(1996)
Neuron
, vol.16
, pp. 921-932
-
-
Yankner, B.A.1
-
84
-
-
0033712477
-
Presenilin-mediated modulation of capacitative calcium entry
-
(2000)
Neuron
, vol.27
, pp. 561-572
-
-
Yoo, A.S.1
Cheng, I.2
Chung, S.3
Grenfell, T.Z.4
Lee, H.5
Pack-Chung, E.6
Handler, M.7
Shen, J.8
Xia, W.9
Tesco, G.10
Saunders, A.J.11
Ding, K.12
Frosch, M.P.13
Tanzi, R.E.14
Kim, T.W.15
-
85
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.9
Kawarai, T.10
Supala, A.11
Levesque, L.12
Yu, H.13
Yang, D.S.14
Holmes, E.15
Milman, P.16
Liang, Y.17
Zhang, D.M.18
Xu, D.H.19
Sato, C.20
Rogaev, E.21
Smith, M.22
Janus, C.23
Zhang, Y.24
Aebersold, R.25
Farrer, L.S.26
Sorbi, S.27
Bruni, A.28
Fraser, P.29
St George-Hyslop, P.30
more..
-
86
-
-
0032531793
-
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
-
(1998)
Nature
, vol.395
, pp. 698-702
-
-
Zhang, Z.1
Hartmann, H.2
Do, V.M.3
Abramowski, D.4
Sturchler-Pierrat, C.5
Staufenbiel, M.6
Sommer, B.7
Van de Wetering, M.8
Clevers, H.9
Saftig, P.10
De Strooper, B.11
He, X.12
Yankner, B.A.13
-
88
-
-
0035844283
-
Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human neuroblastoma IMR-32 cells by a caspase-dependent pathway
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16040-16044
-
-
Guo, Q.1
Xie, J.2
Chang, X.3
Du, H.4
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