Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 11, 2000, Pages 5913-5918

  Kulic, Luka ^a   Walter, Jochen ^a   Multhaup, Gerd ^b   Teplow, David B ^c   Baumeister, Ralf ^a   Romig, Helmut ^d   Capell, Anja ^a   Steiner, Harald ^a   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

secretase; Alzheimer's disease

Indexed keywords

AMYLOID BETA PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; CELL CULTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CELLS, CULTURED; CODON; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PRESENILIN-1; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, NOTCH; SUBSTRATE SPECIFICITY;

EID: 0034705196     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.100049897     Document Type: Article

References (55)

1. Selkoe, D. J. (1999) Nature (London) 399, A23-A31.
2. Haass, C. & De Strooper, B. (1999) Science 286, 916-919.
3. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K. & Van Leuven, F. (1998) Nature (London) 391, 387-390.
4. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T. & Selkoe, D. J. (1999) Nature (London) 398, 513-517.
5. Leimer, U., Lun, K., Romig, H., Walter, J., Grunberg, J., Brand, M. & Haass, C. (1999) Biochemistry 38, 13602-13609.
6. Steiner, H., Duff, K., Capell, A., Romig, H., Grim, M. G., Lincoln, S., Hardy, J., Yu, X., Picciano, M., Fechteler, K., et al. (1999) J. Biol. Chem. 274, 28669-28673.
7. Wolfe, M. S., Xia, W., Moore, C. L., Leatherwood, D. D., Ostaszewski, B., Rahmati, T., Donkor, I. O. & Selkoe, D. J. (1999) Biochemistry 38, 4720-4727.
8. Wolfe, M. S., De Los Angeles, J., Miller, D. D., Xia, W. & Selkoe, D. J. (1999) Biochemistry 38, 11223-11230.
9. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., et al. (1996) Neuron 17, 181-190.
10. Capell, A., Grunberg, J., Resold, B., Diehlmann, A., Citron, M., Nixon, R., Beyreuther, K., Selkoe, D. J. & Haass, C. (1998) J. Biol. Chem. 273, 3205-3211.
11. Thinakaran, G., Regard, J. B., Bouton, C. M., Harris, C. L., Price, D. L., Borchelt, D. R. & Sisodia, S. S. (1998) Neurobiol. Dis. 4, 438-453.
12. Yu, G., Chen, F., Levesque, G., Nishimura, M., Zhang, D. M., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., et al. (1998) J. Biol. Chem. 273, 16470-16475.
13. Seeger, M., Nordstedt, C., Petanceska, S., Kovacs, D. M., Gouras, G. K., Hahne, S., Fraser, P., Levesque, L., Czernik, A. J., George-Hyslop, P. S., et al. (1997) Proc. Natl. Acad. Sci. USA 94, 5090-5094.
14. Steiner, H., Romig, H., Pesold, B., Philipp, U., Baader, M., Citron, M., Loetscher, H., Jacobsen, H. & Haass, C. (1999) Biochemistry 38, 14600-14605.
15. Jacobsen, H., Reinhardt, D., Brockhaus, M., Bur, D., Kocyba, C., Kurt, H., Grim, M. G., Baumeister, R. & Loetscher, H. (1999) J. Biol. Chem. 274, 35233-35239.
16. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) Nature (London) 398, 518-522.
17. Chan, Y. M. & Jan, Y. N. (1999) Neuron 23, 201-204.
18. Ray, W. J., Yao, M., Mumm, J., Schroeter, E. H., Saftig, P., Wolfe, M., Selkoe, D. J., Kopan, R. & Goate, A. M. (1999) J. Biol. Chem. 274, 36801-36807.
19. Schroeter, E. H., Kisslinger, J. A. & Kopan, R. (1998) Nature (London) 393, 382-386.
20. Ye, Y., Lukinova, N. & Fortini, M. E. (1999) Nature (London) 398, 525-529.
21. Struhl, G. & Greenwald, I. (1999) Nature (London) 398, 522-525.
22. Song, W., Nadeau, P., Yuan, M., Yang, X., Shen, J. & Yankner, B. A. (1999) Proc. Natl. Acad. Sci. USA 96, 6959-6963.
23. Berechid, B. E., Thinakaran, G., Wong, P. C., Sisodia, S. S. & Nye, J. S. (1999) Curr. Biol. 9, 1493-1496.
24. Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J. & Tonegawa, S. (1997) Cell 89, 629-639.
25. Wong, P. C., Zheng, H., Chen, H., Becher, M. W., Sirinathsinghji, D. J., Trumbauer, M. E., Chen, H. Y., Price, D. L., Van der Ploeg, L. H. & Sisodia, S. S. (1997) Nature (London) 387, 288-292.
26. Herreman, A., Hartmann, D., Annaert, W., Saftig, P., Craessaerts, K., Serneels, L., Umans, L., Schrijvers, V., Checler, F., Vanderstichele, H., et al. (1999) Proc. Natl. Acad. Sci. USA 96, 11872-11877.
27. Donoviel, D. B., Hadjantonakis, A. K., Ikeda, M., Zheng, H., Hyslop, P. S. & Bernstein, A. (1999) Genes Dev. 13, 2801-2810.
28. Levitan, D. & Greenwald, I. (1995) Nature (London) 377, 351-354.
29. Levitan, D., Doyle, T. G., Brousseau, D., Lee, M. K., Thinakaran, G., Slunt, H. H., Sisodia, S. S. & Greenwald, I. (1996) Proc. Natl. Acad. Sci. USA 93, 14940-14944.
30. Baumeister, R., Leimer, U., Zweckbronner, I., Jakubek, C., Grunberg, J. & Haass, C. (1997) Genes Funct. 1, 149-159.
31. Westlund, B., Parry, D., Clover, R., Basson, M. & Johnson, C. D. (1999) Proc. Natl. Acad. Sci. USA 96, 2497-2502.
32. Davis, J. A., Naruse, S., Chen, H., Eckman, C., Younkin, S., Price, D. L., Borchelt, D. R., Sisodia, S. S. & Wong, P. C. (1998) Neuron 20, 603-609.
33. Qian, S., Jiang, P., Guan, X. M., Singh, G., Trumbauer, M. E., Yu, H., Chen, H. Y., Van de Ploeg, L. H. & Zheng, H. (1998) Neuron 20, 611-617.
34. Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I. & Selkoe, D. J. (1992) Nature (London) 360, 672-674.
35. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) Nature (London) 359, 322-325.
36. Walter, J., Grunberg, J., Capell, A., Pesold, B., Schindzielorz, A., Citron, M., Mendla, K., George-Hyslop, P. S., Multhaup, G., Selkoe, D. J. & Haass, C. (1997) Proc. Natl. Acad. Sci. USA 94, 5349-5354.
37. Steiner, H., Romig, H., Grim, M. G., Philipp, U., Pesold, B., Citron, M., Baumeister, R. & Haass, C. (1999) J. Biol. Chem. 274, 7615-7618.
38. Wild-Bode, C., Yamazaki, T., Capell, A., Leimer, U., Steiner, H., Ihara, Y. & Haass, C. (1997) J. Biol. Chem. 272, 16085-16088.
39. Haass, C., Lemere, C. A., Capell, A., Citron, M., Seubert, P., Schenk, D., Lannfelt, L. & Selkoe, D. J. (1995) Nat. Med. 1, 1291-1296.
40. Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) Nature (London) 375, 754-760.
41. Haass, C. (1997) Neuron 18, 687-690.
42. Podlisny, M. B., Citron, M., Amarante, P., Sherrington, R., Xia, W., Zhang, J., Diehl, T., Levesque, G., Fraser, P., Haass, C., et al. (1997) Neurobiol. Dis. 3, 325-337.
43. Steiner, H., Capell, A., Pesold, B., Citron, M., Kloetzel, P. M., Selkoe, D. J., Romig, H., Mendia, K. & Haass, C. (1998) J. Biol. Chem. 273, 32322-32331.
44. Citron, M., Eckman, C. B., Diehl, T. S., Corcoran, C., Ostaszewski, B. L., Xia, W., Levesque, G., St. George Hyslop, P., Younkin, S. G. & Selkoe, D. J. (1998) Neurobiol. Dis. 5, 107-116.
45. Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood, K., Lee, M., Seubert, P., Davis, A., et al. (1997) Nat. Med. 3, 67-72.
46. Capell, A., Steiner, H. Romig, H., Keck, S., Baader, M., Grim, M. G., Baumeister, R. & Haass, C. (2000) Nat. Cell. Biol. 2, 205-211.
47. Thinakaran, G., Harris, C. L., Ratovitski, T., Davenport, F., Slunt, H. H., Price, D. L., Borchelt, D. R. & Sisodia, S. S. (1997) J. Biol. Chem. 272, 28415-28422.
48. Klafki, H. W., Wiltfang, J. & Staufenbiel, M. (1996) Anal. Biochem. 237, 24-29.
49. Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) Nat. Med. 2, 864-870.
50. Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C. M., Kim, G., Seekins, S., Yager, D., et al. (1996) Neuron 17, 1005-1013.
51. Kovacs, D. M., Fausett, H. J., Page, K. J., Kim, T. W., Moir, R. D., Merriam, D. E., Hollister, R. D., Hallmark, O. G., Mancini, R., Felsenstein, K. M., et al. (1996) Nat. Med. 2, 224-229.
52. Annaert, W. G., Levesque, L., Craessaerts, K., Dierinck, I., Snellings, G., Westaway, D., George-Hyslop, P. S., Cordeil, B., Fraser, P. & De Strooper, B. (1999) J. Cell Biol. 147, 277-294.
53. Walter, J., Capell, A., Grunberg, J., Pesold, B., Schindzielorz, A., Prior, R., Podlisny, M. B., Fraser, P., Hyslop, P. S., Selkoe, D. J. & Haass, C. (1996) Mol. Med. 2, 673-691.
54. Skovronsky, D. M., Doms, R. W. & Lee, V. M. (1998) J. Cell Biol. 141, 1031-1039.
55. Perez, R. G., Soriano, S., Hayes, J. D., Ostaszewski, B., Xia, W., Selkoe, D. J., Chen, X., Stokin, G. B. & Koo, E. H. (1999) J. Biol. Chem. 274, 18851-18856.