Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations

Journal of Neuroscience Research

Volumn 56, Issue 5, 1999, Pages 457-470

  Guo, Qing ^a   Fu, Weiming ^a   Holtsberg, Frederick W ^b   Steiner, Sheldon M ^b   Mattson, Mark P ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer's disease; Amyloid; Membrane lipid peroxidation; Mitochondrial transmembrane potential; Peroxynitrite; Uric acid

Indexed keywords

3 NITROTYROSINE; AMYLOID; PRESENILIN 1; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; URIC ACID DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; CELL DEATH; CHROMOSOME 14; FLUORESCENCE; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LIPID PEROXIDATION; MEMBRANE POTENTIAL; NERVE CELL; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CALCIUM; CELL SURVIVAL; CHROMOSOMES, HUMAN, PAIR 14; HUMANS; INTRACELLULAR MEMBRANES; LIPID PEROXIDATION; MEMBRANE LIPIDS; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MITOCHONDRIA; MUTAGENESIS, SITE-DIRECTED; NEURONS; PC12 CELLS; PEPTIDE FRAGMENTS; PRESENILIN-1; RATS; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; SUPEROXIDE DISMUTASE; SUPEROXIDES; TYROSINE;

EID: 0033153450     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990601)56:5<457::AID-JNR2>3.0.CO;2-P     Document Type: Article

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