Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 10, 1997, Pages 5349-5354

  Walter, Jochen ^a   Grünberg, Jürgen ^a   Capell, Anja ^a   Pesold, Brigitte ^a   Schindzielorz, Alice ^a   Citron, Martin ^e   Mendla, Klaus ^b   St George Hyslop, Peter ^c   Multhaup, Gerd ^d   Selkoe, Dennis J ^e   Haass, Christian ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c UNIVERSITY OF TORONTO   (Canada)

^d Center for Molecular Biology   (Germany)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

muscarinic receptors; phorbol ester; protein phosphorylation; signal transduction

Indexed keywords

CARBACHOL; MUSCARINIC M1 RECEPTOR; PHORBOL DIBUTYRATE; PRESENILIN 1; PROTEIN; PROTEIN KINASE C;

ALZHEIMER DISEASE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING;

ALKALINE PHOSPHATASE; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; CONSERVED SEQUENCE; DNA PRIMERS; HUMANS; KIDNEY; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PRESENILIN-1; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 12644264304     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.10.5349     Document Type: Article

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