Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease

Progress in Neurobiology

Volumn 63, Issue 1, 2001, Pages 71-124

  Murer, M G ^a   Yan, Q ^b   Raisman Vozari, R ^c  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b AMGEN INC   (United States)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; ANIMAL CELL; BASAL GANGLION; BRAIN CORTEX; BRAIN REGION; BRAIN STEM; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CLAUSTRUM; COGNITION; DOPAMINERGIC NERVE CELL; FOREBRAIN; GENE EXPRESSION; GLIA CELL; HIPPOCAMPUS; HUMAN; NERVE CELL; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REVIEW; SUBSTANTIA NIGRA;

ALZHEIMER DISEASE; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; HUMAN; PARKINSON DISEASE; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T; TISSUE DISTRIBUTION;

EID: 0035239020     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(00)00014-9     Document Type: Review

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244. Cellular localization of brain-derived neurotrophic factor-like immunoreactivity in the adult monkey brain
245. Activated human T cells, B cells and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?
246. Learning up-regulates brain-derived neurotrophic factor messenger RNA: a mechanism to facilitate encoding and circuit maintenance?
247. Brain-derived neurotrophic factor, acidic and basic fibroblast growth factors, insulin-like growth factors-1, and various antioxidants do not prevent the apoptotic death of developing septal cholinergic neurons following nerve growth factor withdrawal in vitro
248. Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals
249. Zinc entry produces oxidative neuronal necrosis in cortical cell cultures
250. Brain-derived neurotrophic factor prevents low-frequency inputs from inducing long-term depression in the developing visual cortex
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259. Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer
260. Long-term actions of vector-derived nerve growth factor or brain-derived neurotrophic factor on choline acetyltransferase and Trk receptor levels in the adult rat basal forebrain
261. Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus
262. Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin-3
263. Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain
264. Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorilation in rat cortical neurons
265. Potentiated necrosis of cultured cortical neurons by neurotrophins
266. Suppressed epileptogenesis in BDNF mutant mice
267. Coexpression of neurotrophins and their receptors in neurons of the central nervous system
268. Rapid alterations of BDNF protein levels in the rat brain after focal ischemia: evidence for increased synthesis and anterograde axonal transport
269. Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3, on intact and injured basal forebrain cholinergic neurons
270. Brain-derived neurotrophic factor is increased in cerebrospinal fluid of children suffering from asphyxia
271. The neurotrophic factor concept: a reexamination
272. Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor
273. Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice
274. A role for BDNF in the late-phase of hippocampal long-term potentiation
275. The survival response of mesencephalic dopaminergic neurons to the neurotrophins BDNF and NT-4 requires priming with serum: comparison with members of the TGF-β superfamily and characterization of the serum-free culture system
276. Association of the p75 neurotrophin receptor with TRAF6
277. BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons
278. Beta-amyloid binds to p75(NTR) and activates NfκB in human neuroblastoma cells
279. Cloning and expression of a novel neurotrophin, NT-7, from carp
280. TrkC, a new member of the Trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
281. Parkinson's disease
282. Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection
283. BDNF and TrkB expression in the hippocampal formation of aging rats
284. BDNF and TrkB expression in the rat hippocampus following entorhinal cortex lesions
285. Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: evidence from lesion and chronic cholinergic drug treatment studies
286. Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats
287. Modulation of nigrostriatal dopaminergic transmission by antisense oligodeoxynucleotide against brain-derived neurotrophic factor
288. Differential effects of protein synthesis inhibition on the activity-dependent expression of BDNF transcripts: evidence for immediate-early gene responses from specific promoters
289. Transcript-specific effects of adrenalectomy on seizure-induced BDNF expression in rat hippocampus
290. BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurons
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292. Molecular cloning and expression of brain-derived neurotrophic factor
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303. BDNF acutely increases tyrosine phosphorilation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities
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305. Activity-dependent and hormonal regulation of neurotrophin mRNA levels in the brain-implications for neuronal plasticity
306. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3, and NT-4
307. Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the adult rat brain following cerebral ischemia and hypoglycelic coma
308. Learning deficit in BDNF mutant mice
309. Sensory but not motor neuron deficits in mice lacking NT4 and BDNF
310. Neurotrophic factors and synaptic plasticity
311. The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons
312. NGF expression in actively growing brain glia
313. Neurotrophins and hippocampal synaptic transmission and plasticity
314. Brain-derived neurotrophic factor-transduced fibroblasts: production of BDNF and effects of grafting to the adult rat brain
315. Modulation of mRNA expression of the neurotrophins of the nerve growth factor family and their receptors in the septum and hippocampus after transient postnatal thyroxine treatment
316. Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation in rats
317. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
318. NT-3, BDNF and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression
319. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations
320. Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro
321. Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived growth factor
322. Noradrenergic depletion exacerbates MPTP-induced striatal dopamine loss in mice
323. Neutrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons
324. Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine
325. Spontaneous behaviours of rats are differentially affected by substantia nigra infusions of brain-derived neurotrophic factor
326. TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections
327. Ex vivo gene transfer of brain-derived neurotrophic factor to the intact rat forebrain: neurotrophic effects on cholinergic neurons
328. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
329. Molecular and biochemical characterization of the human Trk proto-oncogene
330. Neurotrophins and activity-dependant plasticity of cortical interneurons
331. Brain-derived neurotrophic factor promotes the differentiation of various hippocampal nonpyramidal neurons, including Cajal-Retzius cells, in organotypic slice cultures
332. GABAergic stimulation regulates phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor
333. Granule cell mRNA levels for BDNF, NGF, and NT-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus
334. Nuerotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular calcium concentration, and neurotoxicity, and increase antioxidant enzyme activities in hippocampal neurons
335. Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after MPTP in monkeys: a possible role for the locus coeruleus in the progression of Parkinson's disease
336. Neirotrophins regulate dendritic growth in developing visual cortex
337. Neurotrophin regulation of cortical dendritic growth requires activity
338. Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth
339. Neurotrophins and synaptic plasticity
340. New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor
341. A structural superfamily of growth factors containing a cystine knot motif
342. Molecular cloning of rat TrkC and distribution of cells expressing messenger RNAs for members of the Trk family in the rat central nervous system
343. Increased production of the TrkB protein tyrosine kinase receptor after brain insults
344. Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles
345. Acute intrahippocampal infusion of BDNF induces lasting potentiation changes of synaptic transmission in the rat dentate gyrus
346. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation
347. Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons
348. trkB, a neural receptor protein-tyrosine kinase: evidence for a full length and two truncated receptors
349. Brain-derived neurotrophic factor promotes survival and chemoprotection of human neuroblastoma cells
350. Immunochemical analysis of dopamine transporter protein in Parkinson's disease
351. TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons
352. Essential role for TrkB receptors in hippocampus-mediated learning
353. Neuronal co-localization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions
354. A comparative study of ethanol, hypoglycemia, hypoxia, and neurotrophic factor interactions with fetal rat hippocampal neurons: a multi-factor in vitro model developmental ethanol effects
355. Lipopolysaccharide enhances synthesis of brain-derived neurotrophic factor in cultured rat microglia
356. Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons
357. Brain-derived neurotrophic factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease
358. Intact spatial learning and memory in transgenic mice with reduced BDNF
359. Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-tetrahydropyridine
360. Co-expression of mRNA for neurotrophic factors in human neurons and glial cells in culture
361. Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells
362. Brain-derived neurotrophic factor prevents the degeneration of medial septal cholinergic neurons following fimbria transection
363. Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons
364. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats
365. Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases
366. Brain-derived neurotrophic factor protein in the human brain: an immunocytochemical study with an special reference to Alzheimer's disease
367. Survival factors promote BDNF protein expression in mesencephalic dopaminergic neutrons in culture
368. Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons
369. Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease
370. Attenuation of the seizure-induced expression of BDNF mRNA in adult rat brain by an inhibitor of calcium/calmodulin-dependent protein kinases
371. Altered mRNA expression for brain derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy
372. Neurotrophins regulate the function of cultured microglia
373. Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins
374. Distinctive four promoters collectively direct expression of brain-derived neurotrophic factor gene
375. Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease
376. Differential regulation of hippocampal neurotrophins during aging in rats
377. Brain-derived neurotrophic factor regulates the expression of AMPA receptor proteins in neocortical neurons
378. Effects of PS1 deficiency on membrane protein trafficking in neurons
379. Intraventricular administration of BDNF increases neuropeptide expression in newborn rat brain
380. BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: partial disagreement with mRNA levels
381. Regulation of BDNF and TrkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
382. Expression and function of TrkB variants in developing sensory neurons
383. Role of neurotrophic factors in cerebral ischemia
384. Neurotrophin-7: a novel member of the neurotrophin family from the zebra fish
385. Medial nigral dopamine neurons have rich neurotrophin support in humans
386. Neurotrophin switching in spinal motoneurons of amyotrophic lateral sclerosis patients
387. Brain-derived neurotrophic factor prevents neuronal cell death induced by corticosterone
388. Neurotoxic and neuroprotective actions of catecholamines in cortical neurons
389. Neurotrophin effects on survival and expression of cholinergic properties in cultured rat septal neurons under normal and stress conditions
390. Neurotrophic effect of brain-derived neurotrophic factor on basal forebrain cholinergic neurons in culture from postnatal rats
391. Cultured basal forebrain cholinergic neurons from postnatal rats show both overlapping and non-overlapping responses to the neurotrophins
392. Increased expression of TrkB mRNA in rat caudate-putamen following 6-OHDA lesions of the nigrostriatal pathway
393. Expression of TrkB and TrkC mRNAs by adult midbrain dopamine neurons a double in situ hybridization study
394. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC-γ
395. Apoptotic cell death of cultured cerebral cortical neurons induced by withdrawal of astroglial trophic support
396. Tyrosine phosphorilation and association of BIT with SHP-2 induced by neurotrophins
397. Dopaminergic stimulation up-regulates the in vivo expression of brain-derived neurotrophic factor in the striatum
398. Quantitative evaluation of neurotrophin and Trk mRNA expression in visual and limbic areas along the occipito-temporo- hippocampal pathway in adult macaque monkeys
399. Cell death during development of the nervous system
400. Effects of donor age and brain-derived neurotrophic factor on the survival of dopaminergic neurons and axonal growth in postnatal rat nigrostriatal co-cultures
401. Specific effects of platelet-derived growth factor on fetal rat and human dopaminergic neurons in vitro
402. Chromosomal mapping of brain-derived neurotrophic factor and neurotrophin-3 genes in man and mouse
403. Neurotrophins and basic fibroblast growth factor induce the differentiation of calbindin-containing neurons in the cerebral cortex
404. Reduced expression of BDNF protein in Parkinson's disease substantia nigra
405. Nerve growth factor potentiates the oxidative necrosis of striatal cholinergic neurons
406. Expression of neurotrophins in hippocampal interneurons immunoreactive for the neuropeptides somatostatin, neuropeptide Y, vasoactive intestinal polypeptide and cholecystokinin
407. Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors
408. Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs
409. Recombinant BBDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
410. The effect of intrahippocampal BDNF and NGF on spatial learning in aged Long Evans rats
411. Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons
412. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
413. Forskolin-induced expression of tyrosine hydroxylase in human foetal brain cortex
414. Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice
415. Marked diversity in the action of growth factors on NMDA-induced neuronal degeneration
416. Brain-derived neurotrophic factor, but not neurotrophin-3 prevents ischemia-induced neuronal cell death in organotypic rat hippocampal cultures
417. Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system
418. Identification and characterization of novel substrates of Trk receptors in developing neurons
419. Neurotrophin-like immunoreactivity in the human hippocampal formation
420. Dimeric structure and conformational stability of brain-derived neurotrophic factor and neurotrophin-3
421. Expression of members of the Trk family in the developing postnatal brain
422. BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex
423. BDNF-activated signal transduction in rat cortical glial cells
424. Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer
425. Differential expression of brain-derived neurotrophic factor, neurotrophin-3 and low-affinity nerve growth factor receptor during postnatal development of the rat cerebellar system
426. Expression of NGF and NT3 mRNAs in hippocampal interneurons innervated by GABAergic septohippocampal pathway
427. Upregulation of BDNF mRNA expression in the barrel cortex of adult mice after sensory stimulation
428. Primary structure and biological activity of a novel human neurotrophic factor
429. Primary structure and biological activity of human brain-derived neurotrophic factor
430. A 1.7-Mb YAC contig around the human BDNF gene (11p13): integration of the physical, genetic, and cytogenetic maps in relation to WAGR syndrome
431. Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases
432. Mouse astrocytes store and deliver brain-derived neurotrophic factor using the non-catalytic gp95TrkB receptor
433. Expression of ciliary neurotrophic factor and the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in cultured rat hippocampal astrocytes
434. Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes
435. Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective
436. Brain-derived neurotrophic factor mediates the activity-dependent regulation of inhibition in neocortical cultures
437. BDNF has opposite effects on the quantal amplitude of pyramidal neuron and interneuron excitatory synapses
438. Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease
439. Differential susceptibility to neurotoxicity mediated by neurotrophins and neuronal nitric oxide synthase
440. Brain-derived neurotrophic factor enhances striatal neuropeptide expression in both the intact and the dopamine-depleted rat striatum
441. Brain-derived neurotrophic factor and neurotrophin-4/5 modify neurotransmitter-related gene expression in the 6-hydroxydopamine-lesioned rat striatum
442. Effects of combined BDNF and GDNF treatment on cultured dopaminergic midbrain neurons
443. Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor
444. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone
445. Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis
446. Hiperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor
447. Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus
448. Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons
449. Growth factor signaling by receptor tyrosine kinases
450. Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multuple roles in hippocampus, striatum and cortex
451. Cellular hybridization for BDNF, TrkB and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus
452. A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic Trk and TrkB tyrosine kinase receptors
453. Neurotrophic factor gene expression in astrocytes during development and following injury
454. Abnormal cerebellar development and folliation in BDNF-/- mice reveals a role for neurotrophins in CNS patterning
455. Intracellular signaling pathways activated by neurotrophic factors
456. Cellular processing of the neurotrophin precursors of NT-3 and BDNF by the mammalian pro-protein convertases
457. Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases
458. Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins
459. Expression of neurotrophins by midbrain dopaminergic neurons
460. Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs
461. Brain-derived neurotrophic factor increases the electrical activity of pars compacta dopamine neurons in vivo
462. In vitro survival and differentiation of neurons derived from epidermal-growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor
463. Identification of a signaling pathway involved in calcium regulation of BDNF transcription
464. Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons
465. BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine
466. Severe sensory deficits but normal CNS development in new born mice lacking TrkB and TrkC tyrosine protein kinase receptors
467. Intraventricular administration of BDNF and NT-3 failed to protect nucleus basalis magnocellularis cholinergic neurons
468. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
469. Stress alters the expression of brain-derived neurotrophic factor and neurotrophin-3 in the hippocampus
470. Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers
471. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us
472. Retrograde transport of brain-derived neurotrophic factor (BDNF) following infusion in neo- and limbic-cortex in rat: relationship to BDNF mRNA expressing neurons
473. Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF and NT-3
474. Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor
475. Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos
476. Expression of brain-derived neurotrophic factor protein in activated microglia of human immunodeficiency virus type 1 encephalitis
477. Absence of brain-derived neurotrophic factor and TrkB receptor immunoreactivity in glia of Alzheimer's disease
478. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the TrkB tyrosine kinase receptor
479. Effects of BDNF on dopaminergic, serotoninergic, and GABAergic neurons in cultures of human fetal ventral mesencephalon
480. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: involvement of the glutathione system
481. TrkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
482. Trk receptors use redundant signal transduction pathways involving SHC and PLC-1γ to mediate NGF responses
483. A splice variant of the neurotrophin receptor TrkB with increased specificity for brain-derived neurotrophic factor
484. Comparison of the effects of the neurotrophins on the morphological structure of dopaminergic neurons in cultures of rat substantia nigra
485. Effects of brain-derived neurotrophic factor on neuronal structure of dopaminergic neurons in dissociated cultures of human fetal mesencephalon
486. brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic NMDA receptor subunit 1
487. The cystine-knot growth-factor superfamily
488. Nerve growth factor receptors: characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells
489. Morphogenetic effect of kainate on adult hippocampal neurons associated with a prolonged expression of brain-derived neurotrophic factor
490. Inducibility of BDNF gene promoter I detected by calcium-phosphate-mediated DNA transfection is confined to neuronal but not glial cells
491. Silencer-mediated repression and non-mediated activation of BDNF and c-fos gene promoters in primary glial or neuronal cells
492. Patients with temporal lobe epilepsy show an increase in brain-derived neurotrophic factor protein and its correlation with neuropeptide Y
493. Brain-derived neurotrophic factor increases the stimulation-evoked release of glutamate and the levels of exocytosis associated proteins in cultured cortical neurons from embryonic rats
494. Brain-derived neurotrophic factor induces rapid and transient release of glutamate through the non- exocytotic pathway from cortical neurons
495. Inhibition of GABA(A) synaptic responses by brain-derived neurotrophic factor in rat hippocampus
496. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
497. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
498. The effects of storage conditions and trophic supplementation on the survival of fetal mesencephalic cells
499. The physiological function of nerve growth factor in the central nervous system: comparison with the periphery
500. Neurotrophins and neuronal plasticity
501. Multiple promoters direct tissue-specific expression of the rat BDNF gene
502. Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice
503. Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element
504. Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons
505. Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons
506. Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia
507. Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in monkeys
508. MPTP produces a pattern of nigrostriatal degeneration which coincides with the mosaic organization of the caudate nucleus
509. Human β-nerve growth factor gene sequence highly homologous to that of mouse
510. Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC
511. An immunoglobulin-like domain determines the specificity of neurotrophin receptors
512. Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures
513. Role of 5-HT2A receptors in the stress-induced down-regulation of brain-derived neurotrophic factor expression in the rat hippocampus
514. Survival of cholinergic forebrain neurons in developing p75(NGFR)-deficient mice
515. Early evolutionary origin of the neurotrophin receptor family
516. 6-hydroxydopamine lesions reduce BDNF mRNA levels in adult rat brain substantia nigra
517. Expression of neurotrophin and Trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration
518. Regionally specific induction of BDNF and truncated Trk.B1 receptors in the hippocampal formation after intraseptal injection of kaininc acid
519. The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro
520. Brain-derived neurotrophic factor immunoreactivity in the limbic system of rats after seizures and during spontaneous convulsions: temporal evolution of changes as compared to neuropeptide Y
521. Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system
522. Neurotrophins in the developing and regenerating visual system
523. Cortical interneurons upregulate neurotrophins in vivo in response to targeted apoptotic degeneration of neighboring pyramidal neurons
524. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex
525. Behavioral, biochemical, histological and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats
526. Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization
527. Brain-derived neurotrohic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies
528. Brain-derived neurotrophic factor peptide antibodies: characterization using a Vaccinia virus expression system
529. Neuron-enriched second trimester human cultures: growth factor response and in vivo graft survival
530. BDNF protection of basal forebrain cholinergic neurons after axotomy: complete protection of p75(NGFR)-positive cells
531. Stimulation of GABAergic neuron differentiation by NT-4/5 in cultures of rat cerebral cortex
532. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
533. Glial cell line derived neurotrophic factor sustains axotomized basal forebrain cholinergic neurons in vivo: dose-response comparison to nerve growth factor and brain-derived neurotrophic factor
534. Functional TrkB neurotrophin receptors are intrinsic components of the adult brain postsynaptic density
535. Mutual regulation between the intercellular messengers nitric oxide and brain-derivd neurotrophic factor in rodent neocortical neurons
536. Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease
537. Neurotrophin binding to the p75 receptor modulates Rho activity and axonal growth
538. Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with Trk receptor expression
539. Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system
540. Immunocytochemical localization of TrkB in the central nervoous system of the adult rat
541. Neuronal coexistence of TrkB and glutamic acid decarboxylase 67 mRNAs in rat hippocampus
542. Activity-dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors
543. Interplay between glutamate and GABA transmitter systems in the physiological regulation of NGF and BDNF synthesis in hippocampal neurons
544. Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes
545. Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain
546. Localization of neurotrophin-3-like immunoreactivity in peripheral tissues of the rat
547. The response of human and rat fetal ventral mesencephalon in culture to the brain-derived neurotrophic factor treatment
548. Influence of BDNF on the expression of the dopaminergic phenotype of tissue used for brain transplants
549. Induction of tyrosine hydroxylase gene expression in human foetal cerebral cortex
550. Neurochemical responses to 6-OHDA and L-DOPA therapy: implications for Parkinson's disease