메뉴 건너뛰기




Volumn 100, Issue 9, 1997, Pages 2333-2340

Binding of β-amyloid to the p75 neurotrophin receptor induces apoptosis: A possible mechanism for Alzheimer's disease

Author keywords

Melanocytes; Nerve growth factor; Neurodegenerative; Neurons; Receptor binding

Indexed keywords

AMYLOID BETA PROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR;

EID: 0030723983     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119772     Document Type: Article
Times cited : (319)

References (58)
  • 1
    • 0028913471 scopus 로고
    • Trafficking of cell surface β-amyloid precursor protein: Retrograde and transcytotic transport in cultured neurons
    • Yamazaki, T., D.J. Selkoe, and E.H. Koo. 1995. Trafficking of cell surface β-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. J. Cell Biol. 129:431-442.
    • (1995) J. Cell Biol. , vol.129 , pp. 431-442
    • Yamazaki, T.1    Selkoe, D.J.2    Koo, E.H.3
  • 2
    • 0029126319 scopus 로고
    • Missing Alzheimer's gene found
    • Barinaga, M. 1995. Missing Alzheimer's gene found. Science (Wash. DC). 269:917-918.
    • (1995) Science (Wash. DC) , vol.269 , pp. 917-918
    • Barinaga, M.1
  • 4
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe, D.J. 1991. The molecular pathology of Alzheimer's disease. Neuron. 6:487-498.
    • (1991) Neuron. , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 5
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner, G.G., and C.W. Wong. 1993. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120:885-890.
    • (1993) Biochem. Biophys. Res. Commun. , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 6
    • 0024315598 scopus 로고
    • Nerve growth factor receptor is associated with cholinergic neurons of the basal forebrain but not the pontomesencephalon
    • Woolf, N.J., E. Gould, and L.L. Butcher. 1989. Nerve growth factor receptor is associated with cholinergic neurons of the basal forebrain but not the pontomesencephalon. Neuroscience. 30:143-152.
    • (1989) Neuroscience , vol.30 , pp. 143-152
    • Woolf, N.J.1    Gould, E.2    Butcher, L.L.3
  • 7
  • 8
    • 0029360415 scopus 로고
    • The death domain: A module shared by proteins with diverse cellular functions
    • Feinstein, E., A. Kimchi, D. Wallach, M. Boldin, and E. Varfolomeev. 1995. The death domain: a module shared by proteins with diverse cellular functions [letter]. Trends Biochem. Sci. 20:342-344.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 342-344
    • Feinstein, E.1    Kimchi, A.2    Wallach, D.3    Boldin, M.4    Varfolomeev, E.5
  • 9
    • 0028913550 scopus 로고
    • A novel protein mat interacts with the death domain of Fas/ APO1 contains a sequence motif related to the death domain
    • Boldin, M.P., E.E. Varfolomeev, Z. Pancer, I.L. Mett, J.H. Camonis, and D. Wallach. 1995. A novel protein mat interacts with the death domain of Fas/ APO1 contains a sequence motif related to the death domain. J. Biol. Chem. 270:7795-7798.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7795-7798
    • Boldin, M.P.1    Varfolomeev, E.E.2    Pancer, Z.3    Mett, I.L.4    Camonis, J.H.5    Wallach, D.6
  • 10
    • 0029805770 scopus 로고    scopus 로고
    • Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
    • Casaccia-Bonnefil, P., B.D. Carter, R.T. Dobrowsky, and M.V. Chao. 1996. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature (Lond.). 383:716-719.
    • (1996) Nature (Lond.) , vol.383 , pp. 716-719
    • Casaccia-Bonnefil, P.1    Carter, B.D.2    Dobrowsky, R.T.3    Chao, M.V.4
  • 11
    • 0029787071 scopus 로고    scopus 로고
    • Induction of cell death by endogenous nerve growth factor through its p75 receptor
    • Frade, J.M., A. Rodríguez-Tébar, and Y.A. Barde. 1996. Induction of cell death by endogenous nerve growth factor through its p75 receptor. Nature (Lond.). 383:166-168.
    • (1996) Nature (Lond.) , vol.383 , pp. 166-168
    • Frade, J.M.1    Rodríguez-Tébar, A.2    Barde, Y.A.3
  • 12
    • 0027996904 scopus 로고
    • Expression of the low affinity nerve growth factor receptor enhances β-amyloid peptide toxicity
    • Rabizadeh, S., C.M. Bitler, L.L. Butcher, and D.E. Bredesen. 1994. Expression of the low affinity nerve growth factor receptor enhances β-amyloid peptide toxicity. Proc. Natl. Acad. Sci. USA. 91:10703-10706.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10703-10706
    • Rabizadeh, S.1    Bitler, C.M.2    Butcher, L.L.3    Bredesen, D.E.4
  • 15
    • 0029102993 scopus 로고
    • Neurodegeneration mediated by glutamate and beta-amyloid peptide: A comparison and possible interaction
    • Gray, C.W., and A.J. Patel. 1995. Neurodegeneration mediated by glutamate and beta-amyloid peptide: a comparison and possible interaction. Brain Res. 691:169-179.
    • (1995) Brain Res. , vol.691 , pp. 169-179
    • Gray, C.W.1    Patel, A.J.2
  • 16
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli, Y., Y. Sherman, and S.A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
    • (1992) J. Cell Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 17
    • 0024599294 scopus 로고
    • Isolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding
    • Waugh, S.M., E.E. DiBella, and P.F. Pilch. 1989. Isolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding. Biochemistry. 28:3448-3455.
    • (1989) Biochemistry , vol.28 , pp. 3448-3455
    • Waugh, S.M.1    DiBella, E.E.2    Pilch, P.F.3
  • 18
    • 0028946708 scopus 로고
    • Zone mapping of the binding domain of the rat low affinity nerve growth factor receptor by the introduction of novel N-glycosylation sites
    • Baldwin, A.N., and E.M. Shooter. 1995. Zone mapping of the binding domain of the rat low affinity nerve growth factor receptor by the introduction of novel N-glycosylation sites. J. Biol. Chem. 270:4594-4602.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4594-4602
    • Baldwin, A.N.1    Shooter, E.M.2
  • 19
    • 0028217645 scopus 로고
    • High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors
    • Mahadeo, D., L. Kaplan, M.V. Chao, and B.L. Hempstead. 1994. High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors. J. Biol. Chem. 269:6884-6891.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6884-6891
    • Mahadeo, D.1    Kaplan, L.2    Chao, M.V.3    Hempstead, B.L.4
  • 20
    • 0029998346 scopus 로고    scopus 로고
    • The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-β peptide but not aggregated, cytotoxic amyloid-β peptide
    • Boland, K., M. Behrens, D. Choi, K. Manias, and D.H. Perlmutter. 1996. The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-β peptide but not aggregated, cytotoxic amyloid-β peptide. J. Biol. Chem. 271:18032-18044.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18032-18044
    • Boland, K.1    Behrens, M.2    Choi, D.3    Manias, K.4    Perlmutter, D.H.5
  • 21
    • 0028267440 scopus 로고
    • Normal and abnormal biology of the beta-amyloid precursor protein
    • Selkoe, D.J. 1994. Normal and abnormal biology of the beta-amyloid precursor protein. Ann. Rev. Neurosci. 17:489-517.
    • (1994) Ann. Rev. Neurosci. , vol.17 , pp. 489-517
    • Selkoe, D.J.1
  • 22
    • 0028982272 scopus 로고
    • Amyloid beta-protein aggregation nullifies its pathologic properties in cultured cerebrovascular smooth muscle cells
    • Davis-Salinas, J., and W.E. Van Nostrand. 1995. Amyloid beta-protein aggregation nullifies its pathologic properties in cultured cerebrovascular smooth muscle cells. J. Biol. Chem. 270:20887-20890.
    • (1995) J. Biol. Chem. , vol.270 , pp. 20887-20890
    • Davis-Salinas, J.1    Van Nostrand, W.E.2
  • 23
    • 0027447286 scopus 로고
    • Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state
    • Pike, C.J., D. Burdick, A.J. Walencewicz, C.G. Glabe, and C.W. Cotman. 1993. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci. 13:1676-1687.
    • (1993) J. Neurosci. , vol.13 , pp. 1676-1687
    • Pike, C.J.1    Burdick, D.2    Walencewicz, A.J.3    Glabe, C.G.4    Cotman, C.W.5
  • 24
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid beta protein toxicity
    • Behl, C., J.B. Davis, R. Lesley, and D. Schubert. 1994. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell. 77:817-827.
    • (1994) Cell , vol.77 , pp. 817-827
    • Behl, C.1    Davis, J.B.2    Lesley, R.3    Schubert, D.4
  • 25
    • 0029245289 scopus 로고
    • A potential role for apoptosis in neurodegeneration and Alzheimer's disease
    • Cotman, C.W., and A.J. Andersen. 1995. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol. Neurobiol. 10:19-45.
    • (1995) Mol. Neurobiol. , vol.10 , pp. 19-45
    • Cotman, C.W.1    Andersen, A.J.2
  • 26
    • 0028577208 scopus 로고
    • Immunohistochemical evidence for apoptosis in Alzheimer's disease
    • Su, J.H., A.J. Andersen, B.J. Cummings, and C.W. Cotman. 1994. Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport. 5:2529-2533.
    • (1994) Neuroreport , vol.5 , pp. 2529-2533
    • Su, J.H.1    Andersen, A.J.2    Cummings, B.J.3    Cotman, C.W.4
  • 27
    • 0028207907 scopus 로고
    • Amyloid beta peptide induces necrosis rather than apoptosis
    • Behl, C., J.B. Davis, P.G. Klier, and D. Shubert. 1994. Amyloid beta peptide induces necrosis rather than apoptosis. Brain Res. 645:253-264.
    • (1994) Brain Res. , vol.645 , pp. 253-264
    • Behl, C.1    Davis, J.B.2    Klier, P.G.3    Shubert, D.4
  • 28
    • 0029872640 scopus 로고    scopus 로고
    • Beta-APP cognitive function versus beta-amyloid-induced cell death
    • Gschwind, M., J.R. Martin, J.L. Moreau, and G. Huber. 1996. Beta-APP cognitive function versus beta-amyloid-induced cell death. Ann. NY Acad. Sci. 77:293-296.
    • (1996) Ann. NY Acad. Sci. , vol.77 , pp. 293-296
    • Gschwind, M.1    Martin, J.R.2    Moreau, J.L.3    Huber, G.4
  • 30
    • 0027485950 scopus 로고
    • Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor
    • Deckwerth, T.L., and E.M. Johnson, Jr. 1993. Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol. 123:1207-1222.
    • (1993) J. Cell Biol. , vol.123 , pp. 1207-1222
    • Deckwerth, T.L.1    Johnson Jr., E.M.2
  • 31
    • 0029784838 scopus 로고    scopus 로고
    • Amyloid β-protein and the genetics of Alzheimer's disease
    • Selkoe, D.J. 1996. Amyloid β-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271:18295-18298.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18295-18298
    • Selkoe, D.J.1
  • 33
    • 0031051859 scopus 로고    scopus 로고
    • In vivo NGF treatment increases proliferation on the primary sympathetic ganglia of chick embryos
    • Goldstein, R.S., C. Avivi, and R. Geffen. 1997. In vivo NGF treatment increases proliferation on the primary sympathetic ganglia of chick embryos. Dev. Biol. 181:116-120.
    • (1997) Dev. Biol. , vol.181 , pp. 116-120
    • Goldstein, R.S.1    Avivi, C.2    Geffen, R.3
  • 34
    • 0029886779 scopus 로고    scopus 로고
    • Nerve growth factor (NGF)-mediated protection of neural crest cells from antimitotic agent-induced apoptosis: The role of the low-affinity NGF receptor
    • Cortazzo, M.H., E.S. Kassis, K.A. Sproul, and N.F. Schor. 1996. Nerve growth factor (NGF)-mediated protection of neural crest cells from antimitotic agent-induced apoptosis: the role of the low-affinity NGF receptor. J. Neurosci. 16:3895-3899.
    • (1996) J. Neurosci. , vol.16 , pp. 3895-3899
    • Cortazzo, M.H.1    Kassis, E.S.2    Sproul, K.A.3    Schor, N.F.4
  • 35
    • 0027526580 scopus 로고
    • HSV-1 vector-mediated gene transfer of the human nerve growth factor receptor p75hNGFR defines high-affinity NGF binding
    • Battleman, D.S., A.I. Geller, and M.V. Chao. 1993. HSV-1 vector-mediated gene transfer of the human nerve growth factor receptor p75hNGFR defines high-affinity NGF binding. J. Neurosci. 13:941-951.
    • (1993) J. Neurosci. , vol.13 , pp. 941-951
    • Battleman, D.S.1    Geller, A.I.2    Chao, M.V.3
  • 36
    • 0029021457 scopus 로고
    • p75 and Trk: A two-receptor system
    • Chao, M.V., and B.L. Hempstead. 1995. p75 and Trk: a two-receptor system. Trends Neurosci. 19:321-326.
    • (1995) Trends Neurosci. , vol.19 , pp. 321-326
    • Chao, M.V.1    Hempstead, B.L.2
  • 37
    • 0025452844 scopus 로고
    • Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse
    • Ruit, K.G., P.A. Osborne, R.E. Schmidt, E.M. Johnson, Jr., and W.D. Snider. 1990. Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse. J. Neurosci. 10:2412-2419.
    • (1990) J. Neurosci. , vol.10 , pp. 2412-2419
    • Ruit, K.G.1    Osborne, P.A.2    Schmidt, R.E.3    Johnson Jr., E.M.4    Snider, W.D.5
  • 38
    • 0026700009 scopus 로고
    • Culture of dorsal root ganglion neurons from aged rats: Effects of acetyl-L-carnitine and NGF
    • Manfridi, A., G.L. Forloni, E. Arrigoni-Martelli, and M. Mancia. 1992. Culture of dorsal root ganglion neurons from aged rats: effects of acetyl-L-carnitine and NGF. Inter. J. Develop. Neurosci. 10:321-329.
    • (1992) Inter. J. Develop. Neurosci. , vol.10 , pp. 321-329
    • Manfridi, A.1    Forloni, G.L.2    Arrigoni-Martelli, E.3    Mancia, M.4
  • 39
    • 0027230005 scopus 로고
    • Effects of nerve growth factor on the survival of primary cultured adult and aged mouse sensory neurons
    • Jiang, Z.G., and R.A. Smith. 1993. Effects of nerve growth factor on the survival of primary cultured adult and aged mouse sensory neurons. J. Neurosci. Res. 35:29-37.
    • (1993) J. Neurosci. Res. , vol.35 , pp. 29-37
    • Jiang, Z.G.1    Smith, R.A.2
  • 40
    • 0026659777 scopus 로고
    • Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF
    • Cheng, B., and M.P. Mattson. 1992. Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: prevention by NGF and bFGF. Exp. Neurol. 117:114-123.
    • (1992) Exp. Neurol. , vol.117 , pp. 114-123
    • Cheng, B.1    Mattson, M.P.2
  • 41
    • 0026334402 scopus 로고
    • NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis
    • Cheng, B., and M.P. Mattson. 1991. NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis. Neuron. 7:1031-1041.
    • (1991) Neuron. , vol.7 , pp. 1031-1041
    • Cheng, B.1    Mattson, M.P.2
  • 42
    • 0026723604 scopus 로고
    • Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats
    • Kawaja, M.D., M.B. Rosenberg, K. Yoshida, and F.H. Gage. 1992. Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats. J. Neurosci. 12: 2849-2864.
    • (1992) J. Neurosci. , vol.12 , pp. 2849-2864
    • Kawaja, M.D.1    Rosenberg, M.B.2    Yoshida, K.3    Gage, F.H.4
  • 43
    • 0027521409 scopus 로고
    • NGF augmentation rescues trigeminal ganglion and principalis neurons, but not brainstem or cortical whisker patterns, after infraorbital nerve injury at birth
    • Henderson, T.A., R.W. Rhoades, C.A. Bennett-Clarke, P.A. Osborne, E.M. Johnson, and M.F. Jacquin. 1993. NGF augmentation rescues trigeminal ganglion and principalis neurons, but not brainstem or cortical whisker patterns, after infraorbital nerve injury at birth. J. Comparative Neurol. 336:243-260.
    • (1993) J. Comparative Neurol. , vol.336 , pp. 243-260
    • Henderson, T.A.1    Rhoades, R.W.2    Bennett-Clarke, C.A.3    Osborne, P.A.4    Johnson, E.M.5    Jacquin, M.F.6
  • 44
    • 0025513602 scopus 로고
    • Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration
    • H.S. U
    • Tuszynski, M.H., H.S. U, D.G. Amaral, and F.H. Gage. 1990. Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. J. Neurosci. 10:3604-3614.
    • (1990) J. Neurosci. , vol.10 , pp. 3604-3614
    • Tuszynski, M.H.1    Amaral, D.G.2    Gage, F.H.3
  • 45
    • 0027723303 scopus 로고
    • Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons
    • Shimohama, S., N. Ogawa, Y. Tamura, A. Akaike, T. Tsukahara, H. Iwata, and J. Kimura. 1993. Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons. Brain Res. 632: 296-302.
    • (1993) Brain Res. , vol.632 , pp. 296-302
    • Shimohama, S.1    Ogawa, N.2    Tamura, Y.3    Akaike, A.4    Tsukahara, T.5    Iwata, H.6    Kimura, J.7
  • 47
    • 0027771726 scopus 로고
    • Nerve growth factor pharmacology: Application to the treatment of cholinergic neurodegeneration in Alzheimer's disease
    • Lapchak, P.A. 1993. Nerve growth factor pharmacology: application to the treatment of cholinergic neurodegeneration in Alzheimer's disease. Exp. Neurol. 124:16-20.
    • (1993) Exp. Neurol. , vol.124 , pp. 16-20
    • Lapchak, P.A.1
  • 49
    • 0030010375 scopus 로고    scopus 로고
    • Nerve growth factor rescues pigment cells from ultraviolet-induced apoptosis by up-regulating BCL-2 levels
    • Zhai, S., M. Yaar, S. Doyle, and B.A. Gilchrest. 1996. Nerve growth factor rescues pigment cells from ultraviolet-induced apoptosis by up-regulating BCL-2 levels. Exp. Cell Res. 224:335-343.
    • (1996) Exp. Cell Res. , vol.224 , pp. 335-343
    • Zhai, S.1    Yaar, M.2    Doyle, S.3    Gilchrest, B.A.4
  • 50
    • 0026566772 scopus 로고
    • Gene expression in cells of the central nervous system
    • Takahashi, Y. 1992. Gene expression in cells of the central nervous system. Prog. Neurobiol. (NY). 38:523-569.
    • (1992) Prog. Neurobiol. (NY) , vol.38 , pp. 523-569
    • Takahashi, Y.1
  • 51
    • 0024386959 scopus 로고
    • Limbic seizures increase neuronal production of messenger RNA for nerve growth factor
    • Gall, C.M., and P.J. Isackson. 1989. Limbic seizures increase neuronal production of messenger RNA for nerve growth factor. Science (Wash. DC). 245:758-761.
    • (1989) Science (Wash. DC) , vol.245 , pp. 758-761
    • Gall, C.M.1    Isackson, P.J.2
  • 52
    • 0023574881 scopus 로고
    • Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain
    • Larkfors, L., T. Ebendal, S.R. Whittemore, H. Persson, B. Hoffer, and L. Olson. 1987. Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain. Brain Res. 427:55-60.
    • (1987) Brain Res. , vol.427 , pp. 55-60
    • Larkfors, L.1    Ebendal, T.2    Whittemore, S.R.3    Persson, H.4    Hoffer, B.5    Olson, L.6
  • 53
    • 0000920292 scopus 로고    scopus 로고
    • Amyloid-β peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease
    • Shi, D.Y., Z. Huaijie, J. Fu, S.F. Yan, A. Roher, W.W. Tourtellotte, T. Rajavashisth, X. Chen, G.C. Godman, D. Stern, and A.M. Schmidt. 1997. Amyloid-β peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc. Natl. Acad. Sci. USA. 94:5296-5301.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5296-5301
    • Shi, D.Y.1    Huaijie, Z.2    Fu, J.3    Yan, S.F.4    Roher, A.5    Tourtellotte, W.W.6    Rajavashisth, T.7    Chen, X.8    Godman, G.C.9    Stern, D.10    Schmidt, A.M.11
  • 56
    • 0030248270 scopus 로고    scopus 로고
    • Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
    • Paresce, D.M., R.N. Ghosh, and F.R. Maxfield. 1996. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron. 17:553-565.
    • (1996) Neuron. , vol.17 , pp. 553-565
    • Paresce, D.M.1    Ghosh, R.N.2    Maxfield, F.R.3
  • 57
    • 0025244165 scopus 로고
    • Nerve growth factor potentiates the neurotoxicity of beta amyloid
    • Yankner, B.A., A. Caceres, and L.K. Duffy. 1990. Nerve growth factor potentiates the neurotoxicity of beta amyloid. Proc. Natl. Acad. Sci. USA. 87: 9020-9023.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 9020-9023
    • Yankner, B.A.1    Caceres, A.2    Duffy, L.K.3
  • 58
    • 0027183950 scopus 로고
    • Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness
    • Benedetti, M., A. Levi, and M.V. Chao. 1993. Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc. Natl. Acad. Sci. USA. 90:7859-7863.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7859-7863
    • Benedetti, M.1    Levi, A.2    Chao, M.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.