Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures

European Journal of Neuroscience

Volumn 11, Issue 1, 1999, Pages 327-334

  Kim, Eun Young ^a   Koh, Jae Young ^a   Kim, Yang Hee ^a   Sohn, Seonghyang ^b   Joe, Eunhye ^b   Gwag, Byoung Joo ^b  

^a Ajou University School of Medicine   (South Korea)

^b Ajou University   (South Korea)

Author keywords

Apoptosis; Cortical cell culture; Ischaemia; Necrosis; Oxidative stress; Zinc

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE; FREE RADICAL; GLUTAMATE RECEPTOR; INSULIN; KAINIC ACID; NITRIC OXIDE SYNTHASE; PROTEIN SYNTHESIS INHIBITOR; REACTIVE OXYGEN METABOLITE; TROLOX C; ZINC ION; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; ANTIDIABETIC AGENT; ANTIOXIDANT; BENZOYLCARBONYL ASPARTYL GLUTAMYL VALYL ASPARTYL FLUOROMETHYL KETONE; BENZOYLCARBONYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTYL-FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CHROMAN DERIVATIVE; CYSTEINE PROTEINASE INHIBITOR; DIZOCILPINE MALEATE; DOPAMINE RECEPTOR STIMULATING AGENT; NEUROTOXIN; OLIGOPEPTIDE; PEPTIDE CHLOROMETHYL KETONE; ZINC;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; LIPID PEROXIDATION; MOUSE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; ANIMAL; APOPTOSIS; CELL CULTURE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; ELECTRON MICROSCOPY; FEMALE; METABOLISM; MITOCHONDRION SWELLING; NECROSIS; NERVE CELL; NERVE DEGENERATION; OXIDATIVE STRESS; PATHOLOGY; PREGNANCY; ULTRASTRUCTURE;

2,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-1-PHENYL-1H-3-BENZAZEPINE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CEREBRAL CORTEX; CHROMANS; CYSTEINE PROTEINASE INHIBITORS; DIZOCILPINE MALEATE; DOPAMINE AGONISTS; DRUG SYNERGISM; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; FREE RADICALS; HYPOGLYCEMIC AGENTS; INSULIN; KAINIC ACID; LIPID PEROXIDATION; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIAL SWELLING; NECROSIS; NERVE DEGENERATION; NEURONS; NEUROTOXINS; OLIGOPEPTIDES; OXIDATIVE STRESS; PREGNANCY; ZINC;

EID: 0032588001     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00437.x     Document Type: Article

References (2)

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2. Ankarcrona, M., Dypbukt, J.M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S.A. & Nicotera, P. (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron, 15, 961-973.