메뉴 건너뛰기




Volumn 5, Issue 10, 1998, Pages 832-837

Fatal attractions: Abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

Author keywords

Dementia; Lewy bodies; Neurofilaments; Parkinson's disease; Synuclein

Indexed keywords

NERVE PROTEIN; NEUROFILAMENT PROTEIN;

EID: 0031762949     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400432     Document Type: Review
Times cited : (259)

References (64)
  • 1
    • 0029131979 scopus 로고
    • Peripheral nervous system-specific genes identififed by subtractive cDNA cloning
    • Akopian AN and Wood JN (1995) Peripheral nervous system-specific genes identififed by subtractive cDNA cloning. J. Biol. Chem. 36: 21264-21270
    • (1995) J. Biol. Chem. , vol.36 , pp. 21264-21270
    • Akopian, A.N.1    Wood, J.N.2
  • 4
    • 0030821967 scopus 로고    scopus 로고
    • A gene for Parkinson disease
    • Chase TN (1997) A gene for Parkinson disease. Arch. Neurol. 54 1156-1157
    • (1997) Arch. Neurol. , vol.54 , pp. 1156-1157
    • Chase, T.N.1
  • 6
    • 0025943418 scopus 로고
    • Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: Light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD
    • Dickson DW, Ruan D, Crystal H, Mark MH, Davies P, Kress Y and Yen S-H (1991) Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: Light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD Neurol. 41: 1402-1409
    • (1991) Neurol. , vol.41 , pp. 1402-1409
    • Dickson, D.W.1    Ruan, D.2    Crystal, H.3    Mark, M.H.4    Davies, P.5    Kress, Y.6    Yen, S.-H.7
  • 8
    • 0031730617 scopus 로고    scopus 로고
    • ICE, neuronal apoptosis and neurodegeneration
    • Friedlander RM and Yuan J (1998) ICE, neuronal apoptosis and neurodegeneration. Cell Death Differ 5: 823-831
    • (1998) Cell Death Differ , vol.5 , pp. 823-831
    • Friedlander, R.M.1    Yuan, J.2
  • 10
    • 0029127954 scopus 로고
    • Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
    • George JM, Jin H, Woods WS and Clayton DF (1995) Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15. 361-372
    • (1995) Neuron , vol.15 , pp. 361-372
    • George, J.M.1    Jin, H.2    Woods, W.S.3    Clayton, D.F.4
  • 11
    • 0031576074 scopus 로고    scopus 로고
    • The awakening of α-synuclein
    • Goedert M (1997) The awakening of α-synuclein. Nature 388. 232-233
    • (1997) Nature , vol.388 , pp. 232-233
    • Goedert, M.1
  • 12
    • 0002941489 scopus 로고    scopus 로고
    • The neurofibrillary pathology of Alzheimer's disease
    • Prusiner SB, Rosenberg RN, Di Mauro S and Barchi RL (eds). Boston, MA, Butterworth Heineman Press
    • Goedert M, Trojanowski JQ and Lee VM-Y (1997) The neurofibrillary pathology of Alzheimer's disease. In The Molecular and Genetic Basis of Neurological Disease, 2nd Edition. Prusiner SB, Rosenberg RN, Di Mauro S and Barchi RL (eds). pp 613-627, Boston, MA, Butterworth Heineman Press
    • (1997) The Molecular and Genetic Basis of Neurological Disease, 2nd Edition , pp. 613-627
    • Goedert, M.1    Trojanowski, J.Q.2    Lee, V.M.-Y.3
  • 13
    • 0020517951 scopus 로고
    • Lewy bodies of Parkinson's disease contain neurofilament antigens
    • Goldman JE, Yen SH, Chiu FC and Peress NS (1983) Lewy bodies of Parkinson's disease contain neurofilament antigens. Science 221: 1082-1084
    • (1983) Science , vol.221 , pp. 1082-1084
    • Goldman, J.E.1    Yen, S.H.2    Chiu, F.C.3    Peress, N.S.4
  • 14
    • 0031035211 scopus 로고    scopus 로고
    • Criteria for Alzheimer's disease and the nosology of dementia with Lewy bodies
    • Hansen LA and Samuel W(1997) Criteria for Alzheimer's disease and the nosology of dementia with Lewy bodies. Neurol. 48: 126-132
    • (1997) Neurol. , vol.48 , pp. 126-132
    • Hansen, L.A.1    Samuel, W.2
  • 15
    • 0030860376 scopus 로고    scopus 로고
    • Alpha-synuclein - A link between Parkinson and Alzheimer diseases?
    • Heintz N and Zoghbi H (1997) Alpha-synuclein - A link between Parkinson and Alzheimer diseases? Nature Genetics 16: 325-327
    • (1997) Nature Genetics , vol.16 , pp. 325-327
    • Heintz, N.1    Zoghbi, H.2
  • 16
    • 0025807172 scopus 로고
    • Epitopes located in spatially separate domains of each neurofilament subunit are present in the Lewy bodies of Parkinson's disease
    • Hill WD, Lee VMY, Hurtig HI, Murray JM and Trojanowski JQ (1991) Epitopes located in spatially separate domains of each neurofilament subunit are present in the Lewy bodies of Parkinson's disease. J. Comp. Neurol. 109: 150-160
    • (1991) J. Comp. Neurol. , vol.109 , pp. 150-160
    • Hill, W.D.1    Lee, V.M.Y.2    Hurtig, H.I.3    Murray, J.M.4    Trojanowski, J.Q.5
  • 19
    • 0031944830 scopus 로고    scopus 로고
    • Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein
    • Inzarry MC, Growdon W, Gomez-Isla T, Newell K, George JM, Clayton DF and Hyman BT (1998) Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein. J. Neuropath. Exper. Neurol 57: 334-337
    • (1998) J. Neuropath. Exper. Neurol , vol.57 , pp. 334-337
    • Inzarry, M.C.1    Growdon, W.2    Gomez-Isla, T.3    Newell, K.4    George, J.M.5    Clayton, D.F.6    Hyman, B.T.7
  • 21
    • 0028985267 scopus 로고
    • The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
    • Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, Kittel A and Saitoh T (1995) The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14. 467-475
    • (1995) Neuron , vol.14 , pp. 467-475
    • Iwai, A.1    Masliah, E.2    Yoshimoto, M.3    Ge, N.4    Flanagan, L.5    De Silva, H.A.6    Kittel, A.7    Saitoh, T.8
  • 22
  • 23
    • 0028277520 scopus 로고
    • Identification of two distinct synucleins from human brain
    • Jakes R, Spillantini MG and Goedert M (1994) Identification of two distinct synucleins from human brain. FEBS Lett 345: 27-32
    • (1994) FEBS Lett , vol.345 , pp. 27-32
    • Jakes, R.1    Spillantini, M.G.2    Goedert, M.3
  • 24
    • 0030932673 scopus 로고    scopus 로고
    • Binding of Aβ to α- and β-synucleins: Identification of segments in α-synuclein/NAC precursor that bind Aβ and NAC
    • Jensen PH, Hojrup P, Hager H, Nielsen MS, Jacobsen L, Olesen OF, Gliemann J and Jakes R (1997) Binding of Aβ to α- and β-synucleins: identification of segments in α-synuclein/NAC precursor that bind Aβ and NAC. Biochem J. 32: 539-546
    • (1997) Biochem J. , vol.32 , pp. 539-546
    • Jensen, P.H.1    Hojrup, P.2    Hager, H.3    Nielsen, M.S.4    Jacobsen, L.5    Olesen, O.F.6    Gliemann, J.7    Jakes, R.8
  • 25
    • 0031045589 scopus 로고    scopus 로고
    • Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing
    • Ji H, Liu YE, Jia T, Wang M, Liu J, Xiao G, Joseph BK, Rosen C and Shi YE (1997) Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res. 57: 759-764
    • (1997) Cancer Res. , vol.57 , pp. 759-764
    • Ji, H.1    Liu, Y.E.2    Jia, T.3    Wang, M.4    Liu, J.5    Xiao, G.6    Joseph, B.K.7    Rosen, C.8    Shi, Y.E.9
  • 27
    • 0344431341 scopus 로고    scopus 로고
    • Structural neurology: Are seeds at the root of neuronal degeneration
    • Lansbury PT (1997) Structural neurology: Are seeds at the root of neuronal degeneration. Neuron 19: 1151-1154
    • (1997) Neuron , vol.19 , pp. 1151-1154
    • Lansbury, P.T.1
  • 30
    • 0023722437 scopus 로고    scopus 로고
    • Synuclein. A neuron-specific protein localized to the nucleus and presynaptic nerve terminal
    • Maroteaux L, Campanelli JT and Scheller RH (1998) Synuclein. A neuron-specific protein localized to the nucleus and presynaptic nerve terminal J. Neurosci. 8: 2804-2815
    • (1998) J. Neurosci. , vol.8 , pp. 2804-2815
    • Maroteaux, L.1    Campanelli, J.T.2    Scheller, R.H.3
  • 31
    • 0025943571 scopus 로고
    • The rat brain synuclein Family of proteins transiently associated with neuronal membrane
    • Maroteaux L and Scheller RH (1991) The rat brain synuclein Family of proteins transiently associated with neuronal membrane. Mol Brain Res 11: 335-343
    • (1991) Mol Brain Res , vol.11 , pp. 335-343
    • Maroteaux, L.1    Scheller, R.H.2
  • 35
    • 0030601977 scopus 로고    scopus 로고
    • Distribution of phosphoneuroprotein 14 (PNP 14) in vertebrates. Its levels as determined by enzyme immunoassay
    • Nakajo S, Tsukuda K, Kameyama H, Furuyama Y and Nakaya K (1996) Distribution of phosphoneuroprotein 14 (PNP 14) in vertebrates. Its levels as determined by enzyme immunoassay. Brain Res. 741: 180-184
    • (1996) Brain Res. , vol.741 , pp. 180-184
    • Nakajo, S.1    Tsukuda, K.2    Kameyama, H.3    Furuyama, Y.4    Nakaya, K.5
  • 36
    • 0027429156 scopus 로고
    • A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation
    • Nakajo S, Tsukada K, Omata K, Nakamura Y and Nakaya K (1993) A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation. Eur. J. Biochem. 217 1057-1063
    • (1993) Eur. J. Biochem. , vol.217 , pp. 1057-1063
    • Nakajo, S.1    Tsukada, K.2    Omata, K.3    Nakamura, Y.4    Nakaya, K.5
  • 37
    • 0026648282 scopus 로고
    • Detergent-insoluble cortical Lewy body fibrils share epitopes with neurofilament and tau
    • Pollanen MS, Bergeron C and Weyer L (1992) Detergent-insoluble cortical Lewy body fibrils share epitopes with neurofilament and tau J Neurochem. 58: 1953-1956
    • (1992) J Neurochem. , vol.58 , pp. 1953-1956
    • Pollanen, M.S.1    Bergeron, C.2    Weyer, L.3
  • 38
    • 0027411108 scopus 로고
    • Deposition of detergent-resistant neurofilaments into Lewy body fibrils
    • Pollanen MS, Bergeron C and Weyer L (1993a) Deposition of detergent-resistant neurofilaments into Lewy body fibrils Brain Res. 603: 121-124
    • (1993) Brain Res. , vol.603 , pp. 121-124
    • Pollanen, M.S.1    Bergeron, C.2    Weyer, L.3
  • 39
    • 0028352092 scopus 로고
    • Characterization of a shared epitope in cortical Lewy body fibrils and Alzheimer paired helical filaments
    • Pollanen MS, Bergeron C and Weyer L (1994) Characterization of a shared epitope in cortical Lewy body fibrils and Alzheimer paired helical filaments. Acta Neuropathol. 88: 1-6
    • (1994) Acta Neuropathol. , vol.88 , pp. 1-6
    • Pollanen, M.S.1    Bergeron, C.2    Weyer, L.3
  • 43
    • 0031730496 scopus 로고    scopus 로고
    • BCL-2 family members in the development and degenerative pathologies of the nervous system
    • Sadoul R (1998) BCL-2 family members in the development and degenerative pathologies of the nervous system. Cell Death Differ 5: 805-815
    • (1998) Cell Death Differ , vol.5 , pp. 805-815
    • Sadoul, R.1
  • 44
    • 0029671104 scopus 로고    scopus 로고
    • Neocortical Lewy body counts correlate with dementia in the Lewy body variant of Alzheimer's disease
    • Samuel W, Galasko D, Masliah E and Hansen LA (1996) Neocortical Lewy body counts correlate with dementia in the Lewy body variant of Alzheimer's disease. J Neuropath. Exper Neurol. 55. 44-52
    • (1996) J Neuropath. Exper Neurol. , vol.55 , pp. 44-52
    • Samuel, W.1    Galasko, D.2    Masliah, E.3    Hansen, L.A.4
  • 45
    • 0030004466 scopus 로고    scopus 로고
    • Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders
    • Schmidt ML, Martin JA, Lee VM-Y and Trojanowski JQ (1996) Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer's disease and Lewy body disorders Acta Neuropathol 91: 475-481
    • (1996) Acta Neuropathol , vol.91 , pp. 475-481
    • Schmidt, M.L.1    Martin, J.A.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4
  • 46
  • 47
    • 0029073666 scopus 로고
    • High-resolution mapping of SNCA encoding α-synuclein, the non-Aβ component of Alzheimer's disease amyloid precursor, to human chromosome 4q21.3-q22 by fluorescence in situ hybridization
    • Shibashi Y, Baillie DAM, St Clair D and Brookes AJ (1995) High-resolution mapping of SNCA encoding α-synuclein, the non-Aβ component of Alzheimer's disease amyloid precursor, to human chromosome 4q21.3-q22 by fluorescence in situ hybridization. Cytogenet. Cell Genet 71 54-55
    • (1995) Cytogenet. Cell Genet , vol.71 , pp. 54-55
    • Shibashi, Y.1    Baillie, D.A.M.2    St Clair, D.3    Brookes, A.J.4
  • 49
    • 0032568534 scopus 로고    scopus 로고
    • α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, Hasegawa M and Goedert M (1998) α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl Acad. Sci USA 95: 6469-6473
    • (1998) Proc. Natl Acad. Sci USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 50
    • 0028979612 scopus 로고
    • Assignment of human α-synuclein (SNCA) and β-synuclein (SNCB) genes to chromosomes 4q21 and 5q35
    • Spillantini MG, Divane A and Goedert M (1995) Assignment of human α-synuclein (SNCA) and β-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. Genomics 27: 379-381
    • (1995) Genomics , vol.27 , pp. 379-381
    • Spillantini, M.G.1    Divane, A.2    Goedert, M.3
  • 51
    • 0030887854 scopus 로고    scopus 로고
    • Familial multiple system tauopathy with presenile dementia A disease with abundant neuronal and glial tau filaments
    • Spillantini MG, Goedert M, Crowther RA, Murrell JR, Farlow MR and Ghetti B (1997a) Familial multiple system tauopathy with presenile dementia A disease with abundant neuronal and glial tau filaments. Proc Natl. Acad Sci USA 94. 4113-4118
    • (1997) Proc Natl. Acad Sci USA , vol.94 , pp. 4113-4118
    • Spillantini, M.G.1    Goedert, M.2    Crowther, R.A.3    Murrell, J.R.4    Farlow, M.R.5    Ghetti, B.6
  • 53
  • 54
    • 0031013141 scopus 로고    scopus 로고
    • Apoptotic-like changes in Lewy body-associated disorders and normal aging in substantia nigral neurons
    • Tompkins MM, Basgall EJ, Zamrini E and Hill WD (1997) Apoptotic-like changes in Lewy body-associated disorders and normal aging in substantia nigral neurons. Am. J. Pathol. 150: 119-131
    • (1997) Am. J. Pathol. , vol.150 , pp. 119-131
    • Tompkins, M.M.1    Basgall, E.J.2    Zamrini, E.3    Hill, W.D.4
  • 55
    • 7844233689 scopus 로고    scopus 로고
    • Mechanisms of neuron death in neurodegenerative diseases of the elderly: Role of the Lewy body
    • Wang E and Snyder SD (eds). San Diego, Academic Press
    • Trojanowski JQ, Galvin JE, Schmidt ML, Tu P-H, Iwatsubo T and Lee VM-Y (1998) Mechanisms of neuron death in neurodegenerative diseases of the elderly: Role of the Lewy body. In Handbook of the Aging Brain, Wang E and Snyder SD (eds). pp. 143-152, (San Diego, Academic Press)
    • (1998) Handbook of the Aging Brain , pp. 143-152
    • Trojanowski, J.Q.1    Galvin, J.E.2    Schmidt, M.L.3    Tu, P.-H.4    Iwatsubo, T.5    Lee, V.M.-Y.6
  • 57
    • 0030910404 scopus 로고    scopus 로고
    • Oxidative stress, mutant SODI, and neurofilament pathology in transgenic mouse models of human motor neuron disease
    • Tu P-H, Gurney ME, Julien J-P, Lee VM-Y and Trojanowski JQ (1997a) Oxidative stress, mutant SODI, and neurofilament pathology in transgenic mouse models of human motor neuron disease. Lab. Invest. 76: 441-456
    • (1997) Lab. Invest. , vol.76 , pp. 441-456
    • Tu, P.-H.1    Gurney, M.E.2    Julien, J.-P.3    Lee, V.M.-Y.4    Trojanowski, J.Q.5
  • 60
    • 0032486423 scopus 로고    scopus 로고
    • Mutations in the tau gene of autosomal dominant frontotemporal dementia with parkinsonism linked to chromosome 17
    • Vogel G (1998) Mutations in the tau gene of autosomal dominant frontotemporal dementia with parkinsonism linked to chromosome 17. Science 280: 1524-1525
    • (1998) Science , vol.280 , pp. 1524-1525
    • Vogel, G.1
  • 62
    • 0029904487 scopus 로고    scopus 로고
    • NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
    • Weinreb PH, Zhen W, Poon AW, Conway KA and Lansbury Jr PT (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochem. 35: 13709-13715
    • (1996) Biochem. , vol.35 , pp. 13709-13715
    • Weinreb, P.H.1    Zhen, W.2    Poon, A.W.3    Conway, K.A.4    Lansbury Jr., P.T.5
  • 63
    • 0031051539 scopus 로고    scopus 로고
    • Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons
    • Withers GS, George JM, Banker GA and Clayton DF (1997) Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons. Devel Brain Res. 99: 87-94
    • (1997) Devel Brain Res. , vol.99 , pp. 87-94
    • Withers, G.S.1    George, J.M.2    Banker, G.A.3    Clayton, D.F.4
  • 64
    • 0029056115 scopus 로고
    • NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer disease amyloid, binds Aβ and stimulates Aβ aggregation
    • Yoshimoto M, Iwai A, Kang D, Otero DA, Xia Y and Saitoh T (1995) NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer disease amyloid, binds Aβ and stimulates Aβ aggregation Proc Natl. Acad. Sci. USA 92: 9141-9145
    • (1995) Proc Natl. Acad. Sci. USA , vol.92 , pp. 9141-9145
    • Yoshimoto, M.1    Iwai, A.2    Kang, D.3    Otero, D.A.4    Xia, Y.5    Saitoh, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.