Severe sensory deficits but normal CNS development in newborn mice lacking TrkB and TrkC tyrosine protein kinase receptors

European Journal of Neuroscience

Volumn 9, Issue 10, 1997, Pages 2045-2056

  Silos Santiago, Inmaculada ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Brain; Cochlear neurons; DRG neurons; Neurotrophins; Vestibular neurons

Indexed keywords

BRAIN RECEPTOR; CELL MARKER; NEUROTROPHIN; PROTEIN TYROSINE KINASE; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CELL DIFFERENTIATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GANGLION; GENE MUTATION; GENE TARGETING; HIPPOCAMPUS; INNER EAR; LIFESPAN; MOTONEURON; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SENSORY DYSFUNCTION; SENSORY GANGLION; SENSORY NERVE; THALAMUS;

ANIMALS; ANIMALS, NEWBORN; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CELL DIFFERENTIATION; CELL SURVIVAL; COCHLEA; CROSSES, GENETIC; EAR, INNER; EMBRYONIC AND FETAL DEVELOPMENT; EPITHELIAL CELLS; GANGLIA, SENSORY; GENICULATE BODIES; HETEROZYGOTE; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEURONS; PARVALBUMINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; RECEPTOR, TRKC; RECEPTORS, NERVE GROWTH FACTOR; VESTIBULE;

EID: 0030696661     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1997.tb01372.x     Document Type: Article

References (4)

1. Abercrombie, M. (1946) Estimation of nuclear populations from microtome sections. Anat. Rec., 94, 239-247.
2. Alcántara, S., Frisén, J., Del Río, J. A., Soriano, E., Barbacid, M. and Silos-Santiago, I. (1997) trkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death. J. Neurosci., 17, 3623-3633.
3. Avila, M. A., Varela-Nieto, I., Romero, G., Mato, J. M., Giráldez, F., Van de Water, T. R. and Represa, J. (1993) Brain-derived neurotrophic factor and neurotrophin-3 support the survival and neuritogenesis response of developing cochleovestibular ganglion neurons. Dev. Biol., 159, 266-275.
4. Barbacid, M. (1995) Neurotrophic factors and their receptors. Curr. Opin. Cell Biol., 7, 148-155.