Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by α2-macroglobulin

Journal of Neurochemistry

Volumn 71, Issue 1, 1998, Pages 213-220

  Hu, Yi Qun ^a   Koo, Peter H ^a  

^a NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

Author keywords

Mitogen activated protein kinases; Neurodegenerative diseases; Neurotrophins; Phospholipase C ; Signal transduction; 2 Macroglobulin

Indexed keywords

ALPHA 2 MACROGLOBULIN;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CELL DIFFERENTIATION; CORPUS STRIATUM; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0031842222     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71010213.x     Document Type: Article

References (59)

1. Altar C. A., Boylan C. B., Fritsche M., Jones B. E., Jackson C., Wiegand S. J., Lindsay R. M., and Hyman C. (1994) Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions. J. Neurochem. 63, 1021-1032.
2. Bank R. E., Evans S. W., Van Leuven F., Alexander D., McMahon M. J., and Whicher J. T. (1990) Measurement of the "fast" or complexed form of alpha-2-macroglobulin in biological fluids using a sandwich enzyme immunoassay. J. Immunol. Methods 126, 13-20.
3. Bank R. E., Evans S. W., Alexander D., Van Leuven F., Whicher J. T., and McMahon M. J. (1991) Alpha-2-macroglobulin state in acute pancreatitis. Raised values of alpha-2-macroglobulin-protease complexes in severe and mild attacks. Gut 32, 430-434.
4. Barde Y. A. (1990) The nerve growth factor family. Prog. Growth Factor Res. 2, 237-248.
5. 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism. Biochem. J. 133, 709-724.
6. 2-macroglobulin molecule. Biochem. J. 181, 401-408.
7. Berkemeier L. R., Winslow J. W., Kaplan D. R., Nikolics K., Goeddel D. V., and Rosenthal A. (1991) Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 7, 857-866.
8. Businaro R., Fabrizi C., Fumagalli L., and Lauro G. M. (1992) Synthesis and secretion of alpha-2-macroglobulin by human glioma established cell lines. Exp. Brain Res. 88, 213-218.
9. 2-macroglobulin, an acute phase protein in the brain. J. Neurosci. Res. 43, 282-288.
10. Garton M. J., Keir G., Lakshmi M. V., and Tompson E. J. (1991) Age-related changes in cerebrospinal fluid protein concentrations. J. Neurol Sci. 104, 74-80.
11. Gotz R., Koster R., Winkler C., Raulf F., Lottspeich F., Schartl M., and Thoenen H. (1994) Neurotrophin-6 is a new member of the nerve growth factor family. Nature 372, 266-269.
12. Higuchi M., Ito T., Imai Y., Iwaki T., Hattori M., Kohsaka S., Niho Y., and Sakaki Y. (1994) Expression of the alpha-2-macroglobulin-encoding gene in rat brain and cultured astrocytes. Gene 141, 155-162.
13. 2-macroglobulin decreases dopamine concentrations within the rat caudate putamen. J. Neurosci. Res. 38, 531-537.
14. 2-macroglobulin. J. Neurosci. Res. 43, 71-77.
15. 2-macroglobulins. J. Neurosci. Res. 51, 541-550.
16. Huber L. J. and Chao M. V. (1995) A potential interaction of p75 and trkA NGF receptors revealed by affinity crosslinking and immunoprecipitation. J. Neurosci. Res. 40, 557-563.
17. 2-macroglobulin homologue. Biochim. Biophys. Acta 704, 290-303.
18. Hyman C., Hofer M., Barde Y. A., Juhasz M., Yancopoulos G. D., Squinto S. P., and Lindsay R. M. (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350, 230-232.
19. Hynes M. A., Poulsen K., Armanini M., Berkemeier L., Phillips H., and Rosenthal A. (1994) Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures. J. Neurosci. Res. 37, 144-154.
20. Ip N. Y., Stitt T. N., Tapley P., Klein B., Glass D. J., Fandl J., Greene L. A., Barbacid M., and Yancopoulos G. D. (1993) Similarities and differences in the way neurotrophins interact with the trk receptors in neuronal and non-neuronal cells. Neuron 10, 137-149.
21. 2-macroglobulin. Scand. J. Clin. Lab. Invest. 53, 639-648.
22. Kang H. and Schuman E. M. (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in adult hippocampus. Science 267, 1658-1662.
23. Kaplan D. R. and Miller F. D. (1997) Signal transduction by the neurotrophin receptors. Curr. Opin. Cell Biol. 9, 213-221.
24. Kaplan D. R., Martin-Zanca D., and Parada L. F. (1991) Tyrosine phosphorylation and tyrosine kinase activity of the trk protooncogene product induced by NGF. Nature 350, 158-160.
25. Kaplan D. R., Matsumoto K., Lucarelli E., and Thiele C. J. (1993) Induction of trkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. Neuron 11, 321-331.
26. Klein R., Parada L. F., Coulier F., and Barbacid M. (1989) TrkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 8, 3701-3709.
27. Klein R., Jing S. A., Nanduri V., O'Rourke E., and Barbacid M. (1991) The trk proto-oncogene a receptor for nerve growth factor. Cell 65, 189-197.
28. Klein R., Lamballe F., Bryant S., and Barbacid M. (1992) The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron 8, 947-956.
29. Knüsel B. and Hefti F. (1992) K-252 compounds: modulators of neurotrophin signal transduction. J. Neurochem. 59, 1987-1996.
30. Koizumi S., Contreras M. L., Matsuda Y., and Hama T. (1988) K-252a: a specific inhibitor of the action of nerve growth factor on PC12 cells. J. Neurosci. 8, 715-721.
31. 2-macroglobulin. J. Neurosci. Res. 31, 678-692.
32. 2-macroglobulin binds trk receptor and inhibits nerve growth factor-stimulated trk phosphorylation and signal transduction. J. Biol. Chem. 269, 5369-5376.
33. Koo P. H. and Stach R. W. (1989) Interaction of nerve growth factor with murine alpha-macroglobulin. J. Neurosci. Res. 22, 247-261.
34. Lamballe F., Klein R., and Barbacid M. (1991) TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66, 967-979.
35. Lee K. F., Bachman K., Landis S., and Jaenisch R. (1994) Dependence of p75 for innervation of some sympathetic targets. Science 263, 1447-1449.
36. Levi-Montalcini R. (1987) The nerve growth factor: thirty-five years later. Science 237, 1154-1164.
37. 2-macroglobulin homologues. Ph.D. dissertation, Kent State University/Northeastern Ohio Universities College of Medicine.
38. 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons. J. Neurosci. Res. 35, 170-182.
39. 2-macroglobulin. Biochem. Biophys. Res. Commun. 193, 1255-1261.
40. 2-macro-globulin inhibits choline acetyltransferase of embryonic basal forebrain neurons and reversal of the inhibition by NGF and BDNF but not NT-3. J. Neurosci. Res. 38, 407-414.
41. Lopes M. B., Bogaev C. A., Gonias S. L., and VandenBerg S. R. (1993) Expression of alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein is increased in reactive and neoplastic glial cells. FEBS Lett. 338, 301-305.
42. Marsh H. N. and Palfrey H. C. (1996) Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons. J. Neurochem. 67, 952-963.
43. trkB in primary hippocampal pyramidal cell culture. J. Neurosci. 13, 4281-4292.
44. Martin-Zanca D., Oskam R., Mitra G., Copeland T., and Barbacid M. (1989) Molecular and biochemical characterization of the human trk proto-oncogene. Mol. Cell. Biol. 9, 24-33.
45. Nye S. H., Squinto S. P., Glass D. J., Stitt T. N., Hantzopoulos P., Macchi M. J., Lindsay N. S., Ip N. Y., and Yancopoulos G. D. (1992) K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses. Mol. Biol. Cell 3, 677-686.
46. Ross A. H., Daou M. C., McKinnon C. A., Condon P. J., Lachyankar M. B., Stephens R. M., Kaplan D. R., and Wolf D. E. (1996) The neurotrophin receptor, gp75, forms a complex with the receptor tyrosine kinase TrkA. J. Cell Biol. 132, 945-953.
47. Soppet D., Escandon E., Maragos J., Middlemas D. S., Reid S. W., Blair J., Burton L. E., Stanton B. R., Kaplan D. R., Hunter T., Nikolics K., and Parada L. F. (1991) The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell 65, 895-903.
48. Sottrupp-Jensen L. (1989) α-Macroglobulins: structure, shape, and mechanism of proteinase complex formation. J. Biol. Chem. 264, 11539-11542.
49. 2-macroglobulin by aliphatic amines. Biochim. Biophys. Acta 154, 228-231.
50. 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients. Lab. Invest. 66, 223-230.
51. 2-macroglobulin. Proc. Natl. Acad. Sci. USA 76, 4313-4316.
52. Tapley P., Lamballe F., and Barbacid M. (1992) K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. Oncogene 7, 371-381.
53. 2-macroglobulin receptor in Alzheimer and control postmortem human brain. Mol. Chem. Neuropathol. 18, 153-160.
54. Van Gool D., De Strooper B., Van Leuven F., Triau E., and Dom R. (1993) Alpha-2-macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease. Neurobiol. Aging 14, 233-237.
55. 2-Macroglobulin from cerebral spinal fluid in neurosurgical diseases. Vopr. Med. Khim. 35, 48-51.
56. Volonte C., Rukenstein A., Loeb D. M., and Greene L. A. (1989) Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase. J. Cell Biol. 109, 2395-2403.
57. Wilson C. (1994) Receptor tyrosine kinase signalling: not so complicated after all? Trends Cell Biol. 4, 409-414.
58. Wolf B. B. and Gonias S. L. (1994) Neurotrophin binding to human alpha-2-macroglobulin under apparent equilibrium conditions. Biochemistry 33, 11270-11277.
59. Wood J. A., Wood P. L., Ryan R., Graff-Radford N. R., Pilapil C., Robitaille Y., and Quirion R. (1993) Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1-beta or IL-1-RA but increases in the associated acute phase proteins IL-6, alpha-2-macroglobulin and C-reactive protein. Brain Res. 629, 245-252.