Trk receptors function as rapid retrograde signal carriers in the adult nervous system

Journal of Neuroscience

Volumn 17, Issue 18, 1997, Pages 7007-7016

  Bhattacharyya, Anita ^a   Watson, Fiona L ^a   Bradlee, Tatum A ^a   Pomeroy, Scott L ^a   Stiles, Charles D ^a   Segal, Rosalind A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

Neurotrophin; Receptor tyrosine kinase; Sciatic nerve; Signal transduction; Trk

Indexed keywords

ANIMAL CELL; ARTICLE; CELL SURVIVAL; ENDOCYTOSIS; INTERNALIZATION; LIGAND BINDING; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SCIATIC NERVE; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TRANSCRIPTION REGULATION;

EID: 0030869198     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-18-07007.1997     Document Type: Article

References (18)

1. Acheson A, Conover J, Fandl J, DeChiara T, Russell M, Thadani A, Squinto S, Yancopoulos G, Lindsay R (1995) A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature 374:450-453.
2. Barbacid M (1994) The Trk family of neurotrophin receptors. J Neurobiol 25:1386-1403.
3. Barde YA (1989) Trophic factors and neuronal survival. Neuron 2:1525-1534.
4. Bothwell M (1991) Keeping track of neurotrophin receptors. Cell 65:915-918.
5. Campenot RB (1982) Development of sympathetic neurons in compartmentalized cultures. I. Local control of neurite growth by nerve growth factor. Dev Biol 93:1-12.
6. Campenot RB (1987) Local control of neurite sprouting in cultured sympathetic neurons by nerve growth factor. Brain Res 465:293-301.
7. Campenot RB (1994) NGF and the local control of nerve terminal growth: review. J Neurobiol 25:599-611.
8. Chitnis AB, Kuwada JY (1990) Axonogenesis in the brain of zebrafish embryos. J Neurosci 10:1892-1905.
9. Deckwerth TL, Johnson EJ (1993) Neurotrophic factor deprivation-induced death. Ann NY Acad Sci 679:121-131.
10. Diamond J, Foerster A, Holmes M, Coughlin M (1992a) Sensory nerves in adult rats regenerate and restore sensory function to the skin independently of endogenous NGF. J Neurosci 12:1467-1476.
11. Diamond J, Holmes M, Coughlin M (1992b) Endogenous NGF and nerve impulses regulate the collateral sprouting of sensory axons in the skin of the adult rat. J Neurosci 12:1454-1466.
12. DiStefano PS, Friedman B, Radziejewski C, Alexander C, Boland P, Schick CM, Lindsay RM, Wiegand SJ (1992) The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons. Neuron 8:983-993.
13. Druker B, Mamon H, Roberts T (1989) Oncogenes, growth factors, and signal transduction. N Engl J Med 321:1383-1391.
14. Ehlers M, Kaplan D, Price D, Koliatsos V (1995) NGF-stimulated retrograde transport of trkA in the mammalian nervous system. J Cell Biol 130:149-156.
15. Figurov A, Pozzo-Miller L, Olafsson P, Wang T, Lu B (1996) Regulation of synaptic responses to high frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381:706-709.
16. Friedman B, Kleinfeld D, Ip N, Verge V, Moulton R, Boland P, Zlotchenko E, Lindsay R, Liu L (1995) BDNF and NT4/5 exert neurotrophic influences on injured adult spinal motor neurons. J Neurosci 15:1044-1056.
17. Gold B, Mobley W, Matheson S (1991) Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor. J Neurosci 11:943-955.
18. Grimes M, Zhou J, Beattie E, Yuen E, Hall D, Valletta J, Topp K, LaVail J, Bunnett N, Mobley W (1996) Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. J Neurosci 16:7950-7964.