Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 11, 1999, Pages 1220-1228

  Larsson, Elin ^a   Nanobashvili, Avtandil ^a   Kokaia, Zaal ^a   Lindvall, Olle ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Brain derived neurotrophic factor; Cerebral ischemia; Hippocampus; Neuroprotection; Rat; Striatum

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLINE ACETYLTRANSFERASE; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN REGION; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; FOREBRAIN; HIPPOCAMPUS; INTERNEURON; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

EID: 0033504237     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199911000-00006     Document Type: Article

References (36)

1. Altar CA, DiStefano PS (1998) Neurotrophin trafficking by anterograde transport. Trends Neurosci 21:433-437
2. Beck T, Lindholm D, Castren E, Wree A (1994) Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus. J Cereb Blood Flow Metab 14:689-692
3. Binder DK, Routbort MJ, Ryan TE, Yancopoulos GD, McNamara JO (1999) Selective inhibition of kindling development by intraventricular administration of TrkB receptor body. J Neurosci 19:1424-1436
4. Cabelli RJ, Shelton DL, Segal RA, Shatz CJ (1997) Blockade of endogenous ligands of TrkB inhibits formation of ocular dominance columns. Neuron 19:63-76
5. Cheng B, Mattson MP (1994) NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res 640:56-57
6. Chesslet MF, Gonzales C, Lin CS, Polsky K, Jin BK (1990) Ischemic damage in the stratium of adult gerbils: relative sparing of somatostatinergic and cholinergic interneurons contrasts with loss of efferent neurons. Exp Neurol 110:209-218
7. Croll SD, Chesnutt CR, Rudge JS, Acheson A, Ryan TE, Siuciak JA, DiStefano PS, Wiegand SJ, Lindsay RM (1998) Co-infusion with a TrkB-Fc receptor body carrier enhances BDNF distribution in the adult rat brain. Exp Neurol 152:20-33
8. Croll SD, Wiegand SJ, Anderson KD, Lindsay RM, Nawa H (1994) Regulation of neuropeptides in adult rat forebrain by the neurotrophins BDNF and NCR Eur J Neurosci 6:1343-1353
9. Ernfors P, Wetmore C, Olson L, Persson H (1990) Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron 5:511-526
10. Freund TF, Buzáki G (1996) Interneurons of the hippocampus. Hippocampus 6:347-470
11. Ghosh A, Camahan J, Greenberg ME (1994) Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263:1618-1623
12. Gundersen HJ, Jensen EB (1987) The efficiency of systematic sampling in stereology and its prediction. J Microsc 147:229-263
13. lihara K, Hashimoto N, Tsukahara T, Sakata M, Yanamoto H, Taniguchi T (1997) Platelet-derived growth factor-BB, but not-AA, prevents delayed neuronal death after forebrain ischemia in rats. J Cereb Blood Flow Metab 17:1097-1106
14. Jones KR, Farinas I, Backus C, Reichardt LF (1994) Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76:989-999
15. Kokaia M, Ernfors P, Kokaia Z, Elmér E, Jaenisch R, Lindvall O (1995) Suppressed epileptogenesis in BNDF mutant mice. Exp Neurol 133:215-224
16. Kokaia Z, Airaksinen MS, Nanobashvilli A, Larsson E, Kujamäki E, Lindvall O, Saarma M (1999) GDNF family ligands and receptors are differentially regulated after brain insults in the rat. Eur J Neurosci 11:1202-1216
17. Kokaia Z, Andsberg G, Martinez-Serrano A, Lindvall O (1998) Focal cerebral ischemia in rats induces expression of p75 neurotrophin receptor in resistant striatal cholinergic neurons. Neuroscience 84:1113-1125
18. Kokaia Z, Nawa H, Uchino H, Elmér E, Kokaia M, Carnahan J, Smith ML, Siesjö BK, Lindvall O (1996) Regional brain-derived neurotrophic factor mRNA and protein levels following transient forebrain ischemia in the rat. Mol Brain Res 38:139-144
19. Kokaia Z, Othberg A, Kokaia M, Lindvall O (1994) BDNF makes cultured dentate granule cells more resistant to hypoglycemic damage. NeuroReport 5:1241-1244
20. Kubota Y, Inagaki S, Shimada S, Kito S, Eckenstein F, Tohyama M (1987) Neostriatal cholinergic neurons receive direct synaptic inputs from dopaminergic axons. Brain Res 413:179-184
21. Lamballe F, Klein R, Barbacid M (1991) trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophion3. Cell 66:967-979
22. Lindholm D, Carroll P, Tzimagiogis G, Thoenen H (1996) Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. Eur J Neurosci 8:1452-1460
23. Lindvall O, Ernfors P, Bengzon J, Kokaia Z, Smith M-L, Siesjö BK, Persson H (1992) Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proc Natl Acad Sci USA 89:648-652
24. Lindvall O, Kokaia Z, Bengzon J, Elmér E, Kokaia M (1994) Neurotrophins and brain insults. Trends Neurosci 17:490-496
25. Marty S, Carroll P, Cellerino A, Castren E, Staiger V, Thoenen H, Lindholm D (1996) Brain-derived neurotrophic factor promotes the differentiation of various hippocampal nonpyramidal neurons, including Cajal-Retzius cells, in organotypic slice cultures. J Neurosci 16:675-687
26. McAllister AK, Katz LC, Lo DC (1999) Neurotrophins and synaptic plasticity. Annu Rev Neurosci 22:295-318
27. Merlio J-P, Ernfors P, Jaber M, Persson H (1992) Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous systems. Neuroscience 51:513-532
28. Nakajima K, Kikuchi Y, Ikoma E, Honda S, Ishikawa M, Liu Y, Kohsaka S (1998) Neurotrophins regulate the function of cultured microglia. Glia 24:272-289
29. Nakao N, Kokaia Z, Odin P, Lindvall O (1995) Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons. Exp Neurol 131:1-10
30. Nawa H, Camahan J, Gall C (1995) BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: partial disagreement with mRNA levels. Eur J Neurosci 7:1527-1535
31. Paxinos G, Watson W (1997) The Rat Brain in Stereotaxic Cooridinates. San Diego, Academic Press.
32. Schmued LC, Albertson C, Slikker W, Jr. (1997) Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical of neuronal degeneration. Brain Res 751:37-46
33. Schäbitz WR, Schwab S, Spranger M, Hacke W (1997) Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 17:500-506
34. Shelton DL, Sutherland J, Gripp J, Camerato T, Armanini MP, Phillips HS, Carroll K, Spencer SD, Levinson AD (1995) Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J Neurosci 15:477-491
35. Smith MA, Zhang LX, Lyons WE, Mamounas LA (1997) Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers. NeuroReport 8:1829-1834
36. Smith ML, Bendek G, Dahlgran N, Rosén I, Wieloch T, Siesjö BK (1984) Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model. Acta Neurol Scand 69:385-401