Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos

Journal of Neuroscience

Volumn 19, Issue 1, 1999, Pages 10-20

  Son, Jin H ^a   Chun, Hong S ^a   Joh, Tong H ^a   Cho, Sunghee ^a   Conti, Bruno ^a   Lee, Jong W ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

BDNF; Conditional immortalization; Dopaminergic neuron; Neuronal differentiation; Neuroprotection; Parkinson's disease; Substantia nigra; Transgenic mice

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE; DOPAMINE RECEPTOR; GLUTAMIC ACID; NITRIC OXIDE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL IMMORTALIZATION; CELL SURVIVAL; EMBRYO; MESENCEPHALON; MOUSE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SUBSTANTIA NIGRA; TRANSGENIC MOUSE;

EID: 0032937111     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-01-00010.1999     Document Type: Article

References (44)

1. Altar CA, Boylan CB. Fritsche M, Jones B, Jackson C, Wiegand SJ, Lindsay RM, Hyman C (1994) Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions. J Neurochem 63:1021-1032.
2. Anton R, Kordower JH, Maidment NT, Manaster JS, Kane DJ, Rabizadeh S, Schueller SB, Yang J, Rabizadeh S, Edwards RH, Markham CH, Bredesen DE (1994) Neural-targeted gene therapy for rodent and primate hemiparkinsonism. Exp Neurol 127:207-218.
3. Ben-Shachar D, Zuk R, Glinka Y (1995) Dopamine neurotoxicity: inhibition of mitochondrial respiration. J Neurochem 64:718-723.
4. Boka G, Anglade P, Wallach D, Javoy-Agid F, Agid Y, Hirsch EC (1994) Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease. Neurosci Lett 172:151-154.
5. Brustle O, Maskos U, McKay DG (1995) Host-guided migration allows targeted introduction of neurons into the embryonic brain. Neuron 15:1275-1285.
6. Burns RS, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ (1983) A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 80:4546-4550.
7. Cheng B, Mattson MP (1994) Tumor necrosis factors protect neurons against excitotoxic/metabolic insults and promote maintenance of calcium homeostasis. Neuron 12:139-153.
8. Choi HK, Won LA, Kontur PJ, Hammond DN, Fox AO, Wainer BH, Hoffmann PC, Heller A (1991) Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion. Brain Res 552:67-76.
9. Crawford GD, Le W-D, Smith RG, Xie W-J, Stefani E, Appel SH (1992) A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin. J Neurosci 12:3392-3398.
10. Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH (1993) Mechanism of nitric oxide neurotoxicity in primary brain cultures. J Neurosci 13:2651-2661.
11. Di Porzio U, Zuddas A, Cosenza-Murphy DB, Barker JL (1990) Early appearance of tyrosine hydroxylase immunoreactivc cells in the mesencephalon of mouse embryos. Int J Dev Neurosci 8:523-532.
12. Duffy S, So A, Murphy TH (1996) Activation of endogenous antioxidant defenses in neural cells prevents free radical-mediated damage. J Neurochem 71:69-77.
13. Favaron M, Manev RM, Rimland JM, Candeo P, Beccaro M, Manev H (1993) NMDA-stimulated expression of BDNF mRNA in cultured cerebellar granule neurons. NeuroReport 4:1171-1174.
14. Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381:706-709.
15. Gerlach M, Riederer P (1996) Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man. J Neural Transm 103:987-1041.
16. Hantraye P, Brouiliet E, Ferrante R, Palfi S, Dolan R, Matthews R, Beal F (1996) Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med 2:1017-1021.
17. Hwang O, Baker H, Gross S, Joh TH (1998) Localization of GTP cyclohydrolase in monoaminergic but not nitric oxide-producing cells. Synapse 28:140-153.
18. Hyman C, Hofer M, Barde YA, Juhasz M, Yancopoulos GD, Squinto SP, Lindsay RM (1991) BDNF is a trophic factor for dopaminergic neurons of the substantia nigra. Nature 350:230-233.
19. Hynes M, Porter JA, Chiang C, Chang D, Tessier-Lavigne M, Beachy P, Rosenthal A (1995) Induction of midbrain dopaminergic neurons by sonic hedgehog. Neuron 15:35-44.
20. Jahng J, Houpt T, Kim S, Joh T, Son J (1998) Neuropeptide Y mRNA and serotonin innervation in the arcuate nucleus of anorexia mutant mice. Brain Res 790:67-73.
21. Jat PS, Sharp PA (1989) Cell lines established by temperature-sensitive simian virus 40 large T-antigen gene are growth restricted at the nonpermissive temperature. Mol Cell Biol 9:1672-1681.
22. b-tsA58 transgenic mice. Proc Natl Acad Sci USA 88:5096-5100.
23. Kerr CW, Lee LJ, Romero AA, Stull ND, Iacovitti L (1994) Purification of dopamine neurons by flow cytometry. Brain Res 665:300-306.
24. Kim KS, Huang HM, Zhang H, Wagner J, Joh T, Gibson GE (1995) The role of signal transduction systems in mediating cell density dependent changes in tyrosine hydroxylase gene expression. Mol Brain Res 33:254-260.
25. Knusel B, Winslow J, Rosenthal A, Burton LE, Seid DP, Nikolics K, Hefti F (1991) Promotion of central cholinergic and dopaminergic neurons differentiation by brain-derived neurotrophic factor but not neurotrophin-3. Proc Natl Acad Sci USA 88:961-965.
26. Kokaia Z, Bengzon J, Metsis M, Kokaia M, Persson H (1993) Coexpression of neurotrophins and their receptors in neurons of the central nervous system. Proc Natl Acad Sci USA 90:7611-6715.
27. Krezel W, Ghyselinck N, Samad TA, Dupe V, Kastner P, Borrelli E, Chambon P (1998) Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science 279:863-867.
28. + involves binding at the same site as the respiratory inhibitor, rotenone. Biochem Biophys Res Commun 169:123-128.
29. Lowry O, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
30. Min N, Joh T, Kim KS, Peng C, Son JH (1994) 5′ Upstream DNA sequence of the rat tyrosine hydroxylase directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice. Mol Brain Res 27:281-289.
31. +, a metabolite of the neurotoxin, MPTP. Life Sci 36:2503-2508.
32. O'Malley EK, Black IB, Dreyfus CF (1991) Local support cells promote survival of substantia nigra dopaminergic neurons in culture. Exp Neurol 112:40-48.
33. Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson V, Dawson TM (1996) Role of neuronal nitric oxide in MPTP-induced dopaminergic neurotoxicity. Proc Natl Acad Sci USA 93:4565-4571.
34. Rousselet A, Fetler L, Chamak B, Prochiantz A (1988) Rat mesencephalic neurons in culture exhibit different morphological traits in the presence of media conditioned on mesencephalic or striatal astroglia. Dev Biol 129:495-504.
35. Schambra UB, Lauder JM, Silver J (1992) Atlas of the prenatal mouse brain. San Diego, CA: Academic.
36. Seroogy KM, Lundgren KH, Tran T, Guthrie KM, Isackson PJ, Gall CM (1994) Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs. J Comp Neurol 342:321-334.
37. Schulze-Osthoff K, Beyaert R, Vandevoorde V, Haegeman, Fiers W (1993) Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. EMBO J 12:3095-3104.
38. Son JH, Chung JH, Huh SO, Park DH, Peng C, Rosenblum MG, Chung YI, Job TH (1996a) Immortalization of neuroendocrine pinealocytes from transgenic mice by targeted tumorigenesis using the tryptophan hydroxylase promoter. Mol Brain Res 37:32-40.
39. Son JH, Min N, Joh TH (1996b) Early ontogeny of catecholaminergic cell lineage in brain and peripheral neurons monitored by tyrosine hydroxylase-lacZ transgene. Mol Brain Res 36:300-308.
40. Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett Jr JP, Davis RE, Parker Jr WD (1996) Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 40:663-671.
41. Wetmore C, Olson L, Bean AJ (1994) Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. J Neurosci 14:1688-1700.
42. b-tsA58 transgenic mice. Proc Natl Acad Sci USA 90:587-591.
43. Yoshimoto Y, Lin Q, Collier TJ, Frim DM, Breakefield XO, Bonn MC (1995) Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's disease. Brain Res 691:25-36.
44. Zetterstrom RH, Solomin L, Jansson L, Hoffer, BJ, Olson L, Perlman T (1997) Dopamine neuron agenesis in Nurr1-deficient mice. Science 276:248-250.