Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system

Progress in Neurobiology

Volumn 57, Issue 4, 1999, Pages 421-450

  Hughes, Paul E ^a   Alexi, Tajrena ^a   Walton, Marshall ^a   Williams, Chris E ^a   Dragunow, Mike ^a   G Clark, Ross ^a   Gluckman, Peter D ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR;

APOPTOSIS; BRAIN INJURY; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; KINDLING; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NERVE FIBER TRANSECTION; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; REVIEW; TEMPORAL LOBE EPILEPSY; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BRAIN DISEASES; CENTRAL NERVOUS SYSTEM; CEREBROVASCULAR DISORDERS; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; HIPPOCAMPUS; HUMANS; NEURONAL PLASTICITY; NEURONS; SEIZURES; TRANSCRIPTION FACTORS;

EID: 0032904489     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(98)00057-4     Document Type: Review

References (253)

1. Abraham W. C., Mason S. E. Effects of the NMDA receptor/channel antagonists CPP and MK801 on hippocampal field potentials and long-term potentiation in anaesthetized rats. Brain Res. 462:1988;40-46.
2. Abraham, W. C. and Otani, S. (1991) Macromolecules and the maintenance of long-term potentiation. In: Kindling and Synaptic Plasticity, pp. 92-109. Ed. F. Morell. Birkhauser, Boston.
3. Abraham W. C., Dragunow M., Tate W. P. The role of immediate early genes in the stabilization of long-term potentiation. Mol. Neurobiol. 5:1992;297-314.
4. Abraham W. C., Mason S. E., Demmer J., Williams J. M., Richardson C. L., Tate W. P., Lawlor P. A., Dragunow M. Correlations between immediate early gene induction and the persistence of long-term potentiation. Neuroscience. 56:1993;717-727.
5. Abraham W. C., Christie B. R., Logan B., Lawlor P., Dragunow M. Immediate-early gene expression associated with the persistence of heterosynaptic long-term depression in the hippocampus. Proc. natl Acad. Sci. U.S.A. 91:1994;10049-10053.
6. Acheson A., Conover J. C., Fandl J. P., DeChiara T. M., Russell M., Thadani A., Squinto S. P., Yancopoulos G. D., Lindsay R. M. A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature. 374:1995;450-453.
7. Adams B., Sazgar M., Osehobo P., Van der Zee C. E. E. M., Diamond J., Fahnestock M., Racine R. J. Nerve growth factor accelerates seizure development, enhances mossy fibre sprouting, and attenuates seizure-induced decreases in neuronal density in the kindling model of epilepsy. J. Neurosci. 17:1997;5288-5296.
8. Alberini C. M., Ghirardi M., Metz R., Kandel E. R. C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia. Cell. 76:1994;1099-1114.
9. Anderson A. J., Su J. H., Cotman C. W. DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem ddelay. J. Neurosci. 16:1996;1710-1719.
10. Andreasson K., Worley P. F. Induction of βA activin expression by synaptic activity and during neocortical development. Neuroscience. 69:1995;781-796.
11. Bahr M., Bonhoeffer F. Perspectives on axonal regeneration in the mammalian CNS. Trends Neurosci. 17:1994;473-479.
12. Ballarin M., Ernfors P., Lindefors N., Persson H. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Exp. Neurol. 114:1991;35-43.
13. Barnes C. A., Jung M. W., McNaughton B. L., Korol D. L., Andreasson K., Worley P. F. LTP saturation and spatial learning disruption: effects of task variables and saturation levels. J. Neurosci. 14:1994;5793-5806.
14. Beck T., Lindholm D., Castren E., Wree A. Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus. J. Cereb. Blood Flow Metab. 14:1993;689-692.
15. Beilharz E. J., Klempt N. D., Klempt M., Sirimanne E., Dragunow M., Gluckman P. D. Differential expression of insulin-like growth factor binding proteins (IGFBP) 4 and 5 mRNA in the rat brain after transient hypoxic-ischemic injury. Mol. Brain Res. 18:1993;209-215.
16. Beilharz E. J., Williams C. E., Dragunow M., Sirimanne E. S., Gluckman P. D. Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss. Mol. Brain Res. 29:1995;1-14.
17. Beilharz E. J., Bassett N. S., Sirimanne E. S., Williams C. E., Gluckman P. D. Insulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brain. Mol. Brain Res. 29:1995;81-91.
18. Bengzon J., Soderstrom S., Kokaia Z., Kokaia M., Ernfors P., Persson H., Ebendal T., Lindvall O. Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures. Brain Res. 587:1992;338-342.
19. Bengzon J., Kokaia Z., Ernfors P., Kokaia M., Leanza G., Nilsson O. G., Persson H., Lindvall O. Regulation of neurotrophin and trkA, trkB, and trkC tyrosine kinase receptor mRNA expression in kindling. Neuroscience. 53:1993;433-446.
20. Bengzon J., Kokaia Z., Elmer E., Nanobashvili A., Kokaia M., Lindvall O. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures. Proc. natl Acad. Sci. U.S.A. 94:1997;10432-10437.
21. Bliss T. V. P., Collingridge G. L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
22. Bliss T. V. P., Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J. Physiol. 232:1973;331-356.
23. Blotttner D., Herdegen T. Neuroprotective fibroblast growth factor type-2 downregulates the c-Jun transcription factor in axotomized sympathetic preganglionic neurons of adult rat. Neuroscience. 82:1998;283-292.
24. Bourtchuladze R., Frenguelli B., Blendy J., Cioffi D., Schutz G., Silva A. J. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell. 79:1994;59-68.
25. Brecht S., Martin-Villalba A., Zuschratter W., Bravo R., Herdegen T. Transection of rat fornix-fimbria induces lasting expression of c-Jun protein in axotomized septal neurons immunonegative for choline acetyltransferase and nitic oxide synthase. Exp. Neurol. 134:1995;112-125.
26. Butterworth N. J., Dragunow M. Medial septal cholinergic neurons express c-Jun but do not undergo DNA fragmentation after fornix-fimbria transections. Mol. Brain Res. 43:1996;1-12.
27. Caelles C., Helmberg A., Karin M. p53-dependent apoptosis in the absense of transcriptional activation of p53-target genes. Nature. 370:1994;220-223.
28. Cain D. P. Long-term potentiation and kindling: how similar are the mechanisms? Trends Neurosci. 12:1989;6-10.
29. Castren E., Pitkanen M., Sirvio J., Parsadanian A., Lindholm D., Thoenen H., Riekkinen P. J. The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus. NeuroReport. 4:1993;895-898.
30. Cavazos J. E., Sutula J. P. Progressive neuronal loss induced by kindling: a possible mechanism for mossy fibre synaptic reorganization. Brain Res. 527:1990;1-6.
31. Cheng B., Mattson M. P. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain Res. 640:1994;56-67.
32. Chopp M., Li Y., Zhang Z. G., Freytag S. O. p53 expression in brain after middle cerebral artery occlusion in the rat. Biochem. Biophys. Res. Commun. 182:1992;1201-1207.
33. Clarke A. R., Purdie C. A., Harrison D. J., Morris R. G., Bird C. C., Hooper M. L., Wyllie A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:1993;849-852.
34. Cohen-Cory S., Fraser S. E. Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo. Nature. 378:1995;192-196.
35. Cole A. J., Saffen D. W., Baraban J. M., Worley P. F. Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature. 340:1989;474-476.
36. Conner, B. and Dragunow, M. (1998) The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res. Rev. in press.
37. Cronin J., Obenaur A., Houser C. R., Dudek F. E. Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fibres. Brain Res. 573:1992;302-310.
38. Crumrine R. C., Thomas A. L., Morgan P. F. Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J. Cereb. Blood Flow Metab. 14:1994;887-891.
39. Crutcher K. A., Scott S. A., Liang S., Everson W. V., Weingartner J. Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease. J. Neurosci. 13:1993;2540-2550.
40. D'Mello S. R., Borodeztm K., Soltoff S. P. Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways - possible involvement of PI 3-kinase in IGF-1 signaling. J. Neurosci. 17:1997;1548-1560.
41. Demmer J., Dragunow M., Lawlor P. A., Mason S. E., Leah J. D., Abraham W. C., Tate W. P. Differential expression of immediate early genes after hippocampal long-term potentiation in awake rats. Mol. Brain Res. 17:1993;279-286.
42. Donehower L. A., Harvey M., Slagle B. L., McArthur M. J., Montgomery C. A., Butel J. S., Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 356:1992;215-221.
43. Douglas R. M., Dragunow M., Robertson H. A. High-frequency discharge of dentate granule cells, but not long-term potentiation, induces c-fos protein. Mol. Brain Res. 4:1988;259-262.
44. Dragunow M. Axotomized medial septal-diagonal band neurons express Jun-like immunoreactivity. Mol. Brain Res. 15:1992;141-144.
45. Dragunow M. Ref-1 expression in adult mammalian neurons and astrocytes. Neurosci. Lett. 191:1995;189-192.
46. Dragunow M., Hughes P. Differential expression of immediate-early proteins in non-nerve cells after focal brain injury. Int. J. Dev. Neurosci. 11:1993;249-255.
47. Dragunow, M. and Lawlor, P. (1998) Immediate-early genes in status epilepticus: Roles in programmed cell death and axonal growth. Adv. Neurol. in press.
48. Dragunow M., Preston K. The role of inducible transcription factors in apoptotic nerve cell death. Brain Res. Rev. 21:1995;1-28.
49. Dragunow M., Robertson H. A. Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus. Nature. 329:1987;441-442.
50. Dragunow M., Robertson H. A. Generalized seizures induce c-fos protein(s) in mammalian neurons. Neurosci. Lett. 82:1987;157-161.
51. Dragunow M., Robertson H. A. Seizure-inducible c-fos protein(s) in mammalian neurons. Trends Pharmac. Sci. 9:1988;5.
52. Dragunow M., Peterson M. R., Robertson H. A. Presence of c-fos-like immunoreactivity in the adult rat brain. Eur. J. Pharmac. 135:1987;113-114.
53. Dragunow M., Robertson H. A., Robertson G. Amygdala kindling and c-fos protein(s). Exp. Neurol. 102:1988;261-263.
54. Dragunow M., Abraham W. C., Goulding M., Mason S. E., Robertson H. A., Faull R. L. M. Long-term potentiation and the induction of c-fos mRNA and proteins in the dentate gyrus of unanaesthetised rats. Neurosci. Lett. 101:1989;274-280.
55. Dragunow M., Currie R. W., Faull R. L. M., Robertson H. A., Jansen K. Immediate-early genes, kindling and long-term potentiation. Neurosci. Biobehav. Rev. 13:1989;301-313.
56. Dragunow M., de Castro D., Faull R. L. M. Induction of Fos in glia-like cells after focal brain injury but not during wallerian degeneration. Brain Res. 527:1990;41-54.
57. Dragunow M., Faull R. L. M., Jansen K. L. R. MK-801, an antagonist of NMDA receptors, inhibits injury-induced c-fos protein accumulation in rat brain. Neurosci. Lett. 109:1990;128-133.
58. Dragunow M., Goulding M., Faull R. L. M., Ralph R., Mee E., Frith R. Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: Pharmacological characterization. Exp. Neurol. 107:1990;236-248.
59. Dragunow M., Yamada N., Bilkey D. K., Lawlor P. Induction of immediate-early gene proteins in dentate granule cells and somatostatin interneurons after hippocampal seizures. Mol. Brain Res. 13:1992;119-126.
60. Dragunow M., Sirimanne E., Lawlor P. A., Williams C., Gluckman P. Accumulation of calcitonin-gene related peptide-like immunoreactivity after hypoxic-ischaemic brain injury in the infant rat. Mol. Brain Res. 14:1992;267-272.
61. Dragunow M., Beilharz E., Mason B., Lawlor P., Abraham W., Gluckman P. Brain-derived neurotrophic factor expression after long-term potentiation. Neurosci. Lett. 160:1993;232-236.
62. Dragunow M., Young D., Hughes P., MacGibbon G., Lawlor P., Singleton K., Sirimannne E., Beilharz E., Gluckman P. Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury? Mol. Brain Res. 18:1993;347-352.
63. Dragunow M., Beilharz E., Sirimanne E., Lawlor P., Williams C., Bravo R., Gluckman P. Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain. Mol. Brain Res. 25:1994;19-33.
64. Dragunow M., Abraham W., Hughes P. Activation of NMDA and muscarinic receptors induces nur-77 mRNA in hippocampal neurons. Mol. Brain Res. 36:1996;349-356.
65. Dragunow M., Hughes P., Mason-Parker S. E., Lawlor P., Abraham W. C. TrkB expression in dentate granule cells is associated with a late phase of long-term potentiation. Mol. Brain Res. 46:1997;274-280.
66. Dragunow M., Woodgate A.-M., Xu R. A., Conner B., Lawlor P. A., During M. c-Jun phosphorylation following okadaic acid-induced apoptosis and NGF-induced process sprouting. Soc. Neurosci. Abstr. 27:1997;855.8.
67. Dragunow, M., MacGibbon, G. A., Lawlor, P., Butterworth, N., Conner, B., Henderson, C., Walton, M., Woodgate, A., Hughes, P. and Faull, R. L. M. (1998) Apoptosis, neurotrophic factors and neurodegeneration. Rev. Neurosci. 8, 223-265.
68. Eizenberg O., Faber-Elman A., Gottlieb E., Oren M., Rotter V., Schwartz M. Direct involvement of p53 in programmed cell death of oligodendrocytes. EMBO J. 14:1995;1136-1144.
69. El-Deiry W. S., Kern S. E., Pietenpol J. A., Kinzler K. W., Vogelstein B. Definition of a consensus binding site for p53. Nature Genetics. 1:1992;45-49.
70. El-Deiry W. S., Tokino T., Velculescu V. E., Levy D. B., Parsons R., Trent J. M., Lin D., Edward Mercer W., Kinzler K., Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:1993;817-825.
71. Elmer E., Kokaia Z., Kokaia M., Lindvall O., McIntyre D. C. Mossy fibre sprouting: evidence against a facilitatory role in epileptogenesis. NeuroReport. 8:1997;1193-1196.
72. Enokido Y., Araki T., Aizawa S., Hatanaka H. p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons. Neurosci. Lett. 203:1996;1-4.
73. Enokido Y., Araki T., Tanaka K., Aizawa S., Hatanaka H. Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons. Eur. J. Neurosci. 8:1996;1812-1821.
74. Ernfors P., Bengzon J., Kokaia Z., Persson H., Lindvall O. Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. Neuron. 7:1991;165-176.
75. Estus S., Zaks W. J., Freeman R. S., Gruda M., Bravo R., Johnson E. M. Altered gene expression in neurons during programmed cell death: identification of c-Jun as necessary for neuronal apoptosis. J. Cell Biol. 127:1994;1717-1727.
76. Falkenberg T., Ernfors P., Persson H., Lindefors N. Cortical transynaptic activation of tyrosine kinase receptor trkB messenger RNA expression in rat hippocampus. Neuroscience. 51:1992;883-889.
77. Fischer W., Sirevaag A., Wiegand S. J., Lindsay R. M., Bjorkland A. Reversal of spatial memory impairments in aged rat by nerve growth factor and neurotrophins 3 and 4/5, but not by brain-derived neurotrophic factor. Proc. natl Acad. Sci. U.S.A. 91:1994;8607-8611.
78. Fordyce D. E., Bhat R. V., Baraban J. M., Wehner J. M. Genetic and activity-dependent regulation of Zif268 expression: association with spatial learning. Hippocampus. 4:1994;559-568.
79. Funabashi T., Sasaki H., Kimura F. Intraventricular injection of antiserum to nerve growth factor delays the development of amygdaloid kindling. Brain Res. 458:1988;132-136.
80. Gass P., Herdegen T. Neuronal expression of AP-1 proteins in excitotoxic-neurodegenerative disorders and following nerve fibre lesions. Prog. Neurobiol. 47:1995;257-290.
81. Ghosh A., Carnahan J., Greenberg M. E. Requirement for BDNF in activity-dependent survival of cortical neurons. Science. 263:1994;1618-1623.
82. Gilbert M. E. The NMDA-receptor antagonist, MK-801, suppresses limbic kindling and kindled seizures. Brain Res. 463:1988;90-99.
83. Gilbert M. E., Mack C. M. The NMDA antagonist, MK-801, suppresses long-term potentiation, kindling and kindling-induced potentiation in the perforant path of the unanaesthetized rat. Brain Res. 519:1990;89-96.
84. Gluckman P., Klempt N., Guan J., Mallard E. C., Sirimanne E., Dragunow M., Klempt M., Singh K., Williams C. E., Nikolics K. A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury. Biochem. Biophys. Res. Commun. 182:1992;593-599.
85. Goddard G. V. Development of epileptic seizures through brain stimulation at low intensity. Nature. 214:1967;1020-1021.
86. Goddard G. V., McIntyre D. C., Leech C. K. A permanent change in brain function resulting from daily electrical stimulation. Exp. Neurol. 25:1969;295-330.
87. Goelet P., Castellucci V. F., Schacher S., Kandel E. R. The long and short of long-term memory - a molecular framework. Nature. 322:1986;419-422.
88. Gold B. G. Axonal regeneration of sensory nerves is delayed by continuous intrathecal infusion of nerve growth factor. Neuroscience. 76:1996;1153-1158.
89. Gold B. G., Mobley W. C., Matheson S. F. Regulation of axonal caliber, neurofilament content and nuclear localization in mature sensory neurons by nerve growth factor. J. Neurosci. 11:1991;943-955.
90. Gold B. G., Storm-Dickerson T., Austin D. R. Regulation of the transcription factor c-Jun by nerve growth factor in adult sensory neurons. Neurosci. Lett. 154:1993;129-133.
91. Gonzalez-Martin C., de Diego I., Crespo D., Fairen A. Transient c-fos expression accompanies naturally occurring cell death in the developing interhemispheric cortex of the rat. Dev. Brain Res. 68:1992;83-95.
92. Goto K., Ishige A., Sekiguchi K., Iizuka S., Sugimoto A., Yuzurihara M., Aburada M., Hosoya E., Kogure K. Effects of cycloheximide on delayed neuronal death in rat hippocampus. Brain Res. 534:1990;299-302.
93. Guan J., Skinner S. J. M., Beilharz E. J., Hua K. M., Hodgkinson S., Gluckman P. D., Williams C. E. The movement of IGF-1 into the brain parenchyma after hypoxic-ischemic injury. NeuroReport. 7:1996;632-636.
94. Guan J., Williams C. E., Skinner S. J. M., Mallard E. C., Gluckman P. D. The effects of insulin-like growth factor (IGF)-1, IGF-2, and Des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats - evidence for a role for IGF binding proteins. Endocrinology. 137:1996;893-898.
95. Guan, J., Waldvogel, H. J., Williams, C. E., Faull, R. L. M. and Gluckman, P. D. (1998) Neuroprotective effects of tripeptide of insulin-like growth factor (IGF)-1 GPE following hypoxic-ischemic brain injury in adult rats. Neuroscience in press.
96. Gunn A. J., Dragunow M., Faull R. L. M., Gluckman P. D. Effects of hypoxia-ischemia and seizures on neuronal and glial-like c-fos protein levels in the infant rat. Brain Res. 531:1990;105-116.
97. Haas C. A., Deller T., Naumann T., Frotscher M. Selective expression of the immediate-early gene c-Jun in axotomized rat medial septal neurons is not related to neuronal degeneration. J. Neurosci. 16:1996;1894-1903.
98. Haas C. A., Bach A., Linke R., Frotscher M. Axotomy-induced c-Jun expression is regulated by nerve growth factor in medial septal neurons. Soc. Neurosci. Abstr. 23:1997;353.1.
99. Ham J., Babij C., Whitfield J., Pfarr C. M., Lallemand D., Yaniv M., Rubin L. L. A c-Jun dominant-negative mutant protects sympathetic neurons against programmed cell death. Neuron. 14:1995;927-939.
100. Hefti F. Nerve growth factor promotes the survival of septal cholinergic neurons after fimbrial transections. J. Neurosci. 6:1986;2155-2162.
101. Herdegen T., Skene P., Bahr M. The c-Jun transcription factor - bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci. 20:1997;227-231.
102. Hirata H., Cadet J. L. p53-knockout mice are protected against the long-term effects of methamphetamine on dopaminergic terminals and cell bodies. J. Neurochem. 69:1997;780-790.
103. Hiroi N., Graybiel A. M. Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum. J. Comp. Neurol. 374:1996;70-83.
104. Honkaniemi J., Sagar S. M., Pyykonen I., Hicks K. J., Sharp F. R. Focal brain injury induces multiple immediate early genes encoding zinc finger transcription factors. Mol. Brain Res. 28:1995;157-163.
105. Hope B. T., Kelz M. B., Duman R. S., Nestler E. J. Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics. J. Neurosci. 14:1994;4318-4328.
106. Huang Y. Y., Li X. C., Kandel E. R. cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase. Cell. 79:1994;69-79.
107. Hughes P. Identifying IEGP target genes in vivo. NeuroReport. 5:1994;2005-2006.
108. Hughes P., Dragunow M. Muscarinic receptor-mediated induction of Fos protein in rat brain. Neurosci. Lett. 150:1993;122-126.
109. Hughes P., Dragunow M. Activation of pirenzepine-sensitive muscarinic receptors induces a specific pattern of immediate-early gene expression in rat brain neurons. Mol. Brain Res. 24:1994;166-178.
110. Hughes P., Dragunow M. Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmac. Rev. 47:1995;133-178.
111. Hughes P., Dragunow M. TrkC may be an inducible transcription factor target gene. NeuroReport. 6:1995;465-468.
112. Hughes P., Lawlor P., Dragunow M. Basal expression of Fos, Fos-related, Jun, and Krox 24 proteins in rat hippocampus. Mol. Brain Res. 13:1992;355-357.
113. Hughes P., Beilharz E., Gluckman P., Dragunow M. Brain-derived neurotrophic factor is induced as an immediate-early gene following N-methyl-D-aspartate receptor activation. Neuroscience. 57:1993;319-328.
114. Hughes P., Dragunow M., Beilharz E., Lawlor P., Gluckman P. MK801 induces immediate-early gene proteins and BDNF mRNA in rat cerebrocortical neurons. NeuroReport. 4:1993;183-186.
115. Hughes P., Young D., Dragunow M. MK-801 sensitizes rats to pilocarpine-induced limbic seizures and status epilepticus. NeuroReport. 4:1993;314-316.
116. Hughes P., Singleton K., Dragunow M. MK-801 does not attenuate immediate-early gene expression following an amygdala afterdischarge. Exp. Neurol. 128:1994;276-283.
117. Hughes P. E., Alexi T., Yoshida T., Schreiber S. S., Knusel B. Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation. Neuroscience. 74:1996;1143-1160.
118. Hughes P. E., Alexi T., Schreiber S. S. A role for the tumour-suppressor gene p53 in regulating neuronal apoptosis. NeuroReport. 8:1997;v-xii.
119. Hughes P. E., Alexi T., Dragunow M. Cycloheximide phase-shifts, but does not prevent, de-novo Krox-24 protein expression. NeuroReport. 8:1997;3263-3266.
120. Hughes P. E., Alexi T., Hefti F., Knusel B. Axotomized medial septal cholinergic neurons rescued by NGF or NT-4/5 fail to express the inducible transcription factor c-Jun. Neuroscience. 78:1997;1037-1049.
121. Hughes P. E., Young D., Preston K. M., Qiao Y., Dragunow M. Differential regulation by MK801 of immediate-early genes, brain-derived neurotrophic factor and trk receptor mRNA induced by a kindling afterdischarge. Mol. Brain Res. 53:1998;138-151.
122. Inokuchi K., Kato A., Hiraia K., Hishinuma F., Inoue M., Ozawa F. Increase in activin βA mRNA in rat hippocampus during long-term potentiation. FEBS Lett. 382:1996;48-52.
123. Isenmann S., Bahr M. Expression of c-Jun protein in degenerating retinal ganglion cells after optic nerve lesion in the rat. Exp. Neurol. 147:1997;28-36.
124. Jeffery K. J., Abraham W. C., Dragunow M., Mason S. E. Induction of Fos-like immunoreactivity and the maintenance of long-term potentiation in the dentate gyrus of unanaesthetized rats. Mol. Brain Res. 8:1990;267-274.
125. Johnson T. M., Yu Z.-X., Ferrans V. J., Lowenstein R. A., Finkel T. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc. natl Acad. Sci. U.S.A. 93:1996;11848-11852.
126. Jonec V., Wasterlain C. G. Effect of inhibitors of protein synthesis on the development of kindled seizures in rats. Exp. Neurol. 66:1979;524-532.
127. Jope R. S., Morrisett R. A., Snead O. C. Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats. Exp. Neurol. 91:1986;471-480.
128. Jordan J., Galindo M. F., Prehn J. H. M., Weichselbaum R. R., Beckett M., Ghadge G. D., Roos R. P., Leiden J. M., Miller R. J. p53 expression induces apoptosis in hippocampal pyramidal neuron cultures. J. Neurosci. 17:1997;1397-1405.
129. Kaminska B., Filipowski R. K., Zurkowska G., Lason W., Przewlocki R., Kaczmarek L. Dynamic changes in the composition of the AP-1 transcription factor DNA-binding activity in rat brain following kainate-induced seizures and cell death. Eur. J. Neurosci. 6:1994;1558-1566.
130. Kang H., Schuman E. M. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science. 267:1995;1658-1662.
131. Kang H., Schuman E. M. A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity. Science. 273:1996;1402-1406.
132. Kang H., Welcher A. A., Shelton D., Schuman E. M. Neurotrophins and time: different roles for trkB signaling in hippocampal long-term potentiation. Neuron. 19:1997;653-664.
133. Kelly, J. P. (1991) Reactions of neurons to injury. In: Principles of Neural Science, 3rd edn, pp. 259-269. Eds. E. R. Kandel, J. H. Schwartz and T. M. Jessell. Elsevier, New York.
134. Klein R., Conway D., Parada L. F., Barbacid M. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 61:1990;647-656.
135. Klein R., Nanduri V., Jing S., Lamballe F., Tapley P., Bryant S., Cordon-Cardo C., Jones K. R., Reichardt L. F., Barbacid M. The trkB tyrosine kinase is a receptor for BDNF and NT-3. Cell. 66:1991;395-403.
136. Klempt M., Klempt N. D., Gluckman P. D. Hypoxia and Hypoxia/ischemia affect the expression of insulin-like growth factor binding protein 2 in the developing rat brain. Mol. Brain Res. 17:1993;347-350.
137. Klempt N. D., Klempt M., Gunn A. J., Singh K., Gluckman P. D. Expression of insulin-like growth factor-binding protein 2 (IGF-BP2) following transient hypoxia-ischemia in the infant rat. Mol. Brain Res. 15:1992;55-61.
138. Klempt N. D., Sirimanne E., Gunn A. J., Klempt M., Singh K., Williams C., Gluckman P. D. Hypoxia-ischemia induces transforming growth factor β1 mRNA in the infant rat brain. Mol. Brain Res. 13:1992;93-101.
139. Kokaia M., Ernfors P., Kokaia Z., Elmer E., Jaenisch R., Lindvall O. Suppressed epileptogenesis in BDNF mutant mice. Exp. Neurol. 133:1995;215-224.
140. Korte M., Carroll P., Wolf E., Brem G., Thoenen H., Bonhoeffer T. Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc. natl Acad. Sci. U.S.A. 92:1995;8856-8860.
141. Kulik G., Klippel A., Weber M. J. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and AKT. Molec. Cell. Biol. 17:1997;1595-1606.
142. Labiner D. M., Hosford D. A., Shin C., McNamara J. O. N-Methyl-D-aspartate channel blockers inhibit seizure induced rise in c-fos mRNA in hippocampus of kindled rats. Soc. Neurosci. Abstr. 15:1989;841.
143. Labiner D. M., Butler L. S., Cao Z., Hosford D. A., Shin C., McNamara J. O. Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing. J. Neurosci. 13:1993;744-751.
144. Lai M., Sirimanne E., Williams C. E., Gluckman P. D. Sequential patterns of inhibin subunit gene expression following hypoxic-ischemic injury in the rat brain. Neuroscience. 70:1996;1013-1024.
145. Lai M., Gluckman P., Dragunow M., Hughes P. E. Focal brain injury increases activin βA mRNA expression in hippocampal neurons. NeuroReport. 8:1997;2691-2694.
146. Lane D. P. p53, guardian of the genome. Nature. 358:1992;15-16.
147. Lane D. P., Crawford L. V. T-antigen is bound to host protein in SV40-transformed cells. Nature. 278:1979;261-263.
148. Larmet Y., Reibel S., Carnahan J., Nawa H., Marescaux C., Depaulis A. Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat. NeuroReport. 6:1995;1937-1941.
149. Lauritzen M. Cortical spreading depression as a putative migraine mechanisms. Trends Neurosci. 10:1987;8-13.
150. Lauterborn J. C., Rivera S., Stinis C. T., Hayes V. Y., Isackson P. J., Gall C. M. Differential effects of protein synthesis inhibition on the activity-dependent expression of BDNF transcripts: evidence for immediate-early gene responses from specific promoters. J. Neurosci. 16:1996;7428-7436.
151. Leah J. D., Herdegen T., Bravo R. Selective expression of JUN proteins following peripheral axotomy and axonal transport block in the rat: evidence for a role in the regeneration process. Brain Res. 566:1991;198-207.
152. Leah J. D., Herdegen T., Murashov A., Dragunow M., Bravo R. Expression of immediate-early gene proteins following axotomy and inhibition of axonal transport in the rat CNS. Neuroscience. 57:1993;53-66.
153. Lebmann V., Gottman K., Heumann R. BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurone. NeuroReport. 6:1994;21-25.
154. Lees G. J. Influence of ketamine on the neuronal death caused by NMDA in the rat hippocampus. Neuropharmacology. 34:1995;411-417.
155. LeRoith D., Roberts C. T. Insulin-like growth factor I (IGF-I): a molecular basis for endocrine versus local action? Mol. Cell Endocrinol. 77:1991;C57-C61.
156. Levine A. J., Momand J., Finlay C. A. The p53 tumor suppressor gene. Nature. 351:1991;453-456.
157. Levine E. S., Dreyfus C. F., Black I. B., Plummer M. R. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc. natl Acad. Sci. U.S.A. 92:1995;8074-8077.
158. Levine S. Anoxic encephalopathy in rats. Am. J. Pathol. 36:1960;1-17.
159. Loddick S. A., Liu X.-J., Lu Z.-X., Liu C., Behan D. P., Chalmers D. C., Foster A. C., Vale W. W., Ling N., de Souza E. B. Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke. Proc. natl Acad. Sci. U.S.A. 95:1998;1894-1898.
160. Lopez-Mascaraque L., Price J. L. Protein synthesis inhibitors delay transneuronal death in the piriform cortex of young adult rats. Neuroscience. 79:1997;463-475.
161. Lotem J., Sachs L. Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis. Proc. natl Acad. Sci. U.S.A. 93:1996;12507-12512.
162. Ma Y. L., Wang H. L., Wu H. C., Wei C. L., Lee E. H. Y. Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation. Neuroscience. 82:1998;957-967.
163. MacGibbon G. A., Lawlor P. A., Bravo R., Dragunow M. Clozapine and haloperidol produce a differential pattern of immediate early gene expression in rat caudate-putamen, nucleus accumbens, lateral septum and islands of Calleja. Mol. Brain Res. 23:1994;21-32.
164. MacGibbon G. A., Lawlor P. A., Hughes P., Young D., Dragunow M. Differential expression of inducible transcription factors in basal ganglia neurons. Mol. Brain Res. 34:1995;294-302.
165. MacGibbon G. A., Lawlor P. A., Sirimanne E. S., Walton M. R., Conner B., Young D., Williams C., Gluckman P., Faull R. L. M., Hughes P., Dragunow M. Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus. Mol. Brain Res. 750:1997;223-234.
166. MacGibbon G. A., Lawlor P., Walton M., Sirimanne E., Faull R. L. M., Synek B., Mee E., Conner B., Dragunow M. Expression of Fos, Jun and Krox family proteins in Alzheimer's disease. Exp. Neurol. 147:1997;316-332.
167. Manev H., Kharlamov A., Armstrong D. M. Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72. NeuroReport. 5:1994;2661-2664.
168. Marksteiner J., Ortler M., Bellman R., Sperk G. Neuropeptide Y biosynthesis is markedly induced in mossy fibres during temporal lobe epilepsy in the rat. Neurosci. Lett. 112:1990;143-148.
169. Martin D. P., Schmidt R. E., DeStefano P. S., Lowry O. H., Carter J. G., Johnson E. M. Jr. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol. 106:1988;829-844.
170. McLachlan R. S. Suppression of spreading depression of Leao in neocortex by an N-methyl-D-aspartate receptor antagonist. Can J. Neurol. Sci. 19:1992;487-491.
171. McNamara J. O. Cellular and molecular basis of epilepsy. J. Neurosci. 14:1994;3413-3425.
172. McNamara J. O., Russell R. D., Rigsbee L., Bonhaus D. W. Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models. Neuropharmacology. 27:1988;563-568.
173. McNeill H., Williams C. E., Guan J., Dragunow M., Lawlor P., Sirimanne E., Nikolics K., Gluckman P. D. Neuronal rescue with transforming growth factor-beta(1) after hypoxic-ischaemic brain injury. NeuroReport. 5:1994;901-904.
174. Middlemas D. S., Lindberg R. A., Hunter T. trkB a neuronal receptor protein tyrosine kinase: evidence for a full-length and two truncated receptors. Mol. Cell Biol. 11:1991;143-153.
175. Miyashita T., Reed J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:1995;293-299.
176. Morgan J. I., Cohen D. R., Hempstead J. L., Curran T. Mapping patterns of c-fos expression in the central nervous system after seizure. Science. 237:1987;192-197.
177. Morimoto K., Katayama K., Inoue K., Sato K. Effects of competitive and noncompetitive NMDA receptor antagonists on kindling and LTP. Pharmac. Biochem. Behav. 40:1991;893-899.
178. Morrison R. S., Jurgen Wenzel H., Kinoshita Y., Robbins C. A., Donehower L. A., Schwartzkroin P. A. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death. J. Neurosci. 16:1996;1337-1345.
179. Mudo G., Persson H., Timmusk T., Funakoshi H., Bindoni M., Belluardo N. Increased expression of trkB and trkC messenger RNAs in the rat forebrain after focal mechanical injury. Neuroscience. 57:1993;901-912.
180. Mufson E. J., Conner J. M., Kordower J. H. Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis. NeuroReport. 6:1995;1063-1066.
181. Nakamura T., Pichel J. G., Williams-Simons L., Westphal H. An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele. Proc. natl Acad. Sci. U.S.A. 92:1995;6142-6146.
182. Neeper S. A., Gomez-Pinilla F., Choi J., Cotman C. W. Exercise and brain neurotrophins. Nature. 373:1995;109.
183. Neeper S. A., Gomez-Pinilla F., Choi J., Cotman C. W. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 726:1996;49-56.
184. Nestler E. J. Molecular mechanisms of opiate and cocaine addiction. Curr. Opinion Neurobiol. 7:1997;713-719.
185. Nestler E. J., Aghajanian G. K. Molecular and cellular basis of addiction. Science. 278:1997;58-63.
186. Nguyen P. V., Abel T., Kandel E. R. Requirement of a critical period of transcription for induction of a late phase of LTP. Science. 265:1994;1104-1107.
187. Nieto-Sampedro M., Lewis E. R., Cotman C. W., Manthorpe M., Skaper S. D., Barbin G., Longo F. M., Varon S. Brain injury causes a time-dependent increase in neurotrophic activity at the lesion site. Science. 217:1982;860-861.
188. O'Connor R., Kauffmannzeh A., Liu Y. M., Lehar S., Evan G. I., Baserga R., Blattler W. A. Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. Molec. Cell. Biol. 17:1997;427-435.
189. Oppenheim R. W., Prevette D., Tytell H., Homma S. Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of the cell death genes. Dev. Biol. 13:1990;104-113.
190. Otani S., Marshal C. J., Tate W. P., Goddard G. V., Abraham W. C. Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization. Neuroscience. 28:1989;519-526.
191. Papas S., Crepel V., Hasboun D., Jorguera I., Chinestra P., Ben-Ari Y. Cycloheximide reduces the effects of anoxic insult in vivo and in vitro. Eur. J. Neurosci. 4:1992;758-765.
192. Pardridge, W. M. (1991) Transnasal and intraventricular delivery of drugs. In: Peptide drug delivery to the brain, pp. 99-122. Ed. W. M. Pardridge. Raven Press, New York.
193. Parrizas M., LeRoith D. Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the BCL-X(L) gene product. Endocrinology. 138:1997;1355-1358.
194. Parrizas M., Saltiel A. R., LeRoith D. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 272:1997;154-161.
195. Patterson S. L., Grover L. M., Schwartzkroin P. A., Bothwell M. Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron. 9:1992;1081-1088.
196. Patterson S. L., Abekl T., Deuel T. A. S., Martin K. C., Rose J. C., Kandel E. R. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron. 16:1996;1137-1145.
197. Pennypacker K. R., Thai L., Hong J.-S., McMillan M. K. Prolonged expression of AP-1 transcription factors in the rat hippocampus after systemic kainate treatment. J. Neurosci. 14:1994;3998-4006.
198. Perlin J. B., Gerwin C. M., Panchision D. M., Vick R. S., Jakoi E. R., DeLorenzo R. J. Kindling produces long-lasting and selective changes in gene expression of hippocampal neurons. Proc. natl Acad. Sci. U.S.A. 90:1993;1741-1745.
199. Prehn J. H., Bindokas V. P., Marcuccilli C. J., Krajewski S., Reed J. C., Miller R. J. Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons. Proc. natl Acad. Sci. U.S.A. 91:1994;12599-12603.
200. Racine R. Kindling: the first decade. Neurosurgery. 3:1978;234-252.
201. Rashid K., Van der Zee C. E. E. M., Ross G., Chapman C. A., Stanisz J., Riopelle R., Racine R. J., Fahnestock M. A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy. Proc. natl Acad. Sci. U.S.A. 92:1995;9495-9499.
202. Rennels M. L., Blaumanis O. R., Grady P. A. Rapid solute transport throughout the brain via paravascular fluid pathways. Adv. Neurol. 52:1990;431-439.
203. Represa A., Jorquera I., LeGall La Salle G., Ben-Ari Y. Epilepsy-induced collateral sprouting of hippocampal mossy fibres: does it induce the development of ectopic synapses with granule cell dendrites? Hippocampus. 3:1993;258-268.
204. Richardson C. L., Tate W. P., Mason S. E., Lawlor P. A., Dragunow M., Abraham W. C. Correlation between the induction of an immediate early gene, zif/268, and long-term potentiation in the dentate gyrus. Brain Res. 580:1992;147-154.
205. Russo V. C., Bach L. A., Fosang A. J., Baker N. L., Werther G. A. Insulin-like growth factor binding protein-2 binds to cell surface proteoglycans in the rat brain olfactory bulb. Endocrinology. 138:1997;4858-4867.
206. Saffen D. W., Cole A. J., Worley P. F., Christy B. A., Ryder K., Baraban J. M. Convulsant-induced increase in transcription factor messenger RNAs in rat brain. Proc. natl Acad. Sci. U.S.A. 85:1988;7795-7799.
207. Sakhi S., Bruce A., Sun N., Tocco G., Baudry M., Schreiber S. S. p53 induction is associated with neuronal damage in the central nervous system. Proc. natl Acad. Sci. U.S.A. 91:1994;7525-7529.
208. Sakhi S., Gilmore W., Tran N. D., Schreiber S. S. p53-deficient mice are protected against adrenalectomy-induced apoptosis. NeuroReport. 8:1996;233-235.
209. Sakhi S., Bruce A., Sun N., Tocco G., Baudry M., Schreiber S. S. Induction of tumor suppressor p53 and DNA fragmentation in organotypic hippocampal cultures following excitotoxin treatment. Exp. Neurol. 145:1997;81-88.
210. Sato K., Morimoto K., Okamoto M. Anticonvulsant action of a non-competitive antagonist of NMDA receptors (MK-801) in the kindling model of epilepsy. Brain Res. 463:1988;12-20.
211. Schreiber S. S., Maren S., Tocco G., Shors T. J., Thompson R. F. A negative correlation between the induction of long-term potentiation and activation of immediate early genes. Mol. Brain Res. 11:1991;89-91.
212. Scott S. A., Mufson E. J., Weingartner J. A., Skau K. A., Crutcher K. A. Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J. Neurosci. 15:1995;6213-6221.
213. Selvakumaran M., Lin H.-K., Miyashita T., Wang H. G., Krajewski S., Reed J., Hoffman B., Liebermann D. Immediate-early up-regulation of Bax expression by p53 but not TGFβ1: a paradigm for distinct apoptotic pathways. Oncogene. 9:1994;1791-1798.
214. Serghini R., Froissard P., Sola B., Duval D. Cycloheximide and actinomycin D block the toxic effect of glutamic acid on PC12 cells. NeuroReport. 6:1994;29-32.
215. Shah P. T., Yoon K.-W., Xu X. M., Broder L. D. Apoptosis mediates cell death following traumatic injury in rat hippocampal neurons. Neuroscience. 79:1997;999-1004.
216. Shigeno T., Yamasaki Y., Kato G., Kusaka K., Mima T., Takakura K., Graham D. I., Furukawa S. Reduction of delayed neuronal death by inhibition of protein synthesis. Neurosci. Lett. 120:1990;117-119.
217. Sirimanne E. S., Guan J., Williams C. E., Gluckman P. D. Two models for determining the mechanisms of damage and repair after hypoxic-ischaemic injury in the developing rat brain. J. Neurosci. Meth. 55:1994;7-14.
218. Smeyne R. J., Vendrell M., Hayward M., Baker S. J., Miao G. G., Schilling K., Robertson L., Curran T., Morgan J. I. Continuous c-fos expression precedes programmed cell death in vivo. Nature. 363:1993;166-169.
219. Stevens C. F. CREB and memory consolidation. Neuron. 13:1994;769-770.
220. Sutula T., He X. X., Cavazos J., Scott G. Synaptic reorganization in the hippocampus induced by abnormal functional activity. Science. 239:1988;1147-1150.
221. Sutula T., Cascino G., Cavazos J., Parada I., Ramirez L. Mossy fibre synaptic reorganization in the epileptic human temporal lobe. Ann. Neurol. 26:1989;321-330.
222. Sutula T., Koch J., Golarai G., Watanabe Y., McNamara J. O. NMDA receptor dependence of kindling and mossy fibre sprouting: evidence that the NMDA receptor regulates patterning of hippocampal circuits in the adult brain. J. Neurosci. 16:1996;7398-7406.
223. Tanimoto, K., Handa, S., Ueno, N., Murakami, K. and Fukamizu, A. (1991) Structure and sequence analysis of the human activin beta A subunit gene. DNA Sequence 2, 103-110.
224. Tanimoto, Yoshida, E., Mita, S., Nibu, Y., Murakami, K. and Fukamizu, A. (1996) Human activin beta A gene. Identification of novel 5′ exon, functional promoter and enhancers. J. Biol. Chem. 271, 32760-32769.
225. Taupin P., Roisin M.-P., Ben-Ari Y., Barbin G. A fraction enriched in rat hippocampal mosssy fibre synaptosomes contains trophic activities. NeuroReport. 5:1994;1353-1355.
226. Trimmer P. A., Smith T. S., Jung A. B., Bennett J. P. Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity. Neurodegeneration. 5:1996;233-239.
227. Turski W., Cavalheiro E. A., Bortolotto Z. A., Mello L. M. .M., Schwarz M., Turski L. Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis. Brain Res. 321:1984;237-253.
228. Vezzani A., Wu H. Q., Moneta E., Samanin R. Role of N-methyl-D-aspartate receptors in the development and maintenance of hippocampal kindling in rats. Neurosci. Lett. 87:1988;63-68.
229. Van der Zee C. E. E. M., Fawcett J., Diamond J. Antibody to NGF inhibits collateral sprouting of septohippocampal fibres following entorhinal cortex lesion in adult rats. J. Comp. Neurol. 326:1992;91-100.
230. Van der Zee C. E. E. M., Rashid K., Le K., Moore K., Stanisz J., Diamond J., Racine R. J., Fahnestock M. Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fibre sprouting in adult rats. J. Neurosci. 15:1995;5316-5323.
231. Virdee K., Bannister A. J., Hunt S. P., Tolkovsky A. M. Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones. J. Neurochem. 69:1997;550-561.
232. Walton M., Sirimanne E., Williams C., Gluckman P., Dragunow M. The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair. Mol. Brain Res. 43:1996;21-29.
233. Walton M., Young D., Sirimanne E., Dodd J., Christie D., Williams C., Gluckman P. D., Dragunow M. Induction of clusterin in the immature brain following a hypoxic-ischemic injury. Mol. Brain Res. 39:1996;137-152.
234. Walton M., Lawlor P., Sirimanne E., Williams C., Gluckman P., Dragunow M. Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons. Mol. Brain Res. 44:1997;167-170.
235. Walton M., Sirimanne E., Williams C., Gluckman P. D., Keelan J., Mitchell M. D., Dragunow M. Prostaglandin H synthase-2 and cytosolic phospholipase A2 in the hypoxic-ischemic brain: role in neuronal death or survival? Mol. Brain Res. 50:1997;165-170.
236. Walton M., Sirimanne E., Reutelingsperger C., Williams C., Gluckman P., Dragunow M. Annexin V labels apoptotic neurons following hypoxia-ischemia. NeuroReport. 8:1997;3871-3875.
237. Watanabe Y., Johnson R. S., Butler L. S., Binder D. K., Spiegelman B. M., Papaioannou V. E., McNamara J. O. Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy. J. Neurosci. 16:1996;3827-3836.
238. Waurin J. P., Dudek F. E. Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats. J. Neurosci. 16:1996;4438-4448.
239. Wilcox B. J., Applegate M. D., Portera-Cailliau C., Koliatsos V. E. Nerve growth factor prevents apoptotic cell death in injured central cholinergic neurons. J. Comp. Neurol. 359:1995;573-585.
240. Williams C. E., Gunn A. J., Gluckman P. D. The time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep. Stroke. 22:1991;516-521.
241. Williams J., Dragunow M., Lawlor P., Mason S., Abraham W. C., Leah J., Bravo R., Demmer J., Tate W. Krox20 may play a role in the stabilzation of long-term potentiation. Mol. Brain Res. 28:1995;87-93.
242. Williamson J. M., Lothman E. W. The effect off MK801 on kindled seizures: implications for use and limitations as an antiepileptic drug. Ann. Neurol. 26:1989;85-90.
243. Wisden W., Errington M. L., Williams S., Dunnett S. B., Waters C., Hitchcock D., Evans G., Bliss T. V. P., Hunt S. P. Differential expression of immediate-early genes in the hippocampus and spinal cord. Neuron. 4:1990;603-614.
244. Won J.-S., Kim Y.-H., Song D.-K., Suh H.-W. The effect of cycloheximide on the regulation of proenkephalin and prodynorphin gene expression induced by kainic acid in rat hippocampus. Mol. Brain Res. 47:1997;303-310.
245. Wood K. A., Youle R. J. The role of free radicals and p53 in neuron apoptosis in vivo. J. Neurosci. 15:1995;5851-5857.
246. Worley P. F., Bhat R., Baraban J. M., Erickson C. A., McNaughton B. L., Barnes C. Thresholds for synaptic activation of transcription factors in hippocampus: correlation with long-term enhancement. J. Neurosci. 13:1993;4776-4786.
247. Xiang H., Hochman D. W., Saya H., Fujiwara T., Schwartzkroin P. A., Morrison R. S. Evidence for p53-mediated modulation of neuronal viability. J. Neurosci. 16:1996;6753-6765.
248. Xu R. A., Dragunow M., Lipski J., Young D., During M. High levels of c-Jun expression in PC12 cells induces differentiation into a GAP-43 independent, neuronal-like phenotype. Soc. Neurosci. Abstr. 27:1997;245.2.
249. Yan Q., Matheson C., Sun J., Radeke M. J., Feinstein S. C., Miller J. A. Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with TrK receptor expression. Exp. Neurol. 127:1994;23-26.
250. Yonish-Rouach E., Resnitzky D., Lotem J., Sachs L., Kimchi A., Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibitedby interleukin-6. Nature. 352:1991;345-347.
251. Yoshida T., Okazaki T., Hughes P. E., Schneider E. L., Mori N. Cloning of rat GADD-45 gene and induction analysis following ionizing radiation in vivo. FEBS Lett. 380:1996;87-92.
252. Young D., Dragunow M. Non-NMDA glutamate receptors are involved in the maintenance of status epilepticus. NeuroReport. 5:1993;81-83.
253. Young D., Dragunow M. Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms. Neuroscience. 58:1994;245-261.