Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease

Neuroscience Letters

Volumn 270, Issue 1, 1999, Pages 45-48

  Mogi, Makio ^a   Togari, Akifumi ^a   Kondo, Tomoyoshi ^b   Mizuno, Yoshikuni ^b   Komure, Osamu ^c   Kuno, Sadako ^c   Ichinose, Hiroshi ^d   Nagatsu, Toshiharu ^d  

^a AICHI GAKUIN UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UTANO NATIONAL HOSPITAL   (Japan)

^d FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

Brain; Brain derived neurotrophic factor; Nerve growth factor; Parkinson's disease

Indexed keywords

BRAIN DERIVED GROWTH FACTOR; DOPAMINE; NERVE GROWTH FACTOR; NEUROTROPHIN;

ADULT; AGED; ARTICLE; CAUDATE NUCLEUS; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; MALE; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NIGRONEOSTRIATAL SYSTEM; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PUTAMEN; SUBSTANTIA NIGRA;

ADULT; AGED; AGED, 80 AND OVER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CAUDATE NUCLEUS; CEREBELLUM; FEMALE; FRONTAL LOBE; HUMANS; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; PARKINSON DISEASE; PUTAMEN; REFERENCE VALUES; SUBSTANTIA NIGRA;

EID: 0033597983     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00463-2     Document Type: Article

References (23)

1. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
2. Eldridge R., Ince S.E. The low concordance rate for Parkinson's disease in twins: a possible explanation. Neurology. 34:1984;1354-1356.
3. Fan D.S., Ogawa M., Ikeguchi K., Fujimoto K., Urabe M., Kume K., Nishizawa M., Matsushita N., Kiuchi K., Ichinose H., Nagatsu T., Kurzman G.J., Nakano I., Ozawa K. Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro. Neurosci. Lett. 248:1998;61-64.
4. Gash D.M., Zhang Z., Ovadia A., Cass W.A., Yi A., Simmerman L., Russel D., Martin D., Lapchak P.A., Collins F., Hoffer B.J., Gerhardt G.A. Functional recovery in parkinsonian monkeys treated with GDNF. Nature. 380:1996;252-255.
5. Hyman C., Hofer M., Barde Y.A., Juhasz M., Yancopoulos G.D., Squinto S.P., Lindsay R.M. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature. 350:1991;230-232.
6. Hynes M.A., Poulsen K., Armanini M., Berkemeier L., Phillips H., Rosenthal A. Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures. J. Neurosci. Res. 37:1994;144-154.
7. Knusel B., Winslow J.W., Rosenthal A., Burton L.E., Seid D.P., Nikoliks K., Hefti F. Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. Proc. Natl. Acad. Sci. USA. 88:1991;961-965.
8. Kokaia Z., Bengzon J., Metsis M., Kokaia M., Persson H., Lindvall O. Coexpression of neurotrophins and their receptors in neurons of the central nervous system. Proc. Natl. Acad. Sci. USA. 90:1993;6711-6715.
9. Koller W.C., Hubble J.P. Levodopa therapy in Parkinson's disease. Neurology. 40:1990;40-47.
10. Levivier M., Przedborski S., Bencsics C., Kang U.J. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J. Neurosci. 15:1995;7810-7820.
11. Lindsay R.M., Wiegand S.J., Altar C.A., DiStefano P.S. Neurotrophic factors: from molecule to man. Trends Neurosci. 17:1994;182-190.
12. Maisonpierre P.C., Belluscio L., Friedman B., Alderson R.F., Wiegand S.J., Furth M.E., Lindsay R.M., Yancopoulos G.D. NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron. 5:1990;501-509.
13. Mogi M., Harada M., Riederer P., Narabayashi H., Fujita K., Nagatsu T. Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci. Lett. 165:1994;208-210.
14. Mogi M., Harada M., Kondo T., Riederer P., Inagaki H., Minami M., Nagatsu T. Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients. Neurosci. Lett. 180:1994;147-150.
15. Mogi M., Harada M., Kondo T., Narabayashi H., Riederer P., Nagatsu T. Transforming growth factor-β1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease. Neurosci. Lett. 193:1995;129-132.
16. Mogi M., Harada M., Kondo T., Riederer P., Nagatsu T. Interleukin-2 but not basic fibroblast growth factor is elevated in parkinsonian brain. J. Neural Transm. 103:1996;1077-1081.
17. Mogi M., Togari A., Ogawa M., Ikeguchi K., Shizuma N., Fan D-S., Nakano I., Nagatsu T. Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1β and nerve growth factor in the striatum. Neurosci. Lett. 250:1998;25-28.
18. Olanow C.W., Kordower J.H., Freeman T.B. Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci. 19:1996;102-109.
19. Scott S.A., Mufson E.J., Weingartner J.A., Skau K.A., Crutcher K.A. Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis. J. Neurosci. 15:1995;6213-6221.
20. Spina M.B., Squinto S.P., Miller J., Lindsay R.M., Hyman C. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: involvement of the glutathione system. J. Neurochem. 59:1992;99-106.
21. Weskamp G., Otten U. An enzyme-linked immunoassay for nerve growth factor (NGF): a tool for studying regulatory mechanisms involved in NGF production in brain and peripheral tissues. J. Neurochem. 48:1987;1779-1786.
22. Yan Q., Radeke M.J., Matheson C.R., Talvenheimo J., Welcher A.A., Feinstein S.C. Immunocytochemical localization of TrkB in the central nervous system of the adult rat. J. Comp. Neurol. 378:1997;135-157.
23. Yurek D.M., Lu W., Hipkens S., Wiegand S.J. BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons. Exp. Neurol. 137:1996;105-118.