β-Amyloid binds to p75(NTR) and activates NFκB in human neuroblastoma cells

Journal of Neuroscience Research

Volumn 54, Issue 6, 1998, Pages 798-804

  Kuner, Pascal ^a   Schubenel, Robert ^a   Hertel, Cornelia ^a,b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Alzheimer's disease; Apoptosis; Neurotrophin; p75(NTR); amyloid

Indexed keywords

AMYLOID BETA PROTEIN; CURCUMIN; DNA FRAGMENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR; PROTEIN P75; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; FOREBRAIN; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; OLIVARY NUCLEUS; PRIORITY JOURNAL; RECEPTOR BINDING;

EID: 0032534629     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-4547(19981215)54:6<798::aid-jnr7>3.3.co;2-k     Document Type: Article

References (28)

1. Batistatou A, Greene LA. 1991. Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: Correlation with suppression of endonuclease activity. J Cell Biol 115:461-471.
2. Behl C, Davis JB, Lesley R, Schubert D. 1994. Hydrogen peroxidase mediates amyloid β protein toxity. Cell 77:817-827.
3. Behl C, Skutella T, Lezoualc'h F, Post A, Widmann M, Newton CJ, Holsboer F. 1997. Neuroprotection against oxidative stress by estrogens: Structure-activity relationship. Mol Pharmcol 51:535-541.
4. Carter BD, Kaltschmidt C, Dechant G, Casedemut E, Chao MV, Barde Y. 1996a. Mechanism of signal transduction through the p75 neurotrophin receptor. Soc Neurosci Abstr 22:1213.
5. Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhäuser N, Böhm-Matthaei R, Baeuerle PA, Barde YA. 1996b. Selective activation of NF-κB by nerve growth factor through the neurotrophin receptor p75. Science 272:542-545.
6. Chao MV. 1994. The p75 neurotrophin receptor. J Neurobiol 25:1373-1385.
7. Cheng Y, Prusoff WH. 1973. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (150) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
8. Da Silva J, Pierrat B, Mary J-L, Lesslauer W. 1997. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression. J Biol Chem 272:28373-28380.
9. El Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD. 1996. Scavenger receptor-mediated adhesion of microglia to β-amyloid. Nature 382:716-719.
10. Ernfors P, Lindefors N, Chan-Palay V, Persson H. 1990. Cholinergic neurons of the nucleus basalis express elevated levels of nerve growth factor receptor mRNA in senile dementia of the Alzheimer Type. Dementia 1:138-145.
11. Grilli M, Pizzi M, Memo M, Spano P. 1996. Neuroprotection by aspirin and sodium salicyclate through blockade of NF-kB activation. Science 274:1383-1385.
12. Hartman DS, Hertel C. 1994. Nerve growth factor-induced differentiation in neuroblastma cell expressing TrkA but lacking p75NGFR. J Neurochem 63:1261-1270.
13. Hertel C, Hauser N, Schubenel R, Seilheimer B, Kemp JA. 1996. β-amyloid-induced cell toxicity: Enhancement of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide-dependent cell death. J Neurochem 67:272-276.
14. Hertel C, Terzi E, Hauser N, Jakob-Rotne R, Seelig J, Kemp JA. 1997. Inhibition of the electrostatic interaction between β-amyloid peptide and membranes prevents β-amyloid-induced toxicity. Proc Natl Acad Sci USA 94:9412-9416.
15. Joslin G, Krause JE, Hershey AD, Adams SP, Fallon RJ, Perlmutter DH. 1991. Amyloid-beta peptide substance P, bombesin bind to the serpin-enzyme complex receptor. J Biol Chem 266:21897-21902.
16. Kosik KS. 1994. The Alzheimer's disease sphinx: A riddle with plaques and tangles. J Cell Biol 127:1501-1504.
17. Kuner P, Hertel C. 1998. NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR. J Neurosci Res 54:465-474.
18. Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J. 1995. Inhibition of nuclear translocation of transcription factor NFkB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 270: 14255-14258.
19. Meda L, Cassatella MA, Szendrei GI, Otvos LJ, Baron P Villaba M, Ferrari D, Rossi F. 1995. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374:647-650.
20. Mufson EJ, Kordower JH. 1992. Cortical neurons express nerve growth factors in advanced age and Alzheimer disease. Proc Natl Acad Sci USA 89:569-573.
21. Mullan M, Crawford F. 1993. Genetic and molecular advances in Alzheimer's disease. Trends Neurosci 16:398-402.
22. Rabizadeh S, Bitler M, Butcher LL, Bredesen DE. 1994. Expression of the low-affinity nerve growth factor receptor enhances β-amyloid peptide toxicity. Proc Natl Acad Sci USA 91:10703-10706.
23. Shearman MS, Ragan CI, Iversen LL. 1994. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death. Proc Natl Acad Sci USA 91:1470-1474.
24. Singh S, Aggarwal B. 1995. Activation of transcription factor NF-KB is suppressed by Curcurmin (diferulolymethane). J Biol Chem 270:24995-25000.
25. Yaar M, Zhai S, Pilch PF, Doyle SM, Eisenhauer PB, Fine RE, Gilchrest BA. 1997. Binding of β-amyloid to the p75 neurotrophin receptor induces apoptosis. J Clin Invest 100:2333-2340.
26. Yan SD, Chen X, Fu J, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM. 1996. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382:685-691.
27. Yang K, Mu XS, Hayes RL. 1995. Increased cortical nuclear factor-kappa-B (NF-kappa B) DNA binding activity after traumatic brain injury in rats. Neurosci Lett 197:101-104.
28. Yankner B, Duffy LK, Kirschner DA. 1990. Neurotrophic effects of amyloid β protein: Reversal by tachykinin neuropeptides. Science 250:279-282.