Absence of brain-derived neurotrophic factor and trkB receptor immunoreactivity in glia of Alzheimer's disease

Acta Neuropathologica

Volumn 98, Issue 4, 1999, Pages 345-348

  Soontornniyomkij, Virawudh ^a   Wang, Guoji ^a   Pittman, Christopher A ^a   Hamilton, Ronald L ^a   Wiley, Clayton A ^a   Achim, Cristian L ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Brain derived neurotrophic factor; Glia trkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN; RECEPTOR PROTEIN; TYROSINE KINASE RECEPTOR;

AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; AUTOPSY; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; GLIA; HIPPOCAMPUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOFLUORESCENCE TEST; IMMUNOREACTIVITY; MICROGLIA; NEOCORTEX; NORMAL HUMAN; PRIORITY JOURNAL; SENILE PLAQUE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; NEUROGLIA; RECEPTOR, TRKB;

EID: 0032846365     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010051092     Document Type: Article

References (19)

1. Boissiere F, Faucheux B, Ruberg M, Agid Y, Hirsch EC (1997) Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease. Exp Neurol 145:245-252
2. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239-259
3. DeWitt DA, Perry G, Cohen M, Doller C, Silver J (1998) Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease. Exp Neurol 149:329-340
4. Dickson DW (1997) The pathogenesis of senile plaques. J Neuropathol Exp Neurol 56:321-339
5. Elkabes S, DiCicco-Bloom EM, Black IB (1996) Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 16: 2508-2521
6. Fenton H, Finch PW, Rubin JS, Rosenberg JM, Taylor WG, Kuo-Leblanc V, Rodriguez-Wolf M, Baird A, Schipper HM, Stopa EG (1998) Hepatocyte growth factor (HGF/SF) in Alzheimer's disease. Brain Res 779:262-270
7. Foschini DR, Kestler AM, Egger MD, Crockett DP (1994) The up-regulation of trkA and trkB in dorsal column astrocytes following dorsal rhizotomy. Neurosci Lett 169:21-24
8. Griffin WS, Sheng JG, Royston MC, Gentleman SM, McKenzie JE, Graham DI, Roberts GW, Mrak RE (1998) Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression. Brain Pathol 8:65-72
9. Lindsay RM, Wiegand SJ, Altar CA, DiStefano PS (1994) Neurotrophic factors: from molecule to man. Trends Neurosci 17:182-190
10. Mallat M, Houlgatte R, Brachet P, Prochiantz A (1989) Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro. Dev Biol 133:309-311
11. McKeon RJ, Silver J, Large TH (1997) Expression of full-length trkB receptors by reactive astrocytes after chronic CNS injury. Exp Neurol 148:558-567
12. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, Belle G van, Berg L (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41:479-486
13. Mufson EJ, Lavine N, Jaffar S, Kordower JH, Quirion R, Saragovi HU (1997) Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease. Exp Neurol 146:91-103
14. Murray KD, Gall CM, Jones EG, Isackson PJ (1994) Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease. Neuroscience 60:37-48
15. Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, Winslow JW (1991) BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7: 695-702
16. Schoonover S, Davies P, Bowser R (1996) Immunolocalization and redistribution of the FAC1 protein in Alzheimer's disease. J Neuropathol Exp Neurol 55:444-455
17. Soontornniyomkij V, Wang G, Kapadia SB, Achim CL, Wiley CA (1998) Confocal assessment of lymphoid tissues with follicular hyperplasia from patients infected with human immunodeficiency virus type 1. Arch Pathol Lab Med 122:534-538
18. Soontornniyomkij V, Wang G, Pittman CA, Wiley CA, Achim CL (1998) Expression of brain-derived neurotrophic factor protein in activated microglia of human immunodeficiency virus type 1 encephalitis. Neuropathol Appl Neurobiol (in press)
19. Yamada T, Tsubouchi H, Daikuhara Y, Prat M, Comoglio PM, McGeer PL, McGeer EG (1994) Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues. Brain Res 637:308-312