A comparative study of ethanol, hypoglycemia, hypoxia and neurotrophic factor interactions with fetal rat hippocampal neurons: A multi-factor in vitro model for developmental ethanol effects

Developmental Brain Research

Volumn 105, Issue 2, 1998, Pages 241-250

  Mitchell, J Jean ^a   Paiva, Michael ^a   Moore, D Blaine ^a   Walker, Don W ^a,b   Heaton, Marieta Barrow ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Brain derived neurotrophic factor; Ciliary neurotrophic factor; Fetal alcohol syndrome; Hippocampus; MTT; Nerve growth factor; Neuroprotection

Indexed keywords

ALCOHOL; BRAIN DERIVED GROWTH FACTOR; CILIARY NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR;

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CELL PROTECTION; COMPARATIVE STUDY; FETAL ALCOHOL SYNDROME; GLUCOSE METABOLISM; HIPPOCAMPUS; HYPOGLYCEMIA; HYPOXIA; NERVE GROWTH; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; FETAL ALCOHOL SYNDROME; HIPPOCAMPUS; HYPOGLYCEMIA; HYPOXIA, BRAIN; MODELS, NEUROLOGICAL; NERVE GROWTH FACTORS; NEUROPROTECTIVE AGENTS; RATS;

EID: 0032502049     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(97)00182-X     Document Type: Article

References (55)

1. E.L. Abel, Fetal alcohol syndrome: II. Human studies, CRC Press, Boca Raton, FL, 1982a.
2. E.L. Abel, Fetal alcohol syndrome: III. Animal studies, CRC Press, Boca Raton, FL, 1982b.
3. Abel E.L. Alcohol-induced changes in blood gases, glucose, and lactate in pregnant and nonpregnant rats. Alcohol. 13:1996;281-285.
4. Abel E.L., Hannigan J.H. Maternal risk factors in fetal alcohol syndrome: provocative and permissive influences. Neurotoxicol. Teratol. 17:1995;445-462.
5. Barnes D.E., Walker D.W. Prenatal ethanol exposure permanently reduces the number of pyramidal neurons in rat hippocampus. Dev. Brain Res. 1:1981;333-340.
6. Beck T., Lindholm D., Castren E., Wree A. Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus. J. Cereb. Blood Flow Metab. 14:1994;689-692.
7. Bradley D.M., Paiva M., Tonjes L.A., Heaton M.B. In vitro comparison of the effects of ethanol and acetaldehyde on dorsal root ganglion neurons. Alcohol. Clin. Exp. Res. 19:1995;1345-1350.
8. Cellerino A. Expression of messenger RNA coding for the nerve growth factor receptor trkA in the hippocampus of the adult rat. Neuroscience. 70:1996;613-616.
9. Center for Disease Control, Update: Trends in fetal alcohol syndrome - United States, 1979-1993, Morbidity and Mortality Weekly Report, 44 (1995) 249-251.
10. Chao M.V. Neurotrophin receptors: a window into neuronal differentiation. Neuron. 9:1992;583-593.
11. Cheng B., Mattson M.P. NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis. Neuron. 7:1991;1031-1041.
12. Davies A.M., Smith D.E. A Golgi study of mouse hippocampal CA1 pyramidal neurons following perinatal ethanol exposure. Neurosci. Lett. 26:1981;49-54.
13. Denizot F., Lang R. Rapid colorimetric assay for cell growth and survival: modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Meth. 89:1986;271-277.
14. Ebendal T. Function and evolution in the NGF family and its receptors. J. Neurosci. Res. 32:1992;461-470.
15. Fryer R.H., Kaplan D.R., Feinstein S.C., Radeke M.J., Grayson D.R., Kromer L.F. Developmental and mature expression of full-length and truncated TrkB receptors in the rat forebrain. J. Comp. Neurol. 374:1996;21-40.
16. Gidday J.M., Fitzgibbons J.C., Shah A.R., Park T.S. Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat. Neurosci. Lett. 168:1994;221-224.
17. M.P. Goldberg, D.W. Choi, Intracellular free calcium increases in cultured cortical neurons deprived of oxygen and glucose, Stroke, 21 (1990) III-75-77.
18. D.A. Greenberg, J. Chan, Ethanol, calcium channels, and intracellular calcium in cultured neural cells, in: R.R. Watson, (Ed.), Alcohol and Neurobiology, CRC Press, Boca Raton, FL, 1992, pp. 141-160.
19. Heaton M.B., Paiva M., Swanson D.J., Walker D.W. Modulation of ethanol neurotoxicity by nerve growth factor. Brain Res. 620:1993;78-85.
20. Heaton M.B., Paiva M., Swanson D.J., Walker D.W. Responsiveness of cultured septal and hippocampal neurons to ethanol and neurotrophic substances. J. Neurosci. Res. 39:1994;305-318.
21. Heaton M.B., Paiva M., Swanson D.J., Walker D.W. Alterations in responsiveness to ethanol and neurotrophic substances in fetal septohippocampal neurons following chronic prenatal ethanol exposure. Dev. Brain Res. 85:1995;1-13.
22. Ip N.Y., Li Y.P., van-de Stadt I., Panayotatos N., Alderson R.F., Lindsay R.M. Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures. J. Neurosci. 11:1991;3124-3134.
23. Ip N.Y., Nye S.H., Boulton T.G., Davis S., Taga T., Li Y., Birren S.J., Yasukawa K., Kishimoto T., Anderson D.J., Stahl N., Yancopoulos G.D. CNTF and LIF act on neuronal cells via shared signally pathways that involve the IL-6 signal transducing receptor component gp130. Cell. 69:1992;1121-1132.
24. Jones K.L., Smith D.W. Recognition of the fetal alcohol syndrome in early infancy. Lancet. 2:1973;999-1001.
25. Klein R., Conway D., Parada L.F., Barbacid M. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 61:1990;647-656.
26. Lindvall O., Kokaia Z., Bengzon J., Elmer E., Kokaia M. Neurotrophins and brain insults. TINS. 17:1994;490-496.
27. MacLennan A.J., Lee N., Walker D.W. Chronic ethanol administration decreases brain-derived neurotrophic factor gene expression in the rat hippocampus. Neurosci. Lett. 197:1995;105-108.
28. Magal E., Burnham P., Varon S. Effect of low-affinity NGF receptor expression by cultured neurons from different rat brain regions. J. Neurosci. Res. 30:1991;560-566.
29. Maisonpierre P.C., Belluscio L., Friedman B., Alderson R.F., Wiegand S.J., Furth M.E., Lindsay R.M., Yancopoulos G.D. NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron. 5:1990;501-509.
30. Manthorpe M., Fagnani R., Skaper S.D., Varon S. An automated colorimetric microassay for neuronotrophic factors. Dev. Brain Res. 25:1986;191-198.
31. M.P. Mattson, B. Cheng, Growth factors protect neurons against excitotoxic/ischemic damage by stabilizing calcium homeostasis, Stroke, 24 (1993) I-136-140.
32. Mattson M.P., Murrain M., Guthrie P.B., Kater S.B. Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture. J. Neurosci. 9:1989;3728-3740.
33. J.J. Mitchell, M. Paiva, M.B. Heaton, Optimal 96-well plate set-up to avoid ethanol volatility when assessing ethanol cytotoxicity (in press).
34. Mitsumoto H., Ikeda K., Klinkosz B., Cedarbaum J.M., Wong V., Lindsay R.M. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science. 265:1994;1107-1110.
35. Moore D.B., Paiva M., Walker D.W., Heaton M.B. Postnatal ethanol inhalation reduces neurotrophic activity in the developing rat hippocampus. Alcohol. Clin. Exp. Res. 20:1996;158.
36. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J. Immunol. Meth. 65:1983;55-63.
37. Nakao N., Kokaia Z., Odin P., Lindvall O. Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons. Exp. Neurol. 131:1995;1-10.
38. T. Persuad (Ed.), Alcohol: In Environmental Causes of Birth Defects, Charles C. Thomas, Toronto, Ontario, 1990, pp. 97-129.
39. Rabe C.S., Weight J.F. Effects of ethanol on neurotransmitter release and intracellular free calcium in PC12 cells. J. Pharm. Ext. Ther. 244:1988;417-422.
40. Richardson B., Patrick J., Bousquet J., Homan J., Brien J. Cerebral metabolism in fetal lamb after maternal infusion of ethanol. Am. J. Physiol. 249:1985;R505-R509.
41. Riley J.N., Walker D.W. Morphological alterations in hippocampus after long-term alcohol consumption in mice. Science. 201:1978;646-648.
42. Roback J.D., Diede S.J., Downen M., Lee H.J., Kwon J., Large T.H., Otten U., Wainer B.H. Expression of neurotrophins and the low-affinity NGF receptor in septal and hippocampal reaggregate cultures: local physiologic effects of NGF synthesized in the septal region. Dev. Brain Res. 70:1992;123-133.
43. Rudge J.S., Alderson R.F., Pasnikowski E., McClain J., Ip N.Y., Lindsay R.M. Expression of ciliary neurotrophic factor and the neurotrophins-nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in cultured rat hippocampal astrocytes. Eur. J. Neurosci. 4:1992;459-471.
44. Sakaki T., Yamada K., Otsuki H., Yuguchi T., Kohmura E., Hayakawa T. Brief exposure to hypoxia induces bFGF mRNA and protein and protects rat cortical neurons from prolonged hypoxic stress. Neurosci. Res. 23:1995;289-296.
45. Seniuk-Tatton N.A., Henderson J.T., Roder J.C. Neurons express ciliary neurotrophic factor mRNA in the early postnatal and adult rat brain. J. Neurosci. Res. 41:1995;663-676.
46. B.K. Siesjo, The role of calcium in cell death, in: D.L. Price, H. Thoenen, A.J. Aguayo (Eds.), Neurodegenerative Disorders: Mechanisms and Prospects for Therapy, Wiley, New York, 1991, pp. 35-39.
47. Slater T., Sawyer B., Stravli U. Studies on succinate-tetrazolium systems: III. Points of coupling of four different tetrazolium salts. Biochem. Biophys. Acta. 77:1963;383-393.
48. Sulik K.K., Lauder J.M., Dehart D.B. Brain malformations in prenatal mice following acute maternal ethanol administration. Int. J. Dev. Neurosci. 2:1984;203-214.
49. Walker D.W., Barnes D.E., Zornetzer S.F., Hunter B.E., Kubanis P. Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats. Science. 209:1980;711-713.
50. Walker D.W., Heaton M.B., Lee N., King M.A., Hunter B.E. The effects of chronic ethanol on the septohippocampal system: a role for neurotrophic factors? Alcohol. Clin. Exp. Res. 17:1993;12-18.
51. J.R. West, D. Pierce, Perinatal alcohol exposure and neuronal damage, in: J.R. West (Ed.), Alcohol and Brain Development, Oxford Univ. Press, New York, 1986, pp. 121-157.
52. West J.R. Long-term effects of developmental exposure to alcohol. Neurotoxicology. 7:1986;245-256.
53. West J.R., Hamre K.M., Cassell M.D. Effects of ethanol exposure during the third trimester equivalent on neuron number in rat hippocampus and dentate gyrus. Alcohol. Clin. Exp. Res. 10:1986;190-197.
54. West J.R., Chen W.-J.A., Pantazis N.J. Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage. Metab. Brain Dis. 9:1994;291-322.
55. Zajac C.S., Abel E.L. Animal models of prenatal alcohol exposure. Int. J. Epidemiol. 21:1992;S24-32.