Cellular and synaptic adaptations mediating opioid dependence

Physiological Reviews

Volumn 81, Issue 1, 2001, Pages 299-343

  Williams, J T ^a   Christie, M J ^a   Manzoni, O ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE; OPIATE; OPIATE RECEPTOR; RECEPTOR SUBTYPE;

ADAPTATION; DRUG ABUSE; DRUG EFFICACY; DRUG TOLERANCE; NERVE CELL; OPIATE ADDICTION; PRIORITY JOURNAL; RECEPTOR AFFINITY; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; SYNAPSE;

EID: 0035138995     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2001.81.1.299     Document Type: Review

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262. Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy
263. Agonist-induced desensitization of the mu opioid receptor-coupled potassium channel (GIRK1)
264. Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 in Xenopus oocytes
265. The role of receptor kinases and arrestins in G protein-coupled receptor regulation
266. Extrasynaptic glutamate spillover in the hippocampus: Evidence and implications
267. Role of heteromer formation in GABA-B receptor function
268. 2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta
269. Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and actions of dopamine and opioids
270. Actions of cocaine on rat dopaminergic neurones in vitro
271. Heterogeneity in presynaptic regulation of GABA release from hippocampal inhibitory neurons
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273. Regulation of opioid receptor activities
274. Cellular responses of nucleus accumbens neurons to opiate-seeking behavior. I. Sustained responding during heroin self-administration
275. The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express μ-opioid receptors
276. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice
277. Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons
278. The CaM kinase II hypothesis for the storage of synaptic memory
279. Electrical stimulation of nucleus paragigantocellularis induces opioid withdrawal-like behaviors in the rat
280. The neuroanatomical basis of central cardiovascular control
281. Membrane properties and response to opioids of identified dopamine neurons in the guinea pig hypothalamus
282. Endogenous opioid peptides: Multiple agonists and receptors
283. Masking of forskolin-induced long-term potentiation by adenosine accumulation in area CA1 of the rat hippocampus
284. Expression of D1 receptor, D2 receptor, substance P and enkephalin messenger RNAs in the neurons projecting from the nucleus accumbens
285. A family of hyperpolarization-activated mammalian cation channels
286. Delta and mu enkephalins inhibit spontaneous GABA-mediated IPSCs via a cyclic AMP-independent mechanism in the rat hippocamus
287. Differential effects of mu- and delta-receptor selective opioid agonists on feedforward and feedback GABAergic inhibition in hippocampal brain slices
288. Dissociation of mu and delta opioid receptor-mediated reductions in evoked and spontaneous synaptic inhibition in the rat hippocampus in vitro
289. β-Arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes
290. Kappa-opioid receptor activates an inwardly rectifying K channel by a G protein linked mechanism: Coexpression in Xenopus oocytes
291. Dynorphin selectively augments the M-current in hippocampal CA1 neurons by an opiate receptor mechanism
292. Enkephalin hyperpolarizes interneurones in the rat hippocampus
293. Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression
294. Participation of noradrenergic pathways in the expression of opiate withdrawal: Biochemical and pharmacological evidence
295. Destruction of the locus coeruleus decreases physical signs of opiate withdrawal
296. Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
297. Role of different brain structures in the expression of the physical morphine withdrawal syndrome
298. Protein kinases in the locus coeruleus and periaqueductal gray matter are involved in the expression of opiate withdrawal
299. Long-term depression: Not so depressing after all
300. LTP expression: Hanging like a yo-yo?
301. Two forms of hippocampal long-term depression, the counterpart of long-term potentiation
302. Functional implications of kappa opioid receptor-mediated modulation of glutamate transmission in the output regions of the basal ganglia in rodent and primate models of Parkinson's disease
303. Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study
304. Anatomy of CNS opioid receptors
305. Metabotropic glutamate receptors in the rat nucleus accumbens
306. Decreased presynaptic sensitivity to adenosine after cocaine withdrawal
307. Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal
308. μ-Opioid receptors modulate NMDA receptor-mediated responses in nucleus accumbens neurons
309. Chronic morphine treatment selectively augments metabotropic glutamate receptor-induced inhibition of N-methyl-D-aspartate receptor-mediated neurotransmission in nucleus accumbens
310. Chronic morphine treatment alters NMDA receptor-mediated synaptic transmission in the nucleus accumbens
311. The effects of morphine- and nalorphine-like drugs in the non-dependent and morphine-dependent spinal dog
312. Are detoxification programs effective?
313. Kappa opioid receptor activation depresses excitatory synaptic input to rat locus coeruleus neurons in vitro
314. The opioid receptor in the hamster vas deferens are of the delta-type
315. The mechanism of amphetamine-induced inhibition of rat substantia nigra compacta neurones investigated with intracellular recording in vitro
316. Ultrastructural characteristics of enkephalin-immunoreactive boutons and their postsynaptic targets in the shell and core of the nucleus accumbens of the rat
317. Glutamate receptor subtypes mediated excitatory synaptic currents of dopamine neurons in midbrain slices
318. Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats
319. Somatostatin-induced inhibition of neuronal calcium channel current modulated by cGMP-dependent protein kinase
320. Opioid increase potassium conductance in submucous neurones of guinea-pig caecum by activating ∂-receptors
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322. Single potassium channels opened by opioids in rat locus ceruleus neurons
323. Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons
324. mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein
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326. Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses
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329. 2+ channel inhibition in NG108-15 cells
330. A role for hippocampal opioids in long-term functional plasticity
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336. 2+-calmodulin kinase II in cholinergic modulation of neuronal responsiveness
337. Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo
338. o in smooth muscle
339. Pertussis toxin-insensitive G protein mediates substance P-induced inhibition of potassium channels in brain neurons
340. Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered mu-opioid receptor agonist in the mouse
341. Ethanol, like psychostimulants and morphine, causes long-lasting hyperreactivity of dopamine and acetylcholine neurons of rat nucleus accumbens: Possible role in behavioral sensitization
342. Molecular mechanisms of drug addiction
343. Molecular control of locus coeruleus neurotransmission
344. Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus
345. Dopamine depresses excitatory and inhibitory synaptic transmission by distinct mechanisms in the nucleus accumbens
346. Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors
347. Enkephalin blocks inhibitory pathways in the vertebrate CNS
348. Expression mechanisms underlying NMDA receptor-dependent long-term potentiation
349. Differential desensitization of mu- and delta-opioid receptors in selected neural pathways following chronic morphine treatment
350. Opioid inhibition and desensitization of calcium channel currents in rat dorsal root ganglion neurons
351. A study of the role of cyclic adenosine 3′,5′-monophosphate in the depression by opiates and opioid peptides of excitatory junction potentials in the mouse vas deferens
352. μ and ∂-opioid receptors both belong to a family of receptors which couple to a potassium conductance
353. Modulation of cell firing in the nucleus accumbens
354. Enkephalin activates the phospholipase C/Ca system through cross-talk between opioid receptors and P-2-purinergic or bradykinin receptors in NG108-15 cells. A permissive role for pertussis toxin-sensitive G proteins
355. Opioid-glutamate interactions in rat locus coeruleus neurons
356. Mediation by G protein ßγ subunits of the opioid stimulation of adenylyl cyclase activity in rat olfactory bulb
357. Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells
358. Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb
359. Characterization of acute homologous desensitization of mu-opioid
360. Forskolin enhancement of opioid currents in rat locus coeruleus neurons
361. Opioid inhibition of rat periaqueductal gray neurones with identified projections to rostral ventromedial medulla in vitro
362. Agonist-induced functional desensitization of the muopioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein
363. Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail
364. Identification and characterization of three new alternatively spliced μ-opioid receptor isoforms
365. Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor
366. Opioid actions on single nucleus raphe magnus neurons from rat and guinea pig in vitro
367. The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea pig ileum
368. Synaptic plasticity in an in vitro slice preparation of the rat nucleus accumbens
369. Presynaptic dopamine D1 receptors attenuate excitatory and inhibitory limbic inputs to the shell region of the rat nucleus accumbens studied in vitro
370. Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro
371. Amphetamine administered to the ventral tegmental area sensitizes rats to the locomotor effects of nucleus accumbens amphetamine
372. Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses
373. Nicotine activates and desensitizes midbrain dopamine neurons
374. Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization
375. A highly selective kappa-opioid receptor agonist, CI-977, reduces excitatory synaptic potentials in the rat locus coeruleus in vitro
376. 3 cells by cloned mu and delta opioid receptors
377. 3 cells
378. A mitogen-activated protein kinase pathway is required for muopioid receptor desensitization
379. μ-Opioid receptor activates signaling pathways implicated in cell survival and translational control
380. Opioid enhancement of calcium oscillations and burst events involving NMDA receptors and L-type calcium channels in cultured hippocampal neurons
381. Opposite modulation of opiate withdrawal behaviors on microinfusion of protein kinase A inhibitor versus activator into the locus coeruleus or periaqueductal gray
382. Effects of chronic morphine exposure on opioid inhibition of adenylyl cyclase in 7315c cell membranes: A useful model for the study of tolerance at mu opioid receptors
383. Morphine and naloxone, IP or locally, affect extracellular acetylcholine in the accumbens and prefrontal cortex
384. ß-Adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase
385. κ-Opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord
386. Effect of chronic treatment with morphine, midazolam and both together on dynorphin (1-13) levels in the rat
387. Presynaptic kappa-opioid and muscarinic receptors inhibit the calcium-dependent component of evoked glutamate release from striatal synaptosomes
388. Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors
389. Molecular biology of opioid receptors
390. Selective opioid agonists modulate afferent transmission in the rat nucleus tractus solitarius
391. Activation of coeruleospinal noradrenergic inhibitory controls during withdrawal from morphine in the rat
392. Nucleus accumbens lesions impair context, but not cue, conditioning in rats
393. Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animals models of amphetamine psychosis
394. The neural basis of drug craving: An incentive-sensitization theory of addiction
395. Activation of mu- and delta-opioid receptor present on the same nerve terminals depresses transmitter release in the mouse hypogastric ganglion
396. Chronic opiate agonists down-regulate prodynorphin gene expression in rat brain
397. Forskolin evokes extracellular adenosine accumulation in rat cortical cultures
398. Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons
399. Marked inhibition of mesolimbic dopamine release: A common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats
400. 3H]dopamine from rat striatal synaptososmes
401. Silent synapses in the developing rat visual cortex: Evidence for postsynaptic expression of synaptic plasticity
402. 2+ currents and secretion in isolated neuroendocrine nerve terminals
403. mu-Opioid receptor activation reduces multiple components of high-threshold calcium current in rat sensory neurons
404. Effect of adenosine receptor agonists and antagonist on the expression of opiate withdrawal in rat
405. Cyclic AMP mediates a presynaptic form of LTP at cerebellar parallel fiber synapses
406. A comparison of the role of dynorphin in the hippocampal mossy fiber pathway in guinea pig and rat
407. Can molecules explain long-term potentiation?
408. Identification of a gene encoding a hyperpolarisation-activated pacemaker channel of brain
409. Electrophysiological evidence for a reciprocal interaction between amphetamine and cocaine-related drugs on rat midbrain dopaminergic neurons
410. Opioid-activated postsynaptic, inward rectifying potassium currents in whole cell recordings in substantia gelatinosa neurons
411. 3H]-noradrenaline release from rat brain cortex slices
412. 2+ currents, but spares a sustained current
413. 2+ currents by a mu-opioid in a defined subset of rat sensory neurons
414. Predictive reward signal of dopamine neurons
415. Pharmacological characterization of the epsilon-opiate receptor
416. Opioid withdrawal activates MAP kinase in locus coeruleus neurons in morphine-dependent rats in vivo
417. Immunolocalization of two mu-opioid receptor isoforms (MOR1 and MOR1B) in the rat central nervous system
418. Molecular mechanisms of drug reinforcement and addiction
419. Opioid receptor-coupled G proteins in rat locus coeruleus membranes: Decrease in activity after chronic morphine treatment
420. Mu-opioid-receptor-mediated inhibition of the N-type calcium-channel current
421. Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance
422. Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance
423. Lack of evidence for ε-opioid receptors in the rat vas deferens
424. A slow excitatory postsynaptic current mediated by G protein-coupled metabotropic glutamate receptors in rat ventral tegmental dopamine neurons
425. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation
426. Presynaptic inhibition of GABA-B-mediated synaptic potentials in the VTA during morphine withdrawal
427. + channels expressed in Chinese hamster ovary cells
428. Stimulus dependent translocation of κ opioid receptors to the plasma membrane
429. CREB and memory
430. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice
431. 35S]GTPγS autoradiography in rat brain
432. Endogenous opioid regulation of hippocampal function
433. Kappa-opioid receptor activation of a dendrotoxin-sensitive potassium channel mediates presynaptic inhibition of mossy fiber neurotransmitter release
434. Inhibition of glutamate release by presynaptic kappa 1-opioid receptors in the guinea pig dentate gyrus
435. L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells
436. Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons
437. i and adenylyl cyclase
438. Opiate receptor in the rat vas deferens
439. 3H]dopamine release from rat ventral mesencephalic dissociated cell cultures
440. GABA-B receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons
441. Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons: Interactions among multiple receptors
442. 2+ current in magnocellular neurons of the rat basal forebrain
443. 2+ channel currents in magnocellular neurones of the rat supraoptic nucleus
444. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway
445. The dopamine hypothesis of reward: Past and current status
446. Presynaptic μ and δ opioid receptor modulation of GABA-A IPSCs in the rat globus pallidus in vitro
447. Opioids decrease high-voltage activated calcium currents in acutely dissociated neostriatal neurons
448. Electrophysiological characterization of GABAergic neurons in the ventral tegmental area
449. Membrane potential synchrony of simultaneously recorded striatal spiny neurons in vivo
450. Spontaneous subthreshold membrane potential fluctuations and action potential variability of rat corticostraial and striatal neurons in vivo
451. Agonist-selective endocytosis of mu opioid receptor by neurons in vivo
452. A comparison of the effects of intraaccumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior
453. Microinjections of SCH-23390 into the ventral tegmental area and substantia nigra pars reticulata attenuate the development of sensitization to the locomotor activating effects of systemic amphetamine
454. Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal
455. Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum
456. Autonomic areas of the rat brain exhibit increased Fos-like immunoreactivity during opiate withdrawal in rats
457. Inhibition of calcium currents in rat colon sensory neurons by kappa- but not mu- or delta-opioids
458. Opioid actions on neurons of the rat lateral amygdala in vitro
459. Opioid inhibition of rat medial vestibular nucleus neurones in vitro and its dependence on age
460. Coordinated expression of dopamine receptors in neostriatal medium spiny neurons
461. Local cooling of pre-frontal cortex induces pacemaker-like firing of dopamine neurons in rat ventral tegmental area in vivo
462. 5-enkephalin
463. Cellular sites for dynorphin activation of κ-opioid receptors in the rat nucleus accumbens shell
464. 5-enkephalin
465. μ-Opioid receptors are localized to extrasynaptic plasma membranes of GABAergic neurons and their targets in the rat nucleus accumbens
466. Opioid receptor subtype expression defines morphologically distinct classes of hippocampal interneurons
467. h) currents
468. Selective opioid inhibition of small nociceptive neurons
469. The cloned kappa opioid receptor couples to an N-type calcium current in undifferentiated PC-12 cells
470. Opioid actions on rat anterior cingulate cortex neurons in vitro
471. Opioids acting through delta receptors elicit a transient increase in the intracellular free calcium concentration in dorsal root ganglion-neuroblastoma hybrid ND8-47 cells
472. Opioid regulation of intracellular free calcium in cultured mouse dorsal root ganglion neurons
473. Immunohistochemical evidence of down-regulation of mu-opioid receptor after chronic PL-017 in rats
474. Potassium conductance increased by noradrenaline, opioids, somatostatin, and G proteins: Whole-cell recording from guinea pig submucous neurons
475. A general role for adaptations in G proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function
476. Intermittent and chronic morphine treatment induces long-lasting changes in delta-opioid receptor-regulated acetylcholine release in rat striatum and nucleus accumbens
477. Stimulus-dependent phosphorylation of G protein coupled receptors by casein kinase 1 alpha
478. Necessary role for central tegmental area adenylate cyclase and protein kinase A in induction of behavioral sensitization to intraventral tegmental area amphetamine
479. Mu and delta opioid receptor activation inhibits omega-conotoxin-sensitive calcium channels in a voltage- and time-dependent mode in the human neuroblastoma cell line SH-SY5Y
480. Sequestration of the ∂-opioid receptor: Role of the C terminus in agonist-mediated internalization
481. Opioid inhibition in locus coeruleus
482. The dendritic arbor of locus coeruleus neurons contributes to opioid inhibition
483. Influence of reward expectation on behavior-related neuronal activity in primate striatum
484. Modifications of reward expectation-related neuronal activity during learning in primate striatum
485. Long-term potentiation and depression in the cerebral neocortex
486. 2+ currents in bovine adrenal chromaffin cells
487. A role for cAMP in long-term depression at hippocampal mossy fiber synapses
488. Inward rectification in rat nucleus accumbens neurons
489. Hyperpolarizing and depolarizing actions of dopamine via D-1 and D-2 receptor on nucleus accumbens neurons
490. i1-phospholipase C activation in Xenopus oocytes
491. Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal
492. GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brain
493. μ-Opioid receptor-regulated adenylate cyclase activity in primary cultures of rat striatal neurons upon chronic morphine exposure
494. Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal gray in vitro
495. How opioids inhibit GABA-mediated neurotransmission
496. Opposing mechanisms of regulation of a G protein-coupled inward rectifier K channel in rat brain neurons
497. 1 dopamine receptor activation is necessary for the induction of sensitization by amphetamine in the ventral tegmental area
498. Sensitization occurs to the locomotor effects of morphine and the specific μ opioid receptor agonist, DAGO, administered repeatedly to the ventral tegmental area but not to the nucleus accumbens
499. Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus
500. Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus
501. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases
502. Calmodulin binding to G protein-coupling domain of opioid receptors
503. Improved assays for the assessment of kappa- and delta-properties of opioid ligands
504. Physical dependence on opiate-like peptides
505. Brain sites of precipitated abstinence in morphine-dependent rats
506. Central sites of naloxone-precipitated shaking in the anesthetized, morphine-dependent rat
507. Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP
508. Presynaptic changes during mossy fibre LTP revealed by NMDA receptor-mediated synaptic responses
509. The opioid peptide dynorphin mediates heterosynaptic depression of hippocampal mossy fiber synapses and modulates long-term potentiation
510. Selective changes in mu opioid receptor properties induced by chronic morphine exposure
511. Microinjection of morphine into the nucleus accumbens impairs contextual learning in rats
512. Functional dissociation of μ opioid receptor signaling and endocytosis: Implications for the biology of opiate tolerance and addiction
513. Morphine-activated opioid receptors elude desensitization by beta-arrestin
514. Synaptic regulation of mesocorticolimbic dopamine neurons
515. Heterodimerization is required for the formation of a functional GABA(B) receptor
516. Regulation of action-polential firing in spiny neurons of the rat neostriatum in vivo
517. 2+ channels
518. Opiate-receptor interactions on single locus coeruleus neurones
519. Inward rectification of resting and opiate-activated potassium currents in rat locus coeruleus neurons
520. The origins of two-state spontaneous membrane potential fluctuations of neostriatal spiny neurons
521. Chronic morphine exposure blocks opioid effects on both the early and late inhibitory postsynaptic potentials in hippocampal CA1 pyramidal cells
522. Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation
523. Effects of chronic morphine administration on the mu and delta opioid responses in the CA1 region of the rat hippocampus
524. Addictive drugs and brain stimulation reward
525. Regulation of phospholipase Cγ in the mesolimibic dopamine system by chronic morphine administrations
526. Effects of lesions of prefrontal cortex, amygdala, or fornix on behavioral sensitization to amphetamine: Comparison with N-methyl-D-aspartate antagonists
527. Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP
528. Presynaptic inhibition of γ-aminobutyric acid B-mediated synaptic current by adenosine recorded in vitro in midbrain dopamine neurons
529. Dopamine release in the nucleus accumbens during heroin self-administration is modulated by kappa opioid receptor: An in vivo fast-cyclic voltammetry study
530. Quantal mechanism of long-term potentiation in hippocampal mossy-fiber synapses
531. Opioid-mediated facilitation of long-term potentiation at the lateral perforant path-dentate granule cell synapse
532. Mu opioid receptor-mediated modulation of synaptic currents in dentate granule cells of rat hippocampus
533. Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling
534. Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2
535. Delta-opioid-induced liberation of G-beta/gamma mobilizes Ca stores in NH108-15 cells
536. Substantia gelatinosa neurones hyperpolarized in vitro by enkephalin
537. Mu opioid receptor phosphorylation, desensitization, and ligand efficacy
538. Opioid peptides reduce synaptic transmission in the nucleus accumbens
539. Electrophysiology of dopaminergic and non-dopaminergic neurons of the guinea-pig substantia nigra pars compacta in vitro
540. Mu opiate receptor down-regulation by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells
541. Comparison of two forms of long-term potentiation in single hippocampal neurons
542. Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization
543. Localization and regulation of the δ-opioid receptor in dorsal root ganglia and spinal cord of the rat and monkey: Evidence for association with the membrane of large dense-core vesicles
544. Developmental expression of the μ, κ and δ opioid receptor mRNA in mouse
545. Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons