Efficacy and kinetics of opioid action on acutely dissociated neurons

Molecular Pharmacology

Volumn 52, Issue 1, 1997, Pages 136-143

  Ingram, Susan ^a   Wilding, Tim J ^b   Mccleskey, Ed W ^a   Williams, John T ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BARIUM; BRIMONIDINE; CESIUM; CLONIDINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ETORPHINE; GUANINE NUCLEOTIDE BINDING PROTEIN; LEUCINE ENKEPHALIN[2 DEXTRO SERINE 6 THREONINE]; METENKEPHALIN; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; OPIATE AGONIST;

ANIMAL CELL; ARTICLE; BINDING KINETICS; BRAIN SLICE; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CONTROLLED STUDY; LOCUS CERULEUS; NERVE CELL; NONHUMAN; PATCH CLAMP; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; RECEPTOR AFFINITY; SECOND MESSENGER; SPINAL GANGLION;

EID: 0030797055     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.1.136     Document Type: Article

References (25)

1. Korf, J., B. S. Bunney, and G. K. Aghajanian. Noradrenergic neurons: morphine inhibition of spontaneous activity. Eur. J. Pharmacol. 25:165-169 (1974).
2. North, R. A., and J. T. Williams. On the potassium conductance increased by opioids in rat locus coeruleus neurones. J. Physiol. 364:265-280 (1985).
3. Williams, J. T., R. A. North, and T. Tokimasa. Inward rectification of resting and opioid-activated potassium currents in rat locus coeruleus neurons. J. Neurosci. 8:4299-4306 (1988).
4. Williams, J. T., and R. A. North. Opiate-receptor interactions on single locus ceruleus neurons. Mol. Pharmacol. 26:489-497 (1984).
5. Miyake M., M. J. Christie, and R. A. North. Single potassium channels opened by opioids in rat locus ceruleus neurons. Proc. Natl. Acad. Sci. USA 86:3419-3422 (1989).
6. Schroeder, J. E., P. S. Fischbach, D. Zheng, and E. W. McCleskey Activation of μ opioid receptors inhibits transient high- and low-threshold Ca currents, but spares a sustained current. Neuron 5:445-452 (1991).
7. Wilding, T. J., M. D. Womack, and E. W. McCleskey. Fast, local signal transduction between the μ opioid receptor and Ca channels. J. Neurosci. 15:4124-4132 (1995).
8. Hille, B. Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci. 17:531-536 (1994).
9. B receptor-activated inwardly rectifying potassium current in dissociated hippocampal CA3 neurons. J. Neurosci. 16:6374-6385 (1996).
10. Travagli, R. A., T. V. Dunwiddie, and J. T. Williams. Opioid inhibition in locus coeruleus. J. Neurophysiol. 74:519-528 (1995).
11. Alreja, M., and G. Aghajanian. Opiates suppress a resting sodium-dependent inward current and activate an outward potassium current in locus coeruleus neurons. J. Neurosci. 13:3525-3532 (1993)
12. Harris, G. C., and J. T. Williams. Sensitization of locus ceruleus neurons during withdrawal from chronic stimulants and antidepressants. J. Pharmacol. Exp. Ther. 261:476-483 (1992).
13. Bean, B. P. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature (Lond.) 340:153-156 (1989).
14. Surprenant, A., and R. A. North. Mechanism of synaptic inhibition by noradrenaline acting at α2-adrenoceptors. Proc. R. Soc. Lond. Ser. B Biol. Sci. 234:85-114 (1988).
15. Pan, Z. Z., W. F. Colmers, and J. T. Williams. 5-HT mediated synaptic potentials in the dorsal raphe nucleus: interactions with excitatory amino acid and GABA neurotransmission. J. Neurophysiol. 62:481-486 (1989).
16. Inomata, N., T. Ishihara, and N. Akaike. Activation kinetics of the acetylcholine-gated potassium current in isolated atrial cells. Am. J. Physiol. 257:C646-C650 (1989).
17. B responses using patch clamp recordings in rat hippocampal slices. J. Physiol. 463:391-407 (1993).
18. Emmerson, P. J., M. J. Clark, A. Mansour, H. Akil, J. H. Woods, and F. Medzihradsky. Characterization of opioid agonist efficacy in a C6 glioma cell line expressing the μ opioid receptor. J. Pharmacol. Exp. Ther. 278: 1121-1127 (1996).
19. Frances B., C. Moisand, and J. C. Meunier. Na ions and Gpp(NH)p selectively inhibit agonist interactions at μ- and κ-opioid receptor sites in rabbit and guinea-pig cerebellum membranes. Eur. J. Pharmacol. 117:223-232 (1985).
20. Osborne, P. B., and J. T. Williams. Characterization of acute homologous desensitization of μ-opioid receptor induced currents in locus coeruleus neurons. Br. J. Pharmacol. 115:925-932 (1995).
21. Christie, M. J., J. T. Williams, and R. A. North. Cellular mechanisms of opioid tolerance: studies in single brain neurons. Mol. Pharmacol. 32:633-638 (1987).
22. Law P. Y., D. S. Hom., and H. H. Loh. Opiate regulation of adenosine 3′,5′-monophosphate level in neuroblastoma X glioma NG108-15 hybrid cells: relationship between receptor occupancy and effect. Mol Pharmacol. 23:26-35 (1983).
23. Higashi, H., P. Shinnick-Gallagher, and J. P. Gallagher. Morphine enhances and depresses Ca-dependent responses in visceral primary afferent neurons. Brain Res. 25:186-191 (1982).
24. Smith, C. F. C, and M. J. Rance. Opiate receptors in the rat vas deferens. Life Sci. 33 (Suppl. I):327-330 (1983).
25. Sheehan, M. J., A. G. Hayes, and M. B. Tyers. Lack of evidence for e-opioid receptors in the rat vas deferens. Eur. J. Pharmacol. 154:237-245 (1988).