Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal

European Journal of Neuroscience

Volumn 8, Issue 12, 1996, Pages 2671-2678

  Valverde, Olga ^a   Tzavara, Eleni ^b   Hanoune, Jacques ^b   Roques, Bernard P ^a   Maldonado, Rafael ^a  

^a Laboratoire de Pharmacochimie   (France)

^b HENRI MONDOR HOSPITAL   (France)

Author keywords

Adenylate cyclase; Amygdala; H7; H8; Mesolimbic system; Morphine; Nucleus accumbens; Place aversion

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ADENYLATE CYCLASE; MORPHINE; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; OPIATE; PROTEIN KINASE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; LIMBIC SYSTEM; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; WITHDRAWAL SYNDROME;

EID: 0030461745     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1996.tb01562.x     Document Type: Article

References (37)

1. Aloyo, V. J. (1995) Modulation of μ opioid binding by protein kinase inhibitors. Biochem. Pharmacol., 47, 17-21.
2. Bläsig, J., Herz, A., Reinhold, K. and Zieglgänsberger, S. (1973) Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats. Psychopharmacologia, 33, 221-232.
3. Bradford, M. A. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248.
4. Childers, S. (1991) Opioid receptor-coupled second messenger systems. Life Sci., 48, 1991-2003.
5. Cox, B. M. (1991) Molecular and cellular mechanisms in opioid tolerance. In Basbaum, A. and Besson, J. M. (eds), Towards a New Pharmacotherapy of Pain. Dahlam Workshop Reports. Wiley, New York, pp. 137-149.
6. Duman, R. S., Tallman, J. F. and Nestler, E. J. (1988) Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus. J. Pharmacol. Exp. Ther., 246, 1033-1039.
7. Gacel, G., Zajac, J. M., Delay-Goyet, P., Daugé, V. and Roques, B. P. (1988) Investigation of the structural parameters involved in the mu and delta opioid receptors discrimination of linear enkephalin-related peptides. J. Med. Chem., 31, 374-383.
8. Guitart, X. and Nestler, E. J. (1989) Identification of morphine- and cyclic AMP-regulated phosphoproteins (MARPPs) in the locus coeruleus and other regions of the rat brain: regulation by acute and chronic morphine. J. Neurosci., 9, 4371-4387.
9. Hanoune, J., Stengel, D., Lacombe, M. L., Feldmann, G. and Coudrier, E. (1977) Proteolytic activation of rat liver adenylate cyclase by a contaminant of crude collagenase from clostridium histolyticum. J. Biol. Chem., 252, 2039-2045.
10. Hidaka, H., Inagaki, M., Kawamoto, S. and Sasaki, Y. (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry, 23, 5036-5041.
11. Koob, G. F., Wall, T. L. and Bloom, F. E. (1989) Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal. Psychopharmacology, 98, 530-534.
12. Koob, G. F., Maldonado, R. and Stinus, L. (1992) Neural substrates of opiate withdrawal. Trends Neurosci., 15, 186-191.
13. Le Moal, M. (1995) Mesocorticolimbic dopaminergic neurons In Bloom, F. E. and Kupfer, D. J. (eds), Psychopharmacology: the Fourth Generation of Progress. Raven Press Ltd. New York, pp. 283-294.
14. Maldonado, R., Stinus, L., Gold, L. H. and Koob, G. F. (1992) Role of different brain structures in the expression of the physical morphine withdrawal syndrome. J. Pharmacol. Exp. Ther., 261, 669-677.
15. Maldonado, R., Valverde, O., Garbay, C. and Roques, B. P. (1995) Protein kinases in the locus coeruleus and periaqueductal gray matter are involved in the expression of opiate withdrawal. Naunyn-Schmied. Arch. Pharmacol., 352, 565-575.
16. Malenka, R. C., Kauer, J. A., Perkel, D. J., Mauk, M. D., Kelly, P. T., Nicoll, R. A. and Waxham, P. A. (1989) An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature, 340, 554-557.
17. Matsuoka, I., Maldonado, R., Defer, N., Noël, F., Hanoune, J. and Roques, B. P. (1994) Chronic morphine administration causes region-specific increase of brain type VIII adenylyl cyclase mRNA. Eur. J. Pharmacol., 268, 215-221.
18. Mucha, R. F. and Herz, A. (1985) Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology, 86, 274-280.
19. Mucha, R. F. and Walker, M. J. K. (1987) Aversive properties of opioid receptor blockade in drug-naive mice. Psychopharmacology, 93, 483-488.
20. McDonald, A. J. (1991) Topographical organization of amygdaloid projections to the caudatoputamen, nucleus accumbens and related striatal-like areas of the rat brain. Neuroscience, 44, 15-33.
21. Nestler, E. J. and Tallman, J. F. (1988) Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus. J. Pharmacol. Exp. Ther., 33, 127-132.
22. Nestler, E. J. (1992) Molecular mechanisms of drug addiction. J. Neurosci., 12, 2439-2450.
23. Nestler, E. J., Hope, B. T. and Widnell, K. L. (1993) Drug addiction: a model for the molecular basis of neural plasticity. Neuron, 11, 995-1006.
24. Ortiz, J., Harris, H. W., Guitart, X., Terwilliger, R. Z., Haycock, J. W. and Nestler, E. J. (1995) Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine. J. Neurosci., 15, 1285-1297.
25. Pellegrino, L. J., Pellegrino, A. S. and Cushman, A. J. (1979) A Stereotaxic Atlas of the Rat Brain. Plenum Press, New York.
26. Rasmussen, K., Beitner-Johnson, D. B., Krystal, J. H., Aghajanian, G. K. and Nestler, E. J. (1990) Opiate withdrawal and the locus coeruleus: behavioral, electrophysiological and biochemical correlates. J. Neurosci., 10, 2308-2317.
27. Self, D. W., Chi, S. and Nestler, E. J. (1993) Modulation of cocaine self-administration by cyclic AMP analogues in the nucleus accumbens. Soc. Neurosci. Abstr., 19, 1858.
28. Self, D. W., Terwilliger, R. Z., Nestler, E. J. and Stein, L. (1994) Inactivation of Gi and Go proteins in nucleus accumbens reduces both cocaine and heroine reinforcement. J. Neurosci., 14, 6239-6247.
29. Spooren, W. P. J. M., Veening, J. G., Groenewegen, H. J. and Cools, A. R. (1991) Efferent connections of the striatopallidal and amygdaloid components of the substantia innominata in the cat: projections to the nucleus accumbens and caudate nucleus. Neuroscience, 44, 431-447.
30. Steketee, J. D. (1993) Injection of the protein kinase inhibitor H7 into the A10 dopamine region blocks the acute responses to cocaine: behavioral and in vivo microdialysis studies. Neuropharmacology, 32, 1289-1297.
31. Stinus, L., Le Moal, M. and Koob, G. F. (1990) Nucleus accumbens and amygdala are possible substrate for the aversive stimulus effects of opiate withdrawal. Neuroscience, 37, 767-773.
32. Terwilliger, R. Z., Beitner-Johnson, D., Sevarino, K. A., Crain, S. M. and Nestler, E. J. (1991) A general role for adaptations in G-protein and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res., 548, 100-110.
33. Tokuyama, S., Feng, Y., Wakabayashi, H. and Ho, I. K. (1995) Possible involvement of protein kinases in physical dependence on opioids: studies using protein kinase inhibitors, H-7 and H-8. Eur. J. Pharmacol., 284, 101-107.
34. B antagonist PD-134,308 facilitates rewarding effects of endogenous enkephalins but does not induce place preference in rats. Psychopharmacology, 123, 119-126.
35. Wei, E., Loh, H. H. and Way, E. L. (1973) Quantitative aspects of precipitated abstinence in morphine dependent rats. J. Pharmacol. Exp. Ther., 184, 398-403.
36. Widnell, K. L., Self, D. W., Lane, S. B., Russell, D. S., Vaidya, V. A., Miserendino, M. J. D., Rubin, C. S., Durnan, R. S. and Nestler, E. J. (1996) Regulation of CREB expression: in vivo evidence for a functional role in morphine action in the nucleus accumbens. J. Pharmacol. Exp. Ther., 276, 306-315.
37. Zahm, D. S. and Brog, J. S. (1992) On the significance of subterritories in the accumbens part of the rat ventral striatum. Neuroscience, 50, 751-767.