Opioid receptor signalling mechanisms

Clinical and Experimental Pharmacology and Physiology

Volumn 26, Issue 7, 1999, Pages 493-499

  Connor, Mark ^a   Christie, MacDonald J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

receptor; receptor; receptor; Adenylyl cyclase; Calcium channel; G proteins; NG108 15 cell; Opioid receptors; Potassium channel; SH SY5Y cell

Indexed keywords

ANALGESIC AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; KAPPA OPIATE RECEPTOR; KETAZOCINE; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; NOCICEPTIN; OPIATE RECEPTOR; PERTUSSIS TOXIN; SIGMA OPIATE RECEPTOR;

HUMAN; NERVE CELL; NONHUMAN; RECEPTOR GENE; SHORT SURVEY; SIGNAL TRANSDUCTION; STOICHIOMETRY;

ANIMALS; GTP-BINDING PROTEINS; HUMANS; NEURONS; RECEPTORS, OPIOID;

EID: 0033057206     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.1999.03049.x     Document Type: Short Survey

References (77)

1. 1. Dhawan BN, Cesselin F, Raghubir R et al. Classification of opioid receptors. Pharmacol. Rev. 1996; 48: 567-92.
2. 2. Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther. 1976; 197: 517-32.
3. 3. Lord JAH, Waterfield AA, Hughes J, Kosterlitz HW. Endogenous opioid peptides: Multiple agonists and receptors. Nature 1977; 267: 495-9.
4. 4. Wuster M, Schulz R, Herz A. Specificity of opioids towards the μ, δ-and ε-opiate receptors. Neurosci. Lett. 1979; 15: 193-8.
5. 5. Walker JM, Bowen WD, Walker FO, Matsumoto RR, de Costa B, Rice KC. Sigma receptors: Biology and function. Pharmacol. Rev. 1991; 42: 355-402.
6. 6. Hanner M, Moebius FF, Flandorfer A et al. Purification, molecular cloning, and expression of the mammalian sigma 1-binding site. Proc. Natl Acad. Sci. USA 1996; 93: 8072-7.
7. 7. Silve S, Dupuy PH, Labit-Lebouteiller C et al. Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits Δ8-Δ7 sterol isomerase activity in yeast. J. Biol. Chem. 1996; 271: 22434-40.
8. 8. Ingram S, Wilding TJ, McCleskey EW, Williams JT. Efficacy and kinetics of opioid action on acutely dissociated neurons. Mol. Pharmacol. 1997; 52: 136-43.
9. 9. Lemaire S, Magnan J, Regoli D. Rat vas deferens: A specific bioassay for endogenous opioid peptides. Br. J. Pharmacol. 1978; 64: 327-9.
10. 10. Smith CFC, Ranee MJ. Opiate receptors in the rat vas deferens. Life Sci. 1983; 33 (Suppl. 1): 327-30.
11. 11. Nock B, Giordano AL, Cicero TJ, O'Connor LH. Affinity of drugs and peptides for U-69 593-sensitive and -insensitive kappa opiate binding sites: The U-69 593-insensitive site appears to be the beta endorphin-specific epsilon receptor. J. Pharmacol. Exp. Ther. 1990; 254: 412-19.
12. 12. Evans CJ, Keith Jr DE, Morrison H, Magendzo K, Edwards RH. Cloning of a delta opioid receptor by functional expression. Science 1992; 258: 1952-5.
13. 13. Kieffer BL, Befort K, Gaveriaux-Ruff C, Hirth CG. The δ-opioid receptor: Isolation of a cDNA by expression cloning and pharmacological characterization. Proc. Natl Acad. Sci. USA 1992; 89: 12048-52.
14. 14. Kieffer BL, Befort K, Gaveriaux-Ruff C, Hirth CG. Correction, Proc. Natl Acad. Sci. USA 1994; 91: 1193.
15. 15. Chen Y, Mestek A, Liu J, Hurley JA, Yu L. Molecular cloning and functional expression of a μ-opioid receptor from rat brain. Mol. Pharmacol. 1993; 44: 8-12.
16. 16. Yasuda K, Raynor K, Kong H et al. Cloning and functional comparison of κ and δ opioid receptors from mouse brain. Proc. Natl Acad. Sci. USA 1993; 90: 6736-40.
17. 17. Bare LA, Mansson E, Yang D. Expression of two variants of the human μ opioid receptor mRNA in SK-N-SH cells and human brain. FEBS Lett. 1994; 354: 213-16.
18. 18. Zimprich A, Simon T, Hollt V. Cloning and expression of an isoform of the rat μ opioid receptor (rMORIB) which differs in agonist induced desensitization from rMOR1. FEBS Lett. 1995; 359: 142-6.
19. 19. Mayer P, Schulzeck S, Kraus J, Zimprich A, Hollt V. Promoter region and alternatively spliced exons of the rat μ-opioid receptor gene. J. Neurochem. 1996; 66: 2272-8.
20. 20. Henderson G, McKnight AT. The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. Trends Pharmacol. Sci. 1997; 18: 293-300.
21. 21. Meunier J-C, Mollereau C, Toll L et al. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 1995; 377: 532-5.
22. 22. Reinscheid RK, Nothacker H-P, Bourson A et al. A neuropeptide that activates an opioid-like G protein-coupled receptor. Science 1995; 270: 792-4.
23. 23. Butour J-L, Moisand C, Mazarguil H, Mollereau C, Meunier J-C. Recognition and activation of the opioid receptor-like ORL1 receptor by nociceptin, nociceptin analogs and opioids. Eur. J. Pharmacol. 1997; 321: 97-103.
24. 24. Strader CD, Fong TM, Tota MR, Underwood D, Dixon RAF. Structure and function of G protein-coupled receptors. Annu. Rev. Biochem. 1994; 63: 101-32.
25. 25. Gudermann T, Kalkbrenner F, Schultz G. Diversity and selectivity of receptor-G protein interaction. Annu. Rev. Pharmacol. Toxicol. 1996; 36: 429-59.
26. 26. Clapham DE, Neer EJ. G protein βγ subunits. Annu. Rev. Pharmacol. Toxicol. 1997; 37: 167-203.
27. 27. Burns DL, Hewlett EL, Moss J, Vaughan M. Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells. J. Biol. Chem. 1983; 258: 1435-8.
28. 28. Kurose H, Katada T, Amano T, Ui M. Specific uncoupling by islet activating protein, pertussis toxin, of negative signal transduction via α-adrenergic, cholinergic, and opiate receptors in neuroblastoma X glioma hybrid cells. J. Biol. Chem. 1983; 258: 4870-5.
29. 12, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells. J. Biol. Chem. 1991; 266: 3365-8.
30. 30. Roerig SC, Loh HH, Law PY. Identification of three separate guanine nucleotide-binding proteins that interact with the δ-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells. Mol. Pharmacol. 1992; 41: 822-31.
31. 31. Tsunoo A, Yoshii M, Narahashi T. Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cells. Proc. Natl Acad. Sci. USA 1986; 83: 9832-6.
32. 6, regulates neuronal calcium channels. Nature 1987; 325: 445-7.
33. 33. Taussig R, Sanchez S, Rifo M, Gilman AG, Belardetti F. Inhibition of the ω-conotoxin-sensitive calcium current by distinct G proteins. Neuron 1992; 8: 799-809.
34. 12. Biochem. J. 1990; 267: 391-8.
35. 0 in neuroblastoma x glioma hybrid cells in response to dibutryl cyclic AMP. Biochem. J. 1988; 256: 649-56.
36. 36. Tang T, Kiang JG, Cox BM. Opioids acting through delta receptors elicit a transient increase in the intracellular free calcium concentration in dorsal root ganglion-neuroblastoma hybrid ND8-47 cells. J. Pharmacol. Exp. Ther. 1994; 270; 40-6.
37. 12 protein α subunit sequence inhibits an opioid-induced increase in the intracellular free calcium concentration in ND8-47 neuroblastoma x dorsal root ganglion hybrid cells. Mol Pharmacol. 1995; 48: 189-93.
38. 0 mediates the coupling of the μ-opioid receptor to adenylyl cyclase in cloned neural cells and brain. Proc. Natl Acad. Sci. USA 1993; 90: 4062-6.
39. 39. Laugwitz K-L, Offermanns S, Spicher K, Schultz G. μ and δ opioid receptors differentially couple to G protein subtypes in membranes of human neuroblastoma SH-SY5Y cells. Neuron 1993; 10: 233-42.
40. 40. Smart D, Smith G, Lambert DG. μ-Opioids activate phospholipase C in SH-SY5Y human neuroblastoma cells via calcium channel opening. Biochem. J. 1995; 305: 577-82.
41. 41. Cruciani RA, Dvorkin B, Morris SA, Crain SM, Makman MH. Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells. Proc. Natl Acad. Sci. USA 1993; 90: 3019-23.
42. 5-coupled excitatory opioid receptor functions on opioid analgesia, tolerance, and dependence. Neurochem. Res. 1996; 21: 1347-51.
43. + and GTP. Proc. Natl Acad. Sci. USA 1979; 76: 5626-30.
44. 44. Koski G, Streaty RA, Klee WA. Modulation of sodium-sensitive GT-Pase by partial opiate agonists. J. Biol Chem. 1982; 257: 14035-40.
45. 45. Tsu RC, Chan JSC, Wong YH. Regulation of multiple effectors by the cloned δ-opioid receptor: Stimulation of phospholipase C and type II adenylyl cyclase. J. Neurochem. 1995; 64: 2700-7.
46. 46. Burford NT, Tolbert LM, Sadee W. Specific G protein activation and μ-opioid receptor internalization caused by morphine, DAMGO and endomorphin I. Eur. J. Pharmacol. 1998; 342: 123-6.
47. 47. Clark MJ, Emmerson PJ, Mansour A et al. Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor. J. Pharmacol. Exp. Ther. 1997; 283: 501-10.
48. 48. Costa T, Herz A. Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins. Proc. Natl Acad. Sci. USA 1989; 86: 7321-5.
49. 6 in smooth muscle. Mol. Pharmacol. 1996; 50: 870-7.
50. 35S]GTPγS binding to membranes: Determination of potencies and efficacies of ligands. J. Pharmacol. Exp. Ther. 1997; 282: 676-84.
51. m GTPase activity in mouse periaqueductal grey matter. Eur. J. Neurosci. 1997; 9; 1194-200.
52. 52. Chan JSC, Chiu TT, Wong YH. Activation of type II adenylyl cyclase by the cloned μ-opioid receptor: Coupling to multiple G proteins. J. Neurochem. 1995; 65: 2682-9.
53. 32P]GTP labeling of multiple G protein α subunits. J. Neurochem. 1995; 64: 2534-43.
54. 54. Prather PL, McGinn TM, Claude PA, Liu-Chen LY, Loh HH, Law PY. Properties of a κ-opioid receptor expressed in CHO cells: Interaction with multiple G-proteins is not specific for any individual Gα subunit and is similar to that of other opioid receptors. Mol. Brain Res. 1995; 29: 336-46.
55. z-mediated hormonal inhibition of cyclic AMP accumulation. Science 1992; 255: 339-42.
56. z1, a guanine nucleotide-binding protein with unique biochemical properties. J. Biol. Chem. 1990; 265: 2383-90.
57. z coupling to the rat κ-opioid receptor. FEBS Lett. 1995; 360: 97-9.
58. 16 proteins. J. Neurochem. 1998; 71: 2203-10.
59. 16 couple a wide variety of receptors to phospholipase C. J. Biol. Chem. 1995; 270: 15 175-80.
60. 60. Lee JWM, Joshi S, Chan JSC, Wong YH. Differential coupling of μ-, δ-, and κ-opioid receptors to Gα16-mediated stimulation of phospholipase C. J. Neurochem. 1998; 70: 2203-11.
61. 61. Tang W-J, Gilman AG. Type specific regulation of adenylyl cyclase by G protein βγ subunits. Science 1991; 254: 1500-3.
62. 62. Wong YH, Demoliou-Mason CD, Barnard EA. Opioid receptors in magnesium-digitonin-solubilized rat brain membranes are tightly coupled to a pertussis toxin-sensitive guanine nucleotide-binding protein. J. Neurochem. 1989; 52: 999-1009.
63. 0-type GTP-binding protein. J. Neurosci. 1994; 14; 3842-51.
64. 0 α-subtype G protein in rat primary afferent neurons. J. Neurophysiol. 1997; 77: 1338-48.
65. 65. Surprenant A, Shen KZ, North RA, Tatsumi H. Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea-pig submucosal neurones. J. Physiol. 1990; 431: 585-608.
66. 66. Tatsumi H, Costa M, Schimerlik M, North RA. Potassium conductance increased by noradrenaline, opioids, somatostatin, and G-proteins: Whole cell recording from guinea pig submucous neurons. J. Neurosci. 1990; 10: 1675-82.
67. 6. Proc. Natl Acad. Sci. USA 1998; 95: 3269-74.
68. 68. Sanchez-Blazquuez P, Garcia-Espana A, Garzon J. In vivo injection of antisense oligodeoxynuclcotides to Gα subunits and supraspinal analgesia evoked by mu and delta opioid agonists. J. Pharmacol. Exp. Ther. 1995; 275: 1590-6.
69. 69. Sanchez-Blazquez P, Garzon J. Delta opioid receptor subtypes activate inositol-signalling pathways in the production of antinociception. J. Pharmacol. Exp. Ther. 1998; 285: 820-7.
70. 12 transducer proteins on μ/δ opioid-mediated supraspinal antinociception. Life Sci. 1993; 53: PL381-6.
71. 71. Standifer KM, Rossi GC, Pasternak GW. Differential blockade of opioid analgesia by antisense oligodeoxynuclcotides directed against various G protein α subunits. Mol. Pharmacol. 1996; 50: 293-8.
72. + channel current by a μ-type opioid receptor. Mol. Pharmacol. 1994; 46: 793-5.
73. 2+ channel current in rat sensory neurons by a G-protein-independent mechanism. J. Neurosci. 1997; 17: 8721-8.
74. + exchange. Nature 1998; 392: 626-30.
75. 75. Vaughan CW, Ingram SL, Connor M, Christie MJ. How opioids inhibit GABAergic neurotransmission. Nature 1997; 390: 611-14.
76. 76. Clarke WP, Bond RA. The elusive nature of intrinsic efficacy. Trends Pharmacol. Sci. 1998; 19: 270-6.
77. 77. Zhang J, Ferguson SSG, Barak LS, Bodduluri S, Laporte SAP-Y, Law Caron MG. Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness. Proc. Natl Acad. Sci. USA 1998; 95: 7157-62.