Immunohistochemical evidence of down-regulation of μ-opioid receptor after chronic PL-017 in rats

European Journal of Pharmacology

Volumn 344, Issue 2-3, 1998, Pages 137-142

  Tao, Pao Luh ^a   Han, Kuang Fen ^a   Wang, Shwun De ^a   Lue, Wei Ming ^a   Elde, Robert ^b   Law, Ping Yee ^b   Loh, Horace H ^b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Antinociception; Down regulation; Immunohistochemistry; Opioid receptor; PL 017; Tolerance

Indexed keywords

AVIDIN; BIOTIN; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MORPHICEPTIN[3 (N METHYLPHENYLALANINE) 4 DEXTRO PROLINAMIDE]; MU OPIATE RECEPTOR;

ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG TOLERANCE; IMMUNOHISTOCHEMISTRY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; TAIL FLICK TEST;

EID: 0032485509     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01596-3     Document Type: Article

References (25)

1. Amatruda, J.M., Newmeyer, H.W., Chang, C.L., 1982. Insulin-induced alterations in insulin binding and insulin action in primary cultures of rat hepatocytes. Diabetes 31, 145-148.
2. Arvidsson, U., Riedl, M., Chakrabarti, S., Lee, J.-H., Nakano, A.H., Dado, R.J., Loh, H.H., Law, P.-Y., Wessendorf, M.W., Elde, R., 1995a. Distribution and targeting of a μ-opioid receptor (MOR1) in brain and spinal cord. J. Neurosci. 15, 3328-3341.
3. Arvidsson, U., Dado, R.J., Riedl, M., Lee, J.-H., Law, P.Y., Loh, H.H., Elde, R., Wessendorf, M.W., 1995b. δ-opioid receptor immumoreactivity: Distribution in brainstem and spinal cord and relationship to biogenic amines and enkephalin. J. Neurosci. 15, 1215-1235.
4. Arvidsson, U., Riedl, M., Chakrabarti, S., Vulchanova, L., Lee, J.-H., Nkano, A.H., Lin, X., Loh, H.H., Law, P.-Y., Wessendorf, M.W., 1995c. The κ-opioid receptor is primarily postsynaptic: Combined immunohistochemical localization of the receptor and endogenous opioids. Proc. Natl. Acad. Sci. USA 92, 5062-5066.
5. Chang, K.-J., Wei, E.T., Killian, A., Chang, J.-K., 1983. Potent morphiceptin analogs: Structure-activity relationships and morphine-like activities. J. Pharmacol. Exp. Ther. 227, 403-408.
6. Conn, P.M., Conti, M., Harwood, J.P., Dufau, M.L., Catt, K.J., 1978. Internalization of gonadotropin-receptor complex in ovarian luteal cells. Nature 274, 598-600.
7. Cox, B.M., 1993. Opioid receptor-G protein interactions: Acute and chronic effects of opioids. In: Herz, A., Akil, H., Simon, E. (Eds.), Handbook of Experimental Pharmacology: Opioids, vol. I. Springer-Verlag, Berlin, pp. 145-148.
8. D'Amour, F.E., Smith, D.L., 1941. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72, 74-79.
9. Dado, R.H., Law, P.Y., Loh, H.H., Elde, R., 1993. Immunoflourescent identification of a delta (δ)-opioid receptor on primary afferent nerve terminals. NeuroReport 5, 341-344.
10. Dixon, W.J., 1965. The up and down method for small samples. Am. Stat. Assoc. J. 60, 967-978.
11. Gillan, M.G.C., Kosterlitz, H.W., Paterson, S.J., 1980. Comparison of the binding characteristics of tritiated opiates and opioid peptides. Br. J. Pharmacol. 70, 481-490.
12. Goldfine, I.D., Jones, A.L., Hradek, G.T., Wong, K.Y., Mooney, J.S., 1978. Entry of insulin into human cultured lymphocytes: Electron microscope autoradiographic analysis. Science 202, 760-763.
13. Hsu, S.M., Raine, L., Fanger, H., 1981. The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem. 29, 579-580.
14. James, I.F., Goldstein, A., 1984. Site-directed alkylation of multiple opioid receptors: Binding selectivity. Mol. Pharmacol. 25, 337-342.
15. Lloyd, C.E., Ascoli, M., 1983. On the mechanisms involved in the regulation of the cell-surface receptors for human choriogonadotropin and mouse epidermal growth factor in cultured Leydig tumor cells. J. Cell Biol. 96, 521-526.
16. Puttfarcken, P.S., Werling, L.L., Cox, B.M., 1988. Effects of chronic morphine exposure on opioid inhibition of adenylate cyclase in 7315c cell membranes: A useful model for the study of tolerance at μ. opioid receptor. Mol. Pharmacol. 33, 520-527.
17. Schlessinger, J., Shechter, Y., Cuatrecasas, P., Willingham, M.C., Pastan, I., 1978. Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts. Proc. Natl. Acad. Sci. USA 75, 5353-5357.
18. Tao, P.L., Law, P.Y., Loh, H.H., 1987. Decrease in δ- and μ-opioid receptor binding capacity in rat brain after chronic etorphine treatment. J. Pharmacol. Exp. Ther. 240, 809-816.
19. 5-enkephalin treatment. Brain Res. 462, 313-320.
20. Tao, P.L., Lee, H.Y., Chang, L.R., Loh, H.H., 1990. Decrease in μ-opioid receptor binding capacity in rat brain after chronic PL-017 treatment. Brain Res. 526, 270-275.
21. Tao, P.L., Lue, W.M., Lee, C.R., Chang, L.R., 1995. Alteration of the interaction of mu-opioid receptor and G protein after chronic PL017 treatment in rats. Chin. J. Physiol. 38, 193-199.
22. Taylor, P., Insel, P.A., 1990. Molecular basis of drug action. In: Pratt, W.B., Taylor, P. (Eds.), Principles of Drug Action, 3rd ed. Churchill Livingstone, New York, pp. 103-200.
23. Tempel, A., Gardner, E.L., Zukin, R.S., 1985. Neurochemical and functional correlates of naltrexone-induced opiate receptor up-regulation. J. Pharmacol. Exp. Ther. 232, 439-444.
24. Wolozin, B.L., Pasternak, G.W., 1981. Classification of multiple morphine and enkephalin binding sites in the central nervous system. Proc. Natl. Acad. Sci. USA 78, 6181-6185.
25. Yoburn, B.C., Sierra, V., Lutfy, K., 1989. Chronic opioid antagonist treatment: Assessment of receptor upregulation. Eur. J. Pharmacol. 170, 193-200.