Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord

Journal of Physiology

Volumn 518, Issue 3, 1999, Pages 803-813

  Kohno, T ^a,b   Kumamoto, E ^a   Higashi, H ^c   Shimoji, K ^b   Yoshimura, M ^a  

^a SAGA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; GLYCINE RECEPTOR; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALTRINDOLE; OPIATE; OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR;

AGONIST; ANIMAL CELL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; NERVE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL CORD; SUBSTANTIA GELATINOSA; SYNAPTIC TRANSMISSION; ADULT; ANIMAL TISSUE; EVOKED RESPONSE; GLUTAMATERGIC SYNAPSE; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; MONOSYNAPTIC POTENTIAL; WHOLE CELL PATCH CLAMP;

ANIMALS; BENZENEACETAMIDES; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; EVOKED POTENTIALS; EXCITATORY POSTSYNAPTIC POTENTIALS; MALE; MEMBRANE POTENTIALS; OPIOID PEPTIDES; PATCH-CLAMP TECHNIQUES; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SPINAL CORD; SUBSTANTIA GELATINOSA; SYNAPTIC TRANSMISSION;

EID: 0033178720     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.0803p.x     Document Type: Article

References (43)

1. BABA, H., KOHNO, T., OKAMOTO, M., GOLDSTEIN, P. A., SHIMOJI, K. & YOSHIMURA, M. (1998). Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn. Journal of Physiology 508, 83-93.
2. BESSE, D., LOMBARD, M. C., ZAJAC, J. M., ROQUES, B. P. & BESSON, J. M. (1990). Pre-and postsynaptic distribution of μ, δ and κ opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord. Brain Research 521, 15-22.
3. BICKNELL, H. R. JR & BEAL, J. A. (1984). Axonal and dendritic development of substantia gelatinosa neurons in the lumbosacral spinal cord of the rat. Journal of Comparative Neurology 226, 508-522.
4. COGGESHALL, R. E. & CARLTON, S. M. (1997). Receptor localization in the mammalian dorsal horn and primary afferent neurons. Brain Research Reviews 24, 28-66.
5. COUSINS, M. J. & MATHER, L. E. (1984). Intrathecal and epidural administration of opioids. Anesthesiology 61, 276-310.
6. CRUZ, L. & BASBAUM, A. I. (1985). Multiple opioid peptides and the modulation of pain: immunohistochemical analysis of dynorphin and enkephalin in the trigeminal nucleus caudalis and spinal cord of the cat. Journal of Comparative Neurology 240, 331-348.
7. DANZEBRINK, R. M., GREEN, S. A. & GEBHART, G. F. (1995). Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat. Pain 63, 39-47.
8. DICKENSON, A. H., SULLIVAN, A. F., KNOX, R., ZAJAC, J. M. & ROQUES, B. P. (1987). Opioid receptor subtypes in the rat spinal cord: electrophysiological studies with μ-and δ-opioid receptor agonists in the control of nociception. Brain Research 413, 36-44.
9. DUGGAN, A. W., HALL, J. G. & HEADLEY, P. M. (1977). Suppression of transmission of nociceptive impulses by morphine: selective effects of morphine administered in the region of the substantia gelatinosa. British Journal of Pharmacology 61, 65-76.
10. 3H]diprenorphine binding sites with the laminar pattern of substance P, myelin and nissl staining. Neuroscience 20, 395-407.
11. GAMSE, R., HOLZER, P. & LEMBECK, F. (1979). Indirect evidence for presynaptic location of opiate receptors on chemosensitive primary sensory neurones. Naunyn-Schmiedeberg's Archives of Pharmacology 308, 281-285.
12. 2-, and μ-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord. Journal of Neuroscience 14, 4965-4971.
13. 125I]FK-33-824-labelled mu opioid receptors in the spinal cord of normal and deafferented rats. Neuroscience 43, 197-209.
14. B agonists. Journal of Physiology 507, 473-483.
15. GRUDT, T. J. & WILLIAMS, J. T. (1993). κ-Opioid receptors also increase potassium conductance. Proceedings of the National Academy of Sciences of the USA 90, 11429-11432.
16. GRUDT, T. J. & WILLIAMS, J. T. (1994). μ-Opioid agonists inhibit spinal trigeminal substantia gelatinosa neurons in guinea pig and rat. Journal of Neuroscience 14, 1646-1654.
17. HORI, Y., ENDO, K. & TAKAHASHI, T. (1992). Presynaptic inhibitory action of enkephalin on excitatory transmission in superficial dorsal horn of rat spinal cord. Journal of Physiology 450, 673-685.
18. HUNT, S. P., KELLY, J. S. & EMSON, P. C. (1980). The electron microscopic localization of methionine-enkephalin within the superficial layers (I and II) of the spinal cord. Neuroscience 5, 1871-1890.
19. JEFTINIJA, S. (1988). Enkephalins modulate excitatory synaptic transmission in the superficial dorsal horn by acting at μ-opioid receptor sites. Brain Research 460, 260-268.
20. KEMP, T., SPIKE, R. C., WATT, C. & TODD, A. J. (1996). The μ-opioid receptor (MOR1) is mainly restricted to neurons that do not contain GABA or glycine in the superficial dorsal horn of the rat spinal cord. Neuroscience 75, 1231-1238.
21. KUMAZAWA, T. & PERL, E. R. (1978). Excitation of marginal and substantia gelatinosa neurons in the primate spinal cord: indications of their place in dorsal horn functional organization. Journal of Comparative Neurology 177, 417-434.
22. LEIGHTON, G. E., RODRIGUEZ, R. E., HILL, R. G. & HUGHES, J. (1988). κ-Opioid agonists produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat. British Journal of Pharmacology 93, 553-560.
23. MAGNUSON, D. S. K. & DICKENSON, A. H. (1991). Lamina-specific effects of morphine and naloxone in dorsal horn of rat spinal cord in vitro. Journal of Neurophysiology 66, 1941-1950.
24. MANSOUR, A., FOX, C. A., AKIL, H. & WATSON, S. J. (1995). Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends in Neurosciences 18, 22-29.
25. MANSOUR, A., FOX, C. A., BURKE, S., MENG, F., THOMPSON, R. C., AKIL, H. & WATSON, S. J. (1994). Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. Journal of Comparative Neurology 350, 412-438.
26. MERCHENTHALER, I., MADERDRUT, J. L., ALTSCHULER, R. A. & PETRUSZ, P. (1986). Immunocytochemical localization of proenkephalin-derived peptides in the central nervous system of the rat. Neuroscience 17, 325-348.
27. NINKOVIC, M., HUNT, S. P. & KELLY, J. S. (1981). Effect of dorsal rhizotomy on the autoradiographic distribution of opiate and neurotensin receptors and neurotensin-like immunoreactivity within the rat spinal cord. Brain Research 230, 111-119.
28. NORTH, R. A. (1993). Opioid actions on membrane ion channels. In Handbook of Experimental Pharmacology, vol. 104, ed. HERZ, A., pp. 773-797. Springer, Berlin, Germany.
29. ONOFRIO, B. M. & YAKSH, T. L. (1990). Long-term pain relief produced by intrathecal morphine infusion in 53 patients. Journal of Neurosurgery 72, 200-209.
30. PAN, Z. Z., WILLIAMS, J. T. & OSBORNE, P. B. (1990). Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro. Journal of Physiology 427, 519-532.
31. RAHMAN, W., DASHWOOD, M. R., FITZGERALD, M., AYNSLEYGREEN, A. & DICKENSON, A. H. (1998). Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia. Developmental Brain Research 108, 239-254.
32. RANDIC, M., CHENG, G. & KOJIC, L. (1995). κ-Opioid receptor agonists modulate excitatory transmission in substantia gelatinosa neurons of the rat spinal cord. Journal of Neuroscience 15, 6809-6826.
33. REXED, B. (1952). The cytoarchitectonic organization of the spinal cord in the cat. Journal of Comparative Neurology 96, 415-495.
34. 2+ currents, but spares a sustained current. Neuron 6, 13-20.
35. STEVENS, C. W., LACEY, C. B., MILLER, K. E., ELDE, R. P. & SEYBOLD, V. S. (1991). Biochemical characterization and regional quantification of μ, δ and κ opioid binding sites in rat spinal cord. Brain Research 550, 77-85.
36. VAUGHAN, C. W. & CHRISTIE, M. J. (1997). Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal grey in vitro. Journal of Physiology 498, 463-472.
37. YAJIRI, Y., YOSHIMURA, M., OKAMOTO, M., TAKAHASHI, H. & HIGASHI, H. (1997). A novel slow excitatory postsynaptic current in substantia gelatinosa neurons of the rat spinal cord in vitro. Neuroscience 76, 673-688.
38. YAKSH, T. L. (1983). The spinal actions of opioids. In Handbook of Experimental Pharmacology, vol. 104, ed. HERZ, A., pp. 53-90. Springer, Berlin, Germany.
39. YAKSH, T. L. & RUDY, T. A. (1976). Analgesia mediated by a direct spinal action of narcotics. Science 192, 1357-1358.
40. YOSHIMURA, M. & JESSELL, T. M. (1989). Primary afferent-evoked synaptic responses and slow potential generation in rat substantia gelatinosa neurons in vitro. Journal of Neurophysiology 62, 96-108.
41. YOSHIMURA, M. & NISHI, S. (1993). Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: pharmacological properties of synaptic currents. Neuroscience 53, 519-526.
42. YOSHIMURA, M. & NISHI, S. (1995). Primary afferent-evoked glycine-and GABA-mediated IPSPs in substantia gelatinosa neurones in the rat spinal cord in vitro. Journal of Physiology 482, 29-38.
43. YOSHIMURA, M. & NORTH, R. A. (1983). Substantia gelatinosa neurones hyperpolarized in vitro by enkephalin. Nature 305, 529-530.