Immunolocalization of two mu-opioid receptor isoforms (MOR1 and MOR1B) in the rat central nervous system

Neuroscience

Volumn 82, Issue 2, 1997, Pages 613-622

  Schulz, S ^a   Schreff, M ^a   Koch, T ^a   Zimprich, A ^a   Gramsch, C ^b   Elde, R ^c   Hollt V ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b Gramsch Laboratories   (Germany)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Antibody; Immunocytochemistry; Isoform; Olfactory bulb; opioid receptor

Indexed keywords

ADENYLATE CYCLASE; MU OPIATE RECEPTOR; POLYCLONAL ANTIBODY; RECEPTOR PROTEIN; RECEPTOR SUBTYPE;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; JUXTAGLOMERULAR CELL; MALE; MITRAL CELL; NONHUMAN; OLFACTORY BULB; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; SPINAL CORD DORSAL HORN; TISSUE DISTRIBUTION; TRIGEMINAL NERVE;

EID: 0343145730     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00288-1     Document Type: Article

References (35)

1. Adams J. C. Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains. J. Histochem. Cytochem. 40:1992;1457-1463.
2. Arvidsson U., Dado R. J., Riedl M., Lee J.-H., Law P. Y., Loh H. H., Elde R., Wessendorf M. W. Delta-opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin. J. Neurosci. 15:1995;1215-1235.
3. Arvidsson U., Riedl M., Chakrabarti S., Lee J.-H., Nakano A. H., Dado R., Loh H., Law P.-Y., Wessendorf M., Elde R. Distribution and targeting of a mu opioid receptor (MOR1) in brain and spinal cord. J. Neurosci. 15:1995;3328-3341.
4. Arvidsson U., Riedl M., Chakrabarti S., Vulchanova L., Lee J.-H., Nakano A. H., Lin X., Loh H. H., Law P.-Y., Wessendorf M. W., Elde R. The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids. Proc. natn. Acad. Sci. U.S.A. 92:1995;5062-5066.
5. Bare L. A., Mansson E., Yang D. Expression of two variants of the human μ opioid receptor mRNA in SK-N-SH cells and human brain. Fedn Eur. biochem. Socs Lett. 354:1994;213-216.
6. Berghorn K. A., Bonnett J. H., Hoffmann G. E. cFos immunoreactivity is enhanced with biotin amplification. J. Histochem. Cytochem. 42:1994;1635-1642.
7. Chen C. A., Okayama H. Calcium phosphate-mediated gene-transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA. Biotechniques. 6:1988;632-638.
8. Chen Y., Mestek A., Liu J., Hurley J. A., Yu L. Molecular cloning and functional expression of mu-opioid receptor from rat brain. Molec. Pharmac. 44:1993;8-12.
9. Cote T., Gosse M. E., Weems H. B. Solubilization of high-affinity, guanine nucleotide-selective mu-opioid receptors from 7315c cell membranes. J. Neurochem. 61:1993;973-978.
10. Dado R., Law P. Y., Loh H. H., Elde R. Immunofluorescent identification of a delta-opioid receptor on primary afferent nerve terminals. NeuroReport. 5:1993;341-344.
11. Delfs J. M., Kong H., Mestek A., Chen Y., Yu L., Reisine T., Chesselet M.-F. Expression of mu opioid receptor mRNA in rat brain. An in situ study at the single cell level. J. comp. Neurol. 345:1994;46-68.
12. Eppler C. M., Hulmes J. D., Johnson B., Corbett M., Luthin D. R., Uhl G. R., Linden J. Purification and partial amino acid sequence of a mu opioid receptor from rat brain. J. biol. Chem. 268:1993;26447-26451.
13. Evans C. J., Keith D. J., Morrison H., Magendzo K., Edwards R. H. Cloning of delta opioid receptor by functional expression. Science. 258:1992;1952-1955.
14. Fukuda K., Kato S., Mori K., Nishi M., Takeshima H. Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes. Fedn Eur. biochem. Socs Lett. 327:1993;311-314.
15. Gerald C., Adham N., Kao H. T., Laz T. M., Schechter L. E., Bard J. A., Vaysse P. J., Harting P. R., Branchek T. A. The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants. Eur. molec. Biol. Org. J. 14:1995;2806-2815.
16. Gramsch C., Meo T., Riethmüller G., Herz A. Binding characteristics of a monoclonal beta-endorphin antibody recognizing the N-terminus of opioid peptides. J. Neurophysiol. 40:1983;1220-1226.
17. Grandes P., Mateos J. M., Ruegg D., Kuhn R., Knopfel T. Differential cellular localization of three splice variants of the mGluR1 metabotropic glutamate receptor in rat cerebellum. NeuroReport. 5:1994;2249-2252.
18. Hampson D. R., Theriault E., Huang X. P., Kristensen P., Pickering D. S., Franck J. E., Mulvihill E. R. Characterization of two alternatively spliced forms of a metabotropic glutamate receptor in the central nervous system of the rat. Neuroscience. 60:1994;325-336.
19. Howard A. D., de L. B. S., Gioannini T. L., Stone E. A., Simon E. J. Covalent labeling of opioid receptors with radioiodinated human beta-endorphin. Identification of binding site subunit. J. biol. Chem. 260:1994;10833-10839.
20. Kaneko T., Minami M., Satoh M., Mizuno N. Immunocytochemical localization of μ-opioid receptor in the rat caudate-putamen. Neurosci. Lett. 184:1995;149-152.
21. Kieffer B. L., Befort K., Gaveriaux R. C., Hirth C. G. The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc. natn. Acad. Sci. U.S.A. 89:1992;12048-12052.
22. Mansour A., Fox C. F., Burke S., Akil H., Watson S. J. Immunohistochemical localization of the cloned μ opioid receptor in the rat CNS. J. chem. Neuroanat. 8:1995;283-305.
23. Mansour A., Fox C. F., Thompson R. C., Akil H., Watson S. J. Mu-opioid receptor mRNA expression in the rat CNS: comparison to mu-receptor binding. Brain Res. 643:1994;245-265.
24. Mansour A., Khachaturian H., Lewis M. E., Akil H., Watson S. J. Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain. J. Neurosci. 7:1987;2445-2464.
25. Mayer P., Schulzeck S., Kraus J., Zimprich A., Höllt V. Promotor region and alternatively spliced exons of the rat mu opioid receptor gene. J. Neurochem. 66:1996;2272-2278.
26. Namba T., Sugimoto Y., Negishi M., Irie A., Ushikubi F., Kakizuka A., Ito S., Ichikawa A., Narumiya S. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specifity. Nature. 365:1993;166-170.
27. Pin J. P., Waeber C., Prezeau L., Bockaert J., Heinemann S. F. Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. Proc. natn. Acad. Sci. U.S.A. 89:1992;10331-10335.
28. Raychowdhury M. K., Yukawa M., Collins L. J., McGrail S. H., Kent K. C., Ware J. A. Alternative splicing produces a divergent cytoplasmatic tail in the human endothelial thromboxane A2 receptor. J. biol. Chem. 269:1994;19256-19261.
29. Shuler K. R., Dunham R. G., Kanda P. A simplified method for determination of protein-protein molar ratios using amino acid analysis. J. immun. Meth. 156:1992;137-149.
30. Thompson R. C., Mansour A., Akil H., Watson S. J. Cloning and pharmacological characterization of a rat mu opioid receptor. Neuron. 11:1993;903-913.
31. Vanetti M., Vogt G., Höllt V. The two isoforms of the mouse somatostatin receptor (mSSTR2A and mSSTR2B) differ in coupling efficiency to adenylate cyclase and in agonist-induced receptor desensitization. Fedn Eur. biochem. Socs Lett. 331:1993;260-266.
32. Vanetti M., Kouba M., Wang X., Vogt G., Höllt V. Cloning and expression of a novel mouse somatostatin receptor (SSTR2B). Fedn Eur. biochem. Socs Lett. 311:1992;290-294.
33. Wahle P., Sanides-Kohlrausch C., Meyer G., Lubke J. Substance P- and opioid-immunoreactive structures in olfactory centers of the cat: adult pattern and postnatal development. J. comp. Neurol. 302:1990;349-369.
34. 2+ mobilization. NeuroReport. 7:1995;54-56.
35. Zimprich A., Simon T., Höllt V. Cloning and expression of an isoform of the rat mu opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1. Fedn Eur. biochem. Socs Lett. 359:1995;142-146.